Hybrid intelligent techniques for MRI brain images classification

This paper presents a hybrid technique for the classification of the magnetic resonance images (MRI). The proposed hybrid technique consists of three stages, namely, feature extraction, dimensionality reduction, and classification. In the first stage, we have obtained the features related to MRI images using discrete wavelet transformation (DWT). In the second stage, the features of magnetic resonance images have been reduced, using principal component analysis (PCA), to the more essential features. In the classification stage, two classifiers have been developed. The first classifier based on feed forward back-propagation artificial neural network (FP-ANN) and the second classifier is based on k-nearest neighbor (k-NN). The classifiers have been used to classify subjects as normal or abnormal MRI human images. A classification with a success of 97% and 98% has been obtained by FP-ANN and k-NN, respectively. This result shows that the proposed technique is robust and effective compared with other recent work.     

An integrated index for identification of fatty liver disease using radon transform and discrete cosine transform features in ultrasound images

Alcoholic and non-alcoholic fatty liver disease is one of the leading causes of chronic liver diseases and mortality in Western countries and Asia. Ultrasound image assessment is most commonly and widely used to identify the Non-Alcoholic Fatty Liver Disease (NAFLD). It is one of the faster and safer non-invasive methods of NAFLD diagnosis available in imaging modalities. The diagnosis of NAFLD using biopsies is expensive, invasive, and causes anxiety to the patients. The advent of advanced image processing and data mining techniques have helped to develop faster, efficient, objective, and accurate decision support system for fatty liver disease using ultrasound images. This paper proposes a novel feature extraction models based on Radon Transform (RT) and Discrete Cosine Transform (DCT). First, Radon Transform (RT) is performed on the ultrasound images for every 1 degree to capture the low frequency details. Then 2D-DCT is applied on the Radon transformed image to obtain the frequency features (DCT coefficients). Further the 2D-DCT frequency coefficients (features) obtained are converted to 1D coefficients vector in zigzag fashion. This 1D array of DCT coefficients are subjected to Locality Sensitive Discriminant Analysis (LSDA) to reduce the number of features. Then these features are ranked using minimum Redundancy and Maximum Relevance (mRMR) ranking method. Finally, highly ranked minimum numbers of features are fused using Decision Tree (DT), k-Nearest Neighbour (k-NN), Probabilistic Neural Network (PNN), Support Vector Machine (SVM), Fuzzy Sugeno (FS) and AdaBoost classifiers to get the highest classification performance. In this work, we have obtained an average accuracy, sensitivity and specificity of 100% in the detection of NAFLD using FS classifier. Also, we have devised an integrated index named as Fatty Liver Disease Index (FLDI) by fusing two significant LSDA components to distinguish normal and FLD class with single number.     

Liver fibrosis staging using CT image texture analysis and soft computing

Liver biopsy is considered to be the gold standard for analyzing chronic hepatitis and fibrosis; however, it is an invasive and expensive approach, which is also difficult to standardize. Medical imaging techniques such as ultrasonography, computed tomography (CT), and magnetic resonance imaging are non-invasive and helpful methods to interpret liver texture, and may be good alternatives to needle biopsy. Recently, instead of visual inspection of these images, computer-aided image analysis based approaches have become more popular. In this study, a non-invasive, low-cost and relatively accurate method was developed to determine liver fibrosis stage by analyzing some texture features of liver CT images. In this approach, some suitable regions of interests were selected on CT images and a comprehensive set of texture features were obtained from these regions using different methods, such as Gray Level Co-occurrence matrix (GLCM), Laws’ method, Discrete Wavelet Transform (DWT), and Gabor filters. Afterwards, sequential floating forward selection and exhaustive search methods were used in various combinations for the selection of most discriminating features. Finally, those selected texture features were classified using two methods, namely, Support Vector Machines (SVM) and k-nearest neighbors (k-NN). The mean classification accuracy in pairwise group comparisons was approximately 95% for both classification methods using only 5 features. Also, performance of our approach in classifying liver fibrosis stage of subjects in the test set into 7 possible stages was investigated. In this case, both SVM and k-NN methods have returned relatively low classification accuracies. Our pairwise group classification results showed that DWT, Gabor, GLCM, and Laws’ texture features were more successful than the others; as such features extracted from these methods were used in the feature fusion process. Fusing features from these better performing families further improved the classification performance. The results show that our approach can be used as a decision support system in especially pairwise fibrosis stage comparisons.     

A hybrid expert system approach for telemonitoring of vocal fold pathology

Acoustical parameters extracted from the recorded voice samples are actively pursued for accurate detection of vocal fold pathology. Most of the system for detection of vocal fold pathology uses high quality voice samples. This paper proposes a hybrid expert system approach to detect vocal fold pathology using the compressed/low quality voice samples which includes feature extraction using wavelet packet transform, clustering based feature weighting and classification. In order to improve the robustness and discrimination ability of the wavelet packet transform based features (raw features), we propose clustering based feature weighting methods including k-means clustering (KMC), fuzzy c-means (FCM) clustering and subtractive clustering (SBC). We have investigated the effectiveness of raw and weighted features (obtained after applying feature weighting methods) using four different classifiers: Least Square Support Vector Machine (LS-SVM) with radial basis kernel, k-means nearest neighbor (kNN) classifier, probabilistic neural network (PNN) and classification and regression tree (CART). The proposed hybrid expert system approach gives a promising classification accuracy of 100% using the feature weighting methods and also it has potential application in remote detection of vocal fold pathology.     

Image mining by spectral features: A case study of scenery image classification

Spectral features of images, such as Gabor filters and wavelet transform can be used for texture image classification. That is, a classifier is trained based on some labeled texture features as the training set to classify unlabeled texture features of images into some pre-defined classes. The aim of this paper is twofold. First, it investigates the classification performance of using Gabor filters, wavelet transform, and their combination respectively, as the texture feature representation of scenery images (such as mountain, castle, etc.). A k-nearest neighbor (k-NN) classifier and support vector machine (SVM) are also compared. Second, three k-NN classifiers and three SVMs are combined respectively, in which each of the combined three classifiers uses one of the above three texture feature representations respectively, to see whether combining multiple classifiers can outperform the single classifier in terms of scenery image classification. The result shows that a single SVM using Gabor filters provides the highest classification accuracy than the other two spectral features and the combined three k-NN classifiers and three SVMs.     

Neural network based texture analysis of CT images for fatty and cirrhosis liver classification

Computational methods are useful for medical diagnosis because they provide additional information that cannot be obtained by simple visual interpretation of clinical presentations and radiologic imaging. As a result an enormous amount of research effort has been targeted at achieving automated medical image analysis. This work reports the texture analysis of Computed Tomography (CT) images and development of Probabilistic Neural Network (PNN), Linear Vector Quantization (LVQ) Neural Network and Back Propagation Neural Network (BPN) for classification of fatty and cirrhosis liver from CT abdominal images. Neural networks are supported by more conventional image processing operations in order to achieve the objective set. To evaluate the classifiers, Receiver Operating Characteristic (ROC) analysis is done and the results are also evaluated by the radiologists. Experimental results show that PNN is a good classifier, giving an accuracy of 95% for classifying fatty and cirrhosis liver using wavelet based statistical texture features.     

Improving brain tumor characterization on MRI by probabilistic neural networks and non-linear transformation of textural features

The aim of the present study was to design, implement and evaluate a software system for discriminating between metastatic and primary brain tumors (gliomas and meningiomas) on MRI, employing textural features from routinely taken T1 post-contrast images. The proposed classifier is a modified probabilistic neural network (PNN), incorporating a non-linear least squares features transformation (LSFT) into the PNN classifier. Thirty-six textural features were extracted from each one of 67 T1-weighted post-contrast MR images (21 metastases, 19 meningiomas and 27 gliomas). LSFT enhanced the performance of the PNN, achieving classification accuracies of 95.24% for discriminating between metastatic and primary tumors and 93.48% for distinguishing gliomas from meningiomas. To improve the generalization of the proposed classification system, the external cross-validation method was also used, resulting in 71.43% and 81.25% accuracies in distinguishing metastatic from primary tumors and gliomas from meningiomas, respectively. LSFT improved PNN performance, increased class separability and resulted in dimensionality reduction.     

A NEW EYENET MODEL FOR DIAGNOSIS OF DIABETIC RETINOPATHY

Diabetic retinopathy (DR) is an eye disease caused by complications of diabetes and it should be detected early for effective treatment. As diabetes progresses, the vision of a patient may start to deteriorate and lead to diabetic retinopathy. Two types were identified: nonproliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR). In this study, to diagnose diabetic retinopathy, we have proposed a new EYENET model that was obtained by combining the modified probabilistic neural network (PNN) and a modified radial basis function neural network (RBFNN), and hence, it possesses the advantages of both models. The features such as blood vessels and hemorrhages of the NPDR image and exudates of the PDR image are extracted from the raw images using image-processing techniques and are fed to the classifier for classification. A total of 600 fundus images were used, out of which 400 were used for training, and 200 images were used for testing. Experimental results show that PNN has an accuracy of 96%, modified PNN has an accuracy of 97.5%, RBFNN has an accuracy of 93.5%, modified RBFNN has an accuracy of 95.5%, and the proposed EYENET model has an accuracy of 98.5%. This infers that our proposed model outperforms all other models.     

Classification of Fatty and Cirrhosis Liver Using Wavelet-Based Statistical Texture Features andNeural Network Classifier

Computational methods are useful for medical diagnosis because they provide additional information that cannot be obtained by simple visual interpretation. As a result an enormous amount of computer vision research effort has been targeted at achieving automated medical image analysis. The study and development of Probabilistic Neural Network (PNN), Linear Vector Quantization (LVQ) Neural Network and Back Propagation Neural Network (BPN) for classification of fatty and cirrhosis liver from Computerized Tomography (CT) abdominal images is reported in this work. Neural networks are supported by more conventional image processing operations in order to achieve the objective set. To evaluate the classifiers, Receiver Operating Characteristic (ROC) analysis is done and the results are also evaluated by the radiologists. Experimental results show that PNN is a good classifier, giving an accuracy of 95% by holdout method and giving an accuracy of 96% by 10 fold cross validation method for classifying fatty and cirrhosis liver using wavelet based statistical texture features.     

Objective evaluation of speech dysfluencies using wavelet packet transform with sample entropy

Dysfluency and stuttering are a break or interruption of normal speech such as repetition, prolongation, interjection of syllables, sounds, words or phrases and involuntary silent pauses or blocks in communication. Stuttering assessment through manual classification of speech dysfluencies is subjective, inconsistent, time consuming and prone to error. This paper proposes an objective evaluation of speech dysfluencies based on the wavelet packet transform with sample entropy features. Dysfluent speech signals are decomposed into six levels by using wavelet packet transform. Sample entropy (SampEn) features are extracted at every level of decomposition and they are used as features to characterize the speech dysfluencies (stuttered events). Three different classifiers such as k-nearest neighbor (kNN), linear discriminant analysis (LDA) based classifier and support vector machine (SVM) are used to investigate the performance of the sample entropy features for the classification of speech dysfluencies. 10-fold cross validation method is used for testing the reliability of the classifier results. The effect of different wavelet families on the classification performance is also performed. Experimental results demonstrate that the proposed features and classification algorithms give very promising classification accuracy of 96.67% with the standard deviation of 0.37 and also that the proposed method can be used to help speech language pathologist in classifying speech dysfluencies.     

Computer-supported diagnosis for endotension cases in endovascular aortic aneurysm repair evolution

An abdominal aortic aneurysm (AAA) is a localized abnormal enlargement of the abdominal aorta with fatal consequences if not treated on time. The endovascular aneurysm repair (EVAR) is a minimal invasive therapy that reduces recovery times and improves survival rates in AAA cases. Nevertheless, post-operation difficulties can appear influencing the evolution of treatment. The objective of this work is to develop a pilot computer-supported diagnosis system for an automated characterization of EVAR progression from CTA images. The system is based on the extraction of texture features from post-EVAR thrombus aneurysm samples and on posterior classification. Three conventional texture-analysis methods, namely the gray level co-occurrence matrix (GLCM), the gray level run length matrix (GLRLM), the gray level difference method (GLDM), and a new method proposed by the authors, the run length matrix of local co-occurrence matrices (RLMLCM), were applied to each sample. Several classification schemes were experimentally evaluated. The ensembles of a k-nearest neighbor (k-NN), a multilayer perceptron neural network (MLP-NN), and a support vector machine (SVM) classifier fed with a reduced version of texture features resulted in a better performance (A_z = 94.35 ± 0.30), as compared to the classification performance of the other alternatives.     

Supervised parametric and non-parametric classification of chromosome images

This paper describes a fully automatic chromosome classification algorithm for Multiplex Fluorescence In Situ Hybridization (M-FISH) images using supervised parametric and non-parametric techniques. M-FISH is a recently developed chromosome imaging method in which each chromosome is labelled with 5 fluors (dyes) and a DNA stain. The classification problem is modelled as a 25-class 6-feature pixel-by-pixel classification task. The 25 classes are the 24 types of human chromosomes and the background, while the six features correspond to the brightness of the dyes at each pixel. Maximum likelihood estimation, nearest neighbor and k-nearest neighbor methods are implemented for the classification. The highest classification accuracy is achieved with the k-nearest neighbor method and k=7 is an optimal value for this classification task.     

Diagnosis of heart disease using artificial immune recognition system and fuzzy weighted pre-processing

This paper presents a novel method for diagnosis of heart disease. The proposed method is based on a hybrid method that uses fuzzy weighted pre-processing and artificial immune recognition system (AIRS). Artificial immune recognition system has showed an effective performance on several problems such as machine learning benchmark problems and medical classification problems like breast cancer, diabetes, liver disorders classification. The robustness of the proposed method is examined using classification accuracy, k-fold cross-validation method and confusion matrix. The obtained classification accuracy is 96.30% and it is very promising compared to the previously reported classification techniques.     

New semi-automated mapping of asbestos cement roofs using rule-based object-based image analysis and Taguchi optimization technique from WorldView-2 images

The use of asbestos cement (AC) roofing materials is a significant concern because of their deleterious effects on human health and the environment. The main objective of this study was to map AC roofs from WorldView-2 (WV-2) images using object-based image analysis (OBIA). A robust Taguchi optimization technique was used to optimize segmentation parameters for WV-2 images in heterogeneous urban areas. In this research, two subsets of WV-2 satellite image sets were utilized to map AC roofs. Rule-based OBIA framework was developed on the first study area. Different supervised OBIA classifiers, such as Bayes, k-nearest neighbour (k-NN), support vector machine (SVM), and random forest (RF), were tested on the first image of the study areas to evaluate the performance of a rule-based classifier. Results of the supervised classifiers showed confusion between AC roof class and some urban features, with overall accuracies of 72.21%, 77%, 81.75%, and 82.02% for Bayes, k-NN, SVM, and RF, respectively. To assess the transferability of the proposed method, the adopted classification framework was applied to larger subsets of WV-2 of the second study area. The results of the proposed approach showed outstanding performance, with overall accuracies of 93.10% and 90.74% for the first and second classified images, respectively. The McNemar test emphasized the statistical reliability of rule-based result (in the first site) compared with supervised classification results. Therefore, the proposed framework of using rule-based classification and Taguchi optimization technique provide an efficient and expeditious approach to mapping and monitoring the presence of AC roofs and help local authorities in their decision-making strategies and policies.     

Effective segmentation and classification for HCC biopsy images

Accurate grading for hepatocellular carcinoma (HCC) biopsy images is important to prognosis and treatment planning. In this paper, we propose an automatic system for grading HCC biopsy images. In preprocessing, we use a dual morphological grayscale reconstruction method to remove noise and accentuate nuclear shapes. A marker-controlled watershed transform is applied to obtain the initial contours of nuclei and a snake model is used to segment the shapes of nuclei smoothly and precisely. Fourteen features are then extracted based on six types of characteristics for HCC classification. Finally, we propose a SVM-based decision-graph classifier to classify HCC biopsy images. Experimental results show that 94.54% of classification accuracy can be achieved by using our SVM-based decision-graph classifier while 90.07% and 92.88% of classification accuracy can be achieved by using k-NN and SVM classifiers, respectively.     

Automated classification of patients with coronary artery disease using grayscale features from left ventricle echocardiographic images

Coronary Artery Disease (CAD), caused by the buildup of plaque on the inside of the coronary arteries, has a high mortality rate. To efficiently detect this condition from echocardiography images, with lesser inter-observer variability and visual interpretation errors, computer based data mining techniques may be exploited. We have developed and presented one such technique in this paper for the classification of normal and CAD affected cases. A multitude of grayscale features (fractal dimension, entropies based on the higher order spectra, features based on image texture and local binary patterns, and wavelet based features) were extracted from echocardiography images belonging to a huge database of 400 normal cases and 400 CAD patients. Only the features that had good discriminating capability were selected using t-test. Several combinations of the resultant significant features were used to evaluate many supervised classifiers to find the combination that presents a good accuracy. We observed that the Gaussian Mixture Model (GMM) classifier trained with a feature subset made up of nine significant features presented the highest accuracy, sensitivity, specificity, and positive predictive value of 100%. We have also developed a novel, highly discriminative HeartIndex, which is a single number that is calculated from the combination of the features, in order to objectively classify the images from either of the two classes. Such an index allows for an easier implementation of the technique for automated CAD detection in the computers in hospitals and clinics.     

A novel Parkinson’s Disease Diagnosis Index using higher-order spectra features in EEG signals

Higher-order spectra (HOS) is an efficient feature extraction method used in various biomedical applications such as stages of sleep, epilepsy detection, cardiac abnormalities, and affective computing. The motive of this work was to explore the application of HOS for an automated diagnosis of Parkinson’s disease (PD) using electroencephalography (EEG) signals. Resting-state EEG signals collected from 20 PD patients with medication and 20 age-matched normal subjects were used in this study. HOS bispectrum features were extracted from the EEG signals. The obtained features were ranked using t value, and highly ranked features were used in order to develop the PD Diagnosis Index (PDDI). The PDDI is a single value, which can discriminate the two classes. Also, the ranked features were fed one by one to the various classifiers, namely decision tree (DT), fuzzy K-nearest neighbor (FKNN), K-nearest neighbor (KNN), naive bayes (NB), probabilistic neural network (PNN), and support vector machine (SVM), to choose the best classifier using minimum number of features. We have obtained an optimum mean classification accuracy of 99.62%, mean sensitivity and specificity of 100.00 and 99.25%, respectively, using the SVM classifier. The proposed PDDI can aid the clinicians in their diagnosis and help to test the efficacy of drugs.

     

A study of cloud classification with neural networks using spectraland textural features

The problem of cloud data classification from satellite imagery using neural networks is considered. Several image transformations such as singular value decomposition (SVD) and wavelet packet (WP) were used to extract the salient spectral and textural features attributed to satellite cloud data in both visible and infrared (IR) channels. In addition, the well-known gray-level cooccurrence matrix (GLCM) method and spectral features were examined for the sake of comparison. Two different neural-network paradigms namely probability neural network (PNN) and unsupervised Kohonen self-organized feature map (SOM) were examined and their performance were also benchmarked on the geostationary operational environmental satellite (GOES) 8 data. Additionally, a postprocessing scheme was developed which utilizes the contextual information in the satellite images to improve the final classification accuracy. Overall, the performance of the PNN when used in conjunction with these feature extraction and postprocessing schemes showed the potential of this neural-network-based cloud classification system.     

Quadratic-radial-basis-function-kernel for classifying multi-class agricultural datasets with continuous attributes

Classification of agricultural data such as soil data and crop data is significant as it allows the stakeholders to make meaningful decisions for farming. Soil classification aids farmers in deciding the type of crop to be sown for a particular type of soil. Similarly, wheat variety classification assists in selecting the right type of wheat for a particular product. Current methods used for classifying agricultural data are mostly manual. These methods involve agriculture field visits and surveys and are labor-intensive, expensive, and prone to human error. Recently, data mining techniques such as decision trees, k-nearest neighbors (k-NN), support vector machine (SVM), and Naive Bayes (NB) have been used in classification of agricultural data such as soil, crops, and land cover. The resulting classification aid the decision making process of government organizations and agro-industries in the field of agriculture. SVM is a popular approach for data classification. A recent study on SVM highlighted the fact that using multiple kernels instead of a single kernel would lead to better performance because of the greater learning and generalization power. In this work, a hybrid kernel based support vector machine (H-SVM) is proposed for classifying multi-class agricultural datasets having continuous attributes. Genetic algorithm (GA) or gradient descent (GD) methods are utilized to select the SVM parameters C and γ. The proposed kernel is called the quadratic-radial-basis-function kernel (QRK) and it combines both quadratic and radial basis function (RBF) kernels. The proposed classifier has the ability to classify all kinds of multi-class agricultural datasets with continuous features. Rigorous experiments using the proposed method are performed on standard benchmark and real world agriculture datasets. The results reveal a significant performance improvement over state of the art methods such as NB, k-NN, and SVM in terms of performance metrics such as accuracy, sensitivity, specificity, precision, and F-score.     

Temporal updating scheme for probabilistic neural network withapplication to satellite cloud classification

In cloud classification from satellite imagery, temporal change in the images is one of the main factors that causes degradation in the classifier performance. In this paper, a novel temporal updating approach is developed for probabilistic neural network (PNN) classifiers that can be used to track temporal changes in a sequence of images. This is done by utilizing the temporal contextual information and adjusting the PNN to adapt to such changes. Whenever a new set of images arrives, an initial classification is first performed using the PNN updated up to the last frame while at the same time, a prediction using Markov chain models is also made based on the classification results of the previous frame. The results of both the old PNN and the predictor are then compared. Depending on the outcome, either a supervised or an unsupervised updating scheme is used to update the PNN classifier. Maximum likelihood (ML) criterion is adopted in both the training and updating schemes. The proposed scheme is examined on both a simulated data set and the Geostationary Operational Environmental Satellite (GOES) 8 satellite cloud imagery data. These results indicate the improvements in the classification accuracy when the proposed scheme is used.