聚苯乙烯多孔吸附微球的制备

通过悬浮聚合和超交联两步法合成了具有介孔结构的改性聚苯乙烯微球用作血液净化材料。首先采用悬浮聚合法制备了亲水改性的苯乙烯马来酸酐共聚微球（MPPS）,然后将MPPS微球以二氯甲烷为溶剂、无水氯化铝为催化剂进行后交联处理,制备了含有介孔结构的、具有较高比表面积的聚苯乙烯(HCLPS)多孔微球。采用比表面积测试、扫描电子显微镜、傅里叶红外光谱、X射线光电子能谱等仪器分析表征了微球的结构和形貌,并测试了HCLPS微球的吸水性和戊巴比妥钠吸附性能。结果表明,超交联反应可以显著提高微球的比表面积,并且随着马来酸酐(MAH)含量增加,微球的吸水性和戊巴比妥钠吸附性能提高;当MAH含量为20 %（质量分数,下同）时HCLPS微球的戊巴比妥钠吸附率为91.90 %。     

Preparation of Anti‐Nonspecific Adsorption Chitosan‐Based Bovine Serum Albumin Imprinted Polymers with Outstanding Adsorption Capacity and Selective Recognition Ability Based on Magnetic Microspheres

Bovine serum albumin (BSA)‐imprinted magnetic microspheres are successfully fabricated by a precipitation copolymerization, in which 2‐hydroxyethyl acrylate (HEA) and water‐soluble chitosan separately work as functional monomers and cross‐linking agents. Hydroxyl derived from HEA as well as hydroxyl, amino, and carboxyl groups, originating from chitosan on the surface of the prepared imprinted microspheres, can form hydrogen bonds and extra electrostatic interaction with proteins. The sulfobetaine methacrylate (SBMA) is introduced into the imprinted polymer as an anti‐protein segment to reduce the nonspecific adsorption and improve the selectivity. Detailed characterization demonstrates that the imprinted layer is about 10 nm, which is extremely beneficial for BSA identification and quality transmission. Furthermore, these microspheres also display an excellent selective adsorption of BSA (IF = 5.0). The results reveal that the prepared imprinted materials can be used as BSA biosensor or separation materials.     

Preparation of Magnetic Porous Microspheres and Their Ability to Remove Oils

Magnetic, porous poly (tripropylene glycol diacrylate) (PTPGDA) microspheres are successfully prepared using a combination of microfluidic emulsification and free‐radical polymerization. The porous structure can be precisely controlled by controlling the amount of the oil‐phase emulsifier polyglycerol polyricinoleate (PGPR). The effects of PGPR content and pH on the contact angle of the microspheres is investigated. The contact angle of the microspheres increases with the raise of PGPR content, and the hydrophobicity of the microspheres remains stable at different pHs. The microstructure, magnetic properties, and oil adsorption abilities of the microspheres are also studied. The as‐prepared microspheres perform adsorption well, the higher the PGPR content, the more pore structures and larger contact angle occurres on the microspheres, which improves the adsorption capacity. In addition, the adsorption capacity of the microspheres for diesel can reach 3.38 g·g^?1 when the mass fraction of PGPR in oil phase is 50% w/v. After adsorbing oil, the microspheres can be separated, recovered, and reused by applying an external magnetic field. The magnetic microspheres have good oil adsorption abilities and recyclability, which shows their potential for use in oil removal.     

交联壳聚糖多孔微球吸附亮绿的研究

利用液体石蜡作有机分散介质,戊二醛作交联剂,制备了交联壳聚糖多孔微球,采用SEM对壳聚糖微球的形貌、大小进行了表征,研究交联壳聚糖微球对亮绿的吸附性能,探讨交联壳聚糖多孔微球用量、亮绿初始浓度、pH值、吸附时间、吸附温度的影响.结果表明,室温下,交联壳聚糖微球粒径为0.5～1.0 mm,亮绿初始浓度10 mg·L-1,pH=6,振摇30 min时,吸附量达1.22 mg·g-1;CODCr去除率达73%.亮绿初始浓度越大,吸附量越大,吸附速率越大;吸附剂用量越大,平衡吸附量越小,吸附速率越大.交联壳聚糖微球对亮绿具有很高的吸附容量和较快的吸附速率,再生重复使用,其脱色率仍达90%以上.等温吸附较好符合Freundlich方程.     

Monodisperse Porous Silica/Polymer Nanocomposite Microspheres with Tunable Silica Loading,Morphology and Porosity

Hybrid organic/inorganic nanocomposites combine the distinct properties of the organic polymer and the inorganic filler, resulting in overall improved system properties. Monodisperse porous hybrid beads consisting of tetraethylene pentamine functionalized poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate) particles and silica nanoparticles (SNPs) were synthesized under Stoeber sol-gel process conditions. A wide range of hybrid organic/silica nanocomposite materials with different material properties was generated. The effects of n(H₂O)/n(TEOS) and c(NH₃) on the hybrid bead properties particle size, SiO₂ content, median pore size, specific surface area, pore volume and size of the SNPs were studied. Quantitative models with a high robustness and predictive power were established using a statistical and systematic approach based on response surface methodology. It was shown that the material properties depend in a complex way on the process factor settings and exhibit non-linear behaviors as well as partly synergistic interactions between the process factors. Thus, the silica content, median pore size, specific surface area, pore volume and size of the SNPs are non-linearly dependent on the water-to-precursor ratio. This is attributed to the effect of the water-to-precursor ratio on the hydrolysis and condensation rates of TEOS. A possible mechanism of SNP incorporation into the porous polymer network is discussed.     

mPEG-PLGA多孔微球的制备及其对降钙素的吸附行为

以聚乙二醇-聚(乳酸-乙醇酸)共聚物(mPEG-PLGA)为材料,采用溶剂挥发法与快速膜乳化法制备了尺寸均一的mPEG-PLGA多孔微球,用其吸附降钙素,考察了降钙素浓度、吸附时间、离子浓度、温度及pH值及微球性质对吸附的影响. 结果表明,优化的吸附条件为：降钙素浓度1.0 mg/mL, pH 7.4, NaCl浓度0.2 mol/L, 14℃下吸附8 h,该条件下,微球吸附量为48.9 mg/g;吸附量与微球比表面积正相关.     

种子溶胀聚合制备苯乙烯-二乙烯苯多孔交联微球

以苯乙烯分散聚合制备单分散种子微球(PS),再用超声分散改进的二步种子溶胀聚合制备了聚苯乙烯-二乙烯苯(PSt-DVB)多孔微球。用光学显微镜、扫描电镜(SEM)和比表面积孔径分布测定仪(BET)等对种子微球和多孔微球的表面形貌及孔结构进行了表征。结果表明,随分散介质极性的增大,所得PS种子微球的粒径变小,相对分子质量增大;固定种子微球用量,随着DBP和DVB用量的增加,交联微球比表面积上升、孔径下降。以乙醇为介质制备种子微球,当DBP体积为1.0 mL,DVB体积为8~10 mL时,能够得到4~7μm单分散性良好的多孔PSt-DVB微球。     

Mono-Sized Anion-Exchange Magnetic Microspheres for Protein Adsorption

In this study, mono-sized anion-exchange microspheres with polyglycidylmethacrylate were engineered and processed to introduce magnetic granules by penetration–deposition approaches. The obtained magnetic microspheres showed a uniform particle diameter of 1.235 μm in average and a good spherical shape with a saturation magnetic intensity of 12.48 emu/g by VSM and 12% magnetite content by TGA. The magnetic microspheres showed no cytotoxicity when the concentration was below 10 μg/mg. The magnetic microspheres possess respective adsorption capacity for three proteins including Bovine albumin, Hemoglobin from bovine blood, and Cytochrome C. These magnetic microspheres are also potential biomaterials as targeting medicine carriers or protein separation carriers at low concentration.     

改性壳聚糖磁性微球对胆红素的吸附

文章以具有良好生物相容性的改性壳聚糖磁性微球为载体吸附血液中的胆红素。研究了改性壳聚糖磁性微球在不同pH、温度、离子强度、初始浓度、牛血清白蛋白等条件下,对胆红素的吸附性能的影响。结果表明,该吸附剂对非结合型胆红素具有良好的吸附性能,在pH为7.5和37℃条件下具有最大吸附量,吸附平衡关系同时符合Frendlich和Langmiur模型。     

环氧基多孔磁性复合微球的制备及性质

以聚醚为致孔剂,通过悬浮聚合法制备了表面带有环氧基的多孔磁性复合微球。用红外光谱(FTIR)、扫描电子显微镜(SEM)、磁强计(VSM)、压汞法等对其进行了表征,考察了分散剂质量分数对多孔磁性微球性能的影响。结果表明,该微球粒径为35～50μm,表面有不规则孔道,w(Fe3O4)≈15.8%,饱和磁化强度8.98 emu/g。水相中w(PVA)由1.5%升至3%时,微球平均粒径由130μm变为40μm,而平均孔径亦由144 nm降为39 nm。     

胆固醇分子印迹聚合微球的制备及其吸附性能

以胆固醇为模板分子、甲基丙烯酸为功能单体、乙二醇二甲基丙烯酸酯为交联剂,在甲苯-乙腈(9:1, j)混合溶剂中沉淀聚合制备了分子印迹聚合物微球. 采用平衡结合法和Scatchard模型评价了该聚合微球的结合性,考察了其吸附行为. 结果表明,胆固醇分子印迹聚合微球中形成两类不同的结合位点,得到高亲和性结合位点的离解常数和最大表观吸附量分别为0.86 mmol/L和80.4 mmol/g,低亲和性结合位点解离常数和最大表观吸附量分别为0.39 mmol/L和61.6 mmol/g. 此方法合成的分子印迹微球对胆固醇有较好的结合性能,可用于胆固醇的分析检测.     

胸腺五肽分子印迹聚合物磁性微球的制备及吸附性能研究

以胸腺五肽(Tp-5)为模板分子、丙烯酰胺(AM)为功能单体、乙二醇二甲基丙烯酸酯(EGDMA)为交联剂、羧基功能化Fe3O4磁性粒子为载体,采用乳液聚合法制备出胸腺五肽分子印迹聚合物磁性微球(Tp-5-MIPMMs)。通过研究交联剂用量、预聚合时间、聚合反应时间对Tp-5-MIPMMs吸附性能和印迹因子的影响,确定了最佳制备条件。扫描电镜(SEM)分析显示微球表面被多孔、均匀聚合物包覆,粒径40μm左右。静态和动态吸附研究表明Tp-5-MIPMMs在2.0 g·L-1的Tp-5溶液中吸附8 h达到饱和,最大吸附量达15.63 mg·g-1,印迹因子达1.51。以谷胱甘肽(GSH)作对比,用薄层色谱(TLC)研究了Tp-5-MIPMMs的选择吸附性能,结果表明Tp-5-MIPMMs对Tp-5分子具有特异选择能力。     

高分子磁性微球的制备及其在工业废水处理中的应用

在总结近年来对高分子磁性微球研究的基础上,对高分子磁性微球的制备方法进行了总结,阐述了高分子磁性微球在工业废水处理中的应用现状。     

Regeneration Research of Porous Magnetic Microspheres during Treatment of Wastewater Containing Cationic Dyes

The application feasibility of porous magnetic microspheres in the removal of cationic dyes from wastewater was investigated. Various desorption solutions were employed for the recovery of cationic dyes from absorbents and regeneration of porous magnetic microspheres. The results showed that 1 M NaCl or 1 M KCl in water/methanol co-solvent had excellent desorption ability for methyl violet. This fact was further demonstrated in the removal cationic gold yellow from its aqueous solution. Overall, this provided a simple methodology for the treatment of wastewater containing cationic dyes and the regeneration of porous magnetic microspheres.     

聚合物模板法制备单分散多孔二氧化硅微球

聚合物模板法是实现无机材料高效制备的有效途径.本研究采用交联聚苯乙烯二乙烯基苯聚合物微球为模板,以有机硅源正硅酸四乙酯(TEOS)为前驱体,通过将硅溶胶沉积到多孔聚合物中形成聚合物和二氧化硅的混合物,再经过高温煅烧将聚合物模板去除的方法,可以方便地制备形貌可控的单分散多孔二氧化硅微球.利用扫描电子显微镜(SEM),傅里叶红外光谱仪(FHR),热重分析仪(TGA),X射线衍射仪(XRD),比表面积孔径分布测定仪(BET)对聚合物模板以及制备的二氧化硅微球进行表征.另外,对单分散多孔二氧化硅微球形成机理进行探讨.     

药物载体磁性高分子微球的制备及应用研究进展

介绍了药物载体磁性高分子微球的研究现状,总结了常用的制备方法及应用进展,展望了磁性高分子微球的发展前景。     

甲基橙印迹磁性壳聚糖聚合物的制备及吸附特性

以通过溶胶-凝胶法自制的Fe₃O₄@壳聚糖（CTS）微球为载体,甲基橙（MO）为模板分子,采用水溶液聚合法制得磁性壳聚糖表面分子印迹聚合物（MMIPs）。通过SEM、XRD、FT-IR和VSM表征了MMIPs的结构和性能,并探究了其对MO的识别与选择性吸附特性。研究表明：与非印迹聚合物（NIMPs,饱和吸附量为20.56 mg/g）相比,在相同条件（pH值6.5、25℃）下,MMIPs对MO具有明显的特异性吸附能力,在60 min左右吸附饱和,饱和吸附量（Q_e）可达113.16 mg/g;MMIPs对MO的吸附符合Langmuir等温吸附模型和准二级吸附动力学模型;在其他干扰染料的存在下,MMIPs的选择性系数（K）最高可达2.85,对MO具有选择识别性;此外,吸附完成后MMIPs可在磁场作用下快速分离,解吸附后循环使用5次,吸附率均在90%以上。     

分散聚合法制备环氧基磁性复合微球

采用化学共沉淀法制备了油酸包覆的Fe3O4磁性纳米粒子,以此为核·采用分散聚合法制备了表面带有环氧基团的Fe3O4／聚甲基丙烯酸缩水甘油酯（PGMA）磁性复合微球,探讨了聚合工艺、聚合条件对甲基丙烯酸缩水甘油酯（GMA）利用效率的影响规律,并用傅立叶变换红外光谱仪（FTIR）、热重分析仪（TGA）、振动样品磁强计（VSM）和扫描电镜（SEM）等对磁性复合微球的结构、磁性能和包覆量进行了表征．采用盐酸一丙酮法测定了磁性复合微球表面环氧基的含量。结果表明,在优化的条件下。GMA利用效率高达61．26％。磁性复合微球具有良好的单分散性·粒径为1～2μm．具有超顺磁性．比饱和磁强度为17．12emu·g^-1。环氧基含量达3．5mmol·g^-1。     

磁性聚合物微球在Cr(VI)吸附分离中的应用(英文)

The magnetic poly-(methacrylate-divinyl benzene) microspheres with micron size were synthesized by modified suspension polymerization method.Adsorption of Cr(VI) from aqueous solution by magnetic poly-(MA-DVB) microspheres with surface amination was investigated.The adsorption processes were carried out under diversified conditions of pH value,adsorption time and temperature to evaluate the performance of the mag-netic microspheres.The optimum pH value for Cr(VI) adsorption was found as 3.The adsorption capacity increased with adsorption time and attained an optimum at 60 min.The adsorption processes for magnetic microspheres was endothermic reaction,and the adsorption capacity increased with increasing temperature.     

反相微乳液法制备磁性分子印迹聚合物微球

以二氯苯酚为模板分子、丙烯酰胺(AM)为功能单体、三羟甲基丙烷三丙烯酸酯(TRIM)为交联单体、Fe3O4为磁性组分,采用反相微乳液悬浮聚合法制备了磁性分子印迹聚合物微球(MMIPMs)。研究了吸附时间、温度、pH对吸附性能的影响,并考察了其重复利用性。结果表明,温度对二氯苯酚-MMIPMs吸附性能影响不大。底物溶液pH对MMIPMs的吸附性能有一定影响,吸附量随pH的升高而增大,当pH为7.0时,吸附量最大。MMIPMs具有良好的重复利用率。