Psychological meaning of separation anxiety in mothers and fathers.

Anxiety about separation from a child is highly salient to parents and, when studied in mothers, has been shown to relate to important personality attributes. This longitudinal study examined origins of separation anxiety, describing the course and significance of separation anxiety in parents of firstborn infants. Although no gender effects were found in mean levels of separation anxiety across the 1st 2 years of parenthood, regression analyses revealed different patterns of relations between separation anxiety and psychological and contextual variables for men and women. For men, only self-criticism and their wife's separation anxiety were significant; for women, separation anxiety was related to personality attributes (such as dependency and self-criticism), role-related beliefs, their spouse's anxiety about separation, and the unique health characteristics of their child. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Behavioral adjustment in children of diabetic mothers

The aim of this study was to evaluate whether maternal diabetes in pregnancy may adversely affect the children's behavioral adjustment, in a sample of 201 mothers (68 with pre-gestational diabetes, 50 with gestational diabetes, and 83 with non-diabetic pregnancies) and their singleton offspring. After accounting for socioeconomic status, ethnicity and maternal attitudes, none of the Child Behavior Checklist ratings correlated significantly with maternal patient group or several indices of antepartum maternal metabolism. Child obesity, a common sequela of diabetic pregnancies, correlated positively with Internalizing Behavior problems and three narrow-band sub-scales: Somatic Complaints, Anxious/Depressed, and Social Problems. Results suggest that children of diabetic mothers are at increased risk for a variety of developmental disturbances. Screening for learning and behavioral difficulties should be made at regular pediatric visits, with follow-up evaluations warranted by positive indications, excessive weight gain, or other evolving medical concerns.     

Developmental psychopathology in children of depressed mothers.

It is suggested that the tripartite model by R. D. Parke et al (1988) of the ways that parents influence their child's social development might be used to organize the study of abnormal development in children of depressed mothers. Parents influence their child through dyadic interaction, coaching and teaching practices, and managing their child's social environment. Disruption in each of these areas has been associated with parental psychopathology and has been implicated in the development of deviant child outcomes. The components of a theoretical model of developmental psychopathology are outlined, as well as theoretical and methodological problems that have yet to be resolved. Issues of concern include the heterogeneity of maternal diagnoses; distinguishing among genetic, parenting, and environmental effects; matching the level of behavioral analysis with the question being answered; the heterogeneity of child outcomes; age-related effects; bidirectional influences; and the role of paternal psychopathology. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

EEG stability in infants/children of depressed mothers

The stability of EEG was examined in infants of depressed (BDI > 16) and non-depressed mothers (BDI < 9) from 3 months to 3 years. Of the 32 infants seen at 3 months, 15 were seen again at 3 years of age. Seven of the eight children who had exhibited right frontal EEG asymmetry as infants still showed that EEG asymmetry pattern at the 3 year visit. Children with right frontal EEG asymmetry at 3 years were observed to be more inhibited during an exploratory play task, and children of depressed versus non-depressed mothers were less empathetic during simulated maternal distress.     

Handicap-related problems in mothers of children with physical impairments

Cancer chemoprevention is defined as the prevention of cancer by the administration of diet supplements or drugs. A drug discovery effort should therefore focus on finding agents that will avert the process of intraepithelial neoplasia which precedes invasive cancer. Over 30 agents developed by the chemoprevention program at the National Cancer Institute are being tested against intraepithelial neoplasia of many organ sites in more than 80 clinical trials. Two basic mechanisms underlie the onset and development of intraepithelial neoplasia. First is the development of the two precursor lesions of chronic diffuse epithelial hyperplasia and genomic instability, the latter being produced by "mutator" mutations in genes responsible for genomic stability, by gene copy amplification or loss from DNA breakage-fusion-anaphase-bridge cycles, by unequal sister chromatid exchange, and by accumulation of double minutes. Second is the development of multicentric intraepithelial neoplastic lesions which independently progress through each of the following processes at a continuously accelerating rate: clonal evolution, hyperproliferation, production of genomic structural variants, and apoptosis. Recommended chemoprevention strategies based on these mechanisms are (i) the development of better technology for early diagnosis, (ii) the development of multiple agents that block intralesional proliferation at steps along the signal pathway of mitotic signal transduction and along the signal pathway of synthesis of daughter cell components, (iii) the development of nontoxic anti-inflammatory agents, anitoxidants, antimutagens, and proapoptotics, (iv) the avoidance of "clonal escape" through use of drug combinations, and (v) the use of computer-assisted quantitative image analysis to assay modulation of surrogate end points in chemoprevention clinical trials.     

Helplessness in children of depressed and nondepressed mothers.

Helpless behaviors in 5- to 7-year-old children of depressed and nondepressed mothers were assessed through direct observation, interviews, and teacher ratings. The affective tone the mothers set in a joint puzzle task and their tendency to encourage mastery or become intrusive when their children became frustrated at the task were also assessed. Although depressed mothers set a more negative affective tone than nondepressed mothers during solvable puzzles, there were few significant differences between the 2 groups of mothers and children. Still, mothers who were more negative and hostile and less able to encourage mastery in their children had children who exhibited more helpless behaviors in the puzzle task, who were less likely to endorse active problem-solving approaches to frustrating situations, and whose teachers rated the children as less competent and more prone to helpless behaviors. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Physiological response to dental anxiety in children

Live attenuated varicella vaccine elicits protection against varicella-zoster virus (VZV), but adults require two doses to achieve optimal seroconversion rates. To assess the potential role of cell-mediated immunity (CMI), T cell proliferation to VZV antigen was compared in children and adults. Mean stimulation indices (SI) in two cohorts of 39 children tested 6 weeks after vaccination were 28.6 +/- 6.21 and 22.1 +/- 3.84, whereas 20 adult vaccines had a mean SI of 9.1 +/- 0.99 (P = .04). Vaccinees had significant increases in CMI after a second dose of vaccine. At 1 year, VZV CMI was significantly lower in adults after two doses (10.0 +/- 1.13 vs. 15.6 +/- 1.77; P = .02), even though 82% of children received one dose. Limitations in the adult helper T cell response to VZV antigens may explain the need for booster doses to elicit effective immunity and the more frequent occurrence of varicella when adult vaccines are exposed to wild type virus.     

Consequences of tobacco use on mothers and children

The effects of smoking on female reproductive life are clear, with a longer time-lapse necessary for conception, alterations in hormonal and placental functions and an increased risk of extra-uterine pregnancy, prematurity and low birth-weight. The effects of passive smoking among children, irrespective of source, are linked to an increased risk of sudden infants death syndrome, as well as a higher frequency of otitis and respiratory ailments. Some authors have also found an increased risk of cancer in children and a negative impact on physical and psychological development.     

Prior childhood sexual abuse in mothers of sexually abused children

OBJECTIVE: To study extensively the therapeutic approach of gastroesophageal reflux disease in intellectually disabled children. DESIGN: We studied the effect of omeprazole sodium on healing and symptom relief in 52 institutionalized intellectually disabled children (male-female, 21:31; mean age, 15.4 years; range, 4-19 years). INTERVENTION: Endoscopically proven esophagitis (grades I-IV, Savary-Miller classification) was treated with omeprazole sodium, 40 mg/d (20 mg/d for children weighing <20 kg) as healing dose for 3 months, and 20 mg/d (10 mg/d for children weighing <20 kg) as maintenance dose for another 3 months. After 3 and 6 months, results of treatment were evaluated using symptom scoring and/or endoscopy. For patients with relapse, the dose was increased. RESULTS: At first endoscopy, 19 patients (36%) of 52 showed grade I esophagitis; 20 (38%), grade II; 6 (12%), grade III; and 7 (13%), grade IV. In 44 (86%) of 51 patients, treatment was effective in healing esophagitis and keeping patients in remission, independent of the severity of esophagitis. In 7 patients (14%), a symptomatic relapse was observed after decreasing the dose. However, these patients became symptom free again after increasing the dose and showed healing on endoscopy at the end of the study. One child did not finish the study for reasons not related to therapy. Marked improvement of persistent vomiting, regurgitation, food refusal, iron deficiency anemia, and signs of depression was seen at the end. CONCLUSIONS: Omeprazole is highly effective for all grades of esophagitis in intellectually disabled children, without adverse effects. The dose needed to maintain the remission can be titrated according to the reflux symptoms. One disadvantage of medical therapy is that it is open ended, in contrast to operation, but surgery in this population has high mortality and complication rates.     

A measure of anxiety symptoms among children

The Spence Children's Anxiety Scale (SCAS) is a child self-report measure designed to evaluate symptoms relating to separation anxiety, social phobia, obsessive-compulsive disorder, panic-agoraphobia, generalized anxiety and fears of physical injury. The results of confirmatory and exploratory factor analyses supported six factors consistent with the hypothesized diagnostic categories. There was support also for a model in which the 1st-order factors loaded significantly on a single 2nd-order factor of anxiety in general. The internal consistency of the total score and subscales was high and 6 month test-retest reliability was acceptable. The SCAS correlated strongly with a frequently used child self-report measure of anxiety. Comparisons between clinically anxious and control children showed significant differences in total SCAS scores, with subscale scores reflecting the type of presenting anxiety disorder of the clinical samples.     

A study of anxiety and learning in children.

"A general anxiety scale and a test anxiety scale were administered to 747 grade school children. Out of this group, 24 HA-LA pairs of subjects were given 2 modified paired-associate learning tasks, separated by neutral, failure, and success instructions. The results showed no differences due to instructions, but LA Ss performed better than HA Ss in the second task. Alternative explanations for the lack of differences on the first task were offered. The study was interpreted as positive evidence for the validity of the anxiety scales." (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The relation between anxiety sensitivity and depression in children and adolescents referred for anxiety

Research conducted with adult samples suggests that anxiety sensitivity is positively related to depression (Otto et al., 1995, Journal of Anxiety Disorders, 10, 117-123). The Childhood Anxiety Sensitivity Index (CASI, Silverman et al., 1991, Journal of Clinical Child Psychology, 20 162-168) was used in this study to provide an examination of the relation between anxiety, anxiety sensitivity, and depression in a sample of children and adolescents (N = 234) referred for anxiety disorders. A significant correlation between depression and anxiety sensitivity was found. This relation remained statistically significant when controlling for other aspects of anxiety (i.e. worry, physiological anxiety, and concentration). The similarities between these findings and findings obtained with adults are discussed, as well as suggestions for future research.     

Social anxiety in children with anxiety disorders: relation with social and emotional functioning

BACKGROUND: Oxygen radicals have been implicated as important mediators in the early pathogenesis of acute pancreatitis, but the mechanism by which they produce pancreatic tissue injury remains unclear. We have, therefore, investigated the effects of oxygen radicals on isolated rat pancreatic acinar cells as to the ultrastructure, cytosolic Ca2+ concentration and energy metabolism. METHODS: Acinar cells were exposed to an oxygen radical-generating system consisting of xanthine oxidase, hypoxanthine and chelated iron ions. Cell injury was assessed by LDH release and electron microscopy. Cytosolic Ca2+ levels and mitochondrial membrane potential were determined by flow cytometry; adenine nucleotide concentrations by HPLC. Mitochondrial dehydrogenase activity was measured by spectrophotometric assay. RESULTS: Oxygen radicals damaged the plasma membrane as shown by a 6-fold LDH increase in the incubation medium within 180 min. At the ultrastructural level, mitochondria were the most susceptible to oxidative stress. In correlation to the pronounced mitochondrial damage, the mitochondrial dehydrogenase activity declined by 70%, whereas the mitochondrial membrane potential was enhanced by 27% after 120 min. Together this may cause the 85% decrease in the ATP concentration and the corresponding increase in ADP/AMP observed in parallel. In addition, an immediate 26% increase in cytosolic Ca2+ was found, a change which could be inhibited by BAPTA, reducing cellular damage. CONCLUSION: Cytosolic Ca2+ synergizes with oxygen radicals causing alterations of the ultrastructure and energy metabolism of acinar cells which might contribute to the cellular changes found in early stages of acute pancreatitis.     

Young children of schizophrenic mothers: difficulties of intervention

Casework by Danish local social agencies on behalf of 11 children of chronically ill schizophrenic mothers is retrospectively analyzed, along with documentation from psychiatric hospitals, consulting child specialists, and other health professionals. Findings point to a need for earlier and more precise assessment of the mother's parenting abilities as measured against the severity of her illness and the vulnerability of her child.     

Patterns of guilt in children of depressed and well mothers.

Expressions of guilt were examined in 87 children, 5–9 years old, in a psychiatric interview and in a semiprojective procedure using vignettes to elicit children's narratives about interpersonal conflict and distress. Psychiatric assessments yielded similar patterns for children of depressed and well mothers, but semiprojective representations differed for the two groups. Children of well mothers showed prototypic expressions of adaptive guilt involving themes of responsibility and reparation, especially at the older ages. In contrast, themes of children of depressed mothers often were aberrant, distorted, and unresolved, indicating possible differences in the etiology and functions of their guilt. Guilt is considered in relation to other dimensions of affect, theories of moral development, patterns of adaptation and maladaptation, and processes of social transmission of emotional problems. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

T-cell receptor V beta-specific expansions in children from HIV-infected mothers

This paper present a tonometer incorporated in a contact lens, which allows simultaneous measurement of intraocular pressure and performance ophthalmoscopy. The tonometer can record the pulse curve continuously, which can give us an indication of any circulatory problem. The device is therefore expected to yield additional information useful for the diagnosis of early glaucoma. Te device has three force sensors built in, which allow continuous measurement of the force exerted on the eye surface by the contact lens. The force of the contact lens on the eye can be altered and makes the adjustment of different eye pressures possible. These induced changes of the eye pressure and their influence on the fundus can be checked. We have taken some measurements on enucleated human eyes to compare our device with a Statham tansducer in the vitreous. We found a good correlation. We are currently taking measurements in volunteers. The clinical relevance of these observations and measurements will be examined in a future study.