共查询到20条相似文献,搜索用时 15 毫秒
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Dongmei Fan Enrica De Rosa Matthew B. Murphy Yang Peng Christine A. Smid Ciro Chiappini Xuewu Liu Paul Simmons Bradley K. Weiner Mauro Ferrari Ennio Tasciotti 《Advanced functional materials》2012,22(2):282-293
In this study, poly(dl ‐lactide‐co‐glycolide)/porous silicon (PLGA/pSi) composite microspheres, synthesized by a solid‐in‐oil‐in‐water (S/O/W) emulsion method, are developed for the long‐term controlled delivery of biomolecules for orthopedic tissue engineering applications. Confocal and fluorescent microscopy, together with material analysis, show that each composite microsphere contained multiple pSi particles embedded within the PLGA matrix. The release profiles of fluorescein isothiocyanate (FITC)‐labeled bovine serum albumin (FITC‐BSA), loaded inside the pSi within the PLGA matrix, indicate that both PLGA and pSi contribute to the control of the release rate of the payload. Protein stability studies show that PLGA/pSi composite can protect BSA from degradation during the long term release. We find that during the degradation of the composite material, the presence of the pSi particles neutralizes the acidic pH due to the PLGA degradation by‐products, thus minimizing the risk of inducing inflammatory responses in the exposed cells while stimulating the mineralization in osteogenic growth media. Confocal studies show that the cellular uptake of the composite microspheres is avoided, while the fluorescent payload is detectable intracellularly after 7 days of co‐incubation. In conclusion, the PLGA/pSi composite microspheres offer an additional level of controlled release and could be ideal candidates as drug delivery vehicles for orthopedic tissue engineering applications. 相似文献
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Chemotherapy: Polymer Nanoparticles Encased in a Cyclodextrin Complex Shell for Potential Site‐ and Sequence‐Specific Drug Release (Adv. Funct. Mater. 30/2014) 下载免费PDF全文
Guillermo U. Ruiz‐Esparza Suhong Wu Victor Segura‐Ibarra Francisca E. Cara Kurt W. Evans Miljan Milosevic Arturas Ziemys Milos Kojic Funda Meric‐Bernstam Mauro Ferrari Elvin Blanco 《Advanced functional materials》2014,24(30):4868-4868
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Drug Delivery: On‐Chip Self‐Assembly of a Smart Hybrid Nanocomposite for Antitumoral Applications (Adv. Funct. Mater. 10/2015) 下载免费PDF全文
Bárbara Herranz‐Blanco Dongfei Liu Ermei Mäkilä Mohammad‐Ali Shahbazi Eloy Ginestar Hongbo Zhang Vladimir Aseyev Vimalkumar Balasubramanian Jarno Salonen Jouni Hirvonen Hélder A. Santos 《Advanced functional materials》2015,25(10):1612-1612
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Cancer Treatment: Biocompatible,Uniform, and Redispersible Mesoporous Silica Nanoparticles for Cancer‐Targeted Drug Delivery In Vivo (Adv. Funct. Mater. 17/2014) 下载免费PDF全文
Quan Zhang Xiaoling Wang Pei‐Zhou Li Kim Truc Nguyen Xiao‐Jun Wang Zhong Luo Huacheng Zhang Nguan Soon Tan Yanli Zhao 《Advanced functional materials》2014,24(17):2413-2413
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Collagen Scaffolds: Iron Oxide‐Labeled Collagen Scaffolds for Non‐Invasive MR Imaging in Tissue Engineering (Adv. Funct. Mater. 6/2014) 下载免费PDF全文
Marianne E. Mertens Alina Hermann Anne Bühren Leon Olde‐Damink Diana Möckel Felix Gremse Josef Ehling Fabian Kiessling Twan Lammers 《Advanced functional materials》2014,24(6):722-722