超临界CO2萃取的研究进展

超临界CO2流体萃取技术是近年来兴起的一项具有精馏和萃取两过程的高新物质分离精制技术，文章主要通过对各类超临界CO2流体萃取实验的文献报道和实验操作进行分析，对超临界CO2流体革取技术的原理、特点和超临界CO2流体萃取的主要影响因素及其优化方法和经验模型进行了综述。     

超临界CO2萃取的研究进展

通过对各类超临界CO2流体萃取实验的文献报道和实验操作进行分析,对超临界CO2流体萃取技术的原理、特点和超临界CO2流体萃取的主要影响因素及其优化方法和经验模型进行了综述.     

超临界CO2清洗技术

介绍了超临界CO2清洗的工艺及其应用,分析了超临界CO2清洗在技术、经济及环保方面的特点。     

超临界CO2在页岩气开发中的应用研究进展

以页岩气的开采技术为研究对象,对超临界CO2在提高页岩气开采率中的应用进行研究.论述了国内外在超临界CO2压裂技术开采页岩气方面的研究进展.目前,使用CO2进行增强的技术被视为页岩气开采的有效手段,该技术可以大幅提高产量,具有很好的应用前景.CO2不仅能够取代水介质对页岩进行压裂作业,还能够高效的驱替页岩中的甲烷,与此...     

超临界CO2中CO2参与的化学反应

超临界CO2中的化学反应是目前的研究热点之一。超临界CO2既为反应介质又为反应物的化学反应的主要优势是将萃取与反应相耦合形成均相体系,排除了传质阻力,提高了反应的速率和选择性;产物与催化剂易于分离;同时CO2作为反应原料无毒、不燃、易得,不但可以代替有机溶剂和有毒原材料,而且可有效利用CO2。介绍了超临界CO2作为反应原料所参与化学反应的类型及特点,简单综述了这些化学反应的研究进展,并对未来的发展提出展望。     

超临界CO2萃取技术工艺研究进展

综述了超临界CO2萃取(SFE-CO2)技术对中草药及其它天然产物中有效成分提取的工艺研究和应用情况.     

超临界CO2络合萃取重金属研究进展

超临界流体萃取作为一种新型分离技术,不能直接萃取重金属等离子型物质,但能萃取离子与配合剂反应生成的配合物。将配合反应与超临界CO2流体萃取结合形成了又一门新型的萃取技术—超临界CO2络合萃取。在总结国内外文献的基础上,介绍了超临界CO2络合萃取重金属的原理、影响因素以及最新进展情况。     

超临界CO2在有机合成中的应用

本文对超临界CO2的特性及其在有机合成中的应用进行了综述,特别强调了它在加氢反应、羰基化反应、异构化反应、氧化反应、环化反应等中的具体应用和重要价值。     

聚合物在超临界CO2中玻璃化转变研究进展

简要介绍了聚合物的玻璃化转变以及超临界CO2在高分子科学中广阔的应用前景,着重对超临界CO2环境下聚合物玻璃化转变的实验研究方法和理论研究的进展进行了综述。     

超临界CO2萃取黄酮类物质的研究进展

介绍了超临界流体萃取(SFE)黄酮类物质的研究现状，总结了影响萃取的因素，并对未来的发展趋势作了展望。     

复合纳米Ag,Ce/TiO_2光催化自洁涂料的超临界CO_2喷涂研究

探讨了SC—CO_2作用对氟碳树脂物性的影响,选择了适合SC—CO_2喷涂的喷嘴结构,考察了SC—CO_2喷涂对复合纳米Ag,Ce/TiO_2氟碳树脂涂料光催化活性的影响。     

Formulation and manufacture of pharmaceuticals by fluidized‐bed impregnation of active pharmaceutical ingredients onto porous carriers

A manufacturing method is presented for solid dosage forms using fluidized‐bed impregnation, which could eliminate many of the challenges during solid dosage manufacturing. The main difference between impregnation and dry blending is the placement of the active pharmaceutical ingredient (API) inside a porous carrier. This makes the final material flow properties independent of the physical properties of the API. The method consists of spraying an API solution in appropriate solvent onto a carefully chosen porous excipient in a fluidized state. The solution penetrates the porous carrier due to capillary forces and the solvent is evaporated soon after that. Impregnation and drying occur simultaneously, which makes this impregnation method suitable for continuous implementation. Carefully choosing the operating conditions allows impregnation to occur without introducing spray drying or spray coating of the API. The method is shown to generate an impregnated excipient with very high degree of homogeneity independent of the API loading. It is also shown that mild milling further improves blend uniformity to RSD levels below 1%, which are challenging to achieve using conventional techniques. On impregnation, the final physical properties of the material are seen to be mainly unchanged from the initial excipient properties. A study of this one‐step manufacturing method is described, using acetaminophen as the model drug and anhydrous calcium phosphate dibasic as the porous excipient. The experimental work presented establishes a proof of concept and investigates in detail blend uniformity, physical state of impregnated API, final physical properties of impregnated material, compressibility during tableting, capsule filling, and release profile of the final capsule formulation. It also discusses potential ways for drug release control and improvements using impregnation. © 2013 American Institute of Chemical Engineers AIChE J, 59: 4538–4552, 2013     

超临界CO2流体萃取中的在线检测技术

综述了超临界CO2流体萃取中的在线检测技术,介绍了超临界CO2流体萃取与超临界流体色谱、气相色谱、高效液相色谱、核磁共振、近红外光谱等技术的联用在线检测,阐述了在线检测技术的优越性,提出了如何发展超临界CO2流体萃取中的在线检测技术。     

加氢处理催化剂制备技术研究进展

从过渡金属硫化物催化剂活性相理论出发,认为在加氢催化剂制备过程中保证活性组分的适度分散和金属-载体之间适度的相互作用能提高加氢催化剂的性能。本文针对加氢处理催化剂的制备技术,综述了添加有机助剂、平衡吸附法、浆液浸渍法等浸渍改进技术以及水热沉积法、原位晶化法、化学气相沉积法等新型的制备技术,并介绍了相关的国内外研究进展。分析指出有机助剂能与载体、金属作用,进而改变金属在载体表面的存在形态,有利于高活性CoMoS相的生成;水热沉积法和原位晶化法能够使活性组分在载体上均匀吸附沉积,从而实现活性组分在载体上的分散,并形成堆积程度更高的高活性Ⅱ型活性中心。     

制药废水处理技术研究进展

制药废水具有成分复杂、浓度高、难降解等特点,针对制药废水的处理难题,本文介绍了国内外近几年来废水处理的一些新技术,如Fenton法、湿式氧化法、光催化氧化法、臭氧氧化法、超声氧化法、微波催化氧化法、超临界水氧化法、电化学法等,并综述了这些高级氧化技术处理制药废水的特点及研究进展。     

Effect of impregnation and in‐situ polymerization of methacrylates on hardness of sugar maple wood

The improvement of Brinell hardness of sugar maple (Acer saccharum Marsh.) samples through impregnation and in‐situ polymerization of methyl methacrylate, 2‐hydroxylethyl methacrylate, and ethylene glycol dimethacrylate monomers was investigated. The formulation combinations were determined by a mixture design. Sugar maple samples were impregnated with these mixtures by a vacuum and pressure process and polymerized in situ by a catalyst‐thermal procedure. The effects of the monomers and their combinations on Brinell hardness and hardness modulus were analyzed. Chemical impregnation enhanced both Brinell hardness and hardness modulus. A significant relationship between hardness modulus and Brinell hardness was found. Modulus of elasticity of sugar maple was also improved through impregnation with methacrylates. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 99: 1674–1683, 2006     

Research progress on leakage characteristics of supercritical CO2 pipeline

Leakage of supercritical CO₂ long-distance pipelines may cause significant accidents such as pipeline fracture propagation, human injury and medium loss. Therefore, it is of great significance to further study the variation of thermodynamic parameters in the process of pipeline leakage. At present, there is insufficient research on the leakage characteristics of supercritical CO₂ pipelines, and it is necessary to conduct a detailed literature review and analysis. This paper introduces the research background and significance of CO₂ pipeline leakage characteristics. The experimental, theoretical analysis and numerical simulation of the decompression process, near-field jet expansion and far-field diffusion of CO₂ pipeline at home and abroad are reviewed in detail. Finally, this paper summarizes the current research deficiencies of supercritical CO₂ pipeline leakage characteristics, and prospects the future research direction.     

超临界CO2管道泄漏特性研究进展

超临界CO₂输运管道泄漏可能造成断裂扩展、人员伤害和输运介质损失等重大事故,因此对泄漏过程中热力学参数变化规律的深入研究具有重要意义。目前对超临界CO₂管道泄漏特性研究不够,有必要进行详细的文献综述分析。介绍了CO₂管道泄漏特性研究背景及意义,综述了国内外CO₂管道泄漏过程中减压过程、近场射流膨胀及远场扩散规律实验、理论分析和数值模拟方面的研究现状,分析了目前超临界CO₂管道泄漏特性的研究不足,并对将来的研究方向进行了展望。     

Improving dissolution kinetics of pharmaceuticals by fluidized bed impregnation of active pharmaceutical ingredients

Investigational drugs are increasingly becoming less soluble in aqueous media, thus, presenting real challenges during development. Previous work has successfully demonstrated the manufacturing of pharmaceuticals using fluidized bed (FB) impregnation of APIs onto porous carriers. This study demonstrates the usefulness of FB impregnation in formulating poorly soluble drugs. We show that dissolution of Fenofibrate is greatly improved by FB impregnation onto Neusilin^® (Fuji Health Science Inc, Burlington, NJ USA), a synthetic amorphous form of magnesium alumino‐metasilicate. We impregnate Neusilin^® for range of loadings and examine Fenofibrate's physical state. Dissolution of impregnated formulations is drug loading dependent and loadings below 40% show great improvement (decrease) in release time compared to physical blend. Release times are further improved by milling. We also examine feasibility of coimpregnating Fenofibrate with additives and observe stability (1.5 years) of the amorphous form of Fenofibrate inside Neusilin^®. This stabilization significantly improves Fenofibrate's dissolution kinetics, making our formulation comparable to one of the current market formulations, TriCor^® tablets (AbbVie Inc, North Chicago, IL USA). © 2016 American Institute of Chemical Engineers AIChE J, 62: 4201–4214, 2016     

超临界CO2萃取技术及其萃取的蛋黄油在抗皱霜中的应用

超临界CO2萃取技术是目前在食品、日化行业新兴的提取方法，它具有不破坏萃取物成分、产品纯度高的优点，用SC—CO2萃取所得蛋黄油加入抗衰霜中，提高了抗衰有效率。