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1.
Young and aged rabbits underwent classical conditioning of the nictitating membrane response (NMR) to a tone conditioned stimulus (CS) and a corneal airpuff unconditioned stimulus (UCS) for 18 consecutive days. Rabbits were then returned to their home cages for a 90-day period in which they received no further conditioning, but they were handled daily. On Day 91 they underwent retention testing during which the CS alone was presented 20 times. This was immediately followed by reacquisition in which the CS and UCS were again paired for 100 trials. Reacquisition was repeated on the following day. As in previous studies, aged rabbits acquired the conditioned response (CR) more slowly than young rabbits; however, by the end of acquisition, both groups reached similar asymptotic levels. Retention of the CR was significantly lower for aged than young rabbits. Reacquisition was also retarded in aged vs young rabbits. Nonassociative factors, such as sensitivity to the stimuli or general health, could not account for these differences. Data are discussed in terms of using retention of the conditioned eyeblink response as a model system for studying age-related memory deficits. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

2.
A nicotinic cholinergic antagonist, mecamylamine (MEC), was administered to rabbits tested on eyeblink classical conditioning (EBCC) in the 750-msec delay paradigm for 10 90-trial sessions. Nicotinic receptors were measured in 3 brain regions in S treatment groups: paired conditioned stimulus–unconditioned stimulus (CS–UCS) presentations with (1) vehicle, young; (2) vehicle, older; (3) 0.5 mg/kg MEC, young; unpaired CS–UCS with (4) 0.5 mg/kg MEC, young; and (5) vehicle, young. Daily MEC injections disrupted acquisition in young rabbits (769 trials to learning criterion vs 323 trials for vehicle-treated young rabbits). MEC-treated young rabbits learned similarly to older rabbits. Brain nicotinic receptors were not affected by 10 daily MEC injections. To our knowledge, this experimental protocol, using a low MEC dose to selectively inhibit nicotinic cholinergic receptors, is the first to demonstrate a role for nicotinic cholinergic receptors in EBCC. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

3.
Normal aging selectively impairs some forms of learning. For example, aging rabbits require more than twice as many trials to acquire 500-ms trace eyeblink conditioning than do young rabbits. N-methyl-{d}-aspartate (NMDA) receptor antagonists also impair trace conditioning. The effects of daily {d}-cycloserine (DCS; a partial agonist of the NMDA receptor-glycine site) treatment were tested on trace conditioning of young or aging rabbits using a conservative quantitative approach. DCS dose dependently improved acquisition, maximally reducing trials to criterion by ≈50%. Dose-response curves were right-shifted by aging (twice the dose was required to achieve the same enhancement compared with controls). DCS did not affect nonassociative performance but sharpened the conditioned stimulus tone intensity discrimination. DCS thus can functionally modulate NMDA receptors in normal aging, enhance associative learning at all ages, and reduce or reverse age-dependent learning deficits. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

4.
Normal aging selectively impairs some forms of learning. For example, aging rabbits require more than twice as many trials to acquire 500-ms trace eyeblink conditioning than do young rabbits. N-methyl-D-aspartate (NMDA) receptor antagonists also impair trace conditioning. The effects of daily D-cycloserine (DCS; a partial agonist of the NMDA receptor-glycine site) treatment were tested on trace conditioning of young or aging rabbits using a conservative quantitative approach. DCS dose dependently improved acquisition, maximally reducing trials to criterion by approximately 50%. Dose-response curves were right-shifted by aging (twice the dose was required to achieve the same enhancement compared with controls). DCS did not affect nonassociative performance but sharpened the conditioned stimulus tone intensity discrimination. DCS thus can functionally modulate NMDA receptors in normal aging, enhance associative learning at all ages, and reduce or reverse age-dependent learning deficits.  相似文献   

5.
Examined age differences in a cer paradigm. 72 sprague-dawley albino rats were treated at 15, 22, 35, or 70 days of age in 1 of 3 ways: (a) paired tone-light and shock trials; (b) unpaired tone-light and shock trials; or (c) no treatment at all. Subsequent tests in a suppression of drinking situation show that only the 15-day old ss failed to acquire a cer, as measured by the difference between paired and unpaired groups. Older ss extinguished more quickly than younger ss and also habituated an unconditioned suppression response more quickly. Results are related to thompson's model, and to the literature on the development of learning abilities. (french summary) (17 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

6.
The possible modulatory role of motor cortex in classical conditioning of the eyeblink response was examined by ablating anterior neocortex in rabbits and training them with an auditory conditioned stimulus (CS) and an airpuff unconditioned stimulus (US) in either a delay (Experiment 1) or a trace (Experiment 2) conditioning paradigm. Topographic measures such as amplitude and onset latency were assessed during conditioning sessions for conditioned responses (CRs) and on separate test days for unconditioned responses (URs) by using a range of US intensities. No lesion effects were observed for learning or performance measures in acquisition or retention of either delay or trace conditioning. During trace conditioning, lesioned rabbits did, however, exhibit a trend toward impairment and demonstrated significantly longer CR latencies. Damage to motor and frontal cortex does not significantly affect eyeblink response performance or learning in either a delay or a trace conditioning paradigm. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

7.
The hypothesis that observed age-related decrements in recall scores derive primarily from degree of acquisition rather than from retention deficits per se was investigated. 40 elderly and 30 young Ss learned 9 paired associates under equal learning opportunity, learning to criterion or overlearning conditions. Retention was measured at 20 min. and 1 wk. Elderly Ss learned less on equal exposure and required more trials to criterion, but once having learned the material retained it as well as young Ss. Trials beyond criterion did not enhance the retention scores of elderly Ss and may have introduced negative motivational factors. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

8.
An investigation was made of the effects of the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME) on the acquisition and retention of two operantly conditioned discrimination tasks. Twenty Long-Evans rats were conditioned to approach one of two spatial locations that was either held constant across trials (spatial task) or was associated with a visual cue (illuminated lamp) that was randomly assigned to one of the locations on each trial (cued task). Rats were assigned to one of two treatment groups in which they received intraperitoneal injections of either NG-nitro-L-arginine methyl ester or saline approximately 2 h before sessions on each day of training. Analysis was made of the trial-by-trial performance in order to identify the characteristics of learning under each condition. Assessment of learning acquisition was based on the number of trials required to reach a criterion of 80% correct responses, whereas retention was assessed by the number of trials to criterion on each day after the criterion was initially reached. Analysis indicated that treatment groups did not differ significantly on acquisition or retention of either the spatial or cued task. These results indicate that inhibition of nitric oxide synthase does not interfere with the learning or retention of basic operant tasks that involve simple spatial or visual analysis. Whereas results from biochemical and physiological investigations have suggested an impact of nitric oxide synthase on behavioural function, behavioural investigations indicate a limited impact of nitric oxide synthase inhibition on learning and memory. Although these results do not discount the role of nitric oxide synthase in a hippocampal mechanism, they illustrate that behavioural analysis should be made in the context of multiple interacting neural systems. Viewed with previous behavioural research on the effects of NG-nitro-L-arginine methyl ester, these results indicate that nitric oxide synthase inhibition results in impairment of certain forms of learning whereas other forms are preserved.  相似文献   

9.
Little research has been conducted on aging and the learning of motor skills. In this study, we examined the effects of different schedules of knowledge of results (KR) on the acquisition and retention of a movement timing task by young adults (20-23 years) and older adults (60-82 years). The results indicated that there were differences between young and older adults in the accuracy and consistency of motor performance when KR was provided. Accuracy effects persisted during a retention interval when KR was no longer provided, although there were no differences in variability. There were no interactions of age with any of the KR-related variables. These findings suggest that the ability to process KR, and the effects of KR on motor learning, are similar in young and older adults. These findings are discussed in terms of age-related issues in movement control and learning processes.  相似文献   

10.
Compared age differences in the rates of acquisition and forgetting of a spatial memory problem with corresponding differences in the rates of increase and decay of long-term synaptic enhancement (LTE) of hippocampal synapses, induced by high-frequency stimulation of perforant path fibers, in 45 young (12 mo of age) and 45 old (27 mo of age) male Fischer 344 rats. Results indicate that old Ss approached their final asymptotic performance levels more slowly than did the young Ss and exhibited faster rates of forgetting of the problem. Similarly, LTE reached its maximum more slowly in the old Ss and decayed more quickly. Although the absolute rates of behavioral acquisition and forgetting were different from the corresponding rates of increase and decay of LTE, the relative differences between age groups were similar. This was particularly true for the comparison of forgetting with LTE decay. The relation of these data to the hypotheses that LTE underlies spatial learning and memory is discussed. (38 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

11.
The nictitating membrane/eyelid responses of 18 rabbits were classically conditioned using cerebellar mossy-fiber stimulation as a conditioned stimulus (CS) and air puff as an unconditioned stimulus (US). The dorsolateral, lateral, and medial pontine nuclei and the middle cerebellar penduncle were effective stimulation-CS sites for training. In one group of rabbits, robust conditioned eyelid responses were produced with paired trials and subsequently extinguished with CS-alone and explicitly unpaired presentation of the CS and US. In a second group of rabbits, no conditioned responses were evident for 4 days of unpaired CS and US presentations. Conditioned responses did develop, however, after paired training was begun. Lesions of the interpositus nucleus of the cerebellum completely abolished the conditioned responses of a third group of rabbits overtrained with the mossy-fiber CS and air-puff US. Results support studies that have demonstrated that the cerebellum is critically involved in acquisition and retention of simple learned responses and theories of cerebellar function which have proposed that mossy fibers supply critical "learning" input to the cerebellum for acquisition and retention of motor skills. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

12.
This research examined age differences in the acquisition and reacquisition of instance-based automaticity. In 2 experiments, young and older adults were trained to enumerate targets presented in otherwise empty displays or in displays that contained distractors. Experiment 1 revealed that older adults required more practice to reach asymptote than young adults. For both age groups, modifications of the identities and locations of targets produced substantial disruptions in performance, whereas modifications of the identities or locations of distractors produced little interference. However, no age differences in the representations of instances in memory were obtained in participants who reached asymptote. Experiment 2 revealed age deficits in the long-term retention and rate of reacquisition of instance-based automaticity 18 months after initial training. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

13.
The relationships among abilities, strategies, and performance on an associative learning task were investigated for young (aged 17 to 34) and older adults (aged 60 to 82). Participants received extensive practice on a noun-pair task in which they could use a visual-scanning strategy or a memory-retrieval strategy. Older adults were more likely to use the scanning strategy. Age differences were reduced when comparisons were made only for participants using a retrieval strategy. Associative memory was predictive of learning on the task, and semantic memory access speed was predictive of practiced performance. Practiced performance on a memory-search task that also required associative learning was predictive of practiced noun-pair performance. Models of ability-performance relationships for skill acquisition are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

14.
The authors examined whether 2 nondeclarative tasks, simple eyeblink classical conditioning (EBCC) and rotary pursuit (RP), would interfere with each other when performed simultaneously. In Experiment 1, 100 participants were assigned to 1 of 5 groups: paired EBCC/RP, unpaired EBCC/RP, paired EBCC as a single task, unpaired EBCC as a single task, and RP as a single task. Participants in the paired EBCC/RP group showed significantly greater acquisition of conditioned responses than did participants in the unpaired EBCC/RP group, and the unconditioned eyeblink response was similar in both groups. Comparisons of the paired EBCC/RP and paired EBCC-as-a-single-task groups indicated no differences in trials to criterion, but on some measures the single-task group conditioned better. Controls introduced in Experiment 2 did not change this pattern. Results provide some evidence for the lack of interference between EBCC and RP. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

15.
Human infants (aged 12–32 mo old) and adults learned a delayed nonmatching-to-sample (DNMS) task and single- and multiple-pair discrimination tasks using nonverbal procedures previously used with monkeys. Infants learned discriminations rapidly and at a young age (12 mo), but they required prolonged training and maturation before learning the DNMS task. Adults learned all tasks rapidly. After learning the DNMS task to criterion, memory performance declined systematically in an inverse relation to age. The dissociation in ability of infants on the DNMS vs discrimination tasks closely resembles the dissociation previously reported with infant monkeys (J. Bachevalier & M. Mishkin, 1984). Results from both infant humans and monkeys support a neurocognitive maturational model. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

16.
Evaluated backward conditioning of appetitive jaw movement and aversive nictitating membrane responses in rabbits, using 3 procedures: test trials, forward acquisition of the same response, and crossmotivational acquisition of the other response system. In both experiments, backward conditioning consisted of 3 conditioned stimulus/stimuli (CS) alone and 22 CS and unconditioned stimulus/stimuli (UCS) pairings. Contrasting the backward conditioning group with explicitly unpaired and no-treatment controls revealed that backward pairings produced no associative effects. The forward acquisition and crossmotivational acquisition tests suggest that excitatory backward acquisition of jaw movement was obtained. The forward acquisition test identified weak inhibitory conditioning of nictitating membrane responses, but the crossmotivational test implicated excitatory conditioning. (French abstract) (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

17.
Rabbits were classically conditioned to emit a nictitating membrane response (NMR) to either a light or tone conditioned stimulus (CS) paired with an eye shock unconditioned stimulus (UCS). They then received lesions of the middle cerebellar peduncle (MCP) or served as unoperated controls. Following surgery, they were given separate presentations of tone, light, and vibratory CSs, each paired with the eye shock UCS. In this way, conditioned responses (CR) to the previously trained light or tone served as a test of retention, whereas CRs to the remaining two conditioned stimuli (tone and vibratory or light and vibratory) served as a test of acquisition. The results of the study revealed that rabbits with complete lesions of the MCP showed disrupted acquisition and retention of the conditioned NMR to all stimuli, rabbits with partial MCP lesions also showed disrupted acquisition and retention to all CSs, but to a lesser degree, and animals with lesions that missed the MCP and unoperated controls both showed normal acquisition and retention of the conditioned NMR. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

18.
Four experiments assessed the effects of trial (T) and intertrial (I) durations on magazine approach behavior in rats. In Experiments 1 and 2, different groups of animals were conditioned with various combinations of I and T durations. The rate of acquisition, in terms of the number of trials required to reach various acquisition criteria, generally was faster in groups trained with large I:T ratios. There also were differences in rate of acquisition and terminal response rates between groups trained with identical I:T ratios but with different absolute I and T durations. Differences evident at the end of conditioning persisted during a common test with various combinations of I and T durations. Experiments 3 and 4 provided a more specific test of the predictions of 2 general classes of theories and found results that were consistent with those theories that characterize group differences as indicative of differences in learning, rather than in performance. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

19.
Investigated the effects of prior item familiarization on the acquisition and retention of paired-associate lists. Ss were 32 undergraduates in 8 experimental and 2 control groups. The critical items were trigrams which were paired with paralogs in the paired-associate task. There were 20 trials of learning, and recall was tested after 1 wk. The experimental treatments formed a 2 * 2 * 2 factorial design. Familiarization was either (a) for stimulus or response terms, (b) relevant or irrelevant to the learning task, or (c) at a frequency of 10 or 40 exposures/item. Control groups were given no preliminary training. Performance on the early learning trials was facilitated by response but not by stimulus familiarization. Both relevant and irrelevant response familiarization increased long-term retention losses, whereas stimulus familiarization had no reliable effect on recall. It is concluded that response familiarization is a source of both facilitation and interference. (French summary) (15 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

20.
Previous research has suggested that an age-related decline in change detection may be due to older adults using a more conservative response criterion. However, this finding may reflect methodological limitations of the traditional change detection design, in which displays are presented continuously until a change is detected. Across 2 experiments, the authors assessed adult age differences in a version of change detection that required a response after each pair of pre- and postchange displays, thus reducing the potential contribution of response criterion. Older adults performed worse than younger adults, committing more errors and requiring a greater number of display cycles for correct detection. These age-related performance declines were substantially reduced after controlling statistically for elementary perceptual speed. Search strategy was largely similar for the 2 age groups, but perceptual speed was less successful in accounting for age-related variance in detectability when a more precise spatial localization of change was required (Experiment 2). Thus, the negative effect of aging in the present tasks lies in a reduction of detection efficiency due largely to processing speed, though some strategy-level effects may also contribute. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   

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