共查询到17条相似文献,搜索用时 62 毫秒
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针对传统光学读出微悬臂梁传感器所需测量系统复杂的局限,将生物素—亲和素系统的放大效应与压阻式微悬臂梁传感技术结合起来,成功构建了一种读出方式简单的压阻式微悬臂梁免疫传感器。利用构建的传感器对相思子毒素进行检测,检测限达8μg/L,反应在20 min内基本完成,具有很好的特异性和重现性,能满足水样、土壤、食品等实际模拟样品检测的要求。建立了压阻式微悬臂梁免疫传感器检测相思子毒素的反应动力学模型,并对实际检测数据进行了拟合分析,相关系数R值在0.971 1以上(P0.001)。根据拟合方程求出的传感器对不同浓度相思子毒素反应达到平衡的响应电压ΔU e、响应时间t0均与实测值非常接近。 相似文献
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针对静态微悬臂梁表面特异性结合产生表面应力信号的响应机制问题,介绍了微悬臂梁生化传感器的工作原理,阐述了应力响应机制的简化模型,从纵向界面上和横向分子间2个方面对特异性吸附引起的悬臂梁表面应力的变化进行了剖析,讨论了界面能变化、位阻作用、静电力、氢键作用等与表面应力大小及方向之间的关系,总结了应力型微悬臂梁生化传感器的响应机理的研究。 相似文献
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为了研究拉伸和大形变弯曲共存状态下硅纳米悬臂梁传感结构的压阻特性,采用CMOS工艺制作了硅纳米悬臂梁传感测试结构,结合原子力显微镜和半导体参数测试仪对其电学参数进行了测量,其位移灵敏度高达1.58216×10-4/nm。在电阻相对变化率实验测量和ANSYS有限元平均应力仿真的基础之上,进而提出了一个非线性压阻模型来提取大弯曲硅纳米悬臂梁的一阶和二阶压阻系数。研究结果表明:其一阶压阻系数约为体硅的5倍,该巨压阻效应为利用硅纳米压阻传感结构来实现超高灵敏度的纳米压力传感器提供了可能的途径。研究结果同时也揭示了要获得高的灵敏度和好的可靠性,硅纳米悬臂梁的长度设计需要折衷考虑。 相似文献
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<正> 压阻式绝对压力传感器是利用单晶硅的压阻效应,在周边固支的圆型膜片上采用半导体平面工艺,在晶片特定的方向和位置上制成电阻并组成全桥电路,最后通过静电封接技术形成真空腔制成。 相似文献
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本文详细介绍集成惠斯顿有源电桥压阻传感器的实用校正方法,有效克服半导体集成传感器输出的共模电压影响,调节静态和满程压力负载条件下的静态零点和满足程输出毫伏值,使传感器在流体或气体的测量线路设计中带业方便。 相似文献
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FPSR^TM系列传感器元是美国Interlink公司最新工艺制造的,对采用它所研制开发的压滑觉传感器进行了介绍,并阐述了其信号的检测方法。 相似文献
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微悬臂梁传感器以其实时、高灵敏度、非标记等优点,成为一种新型环境检测手段。介绍了微悬臂梁传感器的工作原理,包括其工作模式、读出技术,总结了其在环境检测等方面的研究动态,并对其在环境检测领域的发展进行了展望。 相似文献
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Design and analysis of piezoresistive microcantilever for surface stress measurement in biochemical sensor 总被引:4,自引:0,他引:4
Piezoresistive microcantilever has been proposed to measure the surface stress generated by biochemical analytes. Such in situ measurement is desirable for biochemical sensors with on-chip microsystem integration. A two-dimensional model is presented to analyze the four-layer piezoresistive microcantilever subject to the surface stress effect generated by biochemical reaction and the thermal effect induced by the piezoresistive layer. Analysis shows that both effects are detrimental to sensor measurement. Conventional wisdom by changing the aspect ratio of a microcantilever is futile to achieve higher sensitivity. An improved design by having the stripe pattern on the immobilized layer is developed to increase the measurement sensitivity. Higher sensitivity can also be obtained by having thicker bottom insulation layer and thinner piezoresistive layer. It is shown that the microcantilever design is superior to the stress concentration region (SCR) design commonly seen in atomic force microscopy (AFM). 相似文献
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Joseph A. Capobianco Wan Y. Shih Gregory P. Adams Wei-Heng ShihAuthor vitae 《Sensors and actuators. B, Chemical》2011,160(1):349
We have investigated real-time, label-free, in situ detection of human epidermal growth factor receptor 2 (Her2) in diluted serum using the first longitudinal extension mode of a lead zirconate-lead titanate (PZT)/glass piezoelectric microcantilever sensor (PEMS) with H3 single-chain variable fragment (scFv) immobilized on the 3-mercaptopropyltrimethoxysilane (MPS) insulation layer of the PEMS surface. We showed that with the longitudinal extension mode, the PZT/glass PEMS consisting of a 1 mm long and 127 μm thick PZT layer bonded with a 75 μm thick glass layer with a 1.8 mm long glass tip could detect Her2 at a concentration of 6–60 ng/ml (or 0.06–0.6 nM) in diluted human serum, about 100 times lower than the concentration limit obtained using the lower-frequency flexural mode of a similar PZT/glass PEMS. We further showed that with the longitudinal mode, the PZT/glass PEMS determined the equilibrium H3–Her2 dissociation constant Kd to be 3.3 ± 0.3 × 10−8 M consistent with the value, 3.2 ± 0.28 × 10−8 M deduced by the surface plasmon resonance method (BIAcore). 相似文献