蜂胶乙醇提取物对肥胖人群运动后的免疫功能的影响

目的 研究蜂胶乙醇提取物（EEP）与运动对肥胖人群运动后免疫功能的影响。方法 将100例男性肥胖者随机分配到EEP组（n=50）和安慰剂组（n=50）。两组受试者均以65% VO_2max的运动强度进行跑步机运动，每天运动1 h，每周运动5次，共8周。EEP组受试者每天1次服用1粒EEP胶囊（含100 mg EEP），安慰剂组受试者每天服用1粒与EEP胶囊外观相似的胶囊，持续8周。然后检测两组受试者的NK细胞活性、炎症因子［（肿瘤坏死因子-α（TNF-α）、白介素-1β（IL-1β）和IL-10）］水平和淋巴细胞比例（T细胞、B细胞和NK细胞）。结果 与安慰剂组相比，EEP组的NK细胞活性显著升高（50.14%±8.86% vs 55.73%±7.85%，P=0.011）。与安慰剂组相比，EEP组的血清TNF-α（893.46±177.32 pg/mL vs 637.53±152.35 pg/mL，P=0.014）和IL-1β（122.14±18.57 pg/mL vs 99.95±16.46 pg/mL了，P<0.001）水平降低，IL-10升高（7.16±1.58 pg/mL vs 10.45±1.78 pg/mL，P=0.008）。两组的基线及8周后的T细胞、B细胞和NK细胞百分比均无显著变化（P>0.05）。结论 运动期间服用EEP通过刺激NK细胞活化等方式改善免疫功能。     

城市成年居民在外就餐频率与口味偏好的关联性研究

目的 探索我国城市居民在外就餐频率与口味偏好之间的关系。方法 采用方便抽样的方法，选择有完整在外就餐频率及口味偏好调查数据的四个城区中1 957名18～65岁成年居民作为研究对象，分析在外就餐和口味偏好现状，利用多因素Logistics回归模型分析在外就餐频率与口味偏好的关联性。结果 研究对象每周在外就餐频率为<1次、1～3次、4～6次、≥7次的人群比例分别为35.8%（701/1 957）、33.5%（655/1 957）、18.3%（358/1 957）、12.4%（243/1 957）。男性和女性口味偏好上存在差异，男性口味偏咸率、口味偏油率明显高于女性，女性口味偏甜率高于男性。在控制相关混杂因素的基础上，与在外就餐频率<1次/周的城市女性居民相比，在外就餐1～3次/周的城市女性居民口味偏咸的风险增加59%（OR=1.59）；在外就餐1～3次/周、4～6次/周、≥7次/周的城市女性居民口味偏甜的风险均增加范围为51%-77%（OR=1.51，OR=1.71，OR=1.77）；在外就餐1～3次/周、≥7次/周的城市女性居民口味偏辣的风险分别增加54%（OR=1.54）和78%（OR=1.78）。与每周在外就餐频率<1次的城市男性居民相比，每周在外就餐4~6次的城市男性居民偏油口味和偏辣口味的风险分别增加61%（OR=1.61）和85%（OR=1.85）。结论 城市居民在外就餐频率可能与口味偏好存在一定关联。应当加强在外就餐人群的营养宣传教育，引导其养成健康的饮食习惯。     

虾青素和/或有氧运动对D-半乳糖诱导大鼠心脏衰老的干预作用

目的 探究虾青素和/或有氧运动延缓D-半乳糖诱导大鼠心脏衰老的潜在作用机制。方法 SPF级3月龄SD雄性大鼠40只随机分为安静对照组（C组）、急性衰老模型组（D组）、急性衰老+虾青素组（DA组）、急性衰老+有氧运动组（DE组）及急性衰老+虾青素+有氧运动组（DAE组）,每组各8只。C组不进行任何干预,急性衰老各组大鼠腹腔注射100 mg/kg·d的D-半乳糖,同时分别以20 mg/kg·d 虾青素和/或运动强度为60%最大摄氧量的有氧运动进行干预,实验周期为6周。末次训练12 h后取心脏,光学显微镜观察心脏组织形态并检测相关生化指标。结果 心脏组织形态,C组正常;与C组比较,D组出现心肌细胞排列紊乱、心肌纤维断裂及炎性细胞浸润等现象;DA、DE、DAE心肌细胞排列整齐、心肌纤维断裂及炎性细胞浸润情况有所缓解,DAE组最为显著,心肌组织形态更接近于正常状态。与C组比较,D组心脏组织超氧化物歧化酶（SOD）、γ-谷氨酸半胱氨酸合酶（γ-GCS）活性及沉默信息调节因子1（SIRT1）、核因子E2相关因子2（Nrf2）、血红素氧合酶（HO-1）、B淋巴细胞瘤因子-2（Bcl-2）蛋白质表达水平、Bcl-2/Bcl-2相关X蛋白（Bax）比值显著降低（P<0.05或P<0.01）;细胞凋亡水平、Bax蛋白质表达、丙二醛（MDA）含量显著升高（P<0.05或P<0.01）。与D组比较,DA组心肌组织SIRT1、Nrf2、HO-1蛋白质表达均显著升高（P<0.05）,Bax蛋白质表达及MDA含量显著降低（P<0.05或P<0.01）;DE组心肌组织SOD活性和SIRT1、HO-1蛋白质表达显著升高（P<0.05或P<0.01）,Bax蛋白质表达及MDA含量显著降低（P<0.05或P<0.01）;DAE组心肌组织SOD、γ-GCS活性及SIRT1、Nrf2、HO-1、Bcl-2蛋白质表达和Bcl-2/Bax比值显著升高（P<0.05或P<0.01）,细胞凋亡水平、Bax蛋白质表达及MDA含量极显著降低（P<0.01）。与DA、DE组比较,DAE组心肌组织SIRT1、Bcl-2蛋白质表达及Bcl-2/Bax比值均显著升高（P<0.05或P<0.01）,细胞凋亡水平显著降低（P<0.05）;心肌组织细胞凋亡水平、SIRT1和Bcl-2蛋白质表达水平及Bcl-2/Bax比值具有协同效应。结论 虾青素和/或有氧运动干预均可通过上调SIRT1/Nrf2信号通路相关蛋白质表达,缓解和改善D-半乳糖诱导的氧化应激,降低心肌细胞凋亡水平,延缓大鼠心脏衰老。     

稀土元素镧代谢动力学及对血液元素谱的影响

目的 探讨镧经口暴露后在大鼠体内的吸收、分布、蓄积、排泄规律以及镧对大鼠血液元素谱的影响。方法 48只雌性SPF级大鼠随机分为8组进行单次经口暴露实验，一次性灌胃700 mg/kg·BW硝酸镧溶液。于灌胃后1、2、4、8、16、32、64、128 h采用电感耦合等离子体质谱仪（ICP-MS）测定大鼠全血、心、肝、脾、肺、肾、脑、股骨、粪便镧含量。48只SPF级大鼠随机分为4组（雌雄各半）进行重复经口暴露实验，每组含1个对照组和1个实验组。实验组重复灌胃镧含量66 mg/kg·BW的硝酸镧溶液，对照组灌胃等量生理盐水，每天1次，在第7、14、21和28 d时，各取1组（含对照组和实验组），采用ICP-MS法测定大鼠全血44种元素含量以及肝、肾、股骨、粪便和尿液镧含量。结果 大鼠单次经口暴露镧后，镧在全血中达峰时间为2 h，消除半衰期为69.315 h，总体清除率为1.733 L/h/kg；镧随血液广泛分布于心、肝、脾、肺、肾、脑和股骨，以股骨中含量最高（P<0.05）；大鼠重复经口暴露镧14、21和28 d后，与肾含量相比，大鼠肝和股骨镧含量显著升高（P<0.05），且实验组大鼠粪便镧含量显著高于尿液（P<0.001）。大鼠重复给予镧处理后，与对照组相比，实验组大鼠全血中除了镧含量显著升高（P<0.05）外，其余元素（钙、钠、钾、镁、铁、铜、锌、硒、钴、钼、铅、砷）含量在对照组和实验组间未见统计学差异（P>0.05）。结论 本试验镧经口暴露后可快速吸收入血，并广泛分布于心、肝、脾、肺、肾、脑和股骨，重复暴露后易沉积于肝和股骨，且以粪便排泄为主；未观察到镧对大鼠血液元素谱产生影响。     

一起疑似由蜡样芽胞杆菌引起的食源性疾病事件的分子溯源研究

目的 对一起食源性疾病事件中食品分离蜡样芽胞杆菌（B. cereus）进行溯源分析,为确定污染源、切断传播途径提供技术支撑。方法 本研究建立脉冲场凝胶电泳（PFGE）方法,对12株B. cereus进行分子分型,同时对10株B. cereus进行全基因组测序（WGS）,利用BioNumerics软件对测序数据进行拼接组装、多位点序列分型（MLST）、毒力基因、核苷酸多态性（SNP）分析。结果 本起食源性疾病事件中分离自不同食品的12株B. cereus的PFGE分型显示为8种带型,其中3株ST1435型 B. cereus带型相同,且SNP分析显示这3株B. cereus只有3个碱基差异;2株ST24型B. cereus 的PFGE带型完全相同,且SNP分析显示只有1个碱基差异,提示3株ST1435和2株ST24菌株分别为克隆株。2株ST24型B. cereus携带溶血性肠毒素hlbA、hlbC和hlbD,另有4株B. cereus携带腹泻毒力基因（hlbA、hlbC和hlbD）。结论 B. cereus引起的食源性疾病事件比较复杂,污染源也比较复杂,因此加强原辅料监测、从业人员的卫生监测、环境和设备及环节的清洗消毒,对预防控制由其引起的食源性疾病事件非常重要。     

葡萄籽原花青素提取物对运动性骨关节损伤大鼠的影响及其作用机制的研究

目的 揭示葡萄籽原花青素提取物（GSPE）对大鼠运动性骨关节损伤（SJI）的治疗作用及机制。方法 建立SJI大鼠模型后，各组大鼠经口给予不同剂量的GSPE（0、50、100和200 mg/kg），持续4周，并设立正常对照组。受试物给药结束后，通过机械痛阈（PWT）测定法测定各组模型大鼠疼痛情况；取尾静脉血，检测血清超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）、丙二醛（MDA）含量。处死后，取膝关节经番红O-固绿染色后进行病理检查；取膝关节组织，通过Western blot方法检测过氧化物酶体增殖物激活受体γ共激活因子α（PGC-1α）、磷酸化-AMP依赖的蛋白激酶α（p-AMPKα）、AMPKα、核呼吸因子1（NRF1）和线粒体转录因子A（TFAM）的蛋白表达水平。结果 随着GSPE剂量增加，SJI大鼠的PWT显著上升（P<0.05），膝关节病变形态改善，SJI大鼠的血清SOD和GSH-Px含量升高，MDA含量显著降低（P<0.05）。SJI大鼠膝关节组织中PGC-1α、p-AMPKα/AMPKα、NRF-1和TFAM的蛋白表达水平随着GSPE剂量增加而提高（P<0.05）。结论 GSPE摄入有效减轻了SJI大鼠疼痛和膝关节损伤，作用机制与AMPK/PGC-1α线粒体通路的激活抑制了体内氧化应激水平有关。     

2016—2021年无锡市副溶血性弧菌毒力基因和耐药性分析及分子分型研究

目的 分析2016—2021年无锡市不同来源副溶血性弧菌的毒力基因、耐药性和分子分型结果。方法 采用多重荧光PCR、微量肉汤稀释法、脉冲场凝胶电泳（PFGE）分别对204株分离自无锡市各类监测样本中的副溶血性弧菌进行tlh/tdh/trh毒力基因检测、耐药试验和分子分型。数据比较采用χ²检验。结果 204株菌tlh基因携带率为100%（204/204），tdh基因携带率为82.35%（168/204），trh基因携带率为2.45%（5/204），食品及环境分离株与病患分离株tdh基因携带率差异具有统计学意义（P<0.001）。菌株对头孢唑啉耐药率最高达96.08%（196/204），对3种及以上抗菌药物的耐药率为2.94%（6/204），食品及环境分离株与病患分离株对氨苄西林、四环素、磺胺甲??唑/甲氧苄啶、环丙沙星耐药率差异具统计学意义（P<0.05）；204株副溶血性弧菌经过聚类分析，分为123个PFGE带型，相似度49.1%~100.0%，按85%的相似度聚类可分为18个带型簇。结论 无锡市副溶血性弧菌病患分离株大部分携带tdh基因；菌株对头孢唑啉耐药率最高；PFGE型别呈多态性，优势带型不明显。     

环境硒含量对湖北恩施初中生近视情况影响的初步研究

目的 了解环境硒含量与初中生近视情况的相互关系。方法 采用随机抽样方法分别抽取恩施州富硒、足硒及缺硒地区初中学生各200名，共600名，检查学生近视情况，检测血硒发硒含量、谷胱甘肽过氧化物酶（GSH-Px）和血清硒蛋白P（SEPP-1）浓度及居民饮用水和农作物硒含量，进行统计学分析，计量资料两组间均数比较采用正态近似检验z检验，多组间比较采用单因素方差分析，发病率的比较采用卡方检验，相关分析采用Pearson相关检验。结果 研究对象包括近视组244例（40.67%）和非近视组356例（59.33%）。200名缺硒地区学生血硒含量为（71.25±10.31）μg/L，发硒含量为（0.56±0.20）μg/g，GSH-Px含量为（85.26±15.16）μ/L，SEPP-1含量为（7.41±1.65）mg/L，近视例数108例；200名足硒地区人群血硒含量为（86.74±11.25）μg/L，发硒含量为（0.72±0.11）μg/g，GSH-Px活力含量为（95.34±13.20）μ/L，SEPP-1含量为（10.25±2.47）mg/L，近视例数87例；200名富硒地区人群血硒含量为（102.31±10.26）μg/L，发硒含量为（0.81±0.12）μg/g，GSH-Px活力含量为（114.65±12.12）μ/L，SEPP-1含量为（12.36±3.25）mg/L，近视例数49例，不同硒含量地区学生血硒，发硒、GSH-Px含量和SEPP-1含量及近视发病率差异均有统计学意义（F=9.65、12.24、10.32、9.41，χ²=28.29，P<0.01）。富硒地区饮用水及农作物硒含量高于足硒及缺硒地区（F=12.35、5.36，P<0.01）。血硒、发硒与近视发病率存在负相关（r=-0.542、-0.621，P<0.05）。结论 恩施不同地区环境硒含量越高，初中生近视发病率越低；环境硒与初中生近视的发生呈现一定相关性。     

2020—2021年辽宁省食源性单核细胞增生李斯特菌毒力基因分布

目的 分析2020—2021年辽宁省食源性单核细胞增生李斯特菌（Lm）毒力基因分布特征及分子血清分型情况。方法 采用普通PCR方法对Lm的19个毒力基因包括毒力岛Ⅰ在内的6个位点（prfA、plcA、plcB、hlyA、mpl和actA）和毒力岛Ⅱ内化素家族蛋白基因的10个位点（inlA、inlB、inlC、inlD、inlE、inlF、inlG、inlH/C2、inlI、inlJ）,以及3个毒力基因相关位点（iap、fbpA、hpt）进行检测。同时应用多重PCR对所有菌株进行5种（1/2a、1/2b、1/2c、4b和3a）血清型分型检测。结果 在辽宁省食源性分离到的91株Lm中,36株Lm的19种毒力基因全部检出,其检出率高达39.6%。55株Lm菌株出现2种及2种以上毒力基因的不同缺失。inlG和inlF基因缺失率较高,分别为41.8%（38/91）和52.7%（48/91）。依据毒力基因携带情况,可分为13个基因型,其中携带19种毒力基因的Ⅰ型为辽宁省的优势基因型别。辽宁省Lm被分成4组分子血清型,1/2a（3a）血清型占比为59.3%（54/91）,1/2b（3b）占比为34.1%（31/91）,1/2c（3c）占比为3.3%（3/91）,4b（4d、4e）占比为3.3%（3/91）,3株4b血清型均分离自肉及肉制品。结论 辽宁省食源性Lm的毒力基因携带率高,毒力基因缺失具有多样性且存在样品种类上的差异。     

前增菌抗生素添加对产志贺毒素大肠埃希氏菌分离的影响

目的 研究产志贺毒素大肠埃希氏菌（STEC）国际标准检测方法中前增菌肉汤中抗生素种类和浓度对STEC分离的影响。方法 利用STEC和其他非STEC菌株，对国际现行检测STEC标准方法推荐的在前增菌步骤使用3种抗生素的最低抑菌浓度（MICs）进行测定。结果 不同抗生素对STEC抑制存在差异性。在推荐浓度下，吖啶黄及头孢磺啶会抑制stx1a和stx2b亚型STEC的生长，新生霉素则会抑制stx1a、stx1c、stx1d、stx2b、stx2d、stx2e、stx2f、stx2g等亚型菌株的生长。此外，STEC与其他革兰氏阴性菌对吖啶黄、头孢磺啶、新生霉素的MICs无显著性差异（P<0.05）。而革兰氏阳性菌对这3种抗生素的MIC值显著低于革兰氏阴性菌（P<0.01）。结论 本文结果为STEC增菌方法的研发完善提供了有价值的证据。     

Reliable identification of grapevine rootstock varieties using RAPD PCR on woody samples

Since grapevine ( Vitis spp .) rootstock material is being traded increasingly as disbudded woody material a lack of distinctive morphological features on such material necessitates an alternative and reliable means of identification. Methods described here were developed for rapid and efficient extraction of DNA from woody samples rich in phenolic compounds and polysaccharides, and for subsequent identification of varieties by RAPD PCR. Using these methods, and with the application of only one selected RAPD primer, we were able to differentiate sixteen rootstock varieties, including the seven varieties most commonly used in Germany. Problems commonly encountered with reproducibility of RAPD patterns were avoided by choosing primers with a dinucleotide sequence and a high G/C content that allowed a rather high annealing temperature of 45°C. Methods described here should also be useful for other horticultural crops, especially those with woody tissues rich in phenolic compounds and polysaccharides.     

An internet compendium of analytical methods and spectroscopic information for monomers and additives used in food packaging plastics

An internet website (http://cpf.jrc.it/smt/) has been produced as a means of dissemination of methods of analysis and supporting spectroscopic information on monomers and additives used for food contact materials (principally packaging). The site which is aimed primarily at assisting food control laboratories in the European Union contains analytical information on monomers, starting substances and additives used in the manufacture of plastics materials. A searchable index is provided giving PM and CAS numbers for each of 255 substances. For each substance a data sheet gives regulatory information, chemical structures, physico-chemical information and background information on the use of the substance in particular plastics, and the food packaging applications. For monomers and starting substances (155 compounds) the infra-red and mass spectra are provided, and for additives (100 compounds); additionally proton NMR are available for about 50% of the entries. Where analytical methods have been developed for determining these substances as residual amounts in plastics or as trace amounts in food simulants these methods are also on the website. All information is provided in portable document file (PDF) format which means that high quality copies can be readily printed, using freely available Adobe Acrobat Reader software. The website will in future be maintained and up-dated by the European Commission's Joint Research Centre (JRC) as new substances are authorized for use by the European Commission (DG-ENTR formerly DGIII). Where analytical laboratories (food control or other) require reference substances these can be obtained free-ofcharge from a reference collection housed at the JRC and maintained in conjunction with this website compendium.     

Aroma characterization of various apricot varieties using headspace–solid phase microextraction combined with gas chromatography–mass spectrometry and gas chromatography–olfactometry

The characterization of the aromatic profile of several apricot cultivars with molecular tracers in order to obtain objective data concerning the aromatic quality of this fruit was undertaken using headspace–solid phase microextraction (HS–SPME). Six apricot cultivars were selected according to their organoleptic characteristics: Iranien, Orangered, Goldrich, Hargrand, Rouge du Roussillon and A4025. The aromatic intensity of these varieties measured by HS–SPME–Olfactometry were defined and classified according to the presence and the intensity of grassy, fruity and apricot like notes. In the six varieties, 23 common volatile compounds were identified by HS–SPME–GC–MS. Finally, 10 compounds, ethyl acetate, hexyl acetate, limonene, β-cyclocitral, γ-decalactone, 6-methyl-5-hepten-2-one, linalool, β-ionone, menthone and (E)-hexen-2-al were recognized by HS–SPME–GC–O as responsible of the aromatic notes involved in apricot aroma and considered as molecular tracers of apricot aromatic quality which could be utilized to discriminate apricot varieties.     

Tests of potential functional barriers for laminated multilayer food packages. Part I: Low molecular weight permeants

The advent of the functional barrier concept in food packaging has brought with it a requirement for fast tests of permeation through potential barrier materials. In such tests it would be convenient for both foodstuffs and materials below the functional barrier (sub-barrier materials) to be represented by standard simulants. By means of inverse gas chromatography, liquid paraffin spiked with appropriate permeants was considered as a potential simulant of sub-barrier materials based on polypropylene (PP) or similar polyolefins. Experiments were performed to characterize the kinetics of the permeation of low molecular weight model permeants (octene, toluene and isopropanol) from liquid paraffin, through a surrogate potential functional barrier (25 μm-thick oriented PP) into the food simulants olive oil and 3% (w/v) acetic acid. These permeation results were interpreted in terms of three permeation kinetic models regarding the solubility of a particular model permeant in the post-barrier medium (i.e. the food simulant). The results obtained justify the development and evaluation of liquid sub-barrier simulants that would allow flexible yet rigorous testing of new laminated multilayer packaging materials.     

Chlorohydrins of bisphenol A diglycidyl ether (BADGE) and of bisphenol F diglycidyl ether (BFDGE) in canned foods and ready-to-drink coffees from the Japanese market

BADGE.2HCl and BFDGE.2HCl were determined in 28 samples of ready-to-drink canned coffee and 18 samples of canned vegetables (10 corn, 5 tomatoes and 3 others), all from the Japanese market. HPLC was used as the principal analytical method and GCMS for confirmation of relevant LC fractions. BADGE.2HCl was found to be present in one canned coffee and five samples of corn, BFDGE.2HCl in four samples of canned tomatoes and in one canned corn. No sample was found which exceeded the 1mg/kg limit of the EU for the BADGE chlorohydrins. However the highest concentration was found for the sum of BFDGE.2HCl and BFDGE.HCl.H₂O at a level of 1.5mg/kg. A Beilstein test confirmed that all cans containing foods contaminated with BADGE.2HCl or BFDGE.2HCl had at lest one part coated with a PVC organosol.     

European priorities for research to support legislation in the area of food contact materials and articles

A strong science base is required to underpin the planning and decision-making process involved in determining future European community legislation on materials and articles in contact with food. Significant progress has been made in the past 5 years in European funded work in this area, with many developments contributing to a much better understanding of the migration process, and better and simpler approaches to food control. In this paper this progress is reviewed against previously identified work-areas (identified in 1994) and conclusions are reached about future requirements for R&D to support legislation on food contact materials and articles over the next 5 or so years.     

Analysis of benzo[a]pyrene in spiked fatty foods by second derivative synchronous spectrofluorimetry after microwave-assisted treatment of samples

A simple, rapid and inexpensive method has been developed for the determination of benzo[a     

The development of reference materials for paralytic shellfish poisoning toxins in lyophilized mussel. II: Certification study

This paper describes the second part of a project undertaken to develop certified mussel reference materials for paralytic shellfish poisoning toxins. In the first part two interlaboratory studies were undertaken to investigate the performance of the analytical methodology for several PSP toxins, in particular saxitoxin and decarbamoyl-saxitoxin in lyophilized mussels, and to set criteria for the acceptance of results to be applied during the certification exercise. Fifteen laboratories participated in this certification study and were asked to measure saxitoxin and decarbamoyl-saxitoxin in rehydrated lyophilized mussel material and in a saxitoxin-enriched mussel material. The participants were allowed to use a method of their choice but with an extraction procedure to be strictly followed. The study included extra experiments to verify the detection limits for both saxitoxin and decarbamoyl-saxitoxin. Most participants (13 of 15) were able to meet all the criteria set for the certification study. Results for saxitoxin.2HCl yielded a certified mass fraction of <0.07 mg/kg in the rehydrated lyophilized mussels. Results obtained for decarbamoyl-saxitoxin.2HCl yielded a certified mass fraction of 1.59+/-0.20 mg/kg. The results for saxitoxin.2HCl in enriched blank mussel yielded a certified mass fraction of 0.48 +/- 0.06 mg/kg. These certified reference materials for paralytic shellfish poisoning toxins in lyophilized mussel material are the first available for laboratories to test their method for accuracy and performance.     

Announcing a new international peer-reviewed journal:Food Science and Human Wellness now accepting manuscript submission in English

<正>We are pleased to announce the launch of a new international peer-reviewed journal-Food Science and Human Wellness,ISSN 2213-4530,which is an open access journal,produced and hosted by Elsevier B.V.on behalf of Beijing Academy of Food Sciences.Food Science and Human Wellness is an international peer-reviewed English journal that provides a forum for the dissemination of the