Φ400立柱加工及装配工艺的优化

针对大阻力液压支架φ400立柱缸筒及导向套加工中出现的同轴度问题,以及立柱装配中出现的缸筒与导向套配合面啃伤问题,制定了合理的加工及装配工艺,确保了立柱的顺利组装。     

低温泵缸套柱塞防磨损和提高密封性的措施

介绍在KL 15A型制氧制氮车研制过程中 ,解决与之配套的往复式低温柱塞泵缸套柱塞使用寿命短、磨损严重、泄漏量大的方法 ,提高设备运行的可靠性 ,取得一定的经济效益     

制冷装置工艺管常见工艺失效分析与预防

制冷装置如空调、电冰箱制造过程普遍采取工艺（紫铜）管,进行充氮、抽真空、充注和封口焊接等操作,但因其外径小、壁厚薄且加工环境较为恶劣等原因,导致频繁出现制造过程异常。本文综述制冷装置工艺管常见的工艺失效并分析其原因,提供有效的金相微观评定及过程控制方法。     

塑料瓶盖在加工过程中常见的质量故障分析

列举了塑料瓶盖在加工过程中的几种典型质量故障,从工艺、设备和模具方面着手,分析质量故障产生的原因以及解决措施。     

Policy analysis and decision making in a network: how to improve the quality of analysis and the impact on decision making

In a network, parties have different interests and are interdependent. This hampers collective decision making. If, in such a network, a policy analysis is made to support the decision making, the findings from this analysis are likely to lack authority. For a policy analysis to be authoritative and to contribute to collective decision making, a process of interaction between the analyst and the parties concerned should be organized. This is called process management. This article presents a number of guidelines for such a process. They are based on two case studies into the use of policy analysis in networks.     

Assessing the impact of adherence to anti-retroviral therapy on treatment failure and resistance evolution in HIV

The adherence of patients to therapy is a crucial factor for successful HIV anti-retroviral therapy. Imperfect adherence may lead to treatment failure, which can cause the emergence of resistance within viral populations. We have developed a stochastic model that incorporates compartments of latently infected cells and virus genotypes with different susceptibilities to three simultaneously used drugs. With this model, we study the impact of several key parameters on the probability of treatment failure, i.e. insufficient viral suppression, and the emergence of resistance. Specifically, we consider the impact of drug dosage, drug half-lives, fitness costs for resistance, different basic reproductive numbers of the virus and the influence of pre-existing mutations under various levels of adherence. Furthermore, we also investigate the influence of different temporal distributions of non-adherent days (drug holidays) during a treatment. Factors that promote resistance evolution include a high reproductive number, extended drug holidays and poor adherence. Pre-existing mutations only have a substantial effect if they confer resistance against more than one drug. Overall, our study highlights the importance of the interactions between imperfect adherence, pharmacodynamics, pharmacokinetics and latently infected cells for our understanding of drug resistance and therapy failure in HIV anti-retroviral therapy.     

Exploring motorcyclist injury severity in approach-turn collisions at T-junctions: focusing on the effects of driver's failure to yield and junction control measures

Research has suggested that motorcyclists involved in approach-turn crashes were much more injurious than any other crash-type. This paper investigates the determinants of motorcyclist injury severity resulting from such crash types that occurred at T-junctions, with emphasis on the effects of driver's failure to give way and various junction control measures. The ordered probit models of motorcyclist injury severity were estimated using the data extracted from the STATS19 accident injury database (1991-2004). Approach-turn collisions are categorised into two sub-crashes based on the manoeuvres motorcycles and vehicles were making prior to the collisions. The modelling results uncover several important determinants of injury severity: for example, injuries appeared to be greatest when an approaching motorcycle collided with a turning-right vehicle, and such effect was found to exacerbate injury severity when stop, give-way signs and markings controlled the junction. A turning-right driver that was identified to fail to yield to an approaching motorcyclist was also found to severely injure the motorcyclist. The findings of this study may offer guidelines for further research and provide some important preliminary evidence for the development of countermeasures that may help prevent the specific hazards from occurring.