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1.
Coronavirus disease (COVID-19) is an extremely infectious disease and possibly causes acute respiratory distress or in severe cases may lead to death. There has already been some research in dealing with coronavirus using machine learning algorithms, but few have presented a truly comprehensive view. In this research, we show how convolutional neural network (CNN) can be useful to detect COVID-19 using chest X-ray images. We leverage the CNN-based pre-trained models as feature extractors to substantiate transfer learning and add our own classifier in detecting COVID-19. In this regard, we evaluate performance of five different pre-trained models with fine-tuning the weights from some of the top layers. We also develop an ensemble model where the predictions from all chosen pre-trained models are combined to generate a single output. The models are evaluated through 5-fold cross validation using two publicly available data repositories containing healthy and infected (both COVID-19 and other pneumonia) chest X-ray images. We also leverage two different visualization techniques to observe how efficiently the models extract important features related to the detection of COVID- 19 patients. The models show high degree of accuracy, precision, and sensitivity. We believe that the models will aid medical professionals with improved and faster patient screening and pave a way to further COVID-19 research.  相似文献   

2.
COVID-19 has been considered one of the recent epidemics that occurred at the last of 2019 and the beginning of 2020 that world widespread. This spread of COVID-19 requires a fast technique for diagnosis to make the appropriate decision for the treatment. X-ray images are one of the most classifiable images that are used widely in diagnosing patients’ data depending on radiographs due to their structures and tissues that could be classified. Convolutional Neural Networks (CNN) is the most accurate classification technique used to diagnose COVID-19 because of the ability to use a different number of convolutional layers and its high classification accuracy. Classification using CNNs techniques requires a large number of images to learn and obtain satisfactory results. In this paper, we used SqueezNet with a modified output layer to classify X-ray images into three groups: COVID-19, normal, and pneumonia. In this study, we propose a deep learning method with enhance the features of X-ray images collected from Kaggle, Figshare to distinguish between COVID-19, Normal, and Pneumonia infection. In this regard, several techniques were used on the selected image samples which are Unsharp filter, Histogram equal, and Complement image to produce another view of the dataset. The Squeeze Net CNN model has been tested in two scenarios using the 13,437 X-ray images that include 4479 for each type (COVID-19, Normal and Pneumonia). In the first scenario, the model has been tested without any enhancement on the datasets. It achieved an accuracy of 91%. But, in the second scenario, the model was tested using the same previous images after being improved by several techniques and the performance was high at approximately 95%. The conclusion of this study is the used model gives higher accuracy results for enhanced images compared with the accuracy results for the original images. A comparison of the outcomes demonstrated the effectiveness of our DL method for classifying COVID-19 based on enhanced X-ray images.  相似文献   

3.
The exponential increase in new coronavirus disease 2019 ({COVID-19}) cases and deaths has made COVID-19 the leading cause of death in many countries. Thus, in this study, we propose an efficient technique for the automatic detection of COVID-19 and pneumonia based on X-ray images. A stacked denoising convolutional autoencoder (SDCA) model was proposed to classify X-ray images into three classes: normal, pneumonia, and {COVID-19}. The SDCA model was used to obtain a good representation of the input data and extract the relevant features from noisy images. The proposed model’s architecture mainly composed of eight autoencoders, which were fed to two dense layers and SoftMax classifiers. The proposed model was evaluated with 6356 images from the datasets from different sources. The experiments and evaluation of the proposed model were applied to an 80/20 training/validation split and for five cross-validation data splitting, respectively. The metrics used for the SDCA model were the classification accuracy, precision, sensitivity, and specificity for both schemes. Our results demonstrated the superiority of the proposed model in classifying X-ray images with high accuracy of 96.8%. Therefore, this model can help physicians accelerate COVID-19 diagnosis.  相似文献   

4.
The COVID-19 pandemic poses an additional serious public health threat due to little or no pre-existing human immunity, and developing a system to identify COVID-19 in its early stages will save millions of lives. This study applied support vector machine (SVM), k-nearest neighbor (K-NN) and deep learning convolutional neural network (CNN) algorithms to classify and detect COVID-19 using chest X-ray radiographs. To test the proposed system, chest X-ray radiographs and CT images were collected from different standard databases, which contained 95 normal images, 140 COVID-19 images and 10 SARS images. Two scenarios were considered to develop a system for predicting COVID-19. In the first scenario, the Gaussian filter was applied to remove noise from the chest X-ray radiograph images, and then the adaptive region growing technique was used to segment the region of interest from the chest X-ray radiographs. After segmentation, a hybrid feature extraction composed of 2D-DWT and gray level co-occurrence matrix was utilized to extract the features significant for detecting COVID-19. These features were processed using SVM and K-NN. In the second scenario, a CNN transfer model (ResNet 50) was used to detect COVID-19. The system was examined and evaluated through multiclass statistical analysis, and the empirical results of the analysis found significant values of 97.14%, 99.34%, 99.26%, 99.26% and 99.40% for accuracy, specificity, sensitivity, recall and AUC, respectively. Thus, the CNN model showed significant success; it achieved optimal accuracy, effectiveness and robustness for detecting COVID-19.  相似文献   

5.
Coronavirus (COVID-19) infection was initially acknowledged as a global pandemic in Wuhan in China. World Health Organization (WHO) stated that the COVID-19 is an epidemic that causes a 3.4% death rate. Chest X-Ray (CXR) and Computerized Tomography (CT) screening of infected persons are essential in diagnosis applications. There are numerous ways to identify positive COVID-19 cases. One of the fundamental ways is radiology imaging through CXR, or CT images. The comparison of CT and CXR scans revealed that CT scans are more effective in the diagnosis process due to their high quality. Hence, automated classification techniques are required to facilitate the diagnosis process. Deep Learning (DL) is an effective tool that can be utilized for detection and classification this type of medical images. The deep Convolutional Neural Networks (CNNs) can learn and extract essential features from different medical image datasets. In this paper, a CNN architecture for automated COVID-19 detection from CXR and CT images is offered. Three activation functions as well as three optimizers are tested and compared for this task. The proposed architecture is built from scratch and the COVID-19 image datasets are directly fed to train it. The performance is tested and investigated on the CT and CXR datasets. Three activation functions: Tanh, Sigmoid, and ReLU are compared using a constant learning rate and different batch sizes. Different optimizers are studied with different batch sizes and a constant learning rate. Finally, a comparison between different combinations of activation functions and optimizers is presented, and the optimal configuration is determined. Hence, the main objective is to improve the detection accuracy of COVID-19 from CXR and CT images using DL by employing CNNs to classify medical COVID-19 images in an early stage. The proposed model achieves a classification accuracy of 91.67% on CXR image dataset, and a classification accuracy of 100% on CT dataset with training times of 58 min and 46 min on CXR and CT datasets, respectively. The best results are obtained using the ReLU activation function combined with the SGDM optimizer at a learning rate of 10−5 and a minibatch size of 16.  相似文献   

6.
COVID-19 remains to proliferate precipitously in the world. It has significantly influenced public health, the world economy, and the persons’ lives. Hence, there is a need to speed up the diagnosis and precautions to deal with COVID-19 patients. With this explosion of this pandemic, there is a need for automated diagnosis tools to help specialists based on medical images. This paper presents a hybrid Convolutional Neural Network (CNN)-based classification and segmentation approach for COVID-19 detection from Computed Tomography (CT) images. The proposed approach is employed to classify and segment the COVID-19, pneumonia, and normal CT images. The classification stage is firstly applied to detect and classify the input medical CT images. Then, the segmentation stage is performed to distinguish between pneumonia and COVID-19 CT images. The classification stage is implemented based on a simple and efficient CNN deep learning model. This model comprises four Rectified Linear Units (ReLUs), four batch normalization layers, and four convolutional (Conv) layers. The Conv layer depends on filters with sizes of 64, 32, 16, and 8. A 2 × 2 window and a stride of 2 are employed in the utilized four max-pooling layers. A soft-max activation function and a Fully-Connected (FC) layer are utilized in the classification stage to perform the detection process. For the segmentation process, the Simplified Pulse Coupled Neural Network (SPCNN) is utilized in the proposed hybrid approach. The proposed segmentation approach is based on salient object detection to localize the COVID-19 or pneumonia region, accurately. To summarize the contributions of the paper, we can say that the classification process with a CNN model can be the first stage a highly-effective automated diagnosis system. Once the images are accepted by the system, it is possible to perform further processing through a segmentation process to isolate the regions of interest in the images. The region of interest can be assesses both automatically and through experts. This strategy helps so much in saving the time and efforts of specialists with the explosion of COVID-19 pandemic in the world. The proposed classification approach is applied for different scenarios of 80%, 70%, or 60% of the data for training and 20%, 30, or 40% of the data for testing, respectively. In these scenarios, the proposed approach achieves classification accuracies of 100%, 99.45%, and 98.55%, respectively. Thus, the obtained results demonstrate and prove the efficacy of the proposed approach for assisting the specialists in automated medical diagnosis services.  相似文献   

7.
The latest studies with radiological imaging techniques indicate that X-ray images provide valuable details on the Coronavirus disease 2019 (COVID-19). The usage of sophisticated artificial intelligence technology (AI) and the radiological images can help in diagnosing the disease reliably and addressing the problem of the shortage of trained doctors in remote villages. In this research, the automated diagnosis of Coronavirus disease was performed using a dataset of X-ray images of patients with severe bacterial pneumonia, reported COVID-19 disease, and normal cases. The goal of the study is to analyze the achievements for medical image recognition of state-of-the-art neural networking architectures. Transfer Learning technique has been implemented in this work. Transfer learning is an ambitious task, but it results in impressive outcomes for identifying distinct patterns in tiny datasets of medical images. The findings indicate that deep learning with X-ray imagery could retrieve important biomarkers relevant for COVID-19 disease detection. Since all diagnostic measures show failure levels that pose questions, the scientific profession should determine the probability of integration of X-rays with the clinical treatment, utilizing the results. The proposed model achieved 96.73% accuracy outperforming the ResNet50 and traditional Resnet18 models. Based on our findings, the proposed system can help the specialist doctors in making verdicts for COVID-19 detection.  相似文献   

8.
9.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-caused COVID-19 pandemic has rapidly escalated into the largest global health emergency, which pushes to develop detection kits for the detection of COVID-19 with high sensitivity, specificity, and fast analysis. Here, aptamer-functionalized MXene nanosheet is demonstrated as a novel bionanosensor that detects COVID-19. Upon binding to the spike receptor binding domain of SARS-CoV-2, the aptamer probe is released from MXene surface restoring the quenched fluorescence. The performances of the fluorosensor are evaluated using antigen protein, cultured virus, and swab specimens from COVID-19 patients. It is evidenced that this sensor can detect SARS-CoV-2 spike protein at final concentration of 38.9 fg mL−1 and SARS-CoV-2 pseudovirus (limit of detection: 7.2 copies) within 30 min. Its application for clinical samples analysis is also demonstrated successfully. This work offers an effective sensing platform for sensitive and rapid detection of COVID-19 with high specificity.  相似文献   

10.
The ongoing coronavirus disease 2019 (COVID-19) pandemic has wreaked havoc worldwide with millions of lives claimed, human travel restricted and economic development halted. Leveraging city-level mobility and case data, our analysis shows that the spatial dissemination of COVID-19 can be well explained by a local diffusion process in the mobility network rather than a global diffusion process, indicating the effectiveness of the implemented disease prevention and control measures. Based on the constructed case prediction model, it is estimated that there could be distinct social consequences if the COVID-19 outbreak happened in different areas. During the epidemic control period, human mobility experienced substantial reductions and the mobility network underwent remarkable local and global structural changes toward containing the spread of COVID-19. Our work has important implications for the mitigation of disease and the evaluation of the socio-economic consequences of COVID-19 on society.  相似文献   

11.
COVID-19 is a global pandemic disease, which results from a dangerous coronavirus attack, and spreads aggressively through close contacts with infected people and artifacts. So far, there is not any prescribed line of treatment for COVID-19 patients. Measures to control the disease are very limited, partly due to the lack of knowledge about technologies which could be effectively used for early detection and control the disease. Early detection of positive cases is critical in preventing further spread, achieving the herd immunity, and saving lives. Unfortunately, so far we do not have effective toolkits to diagnose very early detection of the disease. Recent research findings have suggested that radiology images, such as X-rays, contain significant information to detect the presence of COVID-19 virus in early stages. However, to detect the presence of the disease in in very early stages from the X-ray images by the naked eye is not possible. Artificial Intelligence (AI) techniques, machine learning in particular, are known to be very helpful in accurately diagnosing many diseases from radiology images. This paper proposes an automatic technique to classify COVID-19 patients from their computerized tomography (CT) scan images. The technique is known as Advanced Inception based Recurrent Residual Convolution Neural Network (AIRRCNN), which uses machine learning techniques for classifying data. We focus on the Advanced Inception based Recurrent Residual Convolution Neural Network, because we do not find it being used in the literature. Also, we conduct principal component analysis, which is used for dimensional deduction. Experimental results of our method have demonstrated an accuracy of about 99%, which is regarded to be very efficient.  相似文献   

12.
高原  陈川  王晶 《计量学报》2020,41(5):513-517
2019新型冠状病毒(SARS-CoV-2)入侵人体引起急性呼吸道传染病,命名为2019冠状病毒病(COVID-19)。新冠病毒在全球范围传播对全球公共卫生安全构成了巨大的威胁,新冠病毒的检测对疫病诊断尤为重要。免疫分析技术作为核酸检测的辅助手段,主要用于对疑似病例和与感染者密切接触人员的筛查。免疫诊断技术包括抗体和抗原检测,通过检测感染部位或者血液样本中是否含有病毒本身的蛋白或是由病毒引起免疫反应而产生的抗体来判断是否携带病毒。对目前用于新冠病毒抗原和抗体检测的免疫分析方法着重进行了分析。  相似文献   

13.
In December 2019, a group of people in Wuhan city of Hubei province of China were found to be affected by an infection called dark etiology pneumonia. The outbreak of this pneumonia infection was declared a deadly disease by the China Center for Disease Control and Prevention on January 9, 2020, named Novel Coronavirus 2019 (nCoV-2019). This nCoV-2019 is now known as COVID-19. There is a big list of infections of this coronavirus which is present in the form of a big family. This virus can cause several diseases that usually develop with a serious problem. According to the World Health Organization (WHO), 2019-nCoV has been placed as the modern generation of Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) coronaviruses, so COVID-19 can repeatedly change its internal genome structure to extend its existence. Understanding and accurately predicting the mutational properties of the genome structure of COVID-19 can form a good leadership role in preventing and fighting against coronavirus. In this research paper, an analytical approach has been presented which is based on the k-means cluster technique of machine learning to find the clusters over the mutational properties of the COVID-19 viruses’ complete genome. This method would be able to act as a promising tool to monitor and track pathogenic infections in their stable and local genetics/hereditary varieties. This paper identifies five main clusters of mutations with as best in most cases in the coronavirus that could help scientists and researchers develop disease control vaccines for the transformation of coronaviruses.  相似文献   

14.
COVID-19 has become a pandemic, with cases all over the world, with widespread disruption in some countries, such as Italy, US, India, South Korea, and Japan. Early and reliable detection of COVID-19 is mandatory to control the spread of infection. Moreover, prediction of COVID-19 spread in near future is also crucial to better plan for the disease control. For this purpose, we proposed a robust framework for the analysis, prediction, and detection of COVID-19. We make reliable estimates on key pandemic parameters and make predictions on the point of inflection and possible washout time for various countries around the world. The estimates, analysis and predictions are based on the data gathered from Johns Hopkins Center during the time span of April 21 to June 27, 2020. We use the normal distribution for simple and quick predictions of the coronavirus pandemic model and estimate the parameters of Gaussian curves using the least square parameter curve fitting for several countries in different continents. The predictions rely on the possible outcomes of Gaussian time evolution with the central limit theorem of statistics the predictions to be well justified. The parameters of Gaussian distribution, i.e., maximum time and width, are determined through a statistical χ2-fit for the purpose of doubling times after April 21, 2020. For COVID-19 detection, we proposed a novel method based on the Histogram of Oriented Gradients (HOG) and CNN in multi-class classification scenario i.e., Normal, COVID-19, viral pneumonia etc. Experimental results show the effectiveness of our framework for reliable prediction and detection of COVID-19.  相似文献   

15.
A chest radiology scan can significantly aid the early diagnosis and management of COVID-19 since the virus attacks the lungs. Chest X-ray (CXR) gained much interest after the COVID-19 outbreak thanks to its rapid imaging time, widespread availability, low cost, and portability. In radiological investigations, computer-aided diagnostic tools are implemented to reduce intra- and inter-observer variability. Using lately industrialized Artificial Intelligence (AI) algorithms and radiological techniques to diagnose and classify disease is advantageous. The current study develops an automatic identification and classification model for CXR pictures using Gaussian Filtering based Optimized Synergic Deep Learning using Remora Optimization Algorithm (GF-OSDL-ROA). This method is inclusive of preprocessing and classification based on optimization. The data is preprocessed using Gaussian filtering (GF) to remove any extraneous noise from the image’s edges. Then, the OSDL model is applied to classify the CXRs under different severity levels based on CXR data. The learning rate of OSDL is optimized with the help of ROA for COVID-19 diagnosis showing the novelty of the work. OSDL model, applied in this study, was validated using the COVID-19 dataset. The experiments were conducted upon the proposed OSDL model, which achieved a classification accuracy of 99.83%, while the current Convolutional Neural Network achieved less classification accuracy, i.e., 98.14%.  相似文献   

16.
A hybrid convolutional neural network (CNN)-based model is proposed in the article for accurate detection of COVID-19, pneumonia, and normal patients using chest X-ray images. The input images are first pre-processed to tackle problems associated with the formation of the dataset from different sources, image quality issues, and imbalances in the dataset. The literature suggests that several abnormalities can be found with limited medical image datasets by using transfer learning. Hence, various pre-trained CNN models: VGG-19, InceptionV3, MobileNetV2, and DenseNet are adopted in the present work. Finally, with the help of these models, four hybrid models: VID (VGG-19, Inception, and DenseNet), VMI(VGG-19, MobileNet, and Inception), VMD (VGG-19, MobileNet, and DenseNet), and IMD(Inception, MobileNet, and DenseNet) are proposed. The model outcome is also tested using five-fold cross-validation. The best-performing hybrid model is the VMD model with an overall testing accuracy of 97.3%. Thus, a new hybrid model architecture is presented in the work that combines three individual base CNN models in a parallel configuration to counterbalance the shortcomings of individual models. The experimentation result reveals that the proposed hybrid model outperforms most of the previously suggested models. This model can also be used in the identification of diseases, especially in rural areas where limited laboratory facilities are available.  相似文献   

17.
2019冠状病毒病(COVID-19)疫情已成为国际关注的突发公共卫生事件。为应对突发病毒疫情事件,加快病毒检测并提高检测准确性变得非常重要。中华人民共和国国家卫生健康委员会《新型冠状病毒肺炎诊疗方案》规定了核酸检测和基因测序作为确诊病例的方法,检测结果是对潜伏期人群、疑似病例人群和隔离期人群的新型冠状病毒(2019-nCoV/SARS-CoV-2)进行确诊的重要依据。对实时荧光RT-PCR检测、数字PCR检测及基因测序方法进行了综述,并对后续监控和生物安全测量(生物计量)标准体系的建立进行了展望。  相似文献   

18.
Deep learning created a sharp rise in the development of autonomous image recognition systems, especially in the case of the medical field. Among lung problems, tuberculosis, caused by a bacterium called Mycobacterium tuberculosis, is a dangerous disease because of its infection and damage. When an infected person coughs or sneezes, tiny droplets can bring pathogens to others through inhaling. Tuberculosis mainly damages the lungs, but it also affects any part of the body. Moreover, during the period of the COVID-19 (coronavirus disease 2019) pandemic, the access to tuberculosis diagnosis and treatment has become more difficult, so early and simple detection of tuberculosis has been more and more important. In our study, we focused on tuberculosis diagnosis by using the chest X-ray image, the essential input for the radiologist’s profession, and researched the effectiveness of the transfer learning approach in the case study of Vietnamese chest X-ray images. We proposed four strategies to clarify our hypothesis in different ways of applying transfer learning and different training set types. We also prepared a Vietnamese X-ray image dataset with the support of the VRPACS team to provide the basis for training and testing deep learning models. Our experiments were carried out by applying three different architectures, Alexnet, Resnet, and Densenet, on international, Vietnamese, and combined X-ray image datasets. After training, all models were verified on a pure Vietnamese X-rays set. The results show that transfer learning is suitable in the case study of Vietnamese chest X-ray images with high evaluating metrics in terms of AUC (Area under the Receiver Operating Characteristic Curve), sensitivity, specificity, and accuracy. In the best strategy, most of the scores were more than 0.93, and all AUCs were more than 0.98.  相似文献   

19.
Early diagnosis of a pandemic disease like COVID-19 can help deal with a dire situation and help radiologists and other experts manage human resources more effectively. In a recent pandemic, laboratories perform diagnostics manually, which requires a lot of time and expertise of the laboratorial technicians to yield accurate results. Moreover, the cost of kits is high, and well-equipped labs are needed to perform this test. Therefore, other means of diagnosis is highly desirable. Radiography is one of the existing methods that finds its use in the diagnosis of COVID-19. The radiography observes change in Computed Tomography (CT) chest images of patients, developing a deep learning-based method to extract graphical features which are used for automated diagnosis of the disease ahead of laboratory-based testing. The proposed work suggests an Artificial Intelligence (AI) based technique for rapid diagnosis of COVID-19 from given volumetric chest CT images of patients by extracting its visual features and then using these features in the deep learning module. The proposed convolutional neural network aims to classify the infectious and non-infectious SARS-COV2 subjects. The proposed network utilizes 746 chests scanned CT images of 349 images belonging to COVID-19 positive cases, while 397 belong to negative cases of COVID-19. Our experiment resulted in an accuracy of 98.4%, sensitivity of 98.5%, specificity of 98.3%, precision of 97.1%, and F1-score of 97.8%. The additional parameters of classification error, mean absolute error (MAE), root-mean-square error (RMSE), and Matthew’s correlation coefficient (MCC) are used to evaluate our proposed work. The obtained result shows the outstanding performance for the classification of infectious and non-infectious for COVID-19 cases.  相似文献   

20.
This study is designed to develop Artificial Intelligence (AI) based analysis tool that could accurately detect COVID-19 lung infections based on portable chest x-rays (CXRs). The frontline physicians and radiologists suffer from grand challenges for COVID-19 pandemic due to the suboptimal image quality and the large volume of CXRs. In this study, AI-based analysis tools were developed that can precisely classify COVID-19 lung infection. Publicly available datasets of COVID-19 (N = 1525), non-COVID-19 normal (N = 1525), viral pneumonia (N = 1342) and bacterial pneumonia (N = 2521) from the Italian Society of Medical and Interventional Radiology (SIRM), Radiopaedia, The Cancer Imaging Archive (TCIA) and Kaggle repositories were taken. A multi-approach utilizing deep learning ResNet101 with and without hyperparameters optimization was employed. Additionally, the features extracted from the average pooling layer of ResNet101 were used as input to machine learning (ML) algorithms, which twice trained the learning algorithms. The ResNet101 with optimized parameters yielded improved performance to default parameters. The extracted features from ResNet101 are fed to the k-nearest neighbor (KNN) and support vector machine (SVM) yielded the highest 3-class classification performance of 99.86% and 99.46%, respectively. The results indicate that the proposed approach can be better utilized for improving the accuracy and diagnostic efficiency of CXRs. The proposed deep learning model has the potential to improve further the efficiency of the healthcare systems for proper diagnosis and prognosis of COVID-19 lung infection.  相似文献   

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