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1.
Straight-through microchannel devices for generating monodisperse emulsion droplets several microns in size 总被引:1,自引:1,他引:0
Isao Kobayashi Takayuki Takano Ryutaro Maeda Yoshihiro Wada Kunihiko Uemura Mitsutoshi Nakajima 《Microfluidics and nanofluidics》2008,4(3):167-177
The authors recently proposed a promising technique for producing monodisperse emulsions using a straight-through microchannel
(MC) device composed of an array of microfabricated oblong holes. This research developed new straight-through MC devices
with tens of thousands of oblong channels of several microns in size on a silicon-on-insulator plate, and investigated the
emulsification characteristics using the microfabricated straight-through MC devices. Monodisperse oil-in-water (O/W) and
W/O emulsions with average droplet diameters of 4.4–9.8 μm and coefficients of variation of less than 6% were stably produced
using surface-treated straight-through MC devices that included uniformly sized oblong channels with equivalent diameters
of 1.7–5.4 μm. The droplet size of the resultant emulsions depended greatly on the size of the preceding oblong channels.
The emulsification process using the straight-through MC devices developed in this research had very high apparent energy
efficiencies of 47–60%, defined as (actual energy input applied to droplet generation/theoretical minimum energy input necessary
for making droplets) × 100. Straight-through MC devices with numerous oblong microfluidic channels also have great potential
for increasing the productivity of monodisperse fine emulsions. 相似文献
2.
Takashi Kuroiwa Hisato Kiuchi Kazuki Noda Isao Kobayashi Mitsutoshi Nakajima Kunihiko Uemura Seigo Sato Sukekuni Mukataka Sosaku Ichikawa 《Microfluidics and nanofluidics》2009,6(6):811-821
We investigated a preparation method of giant vesicles using monodisperse water-in-oil (W/O) emulsions stabilized by bilayer-forming
emulsifiers. A mixture of phosphatidylcholine, cholesterol and stearylamine was used both to stabilize the water droplets
formed in the emulsion and to form the vesicles. Using this lipid mixture, we obtained monodisperse W/O emulsions with mean
droplet diameters of 10–40 μm and coefficients of variation as small as ca 5% by means of the microchannel (MC) emulsification
technique. Utilization of an asymmetric straight-through MC array device enabled a monodisperse droplet productivity of up
to 80 ml/h. The obtained water droplets were converted to giant vesicles via evaporative removal of the continuous-phase solvent
followed by addition of an aqueous buffer solution. The resulting vesicles were similar in size to their starting water droplets,
and a hydrophilic fluorescent marker was entrapped inside the vesicles. 相似文献