共查询到18条相似文献,搜索用时 265 毫秒
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生物催化与生物转化的研究进展 总被引:10,自引:2,他引:8
生物催化与生物转化是生物学、化学、过程工程科学的交叉领域,其核心目标是大规模采用微生物或酶为催化剂生产化学品、医药、能源、材料等。本文指出生物催化与生物转化研究重新崛起,并已成为发达国家的重要科技与产业发展战略,概述了生物催化与生物转化技术的发展现状与趋势,介绍了我国重大基础研究项目生物催化与生物转化的研究动态,该项目的关键问题及主要研究方向是:(1)生物催化多样性理论及其实现方法;(2)催化剂改造的方法学;(3)生物系统催化的理论和方法;(4)生物催化剂适应性原理和方法问题;(5)重要生物催化体系的催化机理。 相似文献
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和化学合成相比,生物催化具有选择性高、反应条件温和、环境友好的特性而成为生物技术中一个快速发展的领域.但生物催化工业常受到底物溶解度低、底物/产物抑制生物催化剂活性、产物进一步降解等限制.非水相催化和原位产物去除新技术是克服上述困难的有力工具,本文综述了其研究进展.以甾醇边链切除的微生物转化为例,介绍了作者最近开发的高度集成了非水相催化和原位产物去除优点的浊点两相分配生物反应器技术.讨论了非水相生物催化工业高度过程集成和深度学科交叉的特征,提出了发展非水相生物催化工业的若干建议. 相似文献
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工业生物技术的研究现状与发展趋势 总被引:11,自引:1,他引:10
工业生物技术是以微生物或酶为催化剂进行物质转化,大规模生产人类所需的化学品、医药、能源、材料等,是解决人类目前面临的资源、能源及环境危机的有效手段.世界经合组织指出:“工业生物技术是工业可持续发展最有希望的技术”.本文指出工业生物技术的新崛起,并已成为发达国家的重要科技与产业发展战略.概述了工业生物技术的发展现状与趋势,特别在生物能源、生物材料以及生物质资源化方面.介绍了工业生物技术的关键问题是:(1)微生物资源库和微生物功能基因组学技术;(2)生物催化剂快速定向改造新技术;(3)重要工业微生物的代谢工程.展望了我国工业生物技术发展前景. 相似文献
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生物催化与生物转化的核心目标,是在化工领域大规模采用微生物或酶为催化剂,大规模生产有机化学品。 相似文献
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Kwang-Il Lee Teh Fu Yen 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》1990,48(1):71-79
A novel bioprocess using micelle biocatalysts was developed to minimize several disadvantages of conventional microbial coal desulfurization processes. The multiphase biocatalysis process consists of an organic medium (mineral oil or a mixture with n-heptane), a surfactant and an aqueous phase containing Thiobacillus ferrooxidans organisms or their cell-free enzyme extracts. Water-in-oil emulsion and reverse micelle processes have been successful for removing sulfur from bituminous coal. The preliminary results indicated that, in the case of water-in-oil emulsion, the process that used the cell-free enzyme extracts of T. ferrooxidans showed higher sulfur reduction than that containing whole cells, and reverse micells were more effective than water-in-oil emulsion. With a high concentration of bacteria, more than 50% total sulfur removal was achieved through the reverse micelle system. These results indicate that multiphase biocatalysis may have a significant potential for developing biotechnical coal desulfurization processes. 相似文献
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Gizem Ölçücü Dr. Ulrich Krauss Prof. Dr. Karl-Erich Jaeger Prof. Dr. Jörg Pietruszka 《化学,工程师,技术》2023,95(4):531-542
For the development of efficient and green industrial processes, the combination of biocatalysis and flow chemistry holds great promises. Flow chemical utilization of biocatalysts, essentially made possible by the immobilization (or retention) of enzymes in flow reactors, has attracted increased academic attention during recent years. In the present review we present an overview of immobilization strategies suitable for flow chemistry, particularly focusing on recently developed carrier-free immobilization methods, highlighting advances in the field and presenting future trends. 相似文献
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This review discusses a recent state of research in the field of enzymatic biocatalysis in application for the production of modified food fats. Properties of biocatalysts for enzymatic interesterification both been currently under development and already applied in industry of vegetable oils are discussed. The main directions of research on development of new biocatalysts, including those based on the novel recombinant lipase enzymes, as well as the potential of targeted modifications in the composition of oils by optimization of the catalytic process are covered. The relevant analysis of the enzymatic interesterification of oils shows its potential for development of energy efficient and environmentally friendly processes for production of the high quality food products with the specified characteristics. 相似文献
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Discovering and developing new biocatalytic reactions and biocatalysts has been the major focus of the activities in the EC FP7 BIOTRAINS network. However, industrial implementation of these new reactions requires engineering of both the biocatalysts and the associated processes, to achieve the necessary targets for economic and sustainable feasibility of full-scale processes. The possible engineering solutions can most rapidly be identified using a series of tools and in this article we will describe some of these as well as giving a perspective on the future of this important element of process research and development. 相似文献
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Pavel Dvorak Dr. Nagendra P. Kurumbang Jaroslav Bendl Dr. Jan Brezovsky Dr. Zbynek Prokop Prof. Jiri Damborsky 《Chembiochem : a European journal of chemical biology》2014,15(13):1891-1895
Multienzyme processes represent an important area of biocatalysis. Their efficiency can be enhanced by optimization of the stoichiometry of the biocatalysts. Here we present a workflow for maximizing the efficiency of a three‐enzyme system catalyzing a five‐step chemical conversion. Kinetic models of pathways with wild‐type or engineered enzymes were built, and the enzyme stoichiometry of each pathway was optimized. Mathematical modeling and one‐pot multienzyme experiments provided detailed insights into pathway dynamics, enabled the selection of a suitable engineered enzyme, and afforded high efficiency while minimizing biocatalyst loadings. Optimizing the stoichiometry in a pathway with an engineered enzyme reduced the total biocatalyst load by an impressive 56 %. Our new workflow represents a broadly applicable strategy for optimizing multienzyme processes. 相似文献