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黄曲霉毒素具有致癌性和致畸性, 即使痕量级水平的摄入也会对人体健康产生长时间的危害。粮食等作物在生长和贮存期间都可被黄曲霉毒素污染。由于其高毒性, 已有很多检测方法来检测不同样品中黄曲霉毒素的含量, 这些方法各有优缺点, 且并不是每个方法都能满足国标限量水平。本文综述了不同黄曲霉毒素对人体的危害, 分析检测技术的发展, 重点讨论几种较成熟方法在不同基质中的应用。 相似文献
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乳品中黄曲霉毒素M1检测方法研究进展 总被引:1,自引:1,他引:0
黄曲霉毒素M1是动物摄入黄曲霉毒素B1后的代谢产物,主要分布在动物的乳汁、尿液中。黄曲霉毒素M1毒性很大,经乳制品摄入会对人体产生巨大的危害。本文主要对乳品中黄曲霉毒素M1毒性、危害、检测方法进行综述。对主要检测方法的特性及适用范围进行分析与概括,并且对未来黄曲霉毒素M1的检测方法的发展进行了合理展望。 相似文献
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van der Fels-Klerx HJ Adamse P Goedhart PW Poelman M Pol-Hofstad IE van Egmond H Gerssen A 《Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment》2012,29(10):1616-1629
Shellfish products may be contaminated with marine biotoxins which, after consumption, may lead to human illness. The Netherlands has a regular monitoring programme for marine biotoxins and the possible toxic phytoplankton in shellfish production waters. The aim of the current study was to evaluate the presence of potential toxic phytoplankton species and marine biotoxins in Dutch production waters over the last decade, and to analyse the relationship between toxin levels and abundance of possible causative phytoplankton species. The results of the monitoring programme of the period 1999-2009 were used. The presence of Alexandrium spp. were negligible, but Pseudo-nitzschia spp. and phytoplankton causing diarrhetic shellfish poisoning (DSP toxin-producing phytoplankton) were present in nearly all three main production areas and years. The main DSP toxin-producing species was Dinophysis acuminata followed by D. rotundata and Prorocentrum lima. Toxins causing paralytic shellfish poisoning (PSP) and amnesic shellfish poisoning (ASP) were present in only a few individual shellfish samples, all at low levels. At the end of 2002, an episode of DSP toxicity was recorded, based on the rat bioassay results. Of the samples that were chemically analysed for DSP toxins in 2007 and 2008, about half of the samples in 2007 contained these toxins, although levels were low and no positive results were obtained using the rat bioassay. There was a slight positive correlation between concentrations of DSP toxin-producing phytoplankton and levels of DSP toxins in 2007. Increased DSP toxin levels were found up to 5 weeks after the peak in DSP toxin-producing phytoplankton. This positive, but weak, relationship needs to be confirmed in future research using more samples and chemical methods to quantify the presence of DSP toxins. If this relationship is further substantiated and quantified, it could be used within the current monitoring programme in the Netherlands to predict the risk areas regarding DSP toxicity in shellfish. 相似文献
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《Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment》2013,30(8):1358-1364
Since 1953, a total of 27 human poisoning cases caused by the consumption of blue humphead parrotfish, Scarus ovifrons, have been reported in Japan. Characteristic symptoms are severe muscle pain associated with rhabdomyolysis. Although it is believed that palytoxin, which is one of the most potent non-protein marine biotoxins, is the most likely causative toxin in blue humphead parrotfish poisoning, palytoxin has not been proven conclusively as the causative toxin because of lack of a reliable and sensitive analytical method for palytoxin. In 2011, human poisoning cases caused by the consumption of blue humphead parrotfish occurred in Miyazaki and Tokyo. In our present study, an LC-MS/MS method for palytoxin and its analogues in the blue humphead parrotfish samples causing the human poisoning cases in 2011 was developed and the samples were analysed by using the newly developed LC-MS/MS method. Palytoxin and its analogues were not detected in the samples from the food poisoning cases. The LC-MS/MS findings therefore do not support the recently accepted hypothesis that palytoxin is the causative agent in blue humphead parrotfish poisoning in Japan. 相似文献
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Monica Mattarozzi Anna Calfapietra Monica Cangini Silvia Pigozzi Federica Bianchi 《Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment》2019,36(4):612-624
Microalgal species growing in marine and aquaculture environments can be responsible for harmful events because of their ability to produce potent natural toxins that can accumulate in edible mollusc species. Their consumption can cause severe illness and even be lethal. The European Union provides comprehensive regulations covering various general food safety aspects to manage the risk of contamination in shellfish farms. Many analytical methods have been proposed to evaluate algal toxins presence in the environment and in food products, for conducting surveillance studies of the main molluscs production sites and, where necessary, immediate monitoring of possible contamination of shellfish. In this work, a one-year analytical surveillance study was carried out to verify the possible presence of algal biotoxins in molluscs from a Mediterranean breeding area. Water and molluscs were sampled from a district of the North-East coast of Sicily, consisting of a unique brackish ecosystem of two lakes connected to each other and to the sea by narrow canals. Water samples were collected to investigate phytoplankton i by microscope analysis to assess the presence of potentially toxin-producing species, such as Pseudo-nitzschia spp, Alexandrium spp and Gonyaulax spinifera, although the presence of toxic phytoplankton has never reached alert levels. Mussels and clams samples were submitted to analysis of paralytic shellfish poisoning toxins, amnesic shellfish poisoning toxins and lipophilic toxins by liquid chromatography-based methods Only a few yessotoxins were detected, having concentrations always below the regulation limits. An existing liquid chromatography-tandem mass spectrometry-based multiresidue method for lipophilic biotoxins was adopted and extended to cover emerging biotoxins such as cyclic imines. The performance of the analytical method for Gymnodimine A and Spirolide 13-desMeC was assessed, obtaining respective quantitation limits of 20 and 10 µg kg?1, a precision always lower than 13% and trueness in the 81–120% range. Method applicability was confirmed using certified materials and a naturally contaminated sample. 相似文献
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生物毒素是自然界一种重要的生命现象,是人们探讨生命科学奥秘和开发新药的重要工具和物质基础,也是食品安全领域的重点防治对象。真菌毒素和海洋生物毒素是与食品安全相关的两类生物毒素,二者均具有毒性强、污染面广的特点,对人类健康具有极大的危害。在生物毒素众多分析检测手段中,液质联用技术因灵敏、高效等特点而被广泛应用。本文以液质联用技术为切入点,综述了该技术用于生物毒素食品安全检测分析的研究与应用进展,同时对相关的样品处理技术研究也进行了概要介绍。 相似文献
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Data describing the distribution of diarrhetic shellfish poisoning toxins in 13 consignments of Danish-produced blue mussels are reported. The content of diarrhetic shellfish poisoning toxins was measured by a liquid chromatography coupled with tandem mass spectrometry detection method, and mean levels in the 13 consignments varied from 58 to 243 μg kg-1. The distributions of diarrhetic shellfish poisoning toxins in the consignments were relatively homogenous as the relative standard deviation of the content varied from 7 to 19%. The results are discussed in relation to food safety, the uncertainty of sampling and analysis, and the newly introduced European Union maximum levels of marine biotoxins in seafood products. 相似文献
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Jonathan Nicolas Peter J. M. Hendriksen Arjen Gerssen Toine F. H. Bovee Ivonne M. C. M. Rietjens 《Molecular nutrition & food research》2014,58(1):87-100
Marine biotoxins can accumulate in fish and shellfish, representing a possible threat for consumers. Many marine biotoxins affect neuronal function essentially through their interaction with ion channels or receptors, leading to different symptoms including paralysis and even death. The detection of marine biotoxins in seafood products is therefore a priority. Official methods for control are often still using in vivo assays, such as the mouse bioassay. This test is considered unethical and the development of alternative assays is urgently required. Chemical analyses as well as in vitro assays have been developed to detect marine biotoxins in seafood. However, most of the current in vitro alternatives to animal testing present disadvantages: low throughput and lack of sensitivity resulting in a high number of false‐negative results. Thus, there is an urgent need for the development of new in vitro tests that would allow the detection of marine biotoxins in seafood products at a low cost, with high throughput combined with high sensitivity, reproducibility, and predictivity. Mode of action based in vitro bioassays may provide tools that fulfil these requirements. This review covers the current state of the art of such mode of action based alternative assays to detect neurotoxic marine biotoxins in seafood. 相似文献
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麻痹性贝类毒素是我国海洋赤潮中最常见的贝类毒素之一,分布最广,危害最大,事故发生率也最高,对人类健康构成了严重威胁,加强对该类毒素的检测监控成为保障海产品安全的重要措施。传统的检测方法主要有小鼠生物检测法、液相色谱法、液相色谱-串联质谱法和酶联免疫法,这些方法均有各自的优势,但在实际应用中还缺少用于现场检测的快速筛查技术。因此,开发快速、灵敏、准确、低成本的麻痹性贝类毒素检测技术具有重要的应用价值。本文主要介绍了麻痹性贝类毒素目前开发出来的快速检测方法,主要包括免疫层析技术和生物传感器技术,对各方法的特点迚行分析。最后对未来麻痹性贝类毒素快速检测技术在实际应用中面临的主要问题迚行了评述,幵对发展趋势迚行了展望。 相似文献
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生物毒素是生物体自然产生的一类化学物质,会对农业、畜牧业、水产业造成严重的损失,同时还会通过污染食物对人类的生命健康和财产安全造成严重影响。然而食品样品基质复杂,严重阻碍了生物毒素的提取和检测。固相微萃取技术可以将目标分析物吸附在微量固相吸附剂表面,从而实现萃取、分离和富集,进而分析检测。因此,将其运用于食品中生物毒素的检测,通过萃取和预浓缩可实现目标物的高灵敏检测。近年来,改进萃取方法与开发新型吸附材料成为微萃取技术发展的关键方向。本文总结了近年来固相微萃取技术在方法学与材料学方面的研究发展,以及其在食品中生物毒素检测领域的应用研究,期望为后续科研人员在固相微萃取领域的进一步开发提供思路,并为生物毒素的高灵敏准确检测提供理论与技术支持。 相似文献
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Rudolf Krsk Eskola Mari Berthiller Franz Nielen Michel Oswald Isabelle Elliott Chris McNerney Oonagh BotanaLuis Miguel Malachová Alexandra 《粮油食品科技》2021,29(6):1-8
确保世界人口不断增长下的食品供应安全和保障是巨大和紧迫的需求。然而,全球农业和食品行业仍易受植物、藻类,尤其是真菌产生的生物毒素污染问题的挑战;随着全球变暖和极端天气事件频发,这些有毒代谢产物的发生愈发难以预测。为了提升食品和饲料链中生物毒素的预警、监测和毒性评估方法,总结在各个科学领域和方法中创新所需的多学科、多部门互补能力,具体包括使用卫星和无人机成像的大数据方法、便携式监测设备以及使用蛋白质组学和转录组学对(新兴)生物毒素进行(联合)毒性测试。 相似文献
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A semi-quantitative seafood safety risk assessment 总被引:1,自引:0,他引:1