共查询到20条相似文献,搜索用时 15 毫秒
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RL Weinsier 《Canadian Metallurgical Quarterly》1982,1(3):219-226
The phagocytosis by mononuclear phagocytes, neutrophils and eosinophils of mast cell granules which are released in the course of anaphylactic reactions was studied in the rat. Degranulation of rat peritoneal mast cells was induced either in vivo or in vitro after passive sensitization with homologous reaginic antiovalbumin serum by challenge with the antigen. The approximate extent of degranulation was assessed by determining histamine release. The anaphylactic reaction was stopped by fixation with glutaraldehyde and the cells were examined by electron microscopy. Phagocytosis was quantified in randomly selected thin section at the magnification of 1,800. Rapid and extensive phagocytosis of mast cell granules was observed both in vivo and in vitro. About one third of the mononuclear phagocytes and between 30 and 53% of the neutrophils present were engaged in phagocytosis and usually contained several mast cell granules. Phagocytosis by eosinophils was less prominent, both with respect to the proportion of phagocytosing cell (10-23%) and to the number of mast cell granules per cell profile. Examination of large numbers of cells indicates that the uptake process is highly efficient since both condensed and already disaggregated granule bodies were seen to adhere to the phagocytes and were taken up rapidly and without the need for opsonization. In the neutrophils, extensive fusion of azurophil granules (as evidenced by peroxidase cytochemistry) with phagosomes containing mast cell granules was observed. Occasionally, mast cell granules were seen within disrupted vacuoles, which could result from the swelling of the granule matrix following engulfment. The result of this study indicate that mononuclear and polymorphonuclear phagocytes have the capacity to scavenge important amounts of mast cell granule products released by anaphylaxis. 相似文献
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RW Dahl 《Canadian Metallurgical Quarterly》1995,1(3):1-6
Developing guidelines for a community-based nursing group practice is a challenge for nursing professionals. Yet the benefits from the development of these guidelines can contribute to increased professionalism among nurses and accountability in nursing practice. In this article, the author describes the development of guidelines. The goal is for the development of guidelines based on health promotion. 相似文献
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MG Sawyer C MacMullin B Graetz JA Said JJ Clark P Baghurst 《Canadian Metallurgical Quarterly》1997,33(5):378-383
OBJECTIVE: To evaluate the effectiveness of the Rochester Social Problem Solving Program to reduce emotional and behavioural problems amongst primary school children. METHODOLOGY: Children in years 3 and 4 at primary school were assessed prior to receiving the program, immediately after the program and 1 year after the program. At each assessment, the functioning of the children who received the program was compared to the functioning of children enrolled in years 3 and 4 at a comparable school who did not receive the program. RESULTS: The program improved the ability of children to cope with potentially difficult social situations. However, the program did not reduce the prevalence of teacher-reported or mother-reported childhood emotional and behavioural problems. CONCLUSIONS: School-based social skills programs may be more effective in reducing childhood emotional and behavioural problems if they include components which focus specifically on childhood behaviour problems as well as components focusing on social skills and peer relationships. 相似文献
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Argues that the clinical practice of health promotion is based on at least 4 assumptions: (a) behaviors increase the risk of certain chronic diseases; (b) changes in behaviors can reduce the probability of risk of certain diseases; (c) behavior can be easily changed; and (d) behavioral interventions are cost-effective. Although data support most of these assumptions, the strength of the support is shown to be much weaker than is assumed by many psychologists. Thus, the expected health benefits from behavioral programs may not match the enthusiasm espoused by some health psychologists. A major problem in this field is that outcomes are frequently not conceptualized in relation to health. Health status is therefore suggested as the focal point for conceptualizations of health psychology. (83 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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J Santelli M Vernon R Lowry J Osorio M DuShaw MS Lancaster N Pham E Song E Ginn LJ Kolbe 《Canadian Metallurgical Quarterly》1998,68(10):434-440
The rapid expansion of managed care creates opportunities and dilemmas for those involved in school health and adolescent health promotion. Managed care organizations (MCOs), public health agencies, and school and adolescent health providers share certain common goals and priorities including an emphasis on prevention, cost-effectiveness, and quality of care--and a willingness to explore innovative approaches to health promotion and disease prevention. However, MCOs often face conflicting challenges, balancing the goals of cost containment and investment in prevention. In considering support for school health programs, MCOs will be interested in evidence about the effectiveness of services in improving health and/or reducing medical expenditures. Mechanisms for improving prevention efforts within MCOs include quality assurance systems to monitor the performance of health plans, practice guidelines from professional organizations, and the contracting process between payers and health care providers. Development of partnerships between MCOs and schools will be a challenge given competing priorities, variation in managed care arrangements, structural differences between MCOs and schools, and variability in services provided by school health programs. 相似文献
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To investigate the mechanism whereby serum dipeptidyl peptidase (DPP) IV activity in oral cancer patients is decreased, we examined the expression of cell surface DPP IV, also known as CD26, in cultured peripheral blood T lymphocytes of these patients and the amounts of DPP IV released into culture medium; values were compared with those found in healthy subjects. When peripheral blood T lymphocytes were cultured in the presence of phytohemagglutinin, concanavalin A and/or interleukin-2, the proliferative response and expression of CD26 (DPP IV) in their plasma membranes were greatly diminished in oral cancer patients as compared with those in healthy subjects. In addition, DPP IV activity in lymphocyte culture medium was reduced more in oral cancer patients than in healthy subjects, indicating decreased shedding of DPP IV from activated T lymphocytes in the patients. Based on these findings, it is suggested that suppression of DPP IV expression in peripheral blood T lymphocytes is one of the important factors involved in the mechanism of decrease of serum DPP IV activity in oral cancer patients. 相似文献
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Writing is a very demanding task, requiring the orchestration of a variety of cognitive resources. For developing writers, it can be especially demanding, as they have not yet mastered important writing processes, skills, and knowledge involved in planning, drafting, and revising text. In the present study, middle school students were directly taught strategies that facilitated the execution of each of these processes. They were also taught the knowledge and skills needed to carry out these strategies. In comparison to peers in the control condition, students in the experimental treatment condition produced essays that were longer, contained more mature vocabulary, and were qualitatively better. These gains were evident immediately following instruction and on a short-term maintenance probe administered 1 month later. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Elderly women require health screening and health promotion services from nurses and other health care providers. Nurses serving this population require knowledge of age-specific health screening and health promotion services. A case study from a geriatric nurse practitioner's practice demonstrates the complexity of these activities. A diary of such services can help nurses focus on elderly women's needs for health promotion interventions. 相似文献
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M Dalziel 《Canadian Metallurgical Quarterly》1998,59(9):723-725
In order to ensure that public health interests are at the forefront of the health agenda, practitioners will need to be able to operate within the political agenda and develop skills in influencing networking and communication, as well as keeping their essential technical and professional competencies. As part of the Chief Medical Officer's project, a health leadership programme is being developed. 相似文献
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Contemporary cardioanaesthesia is based on the use of opioid effects, whereby their dosage is steadily decreased. This calls for supplementation of anaesthesia by further pharmacological preparations which ensure adequate anaesthesia. Despite great efforts, neither, substances available at present nor their combinations are sufficient to suppress surgical stress completely. The authors attempt therefore selective influencing of the sympathetic nerve. In this respect preparations which stimulate sympathetic alpha2 receptors seem promising. The general trend of contemporary cardioanaesthesia is an effort to reduce the time spent by patients in the intensive care unit to a minimum. The motivation are in the first place economic reasons. 相似文献
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Irvine A. Blair; Biglan Anthony; Smolkowski Keith; Metzler Carol W.; Ary Dennis V. 《Canadian Metallurgical Quarterly》1999,67(6):811
This study provides evidence of the effectiveness of behaviorally based parenting skills provided by carefully trained and supervised group leaders who were not mental health clinicians. A program for parents of at-risk middle school students was evaluated in a randomized controlled trial in 8 small Oregon communities. Parents (N?=?303) were randomly assigned to immediate treatment or a wait-list condition. Data were analyzed using latent growth modeling. Participation in the program led to significant improvements in problem-solving interactions as indicated by parent reports and a Taped Situations Test. Parents' overreactivity and laxness toward their children's behavior were reduced and their feelings toward their children improved significantly as a function of treatment. Parent-reported child antisocial behavior was also reduced. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Conducted a 12-wk longitudinal study of the development of social support networks among college freshmen. 42 male and 47 female students who lived either in university residence halls or at home with their parents completed a series of questionnaires in which they described their social networks while attending college and their adaptation to university life. Ss also completed the Hopkins Symptom Checklist as a measure of psychological well-being. In accord with an ecological view of social support, the structural and functional characteristics of Ss' networks varied with gender, living situation, and temporal stage of the network. Network characteristics were significantly associated with successful adaptation to college, although the relative adaptiveness of particular network characteristics varied over time. (31 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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In collaboration with the Zuni pueblo, a culturally tailored intervention program was designed using a model of social cognitive development to remediate the behavioral and cognitive correlates of suicide. The Zuni Life Skills Development curriculum was introduced in the tribal high school and evaluated using a multimethod approach including self-report, behavioral observation, and peer rating. Students exposed to the curriculum scored better than the no-intervention group at posttest on suicide probability and hopelessness. In addition, the intervention group showed greater ability to perform problem-solving and suicide intervention skills in a behavioral assessment. The effectiveness of the program and recommendations for similar prevention programs are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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The majority of thyroid tumors are not homogeneous histologically, this creating difficulties in interpretation of different carcinoma variants. The aim of the study was a complex comparative study of morphogenetic changes in carcinoma, adenoma and surrounding thyroid tissue. Surgical material from 48 patients operated because of nodular (multinodular) euthyroid goiter in Moscow Medical Academy in 1990-1997 was used. It was established that all the observations of early thyroid carcinoma diagnosed clinically as a nodular (multinodular) euthyroid goiter were represented by differentiated forms of thyroid carcinoma. Thyroid carcinoma was characterized by higher values of biomolecular markers as compared to adenomas and surrounding tissue. High values of c-myc expression in adenomas and surrounding tissue may indicate possible genetic rearrangements. A peculiar feature of carcinomas was the fact that deletions and replication errors in malignant tumors in this study were found simultaneously in the three genes investigated. As to different histological types of carcinoma, the most frequent deletions of the genes studied were observed in medullary and papillary-follicular carcinoma. High values of heterozygosity loss were found already in adenomas and surrounding tissues, this indicating the presence of the genetic changes already in the benign tumors and surrounding tissue. 相似文献
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N Mackintosh 《Canadian Metallurgical Quarterly》1995,4(21):1273-1278
There have been many calls for nurses to adopt a self-empowerment model for health promotion practice rather than continuing to work from the medical model. Continuing with our series on health promotion, this article examines features of the self-empowerment approach and questions whether its goals are achievable. 相似文献
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This is a report of a national survey of 490 members of the National Association of School Nurses which described the relevance of 109 nursing diagnoses approved by NANDA (1992) and 29 health promotion (wellness) diagnoses developed by the authors. The relevance of these 138 nursing diagnoses for school nursing was determined by the percent of participants who checked "Yes" for the diagnostic categories they observed in their practice and for which they provided one or more interventions. More than half of the sample checked "Yes" for 67 NANDA diagnoses; health promotion diagnoses were checked "Yes" by 45% to 89% of the sample. The implications are that NANDA and health promotion diagnoses are relevant to school nursing and could readily be incorporated into practice to facilitate data collection that supports both the funding of school nurses and program development for children, families, and school staff. 相似文献