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《Drug development and industrial pharmacy》2013,39(14):2387-2402
AbstractCellulose acetate butyrate microcapsules containing propranolol were prepared by emulsion non-solvent addition method. The effects on drug release of different polyethylene glycols (PEG), various concentrations of PEG 4000, and particle size of the drug to be encapsulated were investigated. In vitro dissolution of microcapsules in simulated intestinal fluid and buffers at different pH was also studied. PEGs were found to increase drug release for this system. The pH dissolution profiles of the microcapsules indicated that dissolution was slightly pH dependent during the first 8 hours of dissolution. 相似文献
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Stability of vitamin B-12 and its uniform mixing in multivitamin solid dosage forms was attempted to increase by microencapsulating the vitamin by emulsion technique. The prepared products were evaluated for their strength, dissolution rate, and size distribution and compared for the biological stability with various other forms of vitamin B-12. The technique and adopted method were realised to be feasible and therefore, attempts were made for scaling up the procedure to manufacturing scale. 相似文献
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乳浊液法制备超细氧化锆粉体 总被引:27,自引:3,他引:24
用乳浊液法制备了平均晶粒尺寸为13~14nm,二次颗粒呈多边形或球形的3mol%Y2O3-ZrO2粉体。运用X射线衍射、X荧光光谱、电感耦合等离子体光谱、比表面仪、透射电镜以及差热-热失重仪等分析手段对粉体进行了表征。实验还表明,制备过程中所采用的非均相共沸蒸馏法是一种排除凝胶中残留水份的有效手段,从而使得合成粉体中的团聚现象得到控制。 相似文献
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《Drug development and industrial pharmacy》2013,39(4):399-407
Microcapsules of methoxybutropate solid particles or of an oily saturated solution of the same drug were prepared by complex coacervation between gelatin and acacia and dried with three different methods: isopropanol addition, spray-drying, and freeze-drying. Successively, microparticles were analyzed by infrared thermobalance, ultraviolet (UV) spectroscopy, optical and scanning electron microscopy, and sieves to find out parameters such as yield, moisture content, encapsulation percentage, morphology of solid particles, and particle size. Results highlighted that the most appropriate drying method for industrial purposes was spray-drying, particularly for oil-containing microcapsule formulations. 相似文献
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《Drug development and industrial pharmacy》2013,39(9-10):951-957
AbstractKetoprofen microcapsules were prepared by complex coacervation between gelatin and acacia, and dried with different methods: isopropanol addition, spray-drying, and freeze-drying, Successively, microparticles were analyzed by infrared thembalance, ultraviolet spectroscopy, optical and scanning electron microscopy, and sieves; and subjected to dissolution studies in order to examine parameters such as yield, moisture content, encapsulation percentage, morphology of solid particles, particle size, and dissolution behavior. Provided that encapsulation and drying methods did not affect ketoprofen dissolution profiles, the most appropriate drying method for industrial purposes was spray-drying. 相似文献
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Giovanni Filippo Palmieri Sante Martell Dario Lauri Pascal Wehrle 《Drug development and industrial pharmacy》1996,22(9):951-957
Ketoprofen microcapsules were prepared by complex coacervation between gelatin and acacia, and dried with different methods: isopropanol addition, spray-drying, and freeze-drying, Successively, microparticles were analyzed by infrared thembalance, ultraviolet spectroscopy, optical and scanning electron microscopy, and sieves; and subjected to dissolution studies in order to examine parameters such as yield, moisture content, encapsulation percentage, morphology of solid particles, particle size, and dissolution behavior. Provided that encapsulation and drying methods did not affect ketoprofen dissolution profiles, the most appropriate drying method for industrial purposes was spray-drying. 相似文献
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用正交试验方法优化乳化炸药设计 总被引:1,自引:0,他引:1
文章运用了正交试验设计的方法,对乳化炸药的配方进行优化设计。通过"正交表"来选择试验条件,利用正交表的特点进行数据分析,从而通过代表性很强的少数次试验摸清各因素对结果的影响情况,并根据影响的大小确定因素主次顺序,找出较好的生产条件或较优的参数组合。试验结果表明,影响乳化炸药作功能力的因素有原材料配比、乳化剂类型、敏化方式,而原材料配比是影响乳化炸药作功能力的关键因素,乳化剂类型是主要因素,敏化方式是次要因素。 相似文献
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采用乳化交联法,以含有表面活性剂的植物油为连续相(油相),聚乙烯醇(PVA)水溶液为分散相(水相),戊二醛为交联剂,盐酸为催化剂,制备了PVA微球.利用FT-IR、SEM及粒度分析仪等设备对微球的组成、形貌及粒径分布进行了测试,并考察了几种关键工艺参数对微球制备的影响.结果表明,在PVA溶液浓度为5%,表面活性剂采用2 g脱水山梨醇单油酸酯(Span 80),乳化温度为50℃,1mol/L稀盐酸催化戊二醛交联的条件下,可以获得球形规整、表面光滑且分散性好的PVA微球.粒径分析结果显示,所得PVA微球的平均粒径约为25 μm,且分布在15~45 μm范围内的微球约占其总量的80%. 相似文献
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文中以炸药理论为基础,根据检测数据建立了乳化炸药的作功能力与爆速之间的基本关系式,并归纳了具体作功能力的计算方法。 相似文献
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It is shown that in the solanzation region more image is developable in a non-solvent physical developer than in a non-solvent chemical developer. 相似文献
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采用破乳剂Tween80,在温度70℃、搅拌速度400 r/min的条件下将乳化基质、乳化炸药在400 mL的水溶液中进行破乳。检测破乳过程中水溶液的电导率变化,绘制电导率-时间曲线,以此判断乳化基质、乳化炸药储存期间的稳定性。论述了实验原理及影响实验的因素。实际检测了乳化基质和乳化炸药在自然储存及冷冻储存条件下电导率-时间曲线的变化规律。检测结果与显微镜观察破乳情况和实际爆破性能对比表明,电导率法检测得到的结论与显微镜观察的析晶破乳状态及实际爆破性能基本一致。最终,通过大量的生产线检测数据确定了一组电导率-时间曲线作为标准曲线,以此为依据可快速判断乳化炸药的储存期。 相似文献
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Carlos E. Astete 《Particulate Science and Technology》2013,31(3):321-328
The goal of this study was to synthesize Poly(DL-lactide-Co-glycolide) nanoparticles with entrapped magnetite, of under 100 nm in diameter, for future drug delivery applications. The emulsion evaporation method was selected to form poly(lactide-co-glycolide) (PLGA) nanoparticles with entrapped magnetite (Fe3O4) in the polymeric matrix, in the presence of sodium dodecyl sulfate (SDS) as a surfactant. Magnetite, a water-soluble compound, was surface functionalized with oleic acid to ensure its efficient entrapment in the PLGA matrix. The inclusion of magnetite with oleic acid (MOA) into the PLGA nanoparticles was accomplished in the organic phase. Synthesis was followed by dialysis, performed to eliminate the excess SDS, and lyophilization. The synthesized nanoparticles ranged in size from 38.6 to 67.1 nm for naked PLGA nanospheres and from 78.8 to 87.2 nm for MOA-entrapped PLGA nanospheres. The entrapment efficiency ranged from 57.36% to 77.3%. 相似文献
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The goal of this study was to synthesize Poly(DL-lactide-Co-glycolide) nanoparticles with entrapped magnetite, of under 100 nm in diameter, for future drug delivery applications. The emulsion evaporation method was selected to form poly(lactide-co-glycolide) (PLGA) nanoparticles with entrapped magnetite (Fe3O4) in the polymeric matrix, in the presence of sodium dodecyl sulfate (SDS) as a surfactant. Magnetite, a water-soluble compound, was surface functionalized with oleic acid to ensure its efficient entrapment in the PLGA matrix. The inclusion of magnetite with oleic acid (MOA) into the PLGA nanoparticles was accomplished in the organic phase. Synthesis was followed by dialysis, performed to eliminate the excess SDS, and lyophilization. The synthesized nanoparticles ranged in size from 38.6 to 67.1 nm for naked PLGA nanospheres and from 78.8 to 87.2 nm for MOA-entrapped PLGA nanospheres. The entrapment efficiency ranged from 57.36% to 77.3%. 相似文献
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采用高低温循环试验测试样品的爆速值、电导率和硝酸铵析出量,综合分析各测试方法的结果来评估乳化炸药的稳定性,并设计了实验原理图。实验研究表明:随着高低温循环次数的增加,乳化炸药的爆炸性能逐渐下降,电导率和AN析出量逐渐增加,且呈现相类似的变化趋势。18次高低温循环后电导率增加更显著,当循环次数在18~30次内,破乳现象加剧,且乳化炸药的爆速逐渐降低,在27次循环后乳化炸药发生拒爆;将常温下爆速与高低温循环的爆速对比,得到高低温循环次数对应的自然存储天数,如高低温循环5次相当于自然存储76.6 d。 相似文献