Adsorption isotherm of ibuprofen on molecular imprinted polymer

A molecular imprinted polymer (MIP) using (+)-(S)-2-(4-isobutylphenyl) propionic acid ((+)-(S)-ibuprofen) as the template and 4-vinylpyridine (4-VPY) as the functional monomer was prepared. Chloroform and acetonitrile were used as the porogen with ethylene glycol dimethacrylate (EGDMA) as the crosslinker and 2,2′-azobis(isobutyronitrile) (AIBN) as the initiator. Comparison of ibuprofen adsorption isotherm on molecular imprinted and blank polymers was made by the static method. The adsorption equilibrium data were correlated into the Freundlich, Langmuir, Sips (Langmuir-Freundlich) and Radke-Prausnitz isotherm models, respectively. By a nonlinear regression analysis, the experimental parameters in the equilibrium isotherms were estimated and compared. The calculated data is well fitted with the experimented data. Through the analysis, the ibuprofen imprinted polymer showed higher adsorption ability than blank polymer.     

Comparison of adsorption equilibrium of glycyrrhizic acid and liquiritin on C18 column

The adsorption isotherms of glycyrrhizic acid (GA) and liquiritin (LQ) on a C₁₈ column were compared and the competitive adsorption of the two compounds was investigated. The experimental parameters in the equilibrium isotherms were estimated by linear and nonlinear regression analyses. The adsorption equilibrium data were correlated into the linear, Langmuir, competitive Langmuir, Freundlich, and Langmuir–Freundlich isotherm models. Over a moderate concentration range, the competitive Langmuir isotherm provided the best fit to the experimental data. The regression coefficients of the competitive Langmuir adsorption isotherms were 0.9754 and 0.9855 for the mixtures of GA and LQ, respectively. The coefficients obtained for the five isotherm models confirmed the superiority of the competitive Langmuir isotherm for analyzing the adsorption data of solutes.     

Competitive adsorption of protocatechuic acid and caffeic acid on C18 particles

Comparisons of protocatechuic acid (PA) and caffeic acid (CA) adsorption isotherm on C₁₈ column and competitive adsorption of the two compounds were investigated. By linear and nonlinear regression analysis, the experimental parameters in the equilibrium isotherms were estimated. Adsorption equilibrium data of the two compounds were investigated using six different models including linear, Langmuir, Freundlich, Langmuir-Freundlich, competitive Langmuir and Quadratic. In the moderate range of concentrations, the competitive Langmuir isotherm proved to be the best model for these experimental data. The regression coefficients of the competitive Langmuir adsorption isotherms were 0.9860 for PA and 0.9898 for CA, respectively. The coefficients obtained for the six isotherm models confirmed the superiority of the competitive Langmuir isotherm for analyzing the competitive adsorption data of solutes.     

Synthesis and characterization of a surface imprinting silica gel polymer functionalized with phosphonic acid groups for selective adsorption of Fe(III) from aqueous solution

A Fe(III) ion‐imprinted silica gel polymer functionalized with phosphonic acid groups (IIP‐PA/SiO₂) was prepared with surface imprinting technique by using Fe(III) ion as template ion, grafted silica gel as support, and vinylphosphonic acid as functional monomer. The polymer was characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, Brunauer–Emmett–Teller, and thermogravimetric analysis. The synthesized imprinted silica gel polymer was used as a sorbent for Fe(III) adsorption. The adsorption properties, such as the effect of solution pH, adsorption kinetic, adsorption isotherm, adsorption selectivity as well as the regeneration of sorbent were studied. The results showd that the prepared sorbent (IIP‐PA/SiO₂) had a short adsorption equilibrium time (12 min) and high adsorption capacity (29.92 mg g^?1) for Fe(III) at the optimal pH of 2.0. The selectivity coefficients of the sorbent for Fe(III) in presence of Cr(III), M_n (II), and Zn(II) were 51.76, 27.86, and 207. 76, respectively. Moreover, the adsorption capacity of the prepared sorbent did not decrease significantly after six repeated use. Thus, the prepared ion‐imprinted silica gel polymer was a promising candidate sorbent for the selective adsorption of Fe(III) from aqueous solutions. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134 , 45165.     

Solid extraction of caffeine and theophylline from green tea by molecular imprinted polymers

This paper involves a feasibility study on using molecular imprinted polymers as the sorbent materials in solid phase extraction for caffeine and theophylline from green tea. Two kinds of MIPs, with caffeine-theophylline mixture and pentoxifylline-theophylline mixture as the templates respectively, MAA as the monomer, EDMA as the crosslinker and ATBN as the initiator, were applied to this purpose. Mixture solution of caffeine and theophylline (1 Μg/ ml in acetonitrile) was applied to the solid extraction cartridges following a load, wash and elute procedure with acetonitrile, methanol, methanol-acetic acid (90/10, v/v) as the solvents, respectively. This solid phase extraction protocol was applied for extraction of caffeine and theophylline from green tea. Comparison between the results obtained with the MIPs cartridges and a traditional C₁₈ reversed-phase cartridge was made. It showed that the MIP-based sorbent on the solid phase extraction was comparable with that of C₁₈ material. HPLC analysis using a C₁₈ column (5 Μm, 250× 4.6 mm from Rstech corporation), methanol: water (60 :40, v/v) as the mobile phase at a flow rate of 0.6 ml/min was applied for the quantitative determination.     

Preparation and evaluation of magnetic imprinted polymers for 2,4,6‐trinitrotoluene by surface imprinting

A safe and facile approach for the preparation of magnetic molecularly imprinted polymer nanospheres for 2,4,6‐trinitrotoluene (TNT) recognition is reported. The imprinted nanospheres were synthesized using TNT as the imprinting molecule, acrylamide as the functional monomer, N,N'‐methylenebisacrylamide as the crosslinker and magnetic particles as the support. The structure of the materials was identified via Fourier transform infrared spectroscopy, X‐ray photoelectron spectroscopy and transmission electron microscopy. Static adsorbing experiments were carried out and Scatchard plot analysis showed that two kinds of receptor sites were formed in the imprinted materials. The adsorption equilibrium constant and the maximum adsorption capacity were evaluated. These results indicated that the imprinted nanospheres have higher adsorption capacity and selectivity for TNT than non‐imprinted polymer nanospheres with the same composition. © 2013 Society of Chemical Industry     

Chitosan-based magnetic molecularly imprinted polymer: synthesis and application in selective recognition of tricyclazole from rice and water samples

A tricyclazole selective chitosan/Fe₃O₄ magnetic molecularly imprinted polymer (MMIP) was synthesized using non-covalent binding polymerization involving methacrylic acid (MAA) as functional monomer, divinylbenzene (DVB-80) as crosslinker, 2,2'-azobisisobutyronitrile as initiator, acetonitrile/toluene (75:25, v/v) as porogenic solvent and tricyclazole as template. Surface morphology and magnetic characterization of the prepared imprinted and non-imprinted polymers were done using scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectrometry and vibrating sample magnetometry, respectively. The adsorption kinetic data fitted best in pseudo-second-order model. The adsorption equilibrium was achieved in 30 min and the maximum binding capacity was 4579.9 µg/g. The Freundlich isotherm model was found suitable for explaining the binding isotherm data (R² > 0.99). Negative values of thermodynamic parameters ∆G (Gibb’s free energy), ∆H (enthalpy), and ∆S (entropy) revealed exothermic and spontaneous nature of adsorption processes. It also revealed decreased randomness at the solid–liquid interface during sorption. The scatchard plot analysis suggested heterogeneity of binding sites on MMIPs. The molecular recognition selectivity of MMIPs towards tricyclazole was much higher, as compared to its structural analogues, tebuconazole (α = 28.58) and hexaconazole (α = 37.16). The MMIPs were successfully applied to separate and enrich tricyclazole from fortified samples of rice and water, with a recovery percentage of 89.4% and 90.9%, respectively. These reusable imprinted polymers possessing high selectivity and specificity can be utilized as an adsorbent for solid-phase extraction in sample preparation for tricyclazole residue analysis in complex environmental matrices.

     

Caffeine Molecular Imprinted Microgel Spheres by Precipitation Polymerization

Imprinted uniform microgel spheres were prepared by precipitation polymerization. Acetonitrile was used as the dilute solvent with MAA as the monomer, EDMA as the crosslinker and caffeine as the print molecule. Comparison of caffeine adsorption on molecular imprinted and blank microgel spheres was made. Langmuir model was used to fit the adsorption data. It was found that the caffeine imprinted microgel spheres show specific binding sites to the target molecules. A binding study of caffeine on imprinted microgel spheres was made by Scatchard analysis; the dissociation constants (K_D) and the maximum binding capacity were K_D= 1.84×10⁻⁴mol/L,Q _max = 16.98 μmol/g for high affinity binding site and K_D=1.33×l0⁻³ mol/L, Q_max=46.84 μmol/g for lower affinity binding site, respectively This microgel spheres can be useful affinity adsorbents in further applications.     

Nonlinear isotherm of benzene and its derivatives by frontal analysis

Adsorption behavior of a solute is one of the most important factors to consider when designing a batch and a continuous liquid chromatographic separation process. In liquid chromatography, this behavior is based on the adsorption equilibrium between the liquid mobile-phase and solid stationary-phase. However, most retention models have been developed under a linear adsorption isotherm: very few researchers have investigated the relationship between the adsorption parameters and the mobile phase composition, and some empirical models have been introduced. In this work, adsorption isotherms were obtained by a frontal analysis for three small molecular compounds (benzene, toluene, and chlorobenzene) on a commercial C₁₈ bonded silica column. The absorption based on the Langmuir, Freundlich, and Langmuir-Freundlich models were investigated according to changes of the composition of methanol highly enriched eluent. The calculations and analysis of the coefficients obtained for the three models confirm that the adsorption data for solutes are best modeled with the Langmuir-Freundlich isotherm. In spite of the acceptable accuracy, Langmuir and Freundlich isotherm models couldn’t satisfactorily describe the mechanism and provide objective information on the physical nature of the absorption.     

Highly effective surface molecularly imprinted polymer for the solid-phase extraction of dihydroquercetin from Prince’s-feather Fruit sample

Highly selective surface molecularly imprinted polymer (DHQ-MPS/SiO₂) for dihydroquercetin (DHQ) was synthesized by molecular imprinting technique on modified silica particles for solid-phase extraction (SPE). The prepared DHQ-MPS/SiO₂ was characterized by Fourier transform infrared spectrometer (FT-IR) and transmission electron microscope (SEM) techniques. Interactions between the functional monomer and template were observed with UV-visible spectroscopy of the solutions of these components as well. The results indicated that a 1:2 molecular complex was formed between DHQ and 2-vinylpridine. The static adsorption experiments indicated that DHQ-MPS/SiO₂ had significantly higher adsorption capacity for DHQ than its non-imprinted polymers (NIP-MPS/SiO₂) and revealed that the Langmuir equation fitted the adsorption isotherm data. The thermodynamics parameters indicated that the binding system for DHQ-MPS/SiO₂ was endothermic and entropy was gained and was spontaneous. The selectivity coefficients of DHQ-MPS/SiO₂ for DHQ in relation to competition species apigenin (API) and rutin (RUT) were 2.1 and 4.9, respectively, which suggested that DHQ-MPS/SiO₂ had high recognition selectivity and binding affinity for the template DHQ. The application of DHQ-MPS/SiO₂ as a selective sorbent material for extraction of DHQ from Prince’s-feather Fruit sample showed that DHQ was well separated and the recovery rate was 79.6%, demonstrating the suitability of the technique for the extraction in real samples.     

Synthesis of novel copper ion-selective material based on hierarchically imprinted cross-linked poly(acrylamide-co-ethylene glycol dimethacrylate)

A novel hierarchically imprinted cross-linked poly(acrylamide-co-ethylene glycol dimethacrylate) using a double-imprinting approach for the Cu²⁺ selective separation from aqueous medium was prepared. In the imprinting process, both Cu²⁺ ions and surfactant micelles (cetyltrimethylammonium bromide – CTAB) were employed as templates. The hierarchically imprinted organic polymer named (IIP-CTAB), single-imprinted (IIP-no CTAB) and non-imprinted (NIP-CTAB and NIP-no CTAB) polymers were characterized by SEM, FTIR, TG, elemental analysis and textural data from BET (Brunauer–Emmett–Teller) and BJH (Barrett–Joyner–Halenda). Compared to these materials, IIP-CTAB showed higher selectivity, specific surface area and adsorption capacity toward Cu²⁺ ions. Good selectivity for Cu²⁺ was obtained for the Cu²⁺/Cd²⁺, Cu²⁺/Zn²⁺ and Cu²⁺/Co²⁺ systems when IIP-CTAB was compared to the single-imprinted (IIP-no CTAB) and non double-imprinted polymer (NIP-CTAB), thereby confirming the improvement in the polymer selectivity due to double-imprinting effect. For adsorption kinetic data, the best fit was provided with the pseudo-second-order model for the four materials, thereby indicating the chemical nature of the Cu²⁺ adsorption process. Cu²⁺ adsorption under equilibrium was found to follow dual-site Langmuir–Freundlich model isotherm, thus suggesting the existence of adsorption sites with low and high binding energy on the adsorbent surface. From column experiments 600 adsorption–desorption cycles using 1.8 mol L⁻¹ HNO₃ as eluent confirmed the great recoverability of adsorbent. The synthesis approach here investigated has been found to be very attractive for the designing of organic ion imprinted polymer and can be expanded to the other polymers to improve performance of ion imprinted polymers in the field of solid phase extraction.     

Preparation and characterization of monodisperse molecularly imprinted polymer microspheres by precipitation polymerization for kaempferol

A new kind of molecularly imprinted polymer (MIP) microspheres for the selective extraction of kaempferol was prepared by precipitation polymerization using 4-vinylpridine (4-VP) and ethylene glycol dimethacrylate (EDMA) as functional monomer and cross-linker respectively. The synthesis conditions, such as ratios of 4-VP/EDMA and polymerization time were discussed in detail. Results showed that the 2% was the optimal concentration of co-monomers to obtain monodisperse MIP microspheres, the best ratio of 4-VP/EDMA was 1:2, and 24 h was considered as the proper polymerization time. Compared with the MIP agglomeration or coagulum particles, monodisperse MIP microspheres showed the better adsorption capacity: the saturated adsorption capacity of monodisperse MIP microspheres was 7.47 mg g^?1, the adsorption equilibrium could be obtained in 30 min. Finally, the adsorption performances of the optimal MIP microspheres were evaluated by kinetic adsorption, adsorption isotherm, and selective adsorption experiments, which indicated that the adsorption mechanism were chemical single layer adsorption and the separation factor was up to 3.91 by comparing with the structure similar compound (quercetin). The MIP microspheres exhibit prospects in the kaempferol efficient and selective separation.     

Grafting of molecularly imprinted polymers from the surface of Fe3O4 nanoparticles containing double bond via suspension polymerization in aqueous environment: A selective sorbent for theophylline

Molecularly imprinted polymers (MIPs) were grafted from the surface of Fe₃O₄ nanoparticles containing double bond via suspension polymerization in aqueous environment, and the leakage of Fe₃O₄ nanoparticles from MIPs was overcome in this study. The effect of different cross‐linker on adsorption capacity of the resultant magnetic MIPs was investigated using pure trimethylolpropane trimethacrylate (TRIM) or the mixture of TRIM and divinylbenzene (DVB) as cross‐linker. Both magnetic MIPs exhibited higher adsorption capacity for the template theophylline than the corresponding non‐imprinted polymer, and Freundlich model fitted reasonably well for theophylline adsorption on both magnetic MIPs. In addition, both magnetic MIPs exhibited good recognition properties for the template theophylline versus caffeine, and the selectivity of magnetic MIPs using pure TRIM as cross‐linker (mag‐MIP‐TRIM) was much higher than those using the mixture of TRIM and DVB as cross‐linker (mag‐MIP‐TRIM and DVB). The adsorption dynamics of theophylline on both magnetic MIPs fitted well with the first‐order kinetic model, but the adsorption equilibrium on mag‐MIP‐TRIM and DVB reached faster than that on mag‐MIP‐TRIM. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011     

Adsorption Studies of Volatile Organic Compound (Naphthalene) from Aqueous Effluents: Chemical Activation Process Using Weak Lewis Acid,Equilibrium Kinetics and Isotherm Modelling

This study deals with the preparation of activated carbon (CDSP) from date seed powder (DSP) by chemical activation to eliminate polyaromatic hydrocarbon—PAHs (naphthalene—C₁₀H₈) from synthetic wastewater. The chemical activation process was carried out using a weak Lewis acid of zinc acetate dihydrate salt (Zn(CH₃CO₂)₂·2H₂O). The equilibrium isotherm and kinetics analysis was carried out using DSP and CDSP samples, and their performances were compared for the removal of a volatile organic compound—naphthalene (C₁₀H₈)—from synthetic aqueous effluents or wastewater. The equilibrium isotherm data was analyzed using the linear regression model of the Langmuir, Freundlich and Temkin equations. The R² values for the Langmuir isotherm were 0.93 and 0.99 for naphthalene (C₁₀H₈) adsorption using DSP and CDSP, respectively. CDSP showed a higher equilibrium sorption capacity (q_e) of 379.64 µg/g. DSP had an equilibrium sorption capacity of 369.06 µg/g for C₁₀H₈. The rate of reaction was estimated for C₁₀H₈ adsorption using a pseudo-first order, pseudo-second order and Elovich kinetic equation. The reaction mechanism for both the sorbents (CDSP and DSP) was studied using the intraparticle diffusion model. The equilibrium data was well-fitted with the pseudo-second order kinetics model showing the chemisorption nature of the equilibrium system. CDSP showed a higher sorption performance than DSP due to its higher BET surface area and carbon content. Physiochemical characterizations of the DSP and CDSP samples were carried out using the BET surface area analysis, Fourier-scanning microscopic analysis (FSEM), energy-dispersive X-ray (EDX) analysis and Fourier-transform spectroscopic analysis (FTIR). A thermogravimetric and ultimate analysis was also carried out to determine the carbon content in both the sorbents (DSP and CDSP) here. This study confirms the potential of DSP and CDSP to remove C₁₀H₈ from lab-scale synthetic wastewater.     

Thermodynamic adsorption data of CH4, C2H6, C2H4 as the OCM process hydrocarbons on SAPO-34 molecular sieve

Adsorption of CH₄, C₂H₆ and C₂H₄, the feed and main products of oxidative coupling process of methane (OCM) has been studied on silicoalumina-phosphate molecular sieve (SAPO-34) in mild conditions. The experiments were conducted in a batch system based on volumetric adsorption measurement technique for determination equilibrium adsorption capacity in the absolute pressure range of 100–1000 kPa and at the isothermal temperatures of 303, 313 and 323 K. Various isotherm equations were fitted on the adsorption equilibrium data and the model parameters were predicted as a function of temperature. Isosteric heats of adsorption were determined using Clausius–Clapeyron equation at different surface coverage. Maximum capacity of SAPO-34 was observed at 303 K and 880–900 kPa equilibrium pressure with 1.25, 2.02 and 4.67 mmol/g adsorbed amount for methane, ethane and ethylene adsorption, respectively. The adsorption selectivity of ethane and ethylene against methane were determined and the appropriate potential of SAPO-34 was observed for separation of OCM products from methane. The isotherm models and enthalpy of adsorption can be efficiently used for the simulation of the adsorption process constructed at the downstream of the OCM process for separation of ethane and ethylene from methane.     

Molecular dynamics simulations of molecularly imprinted polymer approaches to the preparation of selective materials to remove norfloxacin

A novel molecularly imprinted polymer (MIP) designed by molecular dynamics (MD) simulations was successfully prepared with norfloxacin as a template molecule, methyl acrylic acid as a functional monomer, and ethylene glycol dimethacrylate as a crosslinker. According to the theoretical prediction and experimental preparation methods, three kinds of molecular imprinting materials were designed and synthesized with MD simulations and molecular imprinting technology. The best ratio of the template to the functional monomer to the crosslinker was 1:8:40 in these studies. The experimental results illustrate that the MD simulations were credible in compounding the components of the MIPs. The structure of the prepared polymers were characterized with various methods. To analyze the adsorption performances, many kinds of static adsorption tests, including kinetic, isotherm, and selectivity tests, were used. The results indicate that the novel adsorbents conformed to the pseudo–second‐order kinetic equation and followed the Langmuir isotherm model. The adsorption amounts of MIP2 at a ratio of 1:8:40 were about 29.35 mg/g at 298 K_. The selective adsorption and reusable performance of norfloxacin were excellent. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 132, 42817.     

Preparation and characterization of magnetic molecularly imprinted polymers for selective recognition of 3‐methylindole

In this work, magnetic molecularly imprinted polymers (MMIPs) were used as novel adsorbents for selective adsorption of 3‐methylindole from model oil. The MMIPs were synthesized by precipitation polymerization and surface molecularly imprinted technique, using Fe₃O₄ nanoparticles as magnetically susceptible component, methylacrylic acid as dressing agent and functional monomer, ethylene glycol dimethacrylate as crosslinker, and 3‐methylindole as template molecule. The MMIPs were characterized by Fourier‐transform infrared spectroscopy, scanning electron microscopy, vibrating sample magnetometer, and thermogravimetric analyzer, respectively. The adsorption performances of MMIPs were investigated by batch adsorption experiments in terms of kinetics, isotherms, and selective recognition adsorption, respectively. The results indicate that MMIPs have high recognition ability and fast binding kinetics for 3‐methylindole. Meanwhile, the adsorption equilibrium time was about 2 h and the equilibrium adsorption amount was ～38 mg g^?1 at 298 K. The heterogeneous MMIPs were modeled with pseudo‐second‐order and Langmuir isotherm equation. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 2859–2866, 2013     

Molecular Imprinted Polymer of Methacrylic Acid Functionalised β-Cyclodextrin for Selective Removal of 2,4-Dichlorophenol

This work describes methacrylic acid functionalized β-cyclodextrin (MAA-βCD) as a novel functional monomer in the preparation of molecular imprinted polymer (MIP MAA-βCD) for the selective removal of 2,4-dichlorophenol (2,4-DCP). The polymer was characterized using Fourier Transform Infrared (FTIR) spectroscopy, Brunauer-Emmett-Teller (BET) and Field Emission Scanning Electron Microscopy (FESEM) techniques. The influence of parameters such as solution pH, contact time, temperature and initial concentrations towards removal of 2,4-DCP using MIP MAA-βCD have been evaluated. The imprinted material shows fast kinetics and the optimum pH for removal of 2,4-DCP is pH 7. Compared with the corresponding non-imprinted polymer (NIP MAA-βCD), the MIP MAA-βCD exhibited higher adsorption capacity and outstanding selectivity towards 2,4-DCP. Freundlich isotherm best fitted the adsorption equilibrium data of MIP MAA-βCD and the kinetics followed a pseudo-second-order model. The calculated thermodynamic parameters showed that adsorption of 2,4-DCP was spontaneous and exothermic under the examined conditions.     

Preparation of Cu(II)-Imprinted Smart Microgels for Selective Separation of Copper Ions

In this study, we demonstrate a new kind of surface imprinted smart polymer by using methacrylic acid (MAA) as function monomer, attapulgite as the support material, ethylene glycol dimethacrylate (EGDMA) as a crosslinker, and 2, 2’-azobisisobutyronitrile (AIBN) as initiator to prepare Cu(II)-imprinted microgels. The results showed that the prepared imprinted microgels have a high affinity for Cu²⁺ over Ca²⁺ and Mg²⁺, and the adsorption equilibrium data fitted Freundlich isotherm model well. In addition, Cu(II)-imprinted smart microgels had pH sensitivity to control the selection recognition property. Besides, It is suggested that the Cu(II)-imprinted microgels was a material that was efficient, low-cost, and could be reused five times with about 15% regeneration loss.     

Selective solid‐phase extraction of naphazoline using imprinted polymers as matrix prepared by precipitation polymerization

The molecularly imprinted polymers (MIP) for drug naphazoline (NAZ) have been synthesized by precipitation polymerization. The effect of the dispersive solvents dichloromethane (DCM), acetonitrile (ACN), and Methanol (MeOH) on particle size and morphology of MIP (P1, P2, and P3) was investigated by scanning electron microscopy (SEM). The selectivity of P1, compared with nonimprinted polymer (NIP), C₈ and C₁₈ were evaluated via static adsorption using UV spectrophotometer. The result showed that the bond amount of P1 for NAZ was significantly higher than other sorbents. The P1 were applied as a solid‐phase extraction (SPE) stationary phase to extract the NAZ from nasal drops and recoveries of more than 89% (relative standard deviations, RSD <5%) were obtained by high performance liquid chromatograph (HPLC) analyses. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010