共查询到20条相似文献，搜索用时 46 毫秒
1.
大豆及各类豆制品中含有多种生物活性成分，其中含量丰富的大豆异黄酮最为引人注目。这是因为近年来研究发现大豆异黄酮与人类的健康密切相关。同时，体外实验和动物实验证实了这类物质具有多重抑瘤抗癌效应，是一类很有潜力的化学防癌剂。本实验利用SHZ—88乳腺癌细胞株，对两种主要的大豆异黄酮类物质—大豆异黄酮(Daidzein)和染料木素(Genistein)的体外抑癌效应进行了比较研究，并探讨了其作用机理。 相似文献
2.
本实验以人胃癌SGC-7901细胞为体外实验模型,通过MTT实验,分裂指数法和集落形成实验,筛选具有较强抑制胃癌细胞生长作用的大豆异黄酮单体成分。结果表明游离形式的金雀异黄素的抑癌效果最为显著,其他形式的金雀异黄素苷和黄豆苷体外抑制细胞生长作用不明显。金雀异黄素代谢前体物鸡豆苷素亦有较显著的抑制效果,但作用迟缓。苷元形式的大豆异黄酮抑制肿瘤细胞生长作用明显强于苷类形式的大豆异黄酮,三羟异黄酮金雀异黄素是大豆异黄酮发挥生物学作用的最有效单体成分。 相似文献
3.
4.
5.
6.
糖尿病已成为严重威胁人类健康疾病之一。多项研究表明,大豆膳食纤维可改善糖尿病白鼠高血糖、消瘦、多饮多食等症状,具有降血糖、降血脂、预防肥胖症等作用;且对糖尿病白鼠肝肾组织也有保护作用。大豆异黄酮不仅可增加胰岛素敏感性,增强胰岛细胞分泌胰岛素能力,增强糖尿病白鼠免疫力;且具有抗氧化、降低血清胆固醇和甘油三酯等功能,这对预防和减缓糖尿病白鼠并发症具有一定防治作用。该文主要介绍大豆膳食纤维和大豆异黄酮对糖尿病影响,为预防和控制糖尿病提供一定科学依据。 相似文献
7.
大豆异黄酮是以大豆为原料提取制成的植物雌激素。大量研究表明，大豆异黄酮在防癌抗癌、防治心血管疾病、预防骨质疏松症、治疗妇女更年期综合症等方面有重要作用；但是在其稳定性的研究上，而国内还几乎为空白．因此，综述了大豆异黄酮组分稳定性以及该研究在异黄酮制备中的重大意义。 相似文献
8.
9.
10.
11.
Youngjoo Kwon 《Food Science & Nutrition》2014,2(6):613-622
Breast cancer is the most common cancer among women worldwide, and many women with breast cancer live more than 5 years after their diagnosis. Breast cancer patients and survivors have a greater interest in taking soy foods and isoflavone supplements. However, the effect of isoflavones on breast cancer remains controversial. Thus, it is critical to determine if and when isoflavones are beneficial or detrimental to breast cancer patients. According to the available preclinical data, high concentrations of isoflavones inhibit the proliferation of breast cancer cells, regardless of their estrogen receptor (ER) status. In comparison, genistein, a major isoflavone, has stimulated tumor growth at low concentrations and mitigated tamoxifen efficacy in ER‐positive breast cancer. Studies have indicated that the relative levels of genistein and estrogen at the target site are important to determine the genistein effect on the ER‐positive tumor growth. However, studies using ovariectomized mice and subcutaneous xenograft models might not truly reflect estrogen concentrations in human breast tumors. Moreover, it may be an oversimplification that isoflavones stimulate hormone‐dependent tumor growth due to their potential estrogenic effect since studies also suggest nonestrogenic anticancer effects of isoflavones and ER‐independent anticancer activity of tamoxifen. Therefore, the concentrations of isoflavones and estrogen in human breast tumors should be considered better in future preclinical studies and the parameters that can estimate those levels in breast tumors are required in human clinical/epidemiological investigation. In addition, it will be important to identify the molecular mechanisms that either inhibit or promote the growth of breast cancer cells by soy isoflavones, and use those molecules to evaluate the relevance of the preclinical findings to the human disease and to predict the health effects of isoflavones in human breast tumors. 相似文献
12.
苜蓿多糖抗肿瘤活性初探 总被引：1，自引：0，他引：1
为探讨苜蓿多糖的抗肿瘤活性,用热水浸提法得到苜蓿粗多糖,经DEAE-纤维素柱分段层析,获得S1、S2、S3、S44种组分,将它们和粗多糖S0分别通过腹腔注射于移植S-180腹水瘤和H-22腹水瘤的小鼠,测定小鼠体重的变化及生命延长率,结果表明:S1、S2能明显地抑制S-180腹水瘤和H-22腹水瘤小鼠体重的增加,且二者与对照组相比能极显著地延长荷瘤小鼠的生存期。 相似文献
13.
14.
15.
Ming‐Feng Hou Eing‐Mei Tsai Jau‐Nan Lee Hsin‐Lin Liang Yuh‐Jyh Jong Chih‐Hsing Hung Po‐Lin Kuo 《Molecular nutrition & food research》2011,55(2):318-327
Scope: In this study we first report the antimigration, antiinvasive effect of glabridin, a flavonoid obtained from licorice, in MDA‐MB‐231 human breast adenocarcinoma cells. Methods and results: Glabridin exhibited effective inhibition of cell metastasis by decreasing cancer cell migration and invasion of MDA‐MB‐231 cells. In addition, glabridin also blocked human umbilical vein endothelial cells (HUVEC) migration and decreased MDA‐MB‐231‐mediated angiogenesis. Further investigation revealed that the inhibition of cancer angiogenesis by glabridin was also evident in a nude mice model. Blockade of MDA‐MB‐231 cells and HUVEC migration was associated with an increase of αγβ3 integrin proteosome degradation. Glabridin also decreased the active forms of FAK and Src, and enhanced levels of inactivated phosphorylated Src (Tyr 416), decreasing the interaction of FAK and Src. Inhibition of the FAK/Src complex by glabridin also blocked AKT and ERK1/2 activation, resulting in reduced activation of RhoA as well as myosin light chain phosphorylation. Conclusion: This study demonstrates that glabridin may be a novel anticancer agent for the treatment of breast cancer in three different ways: inhibition of migration, invasion and angiogenesis. 相似文献
16.
Stefania Bulotta Rosanna Corradino Marilena Celano Maria D’Agostino Jessica Maiuolo Manuela Oliverio Antonio Procopio Michelangelo Iannone Domenicantonio Rotiroti Diego Russo 《Food chemistry》2011
Olive leaves extracts are a natural source of polyphenols, mainly oleuropein, widely considered to be potentially beneficial for health. This study focused on evaluation of the anti-tumoural activities of some oleuropein peracetylated derivatives, obtained with “green chemical” methodologies, against two human breast cancer cell lines. MCF-7 and T-47D cells were treated with oleuropein, peracetylated oleuropein, peracetylated aglycone and peracetylated hydroxytyrosol and the effects on growth and viability were investigated. Antioxidant effects were analysed after treatment with hydrogen peroxide. The peracetylated compounds exerted higher antiproliferative effects than oleuropein, by an arrest of cell cycle progression, associated with a strong antioxidant activity. Our results demonstrate that olive leaves, a by-product of olive manufacture, may provide a precious source of chemical derivatives, obtainable by peracetylation of oleuropein derivatives, which provide beneficial properties for human health. 相似文献
17.
Sergeev IN Ho CT Li S Colby J Dushenkov S 《Molecular nutrition & food research》2007,51(12):1478-1484
Sweet orange (Citrus sinensis L.) peel is a rich resource of flavonoids, especially polymethoxyflavones (PMFs). Citrus flavonoids exert a broad spectrum of biological activity, including antiproliferative and proapoptotic effects in cancer cells. We have recently shown that individual PMFs from orange peel induce Ca(2+)-mediated apoptosis in human breast cancer cells and that hydroxylation of PMFs is critical for enhancing their proapoptotic activity. Here, we report that the fraction of orange peel extract containing a mixture of non-hydroxylated PMFs (75.1%) and hydroxylated PMFs (5.44%) and the fraction containing only hydroxylated PMFs (97.2%) induce apoptosis in those cells as well. Treatment of MCF-7 breast cancer cells with these fractions inhibited growth and induced apoptosis associated with an increase in the basal level of intracellular Ca(2+). Effective concentrations of the hydroxylated PMFs fraction in inhibiting growth, inducing apoptosis, and increasing intracellular Ca(2+) were lower than those of the non-hydroxylated PMFs fraction. Our results strongly imply that bioactive PMFs from orange peel exert proapoptotic activity in human breast cancer cells, which depends on their ability to induce an increase in intracellular Ca(2+ )and thus, activate Ca(2+)-dependent apoptotic proteases. 相似文献
18.
19.
Le Corre L Chalabi N Delort L Bignon YJ Bernard-Gallon DJ 《Molecular nutrition & food research》2005,49(5):462-471
Despite years of intensive research, breast cancer remains a major cause of death among women. New strategies to combat breast cancer are being developed, one of the most exciting of which is the use of chemopreventive agents. Resveratrol (RES) is a polyphenolic compound found in plants that seems to have a wide spectrum of biological activity. RES has been shown to afford protection against several types of cancer. This review summarizes the chemopreventive effects of RES at the three major stages of breast carcinogenesis: initiation, promotion, and progression. It has anti-oxidant and anti-inflammatory properties, and may induce apoptosis as well as modulate cell cycle and estrogen receptor function in breast cancer cell lines. Although RES has shown remarkable promise as a potent chemopreventive agent in breast cancer, further studies are needed to etablish its usefulness. 相似文献
20.
Breast cancer is the leading cause of cancer-related deaths for women in the United States and the rest of the world. About 8% of women develop breast cancer during the course of their lives. Dietary habits are closely associated with both the risk and progression of breast cancer. Dietary agents have accumulated increasing importance with regards to the prevention and treatment of breast cancer. One such manner by which these compounds can target breast cancer development and progression is through interference with the angiogenic pathways. Angiogenesis is an intricate process that involves the development of new capillaries from previously existing blood vessels. Disruption of this pathway, therefore, provides a novel and effective avenue for therapeutic intervention of breast cancer. Various phytochemicals found in the diet kill breast cancer cells in vitro and prevent as well as suppress breast cancer progression in various preclinical animal models. This review examines the value of dietary phytoconstituents in the prevention and treatment of breast cancer through modulation of the intricate and complex process of angiogenesis. In addition, the potential benefits, challenges, and future directions of research on anti-angiogenic dietary phytochemicals in the prevention and intervention of breast cancer are also addressed. 相似文献