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1.
To compare the relative impact of dietary lauric acid (12∶0) and palmitic acid (16∶0) on plasma lipids, two fat-sensitive
species, Mongolian gerbils and cebus monkeys, were fed cholesterol-free, purified diets enriched with either 12∶0-rich or
16∶0-rich fats, while all other fatty acids were held constant by selective blending of up to five natural fats or oils. The
two gerbil diets (40 en% from fat) allowed for an 8 en% exchange between 12∶0 and 16∶0, and the monkey diets (31 en% from
fat) allowed for 6 en% exchange beteen these two fatty acids. Eight gerbils received the diets for eight weeks, and 12 cebus
monkeys were fed each diet in a cross-over design for up to 22 wk. Both diets resulted in similar plasma cholesterol, triglyceride,
and high density lipoprotein cholesterol concentrations within each species. Additionally, separation of cebus lipoproteins
by discontinuous density-gradient ultracentrifugation failed to show any dietary differences in concentration or composition
of the three major lipoprotein classes (d<1.019, 1.019–1.055, and 1.055–1.168 g/mL). Thus, in two species sensitive to manipulations
in dietary fat while consuming cholesterol-free diets, 16∶0 was not hypercholesterolemic relative to 12∶0.
Based on a paper presented at the PORIM International Palm Oil Congress (PIPOC) held in Kuala Lumpur, Malaysia, September
1993. 相似文献
2.
Purified diets varying in dietary protein, namely casein (CA), soy protein (SP), fish protein (FP), and lipid origin (corn
oil (CN), coconut oil (CO)) were fed to rabbits to evaluate the effects of protein and fat source, as well as protein-lipid
interactions, on serum total, lipoprotein and hepatic lipid levels. Dietary proteins and lipids exerted a separate effect
on serum total cholesterol (C), very low-density lipoprotein cholesterol (VLDL-C), and low-density lipoprotein cholesterol
to high density lipoprotein cholesterol (LDL-C/HDL-C) ratio. Hence, CA increased serum cholesterol compared to SP, while coconut
oil enhanced serum and VLDL-C, and decreased LDL-C/HDL-C compared to corn oil. Dietary proteins interacted with dietary lipids
to modulate HDL-C levels. Thus, FP maintained a high level of HDL-C regardless of lipid origin, compared to CA and SP whose
HDL-C levels were decreased by corn oil, compared to coconut oil. A dietary protein-lipid interaction was also observed in
the regulation of liver cholesterol levels. Coconut oil, compared to corn oil, decreased liver cholesterol in rabbits fed
FP, whereas hepatic cholesterol concentration was unaltered by dietary lipid source in CA- and SP-fed rabbits. These results
demonstrate that dietary proteins act synergistically with dietary lipids to regulate cholesterol metabolism in the rabbit.
This work was presented in part at the 74th Annual FASEB meeting held in Washington, D.C., April 1–5, 1990. 相似文献
3.
In two inbred strains of rabbits with high or low response of plasma cholesterol to dietary saturatedversus polyunsaturated fatty acids, the efficiency of intestinal cholesterol absorption was measured. The feeding of a cholesterol-free
purified diet containing saturated fatty acids in the form of coconut fat, when compared with a diet containing corn oil as
polyunsaturated fatty acids, did not influence the efficiency of cholesterol absorption in the two rabbit strains. Irrespective
of the dietary fat source, the hyperresponsive rabbits absorbed cholesterol more efficiently. It is concluded that the hypercholesterolemic
effect of dietary coconut fatversus corn oil is not exerted by influencing cholesterol absorption. 相似文献
4.
Weanling male Wistar rats were fed for five weeks on standard rat chow (23 g fat/kg diet) or one of four synthetic diets with
butterfat, coconut oil, corn oil, or fish oil as the main lipid source (100 g fat/kg diet). In all diets, 10% of the fat was
provided as corn oil to prevent essential fatty acid deficiency. Significant differences were observed in the saturated, monounsaturated,
and polyunsaturated fatty acid composition, and in the ratio of cholesterol to phospholipid, in the hepatocyte membranes.
The fluidity of hepatocyte plasma membranes was assessed using the fluorescence recovery after photobleaching technique and
steady-state fluorescence anisotropy of diphenylhexatriene. No significant differences were found in the fluidity of plasma
membranes between animals on the different fat diets, despite diet-induced changes in their fatty acid composition. However,
the proportion of lipid free to diffuse in the plasma membrane varied with diet, being significantly greater (P<0.05) in animals fed chow (63.7%), coconut oil (61.5%), and butterfat (57.6%) diets than in those fed the corn oil (47.3%)
diet. Animals fed fish oil showed an intermediate (50.0%) proportion of lipid free to diffuse. The data support the hypothesis
that dietary lipids can change both the chemical composition and lateral organization (lipid domain structure) of rat hepatocyte
plasma membranes. 相似文献
5.
Simin Nikbin Meydani Alice C. Shapiro Mohsen Meydani John B. Macauley Jeffrey B. Blumberg 《Lipids》1987,22(5):345-350
The effect of age and dietary fat type on tocopherol status was investigated using young and old C57BL/6Nia mice fed semipurified
diets containing 5% (by weight) fish, corn or coconut oils and supplemented with 30, 100 or 500 ppm dl-α-tocopheryl acetate
for 6 wk. Tocopherol levels in the diets, plasma, liver, kidney and lung were measured by high performance liquid chromatography
following appropriate extractions. The results indicate that mice fed fish oil maintain lower plasma and tissue tocopherol
concentrations than those fed corn and cononut oils (fish<corn oil<coconut oil). The difference was not due to a loss of tocopherol
prior to consumption, but rather appeared to occur during the absorption process. Old mice had lower plasma and liver tocopherol
concentrations than young mice. Old mice fed fish oil, however, maintained plasma tocopherol levels better than young mice
fed fish oil, presumably due to their larger tocopherol pool. No age effect was detected on kidney and lung tocopherol levels.
It is concluded that tocopherol status is affected by age and dietary fat type, especially fish oil. 相似文献
6.
The influence of hypercholesterolemia on the triglyceride secretion rate was studied in both squirrel and cebus monkeys fed
coconut oil, corn oil, or safflower oil. The triglyceride secretion rate (TGSR) was determined in vivo following the administration
of Triton WR1339, which blocks the clearance of very low density lipoprotein (VLDL). Thus, the increase observed in circulating
triglyceride after Triton administration presumably reflects hepatic triglyceride (VLDL) secretion in the fasted state. The
VLDL-TGSR was lowest in hypercholesterolemic monkeys and highest in those fed unsaturated fat diets and having a low serum
cholesterol. In all instances, TGSR was inversely correlated with the plasma cholesterol concentration. While a definitive
explanation for these observations must await further investigation, the possibility that circulating low density lipoprotein
(LDL) acts to feed back on VLDL secretion is discussed. The decreased TGSR associated with the diet-induced cholesterolemia
also implies clearance of VLDL is impaired under these conditions. 相似文献
7.
Sathanur R. Srinivasan Bhandaru Radhakrishnamurthy Edward R. Dalferes Jr. Gerald S. Berenson 《Lipids》1979,14(6):559-565
Serum α-lipoprotein responses to variations in dietary cholesterol, protein, and carbohydrate were studied in different nonhuman
primate species. Chimpanzee, rhesus, green, patas, squirrel and spider monkeys all showed significant interspecies differences
in serum total cholesterol responses to 1.84 mg/kcal exogenous cholesterol. Dietary cholesterol significantly increased the
α-lipoprotein cholesterol in all species except rhesus and chimpanzee. Among these species, there was no relationship between
the basal serum lipoprotein profile and subsequent lipoprotein responses to dietary cholesterol. Although the level of dietary
protein at 6%, 12%, and 37% of calories had no appreciable main effect on serum total cholesterol in spider monkeys, very
low protein diet (6% of calories) produced a significant elevation in α-lipoprotein cholesterol. Serum α-lipoprotein responses
to exogenous cholesterol (1.84 mg/kcal) was highest for the very low protein diet and lowest for low protein diet (12% of
calories). Diets with high sucrose (76.5% of calories) and low saturated fat (12.5% of calories) containing no added cholesterol
were tested in squirrel and spider monkeys and produced a consistent serum total cholesterol response; the α-lipoprotein response
was significantly higher in squirrel monkeys than in spider monkeys. The above findings have implications in experimentally
induced and comparative atherogenesis.
Presented at the Lipoprotein Symposium AOCS meeting, St. Louis, Missouri, May 1978. 相似文献
8.
Rats were fed diets high in either saturated fat (beef tallow) or α-linolenic acid (linseed oil) or eicosapentaenoic and docosahexaenoic
acids (fish oil) with or without 2% cholesterol supplementation. Consumption of linseed oil and fish oil diets for 28 days
lowered arachidonic acid content of plasma, liver and heart phospholipids. Addition of 2% cholesterol to diets containing
beef tallow or linseed oil lowered 20∶4ω6 levels but failed to reduce 20∶4ω6 levels when fed in combination with fish oil.
Feeding ω3 fatty acids lowered plasma cholesterol levels. Addition of 2% cholesterol to the beef tallow or linseed oil diet
increased plasma cholesterol concentrations but not when fish oil was fed. Feeding the fish oil diet reduced the cholesterol
content of liver, whereas feeding the linseed oil diet did not. Dietary cholesterol supplementation elevated the cholesterol
concentration in liver in the order: linseed oil > beef tallow > fish oil (8.6-, 5.5-, 2.6-fold, respectively). Feeding fish
oil and cholesterol apparently reduced 20∶4ω6 levels in plasma and tissue lipids. Fish oil accentuates the 20∶4ω6 lowering
effect of dietary cholesterol and appears to prevent accumulation of cholesterol in plasma and tissue lipids under a high
dietary load of cholesterol. 相似文献
9.
Consumption of dietary oil, viz., corn, fish, coconut, or olive, induced the secretion of surfactant-like particles (SLP) in rat intestine. These lipoprotein
particles differ in (i) levels of alkaline phosphatase activity, (ii) lipid composition, and (iii) FA composition in response
to feeding of different oils. The secreted particles had similar buoyancy (1.07–1.08 g/mL) and cholesterol/phospholipid molar
ratios (0.61–0.72) except that feeding coconut oil to rats produced SLP with a low (0.18) cholesterol/phospholipid molar ratio
compared to control animals. It is concluded from these observations that feeding different oils induces the secretion of
lipoprotein particles in rat intestine with different chemical compositions. 相似文献
10.
The objective of the present studies was to examine the effect of dietary fat on the lipid composition of rat colonocytes
and their utilization of short-chain fatty acids (SCFA). Rats were fed 14% beef fat, fish oil or safflower oil plus 2% corn
oil in a semi-synthetic base diet for 4 wk. Colonocytes were isolated and their lipid composition was examined. Feeding beef
fat and fish oil resulted in an increase in monounsaturated fatty acids and a reduction in ω-6 fatty acids. Feeding fish oil
resulted in an enrichment with ω-3 fatty acids. These was no dietary influence on the amount of either cholesterol or phospholipids
of colonocytes. Fish oil feeding resulted in significant increase in colonocyte free fatty acids (FFA) as compared to other
diets. Dietary fat was found to have no effect on SCFA utilization by colonocytes. Colonocytes were found to utilize SCFA
in the order of butyrate ≥acetate ≥propionate. The presence of acetate and propionate in the medium had no effect on the rate
of butyrate utilization. 相似文献
11.
In previous studies, zinc-deficient rats force-fed a diet with coconut oil as the major dietary fat developed a fatty liver,
whereas zinc-deficient rats force-fed a diet with linseed oil did not. The present study was conducted to elucidate the reason
for this phenomenon. In a bifactorial experiment, rats were fed zinc-adequate or zinc-deficient diets containing either a
mixture of coconut oil (70 g/kg) and safflower oil (10 g/kg) (“coconut oil diet”) or linseed oil (80 g/kg) (“linseed oil diet”)
as a source of dietary fat, and activities of lipogenic and glycolytic enzymes in liver were determined. In order to ensure
adequate food intake, all the rats were force-fed. Zinc-deficient rats on the coconut oil diet developed a fatty liver, characterized
by elevated levels of triglycerides with saturated and monounsaturated fatty acids. These rats also had markedly elevated
activities of the lipogenic enzymes acetyl-CoA carboxylase, fatty acid synthase (FAS), glucose-6-phosphate dehydrogenase (G6PDH),
6-phosphogluconate dehydrogenase (6PGDH), and citrate cleavage enzyme, whereas activities of malic enzyme and glycolytic enzymes
were not different compared with zinc-adequate rats on the coconut oil diet. In contrast, rats receiving the linseed oil diet
had similar triglyceride concentrations regardless of zinc status, and activities of lipogenic enzymes and glycolytic enzymes
were not different between the two groups. Zinc-deficient rats fed either type of dietary fat exhibited statistically significant
correlations between activities of FAS, G6PDH, 6PGDH and concentrations of saturated and monounsaturated fatty acids in liver.
The concentrations of serum lipids were elevated in zinc-deficient rats fed either type of dietary fat. These results demonstrate
that fatty liver in zinc-deficient rats on the coconut oil diet is caused by elevated activities of lipogenic enzymes, and
not by disturbed lipid secretion from liver. Dietary linseed oil prevents both the elevation of lipogenic enzyme activity
and fatty liver in zinc-deficient rats. 相似文献
12.
Our objective was to determine the relative rates ofin vivo triglyceride (TG) secretion and the composition of very low density lipoproteins (VLDL) in rats fed different dietary saturated
fats. Male Sprague-Dawley rats (150–200 g) were fed diets containing 16% corn oil, or 14% butterfat, 14% beef tallow, 14%
olive oil, or 14% coconut oil plus 2% corn oil for 5 wk. Changes in plasma TG specific radioactivity were determined in individual,
unanesthetized fasted rats after injection of 100 μCi [2-3H]glycerol. Nonlinear regression analysis using a 2-compartment model was used to determine the fractional rate constant for
TG turnover in plasma. The plasma TG pool was 33–40% larger with beef tallow than with corn, olive or coconut oil feeding
(p<0.05), and 20% larger with beef tallow than with butterfat feeding. The rate of TG secretion into plasma (mg/min/100 g
body weight) was 60% higher in animals fed beef tallow than corn or coconut oil (p<0.05) and 26–33% higher in animals fed
beef tallow than olive oil or butterfat. Differences in VLDL composition (% wt) were also noted. Our data suggest that greater
TG secretion is the primary factor contributing to the larger TG pool with ingestion of beef tallow relative to butterfat,
corn or coconut oil. These results suggest that different dietary saturated fats have unique effects on TG metabolism in rats.
Presented in part at the 1990 meeting of the Federation of American Societies for Experimental Biology in Washington, D.C.
(see ref. 1). 相似文献
13.
H. A. Van Lith S. Herman X. Zhang J. G. P. Van Der Palen L. F. M. Van Zutphen A. C. Beynen 《Lipids》1990,25(12):779-786
We studied the effects of dietary fats, especially fish oil, on the activities of esterase-1 (ES-1) and butyrylcholine-sterase
in the plasma of rats. The identification of nutritional determinants of these enzymes could provide clues as to their physiological
function. Fish oil, when compared with corn oil, consistently caused increased activities of both enzymes. Plasma ES-1 activity,
but not butyrylcholinesterase activity, was increased after isocaloric replacement of carbohydrates by coconut fat. Dietary
medium-chain triglycerides, when compared with corn oil, produced decreased and increased activities of butyrylcholinesterase
and ES-1, respectively. Various plant fats, such as corn oil, linseed oil, coconut fat, palm oil, palm kernel oil, soybean
oil and rapeseed oil, did not differentially influence butyrylcholinesterase activities. Plasma triglyceride concentrations
were lowered by fish oil and increased by coconut fat and palm kernel oil. For individual rats in 5 out of 6 experiments,
weak, negative correlation coefficients of the order of 0.3 were found between the changes in plasma butyrylcholinesterase
activities and in plasma triglyceride concentrations. 相似文献
14.
F. J. Sánchez-Muniz P. Oubiña J. Benedí S. Ródenas C. Cuesta 《Journal of the American Oil Chemists' Society》1998,75(2):217-223
The purpose of the present study was to examine the effects of two monounsaturated fatty acid-rich oils, extravirgin olive
oil (EVOO) and high-oleic sunflower oil (HOSO), on platelet aggregation in 14 postmenopausal women (aged 62.9 ± 1.8 yr) with
high-fat dietary habits. Both oils contained oleic acid as the major compound (≈76% of total fatty acids), but the content
of palmitic and linoleic acids and many minor compounds was significantly different. These oils were used as the only culinary
fats during two 28-d periods, and represented ≈62% of the total lipid intake (≈46% of total energy consumption). Other dietary
components were matched. The daily energy contribution of saturated, monounsaturated, and polyunsaturated fatty acids to the
total energy consumption was 11.8, 28.5, and 2.8%, respectively, during the EVOO dietary period and 10.3, 27.8, and 4.6%,
respectively, with HOSO. Aggregation in platelet-rich plasma was measured after addition of ADP. Platelet aggregation (expressed
as cm/5 min) was significantly lower after the EVOO diet than after HOSO (2.1 ± 1.1 and 3.0 ± 1.4, respectively; P<0.05). Although maximal aggregation time was 40.2% higher in HOSO than in EVOO, the difference was not significant. Independent
of serum cholesterol level, platelet aggregation tended to be different on the EVOO diet when women were classified according
to cholesterol levels: <220 mg/dL or ≥220 mg/dL. Results suggest that other compounds present in the oils aside from the fatty
acids may play an important role in modulating platelet aggregation in these postmenopausal women. 相似文献
15.
M. Kruger C. M. Smuts A. J. S. Benadé J. E. Fincham C. J. Lombard E. A. Albertse K. J. van der Merwe 《Lipids》1992,27(10):733-739
The effects of the degree of unsaturation and of the amount of dietary fat on low density lipoprotein (LDL) concentration
and composition were determined in vervet monkeys. Diets with fat contents of 41, 31 and 18% energy, each with a low and a
high polyunsaturated to saturated fatty acid ratio (P/S; 0.27–0.38 and 1.13–1.47) were fed to six female vervet monkeys for
two months. Another six females were given a low fat, high P/S diet for the same period of time, to serve as a reference.
The cholesterol contents of the diets were low (21–33 mg per day) and relatively constant. LDL cholesterol concentrations
decreased significantly (P≤0.01) when the dietary fat content decreased from 31 to 18% of energy. The dietary P/S ratio only affected LDL cholesterol
concentrations during moderate (31% of energy) fat intake, where LDL cholesterol increased (P≤0.01) with a decrease in dietary P/S. Substantial individual variations were observed in LDL cholesterol concentration responses
to dietary fat changes. The changes in LDL cholesterol concentrations were the result of changes in the concentration of LDL
particles, as the molecular composition did not differ significantly between dietary periods. The high density lipoprotein
choelsterol and the plasma triacylglycerol concentrations were not influenced by the dietary fat changes. During the high
P/S diets, the percentage of 18∶2 (linoleic acid) increased (P≤0.01) and that of 18∶1 (oleic acid) decreased (P≤0.01) in LDL esterified cholesterol, as compared to the low P/S diets. In adipose tissue triacylglycerol the percentage of
18∶2 was three times higher (P≤0.01) during the high P/S diets than during the low P/S diets. A decrease in the amount of dietary fat (from 31 to 18% of
energy) was associated with an increase in the percentage of 18∶1 in LDL esterified cholesterol. 相似文献
16.
Rats were fed cholesterol-free or cholesterol-enriched diets containing olive oil or partially hydrogenated corn oil at the
10% level for ca. 30 days (c-18∶1, 77.0% in the former diet andc-18∶1, 24.7% andt-18∶1, 42.5% in the latter). The linoleic acid content of these fat diets was made equivalent (1.7 energy%). After feeding
cholesterol-free diets,trans fat compared tocis fat showed(a) no untoward effects on growth parameters, (b) a reduction of serum cholesterol levels without influencing concentrations
of serum apolipoproteins A-I, B and E, (c) no effects on the bile flow and the concentration of biliary cholesterol and bile
acids, (d) an increasing trend of fecal excretion of neutral and acidic steroids, both in terms of mg/day and mg/g feces,
and (e) rather equivocal change in the composition of fecal, but not biliary steroids. Similar response patterns were also
observed when cholesterol-enriched diets were fed except for a decrease in serum apo B and an ineffectiveness to increase
fecal acidic steroids. Together with the results obtained from experiments simultaneously performed with safflower oil and
completely hydrogenated corn oil, it seems that the steroid metabolism can be specificallymodified by the geometry of dietary
fats. 相似文献
17.
Sheila M. Innis Roger Dyer Louis Wadsworth Paul Quinlan Deborah Diersen-Schade 《Lipids》1993,28(7):645-650
Platelet lipid composition is important to normal platelet morphology and function, and is influenced by dietary fatty acids
and cholesterol. The fatty acid composition and cholesterol content of infant formulas differs from those of human milk, but
the possible effects on platelet lipids in young infants is not known. This was studied in piglets fed from birth to 18 d
of age with one of eight formulas differing in saturated fatty acid chain length, or content of 18∶1, 20∶5n−3 plus 22∶6n−3,
or cholesterol. A reference group of piglets fed sow milk was also studied. Sow milk has a fatty acid composition and cholesterol
content similar to that of human milk. Piglets fed formulas high in 18∶1 (34.9–40.8% wt fatty acids) and low in 16.0 (≤6.5%
wt fatty acids) had lower platelet counts and greater platelet size than piglets fed sow milk (40.4% 18∶1, 30.7% 16∶0). Piglets
fed formulas high in 16∶0 (27–29.6%) and 18∶1 (40–40.6%), or low in both 16∶0 (5.9–6.1%) and 18∶1 (10.8–11.2%), had similar
platelet counts and size to piglets fed sow milk. Platelet phospholipid % 20∶4n−6 was lower in all the groups of piglets fed
formula than in the group fed sow milk. Addition of fish oil with 20∶5n−3 plus 22∶6n−3 to the formula further decreased platelet
phospholipid 20∶4n−6. Addition of cholesterol to the formula increased the platelet phospholipid % 20∶4n−6 and platelet volume. 相似文献
18.
Male Sprague-Dawley weanling rats were fed isocaloric diets consisting of 10% (by wt) fat. The six groups differed in the
ratio of corn oil and butter fat present in the diets such that: 10C, 10% corn oil (C); 8C2B, 8% C/2% butter fat (B); 6C4B,
6% C/4% B; 4C6B, 4% C/6% B; 2C8B, 2% C/8% B; and 10B, 10% B. Liver plasma membranes were analyzed for fatty acid composition
and cholesterol/phospholipid molar ratio. The 18∶2n−6 content was constant in the 10C and 8C2B diets and then decreased linearly
through the 2C8B diet. The 20∶4n−6 and 18∶1n−9 contents were constant except in the 10B diet, in which a significant decrease
and increase, respectively, were observed. The cholesterol/phospholipid molar ratio increased between the 10C and 6C4B diets
and subsequently (4C6B and 10B diets) remained constant. This data indicates that changes in n−6 fatty acid content in the
liver plasma membrane are directly related to dietary intake only for 18∶2n−6. Arachidonic acid content in the membrane is
maintained at a constant level until the linoleic acid content of the diet is reduced to 0.5% of calories. It also indicates
that the cholesterol content of the membrane becomes saturated and does not increase with increasing concentrations of saturated
fat in the diet.
Presented in part at the FASEB Meeting, Washington, D.C., April, 1987. 相似文献
19.
Male Sprague Dawley rats were fed semipurified diets containing 20% fat for 15 weeks. The dietary fats were corn oil, soybean
oil, palm oil, palm olein and palm stearin. No differences in the body and organ weights of rats fed the various diets were
evident. Plasma cholesterol levels of rats fed soybean oil were significantly lower than those of rats fed corn oil, palm
oil, palm olein or palm stearin. Significant differences between the plasma cholesterol content of rats fed corn oil and rats
fed the three palm oils were not evident. HDL cholesterol was raised in rats fed the three palm oil diets compared to the
rats fed either corn oil or soybean oil. The cholesterol-phospholipid molar ratio of rat platelets was not influenced by the
dietary fat type. The formation of 6-keto-PGF1α was significantly enhanced in palm oil-fed rats compared to all other dietary treatments. Fatty acid compositional changes
in the plasma cholesterol esters and plasma triglycerides were diet regulated with significant differences between rats fed
the polyunsaturated corn and soybean oil compared to the three palm oils. 相似文献
20.
Laura J. Jenski Laura Kathleen Sturdevant William D. Ehringer William Stillwell 《Lipids》1991,26(5):353-358
Mice fed menhaden (fish) oil or coconut oil-rich diets were inoculated intraperitoneally with a rapidly growing leukemia,
T27A. After one week, the tumor cells were harvested, and51Cr was used to label intracellular molecules. Spontaneous release of51Cr was used as a measure of plasma membrane permeability. Compared to cells from mice fed coconut oil (rich in saturated fatty
acids), tumor cells from mice fed menhaden oil (rich in long chain polyunsaturated ω3 fatty acids) showed an increased level
of spontaneous51Cr release, which was exacerbated by increased temperature and reduced by extracellular protein. At physiological salt concentrations,
the releated51Cr was detected in particles of ∼2700 daltons. Enhanced permeability correlated with the incorporation of dietary (fish oil)
ω3 polyunsaturated fatty acids docosahexaenoic and eicosapentaenoic acid into the tumor cells. The results demonstrate that
ω3 fatty acids are incorporated into cellular constituents of tumor cells and change properties associated with the plasma
membrane. This result suggests that dietary manipulation may be used to enhance tumor cell permeability and contribute to
tumor eradication. 相似文献