一种双功能的含呋喃和异噁唑环酰腙Cu(Ⅱ)配合物的合成及其性能研究

合成了一种含异噁唑环和呋喃环的新型酰腙的Cu(Ⅱ)配合物,通过红外、紫外光谱和荧光光谱等研究了该配合物的结构及其性质,同时测定了铜配合物对枯草芽孢杆菌、绿脓杆菌、大肠杆菌和金黄色葡萄球菌的抑菌活性。结果表明,铜配合物的水溶液在484 nm处呈现一强蓝色荧光发射峰。铜配合物有较好的抑菌效果,其抑菌活性明显优于配体。该配合物兼有荧光性能和抑菌活性,可应用在材料科学、光动力学疗法等领域。     

N-苯甲酰基-N'-芳基硫脲与铜的配合物的合成及抑菌性研究

以N-苯甲酰基-N'-芳基硫脲和氯化铜为原料,在乙醇中合成了4种未见报道的标题配合物,通过元素分析、红外、紫外及荧光光谱和循环伏安法等对配合物进行了表征,初步确定其组成为[Cu(L)2Cl2]并推测了结构。对金黄色葡萄球菌、枯草芽孢杆菌以及大肠杆菌的抑菌活性测试结果表明,合成的4种配合物均有抑菌活性,且抑菌活性强于相应的配体,其中苯环上为双甲氧基取代的配体及其与铜的配合物对金黄色葡萄球菌的抑制能力强于其他配合物和配体。实验还发现配体的抑菌活性随配体取代基推电子能力呈规律性变化,配体中推电子取代基的数目和推电子能力是影响配合物抑菌活性的主要因素。     

5-溴水杨醛Sclliff碱及其铜（Ⅱ）配合物的表征和抑菌活性的研究

合成了2种新5-溴水杨醛亚胺Schiff碱配体及其与铜(Ⅱ)的2种新配合物，其结构与组成由元素分析和红外光谱所表征。初步抑菌实验表明，这4种化合物对多种菌株有明显的抑菌活性。且比结构改造前的水杨醛亚胺合铜(Ⅱ)配合物具有抗菌谱广、活性高等特点。     

间硝基苯胺水杨醛Schiff碱过渡金属配合物的合成及性质

合成了4种间硝基苯胺水杨醛Schiff碱过渡金属配合物,其结构经UV-Vis、IR、元素分析、摩尔电导率测定等表征。荧光光谱表明,4种配合物都能强烈猝灭牛血清白蛋白（BSA）的内源荧光。生物活性实验表明,配合物对金黄色葡萄球菌（S.aureus）、大肠杆菌（E.coli）、枯草芽孢杆菌（B.subtilis）、绿脓杆菌（P.aeruginosa）均有不同程度的抑菌作用,其中对绿脓杆菌的抑菌活性较强。4种配合物的抑菌活性均大于配体的抑菌活性。     

一种新型三氮唑及其铜配合物的合成与表征

采用两种方法首次成功合成了3-(5’-甲基-4-异噁唑基)-4-氨基-5-巯基-(4H)-1,2,4-三氮唑,并以其为配体进一步合成了铜配合物。通过1H NMR、IR等对配体和铜配合物结构进行表征确认,并测定了其抑菌活性。结果表明配体和铜配合物对枯草芽孢杆菌、大肠杆菌和金黄色葡萄球菌等菌种都有抑菌活性,而铜配合物的抑菌活性比配体更强。     

两种赖氨酸水杨醛Schiff碱稀土金属配合物的合成及表征

采用逐滴反应法合成了两种新型的赖氨酸水杨醛Schiff碱稀土金属配合物[In(Lys-Sal)、Th(Lys-Sal)]。应用电导率测定、元素分析、红外光谱、紫外光谱等方法表征,讨论了配合物的可能组成和结构,并进行抑菌活性的相关探究,结果表明配合物对大肠杆菌、金黄色葡萄球菌、绿脓杆菌及枯草杆菌有较好的抑菌活性。     

2-羟基-1-萘甲醛缩2,6-二氨基吡啶钍的席夫碱配合物的合成及其抑菌活性的研究

合成了2-羟基-1-萘甲醛缩2,6-二氨基吡啶席夫碱配体L,与硝酸钍反应,生成配合物ThL,研究了配体L和配合物ThL的抗菌活性。结果表明,配体L和配合物ThL对枯草杆菌、大肠杆菌、乳酸菌有良好的抑制作用,配合物ThL的抑菌活性好于配体L,最佳抑菌活性浓度是5 mmol/L。     

5-溴水杨醛Schiff碱及其铜(Ⅱ)配合物的表征和抑菌活性的研究

合成了2种新5溴水杨醛亚胺Schiff碱配体及其与铜(Ⅱ)的2种新配合物,其结构与组成由元素分析和红外光谱所表征。初步抑菌实验表明,这4种化合物对多种菌株有明显的抑菌活性,且比结构改造前的水杨醛亚胺合铜(Ⅱ)配合物具有抗菌谱广、活性高等特点。     

赖氨酸水杨醛Schiff碱Ni(Ⅱ)配合物的合成及表征

采用逐滴反应法合成了一种新的L-赖氨酸水杨醛Schiff碱金属配合物[Ni(Lys-Sal)]。应用电导率测定、元素分析、紫外光谱、红外光谱等表征方法,讨论了配合物的可能组成和结构,并进行抑菌活性的相关探究,结果表明,配合物对金黄色葡萄球菌、大肠杆菌、枯草杆菌及绿脓杆菌的抑菌活性较差。     

水-甲苯体系中三唑酮铜配合物的合成、表征及抑菌活性

在水-甲苯体系中,合成了三唑酮与氯化铜配合物.用元素分析、红外光谱、摩尔电导,热重分析对配合物进行了表征,并推测了配合物的结构.同时还测定了配合物和配体三唑酮的抑菌活性.结果表明:配合物具有较好的抑菌活性,其中对丝核菌的活性优于三唑酮.     

纳米Ce/TiO2无机抗菌剂的制备及其性能评价

以纳米锐钛矿型TiO2粉体和硝酸铈为原料,采用浸渍法制备了纳米Ce/TiO2无机抗菌剂,运用抑菌圈法对其抗菌性能进行了评价,并对其抗菌机理进行了探讨. 结果表明,制备得到的纳米Ce/TiO2无机抗菌剂在黑暗中具有优异的抗菌性能,其抗菌机理为稀土元素铈离子溶出抗菌.     

Metal complexes of diisopropylthiourea: synthesis, characterization and antibacterial studies

Co(II), Cu(II), Zn(II) and Fe(III) complexes of diisopropylthiourea have been synthesized and characterized by elemental analyses, molar conductivity, magnetic susceptibility, FTIR and electronic spectroscopy. The compounds are non-electrolytes in solution and spectroscopic data of the complexes are consistent with 4-coordinate geometry for the metal(II) complexes and six coordinate octahedral for Fe(III) complex. The complexes were screened for their antibacterial activities against six bacteria: Escherichia coli, Pseudomonas auriginosa, Klebsiella pneumoniae, Bacillus cereus, Staphylococcus aureus and Bacillus pumilus. The complexes showed varied antibacterial activities and their minimum inhibitory concentrations (MICs) were determined.     

氯化N-苄基-4-乙烯基吡啶聚合物的抗菌活性

氯化N-烷基-4-乙烯基吡啶聚合物,简称可溶性PVP,是一类具有高活性、低毒性和诸多潜在的特殊用途的季铵盐抗菌材料.本研究对聚-N-苄基乙烯基吡啶进行了合成与提纯,并对其在不同物理化学条件下抗菌性能差异进行了研究,结果表明温度、溶液条件等因素的变化对于样品的抗菌性能有重大影响.     

Studies on Some New Ru(III) Complexes Using aryl-azo Pentane- 2,4-dione and 2,6-bis (2'-Benzimidazolyl) Pyridine as Ligands: Synthesis, Spectroscopic, Luminescent, Electrochemical and Biological Activities

Some ruthenium(III) complexes with aryl-azo 2,4-pentanedione as co-ligands (L(1)H - L(3)H(2)) have been synthesized and characterized spectroscopically IR, (1)H NMR, UV/Vis, ESR, conductimetric) along with elemental analysis and FAB-mass data. Their luminescent and redox properties have been studied. The antibacterial, anti-HIV and antitmnour activities have also been reported.     

Chemical,biological, and antibacterial characterization of silica glass containing silver and gold nanoparticles

The aim of this study has been the preparation of sol‐gel glasses with potential antibacterial properties. Bioactive glasses containing different percentages of silver and gold nanoparticles have been synthesized via the sol‐gel method. The obtained glasses have 0.5, 1, 1.5, and 2 wt% silver as well as a constant amount of gold nanoparticles (AuNP) added as colloidal solution (15 wt%). Fourier Transform Infrared (FTIR) spectroscopy was used to characterize the materials. Scanning electron microscopy (SEM) has been used to investigate the surface of each sample. Moreover, the materials have been characterized in order to verify their antibacterial activities as well as their bioactivity and cytocompatibility as a function of Ag and Au content. SEM/EDX analysis has shown that the samples are bioactive because they are able to stimulate hydroxyapatite nucleation on their surface when soaked in a simulated body fluid (SBF). WST‐8 assay of 3T3 cells, placed in contact with the material extracts, has showed that the glass does not induce cytotoxicity. Staphylococcus epidermidis and Pseudomonas aeruginosa strains have been used for the evaluation of the antibacterial properties of each sample. The experimental data have shown that all synthesized materials have antibacterial activity. However, the two bacterial strains respond differently to the materials. The data show that the presence of AuNP causes a decrease in the antibacterial activity of Ag⁺ ions.     

3,4,5-三甲氧基苯甲醛缩乙醇胺席夫碱合成,表征与抑菌活性研究

合成了3,4,5-三甲氧基苯甲醛缩乙醇胺席夫碱,并对其进行了结构表征,初步确认了其组成,抑菌实验表明该席夫碱对枯草杆菌、大肠杆菌、金黄色葡萄球菌、革兰氏阴性细菌(发荧光Q67)均有较好的抑制作用。     

对氟苯甲醛缩乙醇胺席夫碱合成、表征及抑菌活性的测试

通过对氟苯甲醛与乙醇胺的反应，合成了对氟苯甲醛缩乙醇胺席夫碱，并对其进行了元素分析、核磁共振氢谱、红外光谱、紫外光谱表征。抑菌实验表明，该席夫碱对金黄色葡萄球菌和革兰氏阴性菌均有较好的抑制作用。     

Antimicrobial Activities of LL-37 Fragment Mutant-Poly (Lactic-Co-Glycolic) Acid Conjugate against Staphylococcus aureus,Escherichia coli,and Candida albicans

Various peptides and their derivatives have been reported to exhibit antimicrobial activities. Although these activities have been examined against microorganisms, novel methods have recently emerged for conjugation of the biomaterials to improve their activities. Here, we prepared CKR12-PLGA, in which CKR12 (a mutated fragment of human cathelicidin peptide, LL-37) was conjugated with poly (lactic-co-glycolic) acid (PLGA), and compared the antimicrobial and antifungal activities of the conjugated peptide with those of FK13 (a small fragment of LL-37) and CKR12 alone. The prepared CKR12-PLGA was characterized by dynamic light scattering and measurement of the zeta potential, critical micellar concentration, and antimicrobial activities of the fragments and conjugate. Although CKR12 showed higher antibacterial activities than FK13 against Staphylococcus aureus and Escherichia coli, the antifungal activity of CKR12 was lower than that of FK13. CKR12-PLGA showed higher antibacterial activities against S. aureus and E. coli and higher antifungal activity against Candida albicans compared to those of FK13. Additionally, CKR12-PLGA showed no hemolytic activity in erythrocytes, and scanning and transmission electron microscopy suggested that CKR12-PLGA killed and disrupted the surface structure of microbial cells. Conjugation of antimicrobial peptide fragment analogues was a successful approach for obtaining increased microbial activity with minimized cytotoxicity.     

Antibacterial and Bacterium Adsorbing Macromolecules

Currently studies on antibacterial macromolecules, i. e., bactericidal and bacteriostatic ones, have been made to develop a new utilization field of polymeric materials. In these studies, there are immobilizations of iodine to quaternary ammonium salts, antibiotics, antibacterial groups to macromolecular substances, as well as syntheses of polymers with quaternary ammonium salts, biguanide groups, quaternary pyridinium salts, sulphonium salts, phosphonium salts, and other antibacterial groups. On the other hand, studies have been made of bacterium adsorbing macromolecules, which can remove by adsorbing bacterial cells in water. The macromolecules are the ones based on poly(4‐vinylpyridine‐co‐divinylbenzene), crosslinked poly(3‐ and 4‐chloromethylated styrene‐g‐amine), and poly(glycidyl methacrylate‐g‐amine), as well as filters and microporous membranes are covered with a macromolecule based on quaternized poly(4‐vinylpyridine‐co‐styrene). Here, a review is made of the syntheses and preparation of the respective macromolecules, as well as of their antibacterial activities and the bacterium adsorbing activities.     

新型草酸根桥联的锌(Ⅱ)-铁(Ⅲ)异四核配合物的合成、表征及杀菌活性

合成了两种草酸根桥联的异四核配合物[Zn3Fe(C2O4)3(Mephen)6](CIO4)3(1)和[Zn3Fe(C2O4)3(NO2phen](CIO4)3(2),其中Mephen代表5－甲基－1,10－邻菲咯啉;NO2phen代表5－硝基－1,10－邻菲咯啉。通过元素分析、摩尔电导和红外光谱等方法对配合物进行了表征,推定了配合物具有草酸根桥联结构。生物活性试验发现异四核配合物的杀菌活性明显优于桥配体的杀菌活性。