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Effect of cycloheximide on the expression of LPS-inducible iNOS, IFN-beta, and IRF-1 genes in J774 macrophages 总被引:1,自引:0,他引:1
Y Hattori K Akimoto M Matsumura CC Tseng K Kasai S Shimoda 《Canadian Metallurgical Quarterly》1996,40(5):889-896
The effect of cycloheximide (CHX) on the gene expression for inducible NO synthase (iNOS), interferon (IFN)-beta, and IFN regulatory factor (IRF)-1 was examined in LPS-stimulated J774 macrophages. LPS caused increased expression of mRNAs specific for iNOS, IFN-beta, and IRF-1 with different kinetics. Addition of CHX resulted in inhibition of the LPS-induced iNOS gene expression and parallel decrease in NO production. In contrast, expression of IFN-beta and IRF-1 genes in response to LPS was potentiated in the presence of CHX. These results indicate that de novo protein synthesis is not required for IFN-beta and IRF-1 gene expression and that ongoing protein synthesis including IFN-beta and IRF-1 may be involved in the induction process of iNOS in mouse macrophages. 相似文献
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N Fujii N Yokosawa S Ishida S Shirakawa T Kubota T Indoh K Fujinaga T Yashiki 《Canadian Metallurgical Quarterly》1996,40(10):777-781
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SL Schafer R Lin PA Moore J Hiscott PM Pitha 《Canadian Metallurgical Quarterly》1998,273(5):2714-2720
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M Hobart V Ramassar N Goes J Urmson PF Halloran 《Canadian Metallurgical Quarterly》1996,62(12):1895-1901
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