共查询到20条相似文献,搜索用时 15 毫秒
1.
Grandi F Sandal M Guarguaglini G Capriotti E Casadio R Samorì B 《Chembiochem : a European journal of chemical biology》2006,7(11):1774-1782
We wish to propose a novel mechanism by which the triggering of a biochemical signal can be controlled by the hierarchical coupling between a protein redox equilibrium and an external mechanical force. We have characterized this mechanochemical mechanism in angiostatin, and we have evidence that it can switch the access to partially unfolded structures of this protein. We have identified a metastable intermediate that is specifically accessible under thioredoxin-rich reducing conditions, like those met by angiostatin on the surface of a tumor cell. The structure of the same intermediate accounts for the unexplained antiangiogenic activity of angiostatin. These findings demonstrate a new link between redox biology and mechanically regulated processes. 相似文献
2.
Inside Cover: Strategy for Internal Labeling of Large RNAs with Minimal Perturbation by Using Fluorescent PNA (ChemBioChem 9/2015) 下载免费PDF全文
Anita G. Schmitz Susann Zelger‐Paulus Prof. Dr. Gilles Gasser Prof. Dr. Roland K. O. Sigel 《Chembiochem : a European journal of chemical biology》2015,16(9):1250-1250
3.
4.
5.
6.
7.
Cover Picture: Inhibition of Mycobacterium tuberculosis Transaminase BioA by Aryl Hydrazines and Hydrazides (ChemBioChem 4/2014) 下载免费PDF全文
Ran Dai Daniel J. Wilson Dr. Todd W. Geders Prof. Dr. Courtney C. Aldrich Prof. Dr. Barry C. Finzel 《Chembiochem : a European journal of chemical biology》2014,15(4):477-477
8.
9.
10.
Cover Picture: Peptidyl Succinimidyl Peptides as Taspase 1 Inhibitors (ChemBioChem 15/2014) 下载免费PDF全文
Johannes van den Boom Marija Mamić Daniele Baccelliere Dr. Susanne Zweerink Dr. Farnusch Kaschani Prof. Dr. Shirley Knauer Prof. Dr. Peter Bayer Prof. Dr. Markus Kaiser 《Chembiochem : a European journal of chemical biology》2014,15(15):2165-2165
11.
12.
13.
Prof. Dr. Emily R. Derbyshire Dr. Vanessa Zuzarte‐Luís Dr. Andreia D. Magalhães Dr. Nobutaka Kato Dr. Paul C. Sanschagrin Dr. Jinhua Wang Dr. Wenjun Zhou Dr. Chandrasekhar V. Miduturu Prof. Dr. Ralph Mazitschek Prof. Dr. Piotr Sliz Prof. Dr. Maria M. Mota Prof. Dr. Nathanael S. Gray Prof. Dr. Jon Clardy 《Chembiochem : a European journal of chemical biology》2014,15(13):1841-1841
14.
15.
16.
《Chembiochem : a European journal of chemical biology》2003,4(5):357-357
The cover picture shows how a combination of recombinant synthesis and chemical synthesis has been used to obtain chemically modified proteins. N‐terminal protein segments of pro‐neuropeptide Y (proNPY) were produced as intein‐fusion proteins in Escherischia coli in order to obtain thioesters. C‐terminal segments were synthesized by parallel automated peptide synthesis and derivatized to obtain carboxyfluorescein‐ (CF) and biotin‐labeled peptides. Native chemical ligation yielded chemically modified full‐length analogues of proNPY that can be used to monitor the biosynthesis of neuropeptide Y. Futher information can be found in the article by Beck‐Sickinger and co‐workers on p. 425 ff. 相似文献
17.
18.
Cover Picture: Generic Structures of Cytotoxic Liprotides: Nano‐Sized Complexes with Oleic Acid Cores and Shells of Disordered Proteins (ChemBioChem 18/2014) 下载免费PDF全文
Dr. Jørn D. Kaspersen Jannik N. Pedersen Dr. Jon G. Hansted Dr. Søren B. Nielsen Srinivasan Sakthivel Dr. Kristina Wilhelm Dr. Ekaterina L. Nemashkalova Prof. Dr. Sergei E. Permyakov Prof. Dr. Eugene A. Permyakov Prof. Dr. Cristiano Luis Pinto Oliveira Prof. Dr. Ludmilla A. Morozova‐Roche Prof. Dr. Daniel E. Otzen Prof. Dr. Jan Skov Pedersen 《Chembiochem : a European journal of chemical biology》2014,15(18):2629-2629
19.
Cover Picture: Structural and Biochemical Analyses of the Catalysis and Potency Impact of Inhibitor Phosphoribosylation by Human Nicotinamide Phosphoribosyltransferase (ChemBioChem 8/2014) 下载免费PDF全文
Angela Oh Yen‐Ching Ho Mark Zak Yongbo Liu Xukun Chen Po‐wai Yuen Xiaozhang Zheng Yichin Liu Peter S. Dragovich Weiru Wang 《Chembiochem : a European journal of chemical biology》2014,15(8):1053-1053