Epileptic Seizures Diagnosis Using Amalgamated Extremely Focused EEG Signals and Brain MRI

There exists various neurological disorder based diseases like tumor, sleep disorder, headache, dementia and Epilepsy. Among these, epilepsy is the most common neurological illness in humans, comparable to stroke. Epilepsy is a severe chronic neurological illness that can be discovered through analysis of the signals generated by brain neurons and brain Magnetic resonance imaging (MRI). Neurons are intricately coupled in order to communicate and generate signals from human organs. Due to the complex nature of electroencephalogram (EEG) signals and MRI’s the epileptic seizures detection and brain related problems diagnosis becomes a challenging task. Computer based techniques and machine learning models are continuously giving their contributions to diagnose all such diseases in a better way than the normal process of diagnosis. Their performance may sometime degrade due to missing information, selection of poor classification model and unavailability of quality data that are used to train the models for better prediction. This research work is an attempt to epileptic seizures detection by using a multi focus dataset based on EEG signals and brain MRI. The key steps of this work are: feature extraction having two different streams i.e., EEG using wavelet transformation along with SVD-Entropy, and MRI using convolutional neural network (CNN), after extracting features from both streams, feature fusion is applied to generate feature vector used by support vector machine (SVM) to diagnose the epileptic seizures. From the experimental evaluation and results comparison with the current state-of-the-art techniques, it has been concluded that the performance of the proposed scheme is better than the existing models.

     

3d discrete wavelet transform for computer aided diagnosis of Alzheimer's disease using t1‐weighted brain MRI

Early and antemortem diagnosis of Alzheimer's disease (AD) may help in the development of appropriate treatment and in slowing down the disease progression. In this work, a three‐phase computer aided approach is suggested for classification of AD patients and controls using T1‐weighted MRI. In the first phase, smoothed modulated gray matter (GM) probability maps are obtained from T1‐weighted MRIs. In the second phase, 3D discrete wavelet transform is applied on GM of five brain regions, which are well‐documented regions affected in AD, to construct features. In the third phase, a minimal set of relevant and nonredundant features are obtained using Fisher's discriminant ratio and minimum redundancy maximum relevance feature selection methods. To check the efficacy of the proposed approach, experiments were carried out on three datasets derived from the publicly available OASIS database, using three commonly used classifiers. The performance of the proposed approach was evaluated using three performance measures namely sensitivity, specificity and classification accuracy. Further, the proposed approach was compared with the existing state‐of‐the‐art techniques in terms of three performance measures, ROC curves, scoring and computation time. Irrespective of the datasets and the classifiers, the proposed method outperformed the existing methods. In addition, the statistical test also demonstrated that the proposed method is significantly better in comparison to the other existing methods. The appreciable performance of the proposed method supports that it will assist clinicians/researchers in the classification of AD patients and controls.     

An Improved Transfer-Learning for Image-Based Species Classification of Protected Indonesians Birds

This research proposed an improved transfer-learning bird classification framework to achieve a more precise classification of Protected Indonesia Birds (PIB) which have been identified as the endangered bird species. The framework takes advantage of using the proposed sequence of Batch Normalization Dropout Fully-Connected (BNDFC) layers to enhance the baseline model of transfer learning. The main contribution of this work is the proposed sequence of BNDFC that can be applied to any Convolutional Neural Network (CNN) based model to improve the classification accuracy, especially for image-based species classification problems. The experiment results show that the proposed sequence of BNDFC layers outperform other combination of BNDFC. The addition of BNDFC can improve the model’s performance across ten different CNN-based models. On average, BNDFC can improve by approximately 19.88% in Accuracy, 24.43% in F-measure, 17.93% in G-mean, 23.41% in Sensitivity, and 18.76% in Precision. Moreover, applying fine-tuning (FT) is able to enhance the accuracy by 0.85% with a smaller validation loss of 18.33% improvement. In addition, MobileNetV2 was observed to be the best baseline model with the lightest size of 35.9 MB and the highest accuracy of 88.07% in the validation set.     

Feed‐forward neural network optimized by hybridization of PSO and ABC for abnormal brain detection

Automated and accurate classification of MR brain images is of crucially importance for medical analysis and interpretation. We proposed a novel automatic classification system based on particle swarm optimization (PSO) and artificial bee colony (ABC), with the aim of distinguishing abnormal brains from normal brains in MRI scanning. The proposed method used stationary wavelet transform (SWT) to extract features from MR brain images. SWT is translation‐invariant and performed well even the image suffered from slight translation. Next, principal component analysis (PCA) was harnessed to reduce the SWT coefficients. Based on three different hybridization methods of PSO and ABC, we proposed three new variants of feed‐forward neural network (FNN), consisting of IABAP‐FNN, ABC‐SPSO‐FNN, and HPA‐FNN. The 10 runs of K‐fold cross validation result showed the proposed HPA‐FNN was superior to not only other two proposed classifiers but also existing state‐of‐the‐art methods in terms of classification accuracy. In addition, the method achieved perfect classification on Dataset‐66 and Dataset‐160. For Dataset‐255, the 10 repetition achieved average sensitivity of 99.37%, average specificity of 100.00%, average precision of 100.00%, and average accuracy of 99.45%. The offline learning cost 219.077 s for Dataset‐255, and merely 0.016 s for online prediction. Thus, the proposed SWT + PCA + HPA‐FNN method excelled existing methods. It can be applied to practical use.     

Brain Tumor Auto-Segmentation on Multimodal Imaging Modalities Using Deep Neural Network

Due to the difficulties of brain tumor segmentation, this paper proposes a strategy for extracting brain tumors from three-dimensional Magnetic Resonance Image (MRI) and Computed Tomography (CT) scans utilizing 3D U-Net Design and ResNet50, taken after by conventional classification strategies. In this inquire, the ResNet50 picked up accuracy with 98.96%, and the 3D U-Net scored 97.99% among the different methods of deep learning. It is to be mentioned that traditional Convolutional Neural Network (CNN) gives 97.90% accuracy on top of the 3D MRI. In expansion, the image fusion approach combines the multimodal images and makes a fused image to extricate more highlights from the medical images. Other than that, we have identified the loss function by utilizing several dice measurements approach and received Dice Result on top of a specific test case. The average mean score of dice coefficient and soft dice loss for three test cases was 0.0980. At the same time, for two test cases, the sensitivity and specification were recorded to be 0.0211 and 0.5867 using patch level predictions. On the other hand, a software integration pipeline was integrated to deploy the concentrated model into the webserver for accessing it from the software system using the Representational state transfer (REST) API. Eventually, the suggested models were validated through the Area Under the Curve–Receiver Characteristic Operator (AUC–ROC) curve and Confusion Matrix and compared with the existing research articles to understand the underlying problem. Through Comparative Analysis, we have extracted meaningful insights regarding brain tumour segmentation and figured out potential gaps. Nevertheless, the proposed model can be adjustable in daily life and the healthcare domain to identify the infected regions and cancer of the brain through various imaging modalities.     

An automatic channel selection method based on the standard deviation of wavelet coefficients for motor imagery based brain–computer interfacing

The redundant data in multichannel electroencephalogram (EEG) signals significantly reduces the performance of brain–computer interface (BCI) systems. By removing redundant channels, a channel selection strategy increases the classification accuracy of BCI systems. In this work, a novel channel selection method (stdWC) based on the standard deviation of wavelet coefficients across channels is proposed to identify Motor Imagery (MI) based EEG signals. The wavelet coefficients are calculated by employing a Continuous Wavelet Transform (CWT) filter bank to decompose each trial from the EEG channel. The wavelet coefficient's standard deviation values are obtained across the channels, and these values are then sorted to determine the EEG channels with the highest standard deviation values. The channels with the largest wavelet coefficient divergence are chosen. MI trials are then spatially filtered with the Common Spatial Pattern (CSP), and CWT filter bank-based 2D images are generated from the spatially filtered trials. These images are then classified using a unique nine-layered convolutional neural network (CNN) model that combines two feature maps acquired with differing filter sizes. The proposed framework (stdWC-CSP-CNN) is evaluated using kappa score and classification accuracy on two publically accessible datasets (BCI Competition III dataset IVa and BCI Competition IV dataset 2a). The suggested framework achieved a mean test classification accuracy of 88.8% for dataset IVa from BCI Competition III and 75.03% for dataset 2a from BCI Competition IV, according to the results. The proposed channel selection method outperforms the other channel selection methods examined, according to the results. By rejecting redundant channels, the whole framework can improve the performance of MI-based BCIs.     

A new rectangular window based image cropping method for generalization of brain neoplasm classification systems

Classification of brain neoplasm images is one of the most challenging research areas in the field of medical image processing. The main objective of this study is to design a brain neoplasm classification system that can be trained using multiple various sized MR images of different institutions. The proposed method is a generalized classification system; it can be used in a single institute or in a number of institutions at the same time, without any restriction on image size. The generalization and unbiased capability of the proposed method can bring researchers on a single platform to work on some standard forms of computer aided diagnosis system with more efficient diagnostic capabilities. In this study, a suitable size of moveable rectangular window is used between segmentation and feature extraction stages. A semiautomatic, localized region based active contour method is used for segmentation of brain neoplasm region. Discrete wavelet transform for feature extraction, principal component analysis for feature selection and support vector machine is used as classifier. For the first time MR images of 2 sizes and from different institutions are used in training and testing of brain neoplasm classifier. Three glioma grades were classified using 92 MR images. The proposed method achieved the highest accuracy of 88.26%, the highest sensitivity of 92.23% and the maximum specificity of 93.93%. In addition, the proposed method is computationally less complex, requires shorter processing time and is more efficient in terms of storage capacity.     

Compatible abnormality detection technique for CT and MRI brain images

Abstract

An automated computerised tomography (CT) and magnetic resonance imaging (MRI) brain images are used to perform an efficient classification. The proposed technique consists of three stages, namely, pre-processing, feature extraction and classification. Initially, pre-processing is performed to remove the noise from the medical MRI images. Then, in the feature extraction stage, the features that are related with MRI and CT images are extracted and these extracted features which are given to the Feed Forward Back-propagation Neural Network (FFBNN) is exploited in order to classify the brain MRI and CT images into two types: normal and abnormal. The FFBNN is well trained by the extracted features and uses the unknown medical brain MRI images for classification in order to achieve better classification performance. The proposed method is validated by various MRI and CT scan images. A classification with an accomplishment of 96% and 70% has been obtained by the proposed FFBNN classifier. This achievement shows the effectiveness of the proposed brain image classification technique when compared with other recent research works.     

Ozone Depletion Identification in Stratosphere Through Faster Region-Based Convolutional Neural Network

The concept of classification through deep learning is to build a model that skillfully separates closely-related images dataset into different classes because of diminutive but continuous variations that took place in physical systems over time and effect substantially. This study has made ozone depletion identification through classification using Faster Region-Based Convolutional Neural Network (F-RCNN). The main advantage of F-RCNN is to accumulate the bounding boxes on images to differentiate the depleted and non-depleted regions. Furthermore, image classification’s primary goal is to accurately predict each minutely varied case’s targeted classes in the dataset based on ozone saturation. The permanent changes in climate are of serious concern. The leading causes beyond these destructive variations are ozone layer depletion, greenhouse gas release, deforestation, pollution, water resources contamination, and UV radiation. This research focuses on the prediction by identifying the ozone layer depletion because it causes many health issues, e.g., skin cancer, damage to marine life, crops damage, and impacts on living being’s immune systems. We have tried to classify the ozone images dataset into two major classes, depleted and non-depleted regions, to extract the required persuading features through F-RCNN. Furthermore, CNN has been used for feature extraction in the existing literature, and those extricated diverse RoIs are passed on to the CNN for grouping purposes. It is difficult to manage and differentiate those RoIs after grouping that negatively affects the gathered results. The classification outcomes through F-RCNN approach are proficient and demonstrate that general accuracy lies between 91% to 93% in identifying climate variation through ozone concentration classification, whether the region in the image under consideration is depleted or non-depleted. Our proposed model presented 93% accuracy, and it outperforms the prevailing techniques.     

Classification of Alzheimer disease among susceptible brain regions

Statistical and machine learning techniques are frequently employed in the study of neuroimaging data for finding Alzheimer disease (AD) in clinical studies and in additional inquiries about research settings. AD affects the whole brain and as a result the quality of life, where most affected regions are the hippocampus (HP), middle temporal gyrus (MTG), entorhinal cortex, and posterior cingulate cortex (PCC). We used well-known classification methods to diagnose the affected regions of the brain at different stages of age using biomarker modalities and functional magnetic resonance imaging (fMRI) at the resting state, and later marked the affected brain region on MRI. We have used well-known support vector machine (SVM), Fisher's linear discriminant analysis, artificial neural network, and logistic regression for the classification of AD. In the context of receiver operating characteristic (ROC) curves, an SVM provided the best classification among AD stages. Moreover, analysis showed development of AD.     

Brain Tumor Detection and Classification Using PSO and Convolutional Neural Network

Tumor detection has been an active research topic in recent years due to the high mortality rate. Computer vision (CV) and image processing techniques have recently become popular for detecting tumors in MRI images. The automated detection process is simpler and takes less time than manual processing. In addition, the difference in the expanding shape of brain tumor tissues complicates and complicates tumor detection for clinicians. We proposed a new framework for tumor detection as well as tumor classification into relevant categories in this paper. For tumor segmentation, the proposed framework employs the Particle Swarm Optimization (PSO) algorithm, and for classification, the convolutional neural network (CNN) algorithm. Popular preprocessing techniques such as noise removal, image sharpening, and skull stripping are used at the start of the segmentation process. Then, PSO-based segmentation is applied. In the classification step, two pre-trained CNN models, alexnet and inception-V3, are used and trained using transfer learning. Using a serial approach, features are extracted from both trained models and fused features for final classification. For classification, a variety of machine learning classifiers are used. Average dice values on datasets BRATS-2018 and BRATS-2017 are 98.11 percent and 98.25 percent, respectively, whereas average jaccard values are 96.30 percent and 96.57% (Segmentation Results). The results were extended on the same datasets for classification and achieved 99.0% accuracy, sensitivity of 0.99, specificity of 0.99, and precision of 0.99. Finally, the proposed method is compared to state-of-the-art existing methods and outperforms them.     

Hybrid GrabCut Hidden Markov Model for Segmentation

Diagnosing data or object detection in medical images is one of the important parts of image segmentation especially those data which is less effective to identify in MRI such as low-grade tumors or cerebral spinal fluid (CSF) leaks in the brain. The aim of the study is to address the problems associated with detecting the low-grade tumor and CSF in brain is difficult in magnetic resonance imaging (MRI) images and another problem also relates to efficiency and less execution time for segmentation of medical images. For tumor and CSF segmentation using trained light field database (LFD) datasets of MRI images. This research proposed the new framework of the hybrid k-Nearest Neighbors (k-NN) model that is a combination of hybridization of Graph Cut and Support Vector Machine (GCSVM) and Hidden Markov Model of k-Mean Clustering Algorithm (HMMkC). There are four different methods are used in this research namely (1) SVM, (2) GrabCut segmentation, (3) HMM, and (4) k-mean clustering algorithm. In this framework, on the one hand, phase one is to perform the classification of SVM and Graph Cut algorithm to create the maximum margin distance. This research use GrabCut segmentation method which is the application of the graph cut algorithm and extract the data with the help of scale-invariant features transform. On the other hand, in phase two, segment the low-grade tumors and CSF using a method adapted for HMkC and extract the information of tumor or CSF fluid by GCHMkC including iterative conditional maximizing mode (ICMM) with identifying the range of distant. Comparative evaluation is also performing by the comparison of existing techniques in this research. In conclusion, our proposed model gives better results than existing. This proposed model helps to common man and doctor that can identify their condition of brain easily. In future, this will model will use for other brain related diseases.     

Identifying brain regions contributing to Alzheimer's disease using self regulating particle swarm optimization

In this article, we developed an approach for detecting brain regions that contribute to Alzheimer's disease (AD) using support vector machine (SVM) classifiers and the recently developed self regulating particle swarm optimization (SRPSO) algorithm. SRPSO employs strategies inspired by the principles of learning in humans to achieve faster and better optimization results. The classifiers for distinguishing subjects into AD patients and cognitively normal (CN) individuals were built using grey matter (GM) and white matter (WM) volumetric features extracted from structural magnetic resonance (MR) images. It could be observed from results that the classifier built using both GM and WM features provided accuracy of 89.26% which is better than the performance of classifiers built using either GM or WM features only. Moreover, consideration of clinical features in addition to volumetric features improves the accuracy further to 94.63% which is better than the performance reported by recent works in literature. In order to identify the brain regions that are important for AD vs CN classification problem, we used SRPSO to extract GM and WM features that yield better classification performance. Using 50 features identified by SRPSO, an accuracy of 89.39% was obtained which is close to the accuracy based on all features. The features identified by SRPSO were mapped back to the brain to identify brain regions that exhibit degeneration in AD. In addition to identifying areas known to be involved in AD like cerebellum, hippocampus, this helped in finding newer areas that might contribute towards AD.     

Novel Computer-Aided Diagnosis System for the Early Detection of Alzheimer’s Disease

Aging is a natural process that leads to debility, disease, and dependency. Alzheimer’s disease (AD) causes degeneration of the brain cells leading to cognitive decline and memory loss, as well as dependence on others to fulfill basic daily needs. AD is the major cause of dementia. Computer-aided diagnosis (CADx) tools aid medical practitioners in accurately identifying diseases such as AD in patients. This study aimed to develop a CADx tool for the early detection of AD using the Intelligent Water Drop (IWD) algorithm and the Random Forest (RF) classifier. The IWD algorithm an efficient feature selection method, was used to identify the most deterministic features of AD in the dataset. RF is an ensemble method that leverages multiple weak learners to classify a patient’s disease as either demented (DN) or cognitively normal (CN). The proposed tool also classifies patients as mild cognitive impairment (MCI) or CN. The dataset on which the performance of the proposed CADx was evaluated was sourced from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). The RF ensemble method achieves 100% accuracy in identifying DN patients from CN patients. The classification accuracy for classifying patients as MCI or CN is 92%. This study emphasizes the significance of pre-processing prior to classification to improve the classification results of the proposed CADx tool.     

A Novel Hybrid Machine Learning Approach for Classification of Brain Tumor Images

Abnormal growth of brain tissues is the real cause of brain tumor. Strategy for the diagnosis of brain tumor at initial stages is one of the key step for saving the life of a patient. The manual segmentation of brain tumor magnetic resonance images (MRIs) takes time and results vary significantly in low-level features. To address this issue, we have proposed a ResNet-50 feature extractor depended on multilevel deep convolutional neural network (CNN) for reliable images segmentation by considering the low-level features of MRI. In this model, we have extracted features through ResNet-50 architecture and fed these feature maps to multi-level CNN model. To handle the classification process, we have collected a total number of 2043 MRI patients of normal, benign, and malignant tumor. Three model CNN, multi-level CNN, and ResNet-50 based multi-level CNN have been used for detection and classification of brain tumors. All the model results are calculated in terms of various numerical values identified as precision (P), recall (R), accuracy (Acc) and f1-score (F1-S). The obtained average results are much better as compared to already existing methods. This modified transfer learning architecture might help the radiologists and doctors as a better significant system for tumor diagnosis.     

Deep Learning Based Optimal Multimodal Fusion Framework for Intrusion Detection Systems for Healthcare Data

Data fusion is a multidisciplinary research area that involves different domains. It is used to attain minimum detection error probability and maximum reliability with the help of data retrieved from multiple healthcare sources. The generation of huge quantity of data from medical devices resulted in the formation of big data during which data fusion techniques become essential. Securing medical data is a crucial issue of exponentially-pacing computing world and can be achieved by Intrusion Detection Systems (IDS). In this regard, since singular-modality is not adequate to attain high detection rate, there is a need exists to merge diverse techniques using decision-based multimodal fusion process. In this view, this research article presents a new multimodal fusion-based IDS to secure the healthcare data using Spark. The proposed model involves decision-based fusion model which has different processes such as initialization, pre-processing, Feature Selection (FS) and multimodal classification for effective detection of intrusions. In FS process, a chaotic Butterfly Optimization (BO) algorithm called CBOA is introduced. Though the classic BO algorithm offers effective exploration, it fails in achieving faster convergence. In order to overcome this, i.e., to improve the convergence rate, this research work modifies the required parameters of BO algorithm using chaos theory. Finally, to detect intrusions, multimodal classifier is applied by incorporating three Deep Learning (DL)-based classification models. Besides, the concepts like Hadoop MapReduce and Spark were also utilized in this study to achieve faster computation of big data in parallel computation platform. To validate the outcome of the presented model, a series of experimentations was performed using the benchmark NSLKDDCup99 Dataset repository. The proposed model demonstrated its effective results on the applied dataset by offering the maximum accuracy of 99.21%, precision of 98.93% and detection rate of 99.59%. The results assured the betterment of the proposed model.     

Discrete Wavelet Transmission and Modified PSO with ACO Based Feed Forward Neural Network Model for Brain Tumour Detection

In recent years, the development in the field of computer-aided diagnosis (CAD) has increased rapidly. Many traditional machine learning algorithms have been proposed for identifying the pathological brain using magnetic resonance images. The existing algorithms have drawbacks with respect to their accuracy, efficiency, and limited learning processes. To address these issues, we propose a pathological brain tumour detection method that utilizes the Weiner filter to improve the image contrast, 2D- discrete wavelet transformation (2D-DWT) to extract the features, probabilistic principal component analysis (PPCA) and linear discriminant analysis (LDA) to normalize and reduce the features, and a feed-forward neural network (FNN) and modified particle swarm optimization (MPSO) with ant colony optimization (ACO) to improve the accuracy, stability, and overcome fitting issues in the classification of brain magnetic resonance images. The proposed method achieves better results than other existing algorithms.     

Human Emotions Classification Using EEG via Audiovisual Stimuli and AI

Electroencephalogram (EEG) is a medical imaging technology that can measure the electrical activity of the scalp produced by the brain, measured and recorded chronologically the surface of the scalp from the brain. The recorded signals from the brain are rich with useful information. The inference of this useful information is a challenging task. This paper aims to process the EEG signals for the recognition of human emotions specifically happiness, anger, fear, sadness, and surprise in response to audiovisual stimuli. The EEG signals are recorded by placing neurosky mindwave headset on the subject’s scalp, in response to audiovisual stimuli for the mentioned emotions. Using a bandpass filter with a bandwidth of 1–100 Hz, recorded raw EEG signals are preprocessed. The preprocessed signals then further analyzed and twelve selected features in different domains are extracted. The Random forest (RF) and multilayer perceptron (MLP) algorithms are then used for the classification of the emotions through extracted features. The proposed audiovisual stimuli based EEG emotion classification system shows an average classification accuracy of 80% and 88% using MLP and RF classifiers respectively on hybrid features for experimental signals of different subjects. The proposed model outperforms in terms of cost and accuracy.     

Classification of focal and nonfocal EEG signals using ANFIS classifier for epilepsy detection

The electroencephalogram (EEG) is the frequently used signal to detect epileptic seizures in the brain. For a successful epilepsy surgery, it is very essential to localize epileptogenic area in the brain. The signals from the epileptogenic area are focal signals and signals from other area of the brain region nonfocal signals. Hence, the classification of focal and nonfocal signals is important for locating the epileptogenic area for epilepsy surgery. In this article, we present a computer aided automatic detection and classification method for focal and nonfocal EEG signal. The EEG signal is decomposed by Dual Tree Complex Wavelet Transform (DT‐CWT) and the features are computed from the decomposed coefficients. These features are trained and classified using Adaptive Neuro Fuzzy Inference System (ANFIS) classifier. The proposed system achieves 98% sensitivity, 100% specificity, and 99% accuracy for EEG signal classification. The experimental results are presented to show the effectiveness of the proposed classification method to classify the focal and nonfocal EEG signals. © 2016 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 26, 277–283, 2016     

A rapid automatic brain tumor detection method for MRI images using modified minimum error thresholding technique

This proposed work is aimed to develop a rapid automatic method to detect the brain tumor from T2‐weighted MRI brain images using the principle of modified minimum error thresholding (MET) method. Initially, modified MET method is applied to produce well segmented and sub‐structural clarity for MRI brain images. Further, using FCM clustering the appearance of tumor area is refined. The obtained results are compared with corresponding ground truth images. The quantitative measures of results were compared with the results of those conventional methods using the metrics predictive accuracy (PA), dice coefficient (DC), and processing time. The PA and DC values of the proposed method attained maximum value and processing time is minimum while compared to conventional FCM and k‐means clustering techniques. This proposed method is more efficient and faster than the existing segmentation methods in detecting the tumor region from T2‐weighted MRI brain images. © 2015 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 25, 77–85, 2015