Osteoclastogenesis inhibitory factor (OCIF)/OPG

A novel cytokine termed osteoclastogenesis inhibitory factor (OCIF) was purified to homogeneity from conditioned medium of human embryonic lung fibroblasts. OCIF is a heparin-binding basic glycoprotein with Mr of 60 kDa for a monomer and 120 kDa for a homodimer. OCIF specifically inhibits osteoclastogenesis in vitro and increases bone mineral density and bone volume in normal rats. The cloning of OCIF cDNA revealed that OCIF is a soluble member of the tumor necrosis factor receptor (TNFR) superfamily consisting of four cystein-rich domains, two death domain homologous regions (DDHs), and C-terminal basic domain. Mutational analysis of OCIF revealed that N-terminal portion of OCIF consisting of four cystein-rich domains is sufficient to inhibit osteoclastogenesis. OCIF inhibits osteoclastogenesis by binding to the sites expressed on osteoblastic cells and interrupting cell-to-cell signaling between osteoblastic cells and osteoclast progenitors.     

新型太阳能选择性吸收薄膜Cu/SS-TiON(HMVF)/SS-TiON(LMVF)/Al_2O_3的制备与光学性能

对应用于太阳能光热领域的TiO_2进行掺氮,并与不锈钢(stainless steel,SS)复合,采用磁控溅射法制备SS-TiON(HMVF,high metal volume fraction)/SS-TiON(LMVF,low metal volume fraction)串联双吸收层,并制备4层结构的太阳能光谱选择性吸收光热薄膜Cu/SS-TiON(HMVF)/SS-TiON(LMVF)/Al_2O_3。利用紫外–可见分光光度计、红外光谱仪、吸收率发射率测试仪、X射线光电子能谱仪与原子力显微镜等表征该太阳能光热吸收薄膜的光学性能、成分、结构与形貌。结果表明,通过优化双吸收层的厚度与成分,沉积在Al基底上的Cu/SS-TiON(HMVF)/SS-TiON(LMVF)/Al_2O_3太阳能选择性吸收薄膜,具有较高的吸收率(0.902)和较低的发射率(0.052)。该膜系经400℃高温条件下大气退火2 h后,由于出现晶粒团聚现象,光学性能有所下降。