Measurement of wave-front aberration in soft contact lenses by use of a Shack-Hartmann wave-front sensor

Lower- and higher-order wave-front aberrations of soft contact lenses were accurately measured with a Shack-Hartmann wave-front sensor. The soft contact lenses were placed in a wet cell filled with lens solution to prevent surface deformation and desiccation during measurements. Aberration measurements of conventional toric and multifocal soft contact lenses and a customized soft contact lens have proved that this method is reliable. A Shack-Hartmann wave-front sensor can be used to assess optical quality of both conventional and customized soft contact lenses and to assist in enhancing lens quality control.     

角膜接触透镜材料的研究进展

综述了接触透镜材料的研究进展,接触透镜从材料方面主要分为硬镜和软镜;介绍了各种透镜材料的成分、性能,并对其优缺点进行评定.聚甲基丙烯酸甲酯(PMMA)是最初的接触透镜材料,随后研制出透气性硬镜材料(RGP)以保持佩戴角膜健康.为改善佩戴舒适性,广泛研究水凝胶类软接触透镜材料,主要有聚甲基丙烯酸β-羟乙酯(HEMA)、聚乙烯吡咯烷酮(PVP)和聚乙烯醇(PVA)等材料;为提高软镜的透氧性等性能,目前研究的热点是高透氧性软接触透镜材料,主要以有机硅、有机氟等大分子单体合成水凝胶材料,以及生物改性的软镜材料.     

角膜接触镜材料的应用和研究进展

综述了各种透明高分子材料在角膜接触镜领域的应用及其特性,指出了角膜接触镜材料存在的问题,指明了角膜接触镜材料的发展趋势.     

NVP-HEMA角膜接触镜材料的透氧性能

以过氧化二苯甲酰(BPO)为引发剂，N-乙烯基吡咯烷酮(NVP)和甲基丙烯酸β-羟乙酯(HEMA)在一定温度下共聚得水凝胶，可作为软性角膜接触镜材料．实验发现，随NVP含量的增大，水凝胶的含水量越大，透氧性增大，水凝胶材料的透氧率(Dk／L)的倒数与其厚度成正比．并自行设计了一套角膜接触镜材料透氧性能的测试装置、     

水凝胶角膜接触镜材料研究进展

以角膜接触镜材料的基本要求为出发点,在相关文献和专利的基础上综述了目前软性亲水的水凝胶角膜接触镜材料的研究进展及发展趋势.特别针对传统型水凝胶角膜接触镜的透氧和均一成分构建的局限,分别重点介绍了高透氧角膜接触镜材料及互穿网络角膜接触镜材料.前者通过引入硅氧烷成分使角膜接触镜的延长配戴成为可能,后者则通过交联互锁的结构实现了材料的均一性和稳定性,从而为角膜接触镜材料在药物释放和治疗用途上的更广泛应用创造了条件.     

Lens curvature measurements by shadow projection profilometry

A technique is described for measuring spherical and aspherical lens curvature independent of surface contact or dependence on surface smoothness. The shadow of a lens profile is projected onto a CCD pixel array, and its silhouette edge-traced by computer video-image analysis. Nonlinear regression analysis, with correction for axial tilt, calculates lens curvature.     

Noninvasive continuous monitoring of physiological glucose using a monosaccharide-sensing contact lens

We have tested the feasibility of tear glucose sensing using a daily, disposable contact lens embedded with boronic acid-containing fluorophores as a potential alternative to current invasive glucose-monitoring techniques. Our findings show that our approach may, indeed, be suitable for the continuous monitoring of tear glucose levels in the range 50-500 microM, which track blood glucose levels that are approximately 5-10-fold higher. We compare the response of the boronic acid probes in the contact lens to solution-based measurements and can conclude that both the pH and polarity within the contact lens need to be considered with respect to choosing/designing and optimizing glucose-sensing probes for contact lenses.     

New design and analysis for point-focusing of surface waves in contact testing

A method was presented for the intensive focusing of surface ultrasonic waves in contact testing, and an ultrasonic contact transducer was fabricated and characterized. The acoustic contact lens of the transducer was in a shape which was obtained by rotating a right-angled triangle having a critical angle for the generation of surface waves. PVDF film was employed as an ultrasonic transmitter and receiver. The fabricated transducer showed the focusing feature of a narrow lateral half width and high sound intensity at a focal point. Also, a simple model was presented to estimate theoretically the stress pattern on a symmetry axis of the transducer. The stress pattern predicted using the model showed good agreement with the experimental result. This concept can also be used in acoustic microscopy.     

The Effect of Reduced Pressure on the Fit of Contact Lenses

It is shown that the fit of a haptic contact lens is substantially improved by applying a suction of 2 cm of mercury to the fluid between the lens and the eye. No significant further improvement is produced by increasing the suction to 5 cm of mercury. The lower suction causes no discomfort to the subject and is therefore preferred. Methods of testing the accuracy with which the lens follows the movements of the eye are discussed and their accuracy estimated.     

Patch-fed planar dielectric slab waveguide Luneburg lens

The design of a patch-fed planar dielectric slab waveguide Luneburg lens weighing only 45 g and operated at 27 GHz in TM₀ mode is described. The measured half-power beamwidth (HPBW) for a 10.8 lambda, 12-cm diameter lens fed by a microstrip patch placed in intimate contact with the lens rim is 6.9deg with 16.8 dB gain and 10% bandwidth for -10 dB feed return loss, lens cross-polar levels were below -20 dB. The lens is also capable of operating in the TE₀ mode with similar radiation performance to that of the TM₀ mode. Here, measured HPBW and gain is 8 and 15.5 dB at 27 GHz. Unlike other planar lens arrangements, because of its ability to handle both TM₀ and TE₀ modes the lens has the potential to deal with the circularly polarised signals, this aspect is also explored.     

球面投影光刻物镜的设计

针对人工晶体或隐形眼镜的面形上连续浮雕结构加工的特点,本文介绍了基于空间光调制器(DMD)曲面投影光刻物镜系统的设计方法.根据其成像面为曲面的特点,根据光学设计理论多次利用弯向物方的弯月形负透镜结构进行场曲校正,同时运用光的衍射原理优化设计物镜系统的数值孔径以消除DMD投影过程中的栅格效应. 运用ZEMAX工程光学设计软件对系统进行了模拟、优化,并对优化后的结果进行了分析.对于设计实例利用上述设计原则给出了设计结果,工作波长为g线(峰值波长λ=436nm),像面曲率r=22.5mm,视场φ6mm,数值孔径NA=0.1,分辨力为7.8 μm(64Ip/mm)时的光学调制传函值>0.8,畸变<±0.05%.     

Nested shell optical model of the lens of the human eye

A nested shell model of the human lens is developed based on the known anatomical construction of the lens, on the known way in which the lens grows throughout its life, on the measured characteristics of the lens surfaces as a function of the age of the lens, on the measured changes in the shape of the lens during accommodation, and on measured material characteristics of the lens materials, such as density and index of refraction throughout. The observed changes in central surface curvature and thickness force the shell thicknesses to vary in a predictable way and in turn force the shell surface asphericity to take certain values. Thus, in addition to giving the shape of each shell, the model predicts the change expected in the asphericity of the lens surfaces as the lens ages and adds cortical cell layers. Two examples are given, one for a 25-year-old lens and one for a 40-year-old lens, to show how the cortical layers change their shapes throughout the cortex and over time as the lens ages. The performance of the model of this paper is compared to that of two other nested shell models, one where the layers have constant thickness and one where the lens posterior is fixed within the eye over time, to show the superior performance of this model with respect to maintaining a constant refractive error for the eye as the lens ages and grows.     

Microfluidic Contact Lenses

Contact lens is a ubiquitous technology used for vision correction and cosmetics. Sensing in contact lenses has emerged as a potential platform for minimally invasive point‐of‐care diagnostics. Here, a microlithography method is developed to fabricate microconcavities and microchannels in a hydrogel‐based contact lens via a combination of laser patterning and embedded templating. Optical microlithography parameters influencing the formation of microconcavities including ablation power (4.3 W) and beam speed (50 mm s^?1) are optimized to control the microconcavity depth (100 µm) and diameter (1.5 mm). The fiber templating method allows the production of microchannels having a diameter range of 100–150 µm. Leak‐proof microchannel and microconcavity connections in contact lenses are validated through flow testing of artificial tear containing fluorescent microbeads (Ø = 1–2 µm). The microconcavities of contact lenses are functionalized with multiplexed fluorophores (2 µL) to demonstrate optical excitation and emission capability within the visible spectrum. The fabricated microfluidic contact lenses may have applications in ophthalmic monitoring of metabolic disorders at point‐of‐care settings and controlled drug release for therapeutics.     

Reversible grafting of antibiotics onto contact lens mediated by labile chemical bonds for smart prevention and treatment of corneal bacterial infections

Eye trauma, decreased immunity, and contact lens wear often cause serious bacterial infections and irreversible corneal damage. To realize the responsive release of antibiotics such as gentamicin sulfate(GS), a novel antibacterial contact lens was constructed through self-assembly of antibiotics loaded ADAGS/PEI(polyethyleneimine) multilayer films on the surface. Both in vitro and in vivo antibacterial tests demonstrated high efficient and fast antibacterial property based on the smart responsive to bacterial infections and reversible drug loading and release.     

Microparticle trapping in an ultrasonic Bessel beam

This paper describes an acoustic trap consisting of a multi-foci Fresnel lens on 127?μm thick lead zirconate titanate sheet. The multi-foci Fresnel lens was designed to have similar working mechanism to an Axicon lens and generates an acoustic Bessel beam, and has negative axial radiation force capable of trapping one or more microparticle(s). The fabricated acoustic tweezers trapped lipid particles ranging in diameter from 50 to 200?μm and microspheres ranging in diameter from 70 to 90?μm at a distance of 2 to 5?mm from the tweezers without any contact between the transducer and microparticles.     

Contrast sensitivity with presbyopic contact lenses

The purpose of the work was to assess the contrast sensitivity function of individuals wearing gas permeable (GP) multifocal contact lenses, soft bifocal contact lenses, and GP monovision lenses. Twenty-six females and six males between the ages of 42 and 65 participated in this study. The study included subjects wearing monovision (N?=?8), the Acuvue Bifocal (Johnson & Johnson) (N?=?8), Essential GP Multifocal (Blanchard) lenses (N?=?8) and progressive addition spectacle lenses (PAL) (N?=?8), with PAL wearers forming the control group. Measurements of binocular contrast sensitivity were obtained using the VISTECH 6500 system. Thresholds for each spatial frequency were fit to the equation CS(k)?=?ak?exp(?bk) [1?+?c exp(bk)]^?1/2, to describe the human contrast sensitivity function. The area under the contrast sensitivity function (CSF) curve was calculated for all four groups and compared. An index of performance was obtained, which was defined as the ratio of CSF with the contact lens correction to the CSF with spectacles. Of the contact lens wearing groups, GP multifocal contact lens wearers had the highest contrast sensitivity at all the spatial frequencies. Soft bifocal contact lens wearers exhibited higher contrast sensitivity than monovision wearers at all spatial frequencies. Subjects wearing GP multifocals had the largest area under the CSF; followed by those wearing soft bifocals, with monovision wearers having the smallest area. GP multifocals have the best visual function at 0.98, soft bifocals have an index of 0.65 and monovision has an index of 0.59. This study quantifies the visual performance of the three lens systems by measuring the area under the CSF curve. In addition, it provides indices of visual function with the contact lenses that will be helpful for analyses and comparisons in future studies.     

Ophthalmic application of poly(HEMA)s containing nanoparticles and dimethylacrylamide

High functional ophthalmic lens materials, poly(HEMA-co-MMA)s were prepared by the copolymerization of HEMA, MMA, MA, EDGMA, and N,N-dimethylacrylamide in the presence of platinum nanoparticles with antimicrobial properties. The hydrophilic monomer N,N-dimethylacrylamide has excellent biocompatibility and oxygen transmissibility. The combination where platinum nanoparticles were added produced a colorless transparent lens. The water contents were in the range of 36.68-44.08% and the refractive index was measured to be in the range of 1.424-1.436. Meanwhile, the oxygen transmissibility ranged from 11.13 x 10(-11) to 17.63 x 10(-11) (cm2/sec) (mlO2/ml x mm Hg) increased with increasing the addition ratio of N,N-dimethylacrylamide. The physical properties measurements of the produced polymers showed that the nanoparticles did not show significant effect on the water content and refractive index of the hydrogel contact lens, but the materials effected to reduce oxygen permeability to a certain extent. The copolymers have excellent oxygen permeability, indicating that the material can be used to fabricate hydrogel contact lenses with high oxygen transmissibility.     

A numerical model of light adjustable lens

We model numerically the mechanical effects of UV induced photo-polymerization in elastomeric artificial lens. The elastomer is originated upon cross-linking of a silicone matrix. UV irradiation of one side of the lens polymerizes selectively a photosensitive macromer, causing local variations of its concentration. The subsequent diffusion of macromers from high concentration to low concentration zones modifies the shape of the lens and thus its dioptric power. In vitro experiments on artificial lens showed that the power change is dependent on UV exposure time, irradiation intensity and light pattern. With the aim to define a numerical tool able to predict the dioptric power adjustment as a function of the UV irradiation parameters, we setup a purely mechanic finite element model of the lens, adopting a hyperelastic material model embedded with eigen-deformations. Numerical simulations of axis-symmetric irradiation closely reproduced the experimental results, in terms of both lens geometry and dioptric power, for positive, negative and lock-in corrections.     

Lens distortion models evaluation

Many lens distortion models exist with several variations, and each distortion model is calibrated by using a different technique. If someone wants to correct lens distortion, choosing the right model could represent a very difficult task. Calibration depends on the chosen model, and some methods have unstable results. Normally, the distortion model containing radial, tangential, and prism distortion is used, but it does not represent high distortion accurately. The aim of this paper is to compare different lens distortion models to define the one that obtains better results under some conditions and to explore if some model can represent high and low distortion adequately. Also, we propose a calibration technique to calibrate several models under stable conditions. Since performance is hard conditioned with the calibration technique, the metric lens distortion calibration method is used to calibrate all the evaluated models.     

Adaptive model of the gradient index of the human lens. II. Optics of the accommodating aging lens

A simple, parametric model of the gradient refractive index distribution (GRIN) of the human lens with conicoid surfaces able to adapt to individual distributions as well as to the changes of the lens shape and structure with age and accommodation is presented. The first part of this work was published in a companion paper [J. Opt. Soc. Am. A24, 2175 (2007)]. It included the development of the mathematical formulation of the adaptive model; the validation of its customization capability by fitting, sample by sample, a set of in vitro refractive index distributions of lenses of different ages, ranging from 7 to 82 years, from the recent literature; and an average model of the (in vitro) aging crystalline lens. Here we extrapolate that in vitro GRIN model by assuming that the same structural parameters are valid for the living lens. Then, recent data of the changes of the shape of the aging lens with accommodation from the literature are used to build an aging and accommodating lens model. This is straightforward since the GRIN model adapts automatically to the chosen external lens geometry. A strong coupling was found between the adaptive GRIN distributions and the conic constants affecting the refractive power. To account for the lens paradox and the reported changes in lens spherical aberration with age and accommodation, age- and accommodation-dependent functions for the anterior and posterior internal conic constants were derived through optimization.