Preparation and characterization of Mg-6Li and Mg-6Li-1Y alloys

Mg-6Li and Mg-6Li-1Y (wt.%) alloys were prepared using permanent model casting method, and microstructure and mechanical properties were investigated by means of X-ray diffraction (XRD), scanning electron microscopy (SEM), optical microscopy (OM), energy dis-persive spectrometry (EDS), transmission electron microscopy (TEM), etc. The results showed that α-Mg and ?-Li phases existed in both al-loys, and there was also Y-enriched phase in Mg-6Li-1Y alloy. The composition of Y-enriched phase was near to the ma...     

New neplanocin analogues. 6. Synthesis and potent antiviral activity of 6'-homoneplanocin A1

The design, synthesis, and antiviral activities of 6'-homoneplanocin A (HNPA, 3) and its congeners having nucleobases other than adenine, such as 3-deazaadenine (4), guanine (5), thymine (6), and cytosine (7), were described. Starting from the known cyclopentenone derivative 8, the optically active (mesyloxy)cyclopentene derivative 15 was prepared, which was condensed with nucleobases then deprotected to give target compounds 3-7. Of these compounds, HNPA showed an antiviral activity spectrum that was comparable to, and an antiviral specificity that was higher than, that of neplanocin A. HNPA proved particularly active against human cytomegalovirus, vaccinia virus, parainfluenza virus, vesicular stomatitis virus, and arenaviruses, which is compatible with an antiviral action targeted at S-adenosylhomocysteine hydrolase. HNPA appears to be a promising candidate drug for the treatment of these viruses.