共查询到19条相似文献,搜索用时 203 毫秒
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在溶液中,利用自组装方法制备以卟啉化合物为基础的纳米材料具有优良的光物理和光化学性质,在分子器件和人工模拟光合作用等方面具有巨大的应用前景,是目前的研究热点。本文详细介绍了单卟啉组装方法和多卟啉共组装方法,单卟啉组装包括双溶剂法和表面活性剂辅助法两类方法。简要介绍了卟啉自组装纳米材料在集光天线和光催化方面的应用。目前,自组装方法制备的卟啉化合物纳米材料已经出现了丰富的形态,但仍存在不足,即自组装作用机理有待深入研究,且如何将卟啉纳米材料的制备工艺放大并应用于实际,还有待进一步发展。 相似文献
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合成了系列偶氮羟基卟啉-噁二唑化合物,通过1HNMR,FAB-MS,IR,UV-Vis确定了化合物的结构。核磁氢谱中远低场处(δ:13.0-16.0)醌腙体上亚胺基质子的出现及原料羟基卟啉羟基质子的消失表明,这些偶氮羟基卟啉-噁二唑化合物中存在着偶氮体和醌腙体的互变异构;红外光谱中1 725 cm-1附近CO强吸收的出现及3 400 cm-1附近的羟基伸缩振动峰的几乎消失表明,两种异构体中以醌腙异构占绝对优势。对合成化合物进行了光谱性能测定,实验结果表明,基态下,分子中噁二唑基团与卟啉基团相对独立,没有相互作用;而在激发态下,卟啉-噁二唑分子内存在着强烈的相互作用。该文报道了4种化合物的瞬态吸收光谱,为进一步研究卟啉-噁二唑分子激发态行为提供了参考。 相似文献
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卟啉化合物是一类具有共面的18π电子共轭大环体系化合物,其卟啉环上可引入各类取代基,并能与多种金属配位。设计合成了3种带有不同取代基的甲基丙烯酰氧基修饰的尾式卟啉配体,并以有机金属盐法、苯甲腈法合成了与其对应的金属锌、铂配合物。通过红外光谱、核磁共振氢谱和UV-Vis光谱等对卟啉化合物的结构进行表征,证实了所合成的化合物为目标产物,并系统研究了卟啉化合物在二氯甲烷溶剂中的荧光性质与电化学性质。实验结果表明,通过改变卟啉苯环上取代基的种类及中心金属配位,可以对卟啉化合物的光学性质和电化学性质产生明显的影响。 相似文献
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聚合物键联钴卟啉的合成及其催化作用 总被引:1,自引:0,他引:1
合成了 5 -对羟苯基 - 1 0 ,1 5 ,2 0 -三 (对甲氧苯基 )卟啉 (1 )及其钴配合物 (2 )。将(1 )与氯甲基化聚苯乙烯树脂键合得聚合物键联卟啉 (3) ,(3)与钴离子络合得聚合物键联钴卟啉 (4) ,考察了 (4)对丙硫醇的催化氧化作用。对卟啉化合物进行了 IR、UV测定和元素分析。对丙硫醇氧化产物作了 HPL C、UV、IR和 MS分析。 相似文献
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Francesca Persano Giuseppe Gigli Stefano Leporatti 《International journal of molecular sciences》2022,23(6)
In humans, glioblastoma is the most prevalent primary malignant brain tumor. Usually, glioblastoma has specific characteristics, such as aggressive cell proliferation and rapid invasion of surrounding brain tissue, leading to a poor patient prognosis. The current therapy—which provides a multidisciplinary approach with surgery followed by radiotherapy and chemotherapy with temozolomide—is not very efficient since it faces clinical challenges such as tumor heterogeneity, invasiveness, and chemoresistance. In this respect, natural substances in the diet, integral components in the lifestyle medicine approach, can be seen as potential chemotherapeutics. There are several epidemiological studies that have shown the chemopreventive role of natural dietary compounds in cancer progression and development. These heterogeneous compounds can produce anti-glioblastoma effects through upregulation of apoptosis and autophagy; allowing the promotion of cell cycle arrest; interfering with tumor metabolism; and permitting proliferation, neuroinflammation, chemoresistance, angiogenesis, and metastasis inhibition. Although these beneficial effects are promising, the efficacy of natural compounds in glioblastoma is limited due to their bioavailability and blood–brain barrier permeability. Thereby, further clinical trials are necessary to confirm the in vitro and in vivo anticancer properties of natural compounds. In this article, we overview the role of several natural substances in the treatment of glioblastoma by considering the challenges to be overcome and future prospects. 相似文献
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Nitrogen compounds in natural soils are studied in relation to their effect on the soil removal mechanism in detergency.
Nitrogen compounds in various forms and in fairly large amts are found in natural soils, and more than 24% of these nitrogen
compounds are presumed to be high mol wt nitrogen compounds or proteins. These high mol wt nitrogen compounds which cannot
be removed by water can be removed by the detergent action of sodium dodecyl benzene sulfonate (DBS). When the detergency
of DBS was compared with nonyl phenol-polyoxyethylene adduct, the detergency for artificial soil cloths did not coincide with
results obtained with naturally soiled cloths.
These data suggest that some interaction between DBS and nitrogen compounds might have contributed to the detergent action.
If proteins were added to the present artificial soil formulation, better correlation might be expected between artificial
and natural soil detergency results in DBS evaluation. 相似文献
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Phototoxic Activity and DNA Interactions of Water‐Soluble Porphyrins and Their Rhenium(I) Conjugates
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Giuliana Mion Dr. Teresa Gianferrara Dr. Alberta Bergamo Prof. Gilles Gasser Dr. Vanessa Pierroz Dr. Riccardo Rubbiani Prof. Ramon Vilar Dr. Anna Leczkowska Prof. Enzo Alessio 《ChemMedChem》2015,10(11):1901-1914
In the search for alternative photosensitizers for use in photodynamic therapy (PDT), herein we describe two new water‐soluble porphyrins, a neutral fourfold‐symmetric compound and a +3‐charged tris‐methylpyridinium derivative, in which either four or one [1,4,7]‐triazacyclononane (TACN) units are connected to the porphyrin macrocycle through a hydrophilic linker; we also report their corresponding tetracationic ReI conjugates. The in vitro (photo)toxic effects of the compounds toward the human cell lines HeLa (cervical cancer), H460M2 (non‐small‐cell lung carcinoma), and HBL‐100 (non‐tumorigenic epithelial cells) are reported. Three of the compounds are not cytotoxic in the dark up to 100 μm , and the fourfold‐symmetric couple revealed very good phototoxic indexes (PIs). The intracellular localization of all derivatives was studied in HeLa cells by confocal fluorescence microscopy. Although low nuclear localization was observed for some of them, it still prompted us to investigate their capacity to bind both quadruplex and duplex DNA; we observed significant selectivity in the tris‐methylpyridinium derivatives for G‐quadruplex interactions. 相似文献
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介绍了天然界中存在很多含有噻唑/(口恶)唑结构单元的活性分子,其生物合成途径或仿生合成方法通常分别以多肽氨基酸残基的羧酸基团或羧酸衍生物为底物,与半胱氨酸/丝氨酸等天然氨基酸或经过衍生化的非天然氨基酸环合、氧化而成,因此天然产物中的噻唑/(口恶)唑C5位通常以无取代的形式存在。然而,C5位二聚化、烯基化或芳基化的噻唑/(口恶)唑结构单元常见于具有广泛药理活性的人工合成的分子中,构建这类结构单元通常都需预先制备β-取代的非天然氨基酸。并且,关于该类天然产物的结构改造均未涉及噻唑/(口恶)唑C5位上的官能团化修饰,这是由于目前尚缺乏该位点上的官能团化方法而造成的。该现状预示着,开发噻唑/(口恶)唑C5位官能团化新方法,并将其应用于噻唑/(口恶)唑天然产物的结构修饰,具有十分重要的意义和研究价值。 相似文献
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金属卟啉有机框架有机框架材料是一种由卟啉或金属卟啉作为结构单元构筑的新型周期性网状结构材料,既具有卟啉拓宽光谱响应范围、降低光生电子-空穴复合率的独特优势,又具有MOFs材料的多孔道、孔道尺寸可调节、比表面积大的双重优势,成为目前具有良好光电性质的新型光催化剂。近年来,许多科学家们致力于新型光催化剂的开发与应用。尤其是近几年来,随着材料科学的发展,新型光催化剂金属卟啉MOFs成为光催化剂的研究热点并取得了令人欣慰的成果。本文主要综述了近十年来卟啉/金属卟啉MOFs在二氧化碳还原、裂解水制氢、光降解有机染料等领域的最新应用,并对未来MPFs在光催化领域的发展进行了展望. 相似文献
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The widely recognized biofouling phenomenon has many negative consequences for artificial structures that are in contact with
seawater in the form of structural defects and additional expenses for maritime companies due to cleaning and prevention processes.
After having analyzed the serious environmental problems caused by an indiscriminate use of highly toxic biocides coming from
organic derivatives of tin compounds and the uncontrolled emissions of volatile organic compounds (VOC) to the atmosphere,
the evolving technology of antifouling paintings (further mandated by current environmental standards) aims to develop environmentally
innocuous water-based coverings in which extracts of the very same marine world are used as biocide compounds. Water-based
coatings are being developed that use low-toxic elements and natural biocides, where bacteria is isolated from surfaces immersed
in the marine environment, creating a promising source of natural antifouling compounds. The result is a new environmentally
friendly antifouling coating that is able to mitigate the problem of biofouling without affecting the surrounding medium,
and which may be applied on any artificial structure in contact with seawater.
An erratum to this article can be found at 相似文献