3D gradient system for two B 0 field directions in earth’s field MRI

Object

A new gradient system for earth’s field magnetic resonance imaging (EFMRI) is presented that can be rotated relatively to the earth’s field direction while maintaining the ability to encode images. Orthogonal components of the gradient field are exploited to reduce the number of gradient coils.

Materials and methods

Two favorable orientations of the gradient system relative to the earth’s magnetic field (parallel and perpendicular) are discussed. We introduce the theory for the magnetic fields of the new gradient system and illustrate the design of the coil geometries which were worked out with the help of simulations and a numerical optimization algorithm. Field mapping measurements and imaging experiments in the two different orientations of the gradient system were carried out.

Results

Orthogonal components of the gradient field take over the role of the additionally needed gradient fields when the gradient system is rotated relative to the earth’s magnetic field. The results from the field mapping and imaging experiments verify the presented theory and show the functionality of the new gradient system.

Conclusion

The presented system demonstrates that gradient coils can be used for image encoding in multiple directions. This fact can be exploited to realize an EFMRI setup for parallel and perpendicular prepolarization with a single set of gradient coils.     

Monitoring demyelination and remyelination by magnetization transfer imaging in the mouse brain at 9.4 T

OBJECTIVE: The aim of this study was to assess quantitatively structural changes in myelin content occurring during demyelination and remyelination by magnetization transfer imaging (MTI). MATERIALS AND METHODS: In a reversible model of demyelination with no axonal loss, mice intoxicated by cuprizone were studied by MTI in vivo at 9.4 T. MRI data were compared to histopathological examinations. RESULTS: Data revealed that the magnetization transfer ratio (MTR) decreased significantly during demyelination and increased during remyelination with strong correlation to the myelin content (r = 0.79, P = 0.01). CONCLUSIONS: This study demonstrated that MTR is a sensitive and reproducible quantitative marker to assess myelin loss and repair. This may lead to in vivo monitoring of therapeutic strategies promoting remyelination.     

Numerical and experimental evaluation of RF shimming in the human brain at 9.4 T using a dual-row transmit array

Objective

To provide a numerical and experimental investigation of the static RF shimming capabilities in the human brain at 9.4 T using a dual-row transmit array.

Materials and methods

A detailed numerical model of an existing 16-channel, inductively decoupled dual-row array was constructed using time-domain software together with circuit co-simulation. Experiments were conducted on a 9.4 T scanner. Investigation of RF shimming focused on B₁ ⁺ homogeneity, efficiency and local specific absorption rate (SAR) when applied to large brain volumes and on a slice-by-slice basis.

Results

Numerical results were consistent with experiments regarding component values, S-parameters and B₁ ⁺ pattern, though the B₁ ⁺ field was about 25 % weaker in measurements than simulations. Global shim settings were able to prevent B₁ ⁺ field voids across the entire brain but the capability to simultaneously reduce inhomogeneities was limited. On a slice-by-slice basis, B₁ ⁺ standard deviations of below 10 % without field dropouts could be achieved in axial, sagittal and coronal orientations across the brain, even with phase-only shimming, but decreased B₁ ⁺ efficiency and SAR limitations must be considered.

Conclusion

Dual-row transmit arrays facilitate flexible 3D RF management across the entire brain at 9.4 T in order to trade off B₁ ⁺ homogeneity against power-efficiency and local SAR.     

Morphologic and functional changes in the unilateral 6-hydroxydopamine lesion rat model for Parkinson’s disease discerned with μSPECT and quantitative MRI

Object

In the present study, we aimed to evaluate the impact of neurodegeneration of the nigrostriatal tract in a rodent model of Parkinson’s disease on the different MR contrasts (T₂, T₁, CBF and CBV) measured in the striatum.

Material and methods

Animals were injected with 6-hydroxydopamine (6OHDA) in the substantia nigra resulting in massive loss of nigrostriatal neurons and hence dopamine depletion in the ipsilateral striatum. Using 7T MRI imaging, we have quantified T₂, T₁, CBF and CBV in the striata of 6OHDA and control rats. To validate the lesion size, behavioral testing, dopamine transporter μSPECT and tyrosine hydroxylase staining were performed.

Results

No significant differences were demonstrated in the absolute MRI values between 6OHDA animals and controls; however, 6OHDA animals showed significant striatal asymmetry for all MRI parameters in contrast to controls.

Conclusions

These PD-related asymmetry ratios might be the result of counteracting changes in both intact and affected striatum and allowed us to diagnose PD lesions. As lateralization is known to occur also in PD patients and might be expected in transgenic PD models as well, we propose that MR-derived asymmetry ratios in the striatum might be a useful tool for in vivo phenotyping of animal models of PD.     

Reproducibility and regional variations of an improved gagCEST protocol for the in vivo evaluation of knee cartilage at 7 T

Objective

The objective was to establish a gagCEST protocol that would enable robust and reproducible assessment of the glycosaminoglycan (GAG) content in knee cartilage at 7 T within a clinically feasible measurement time.

Materials and methods

Ten young healthy volunteers (mean age 26 years, range 24–28, five males, five females) were examined on a 7 T MR system. Informed consent was obtained from all individual participants prior to enrollment into the study. Each volunteer was measured twice for reproducibility assessment. The examined knee was immobilized using a custom-made fixation device. For the gagCEST measurement, a prototype segmented 3-D RF-spoiled gradient-echo sequence with an improved saturation scheme employing adiabatic pulses was used in a scan time of 19 min. The asymmetry of the Z-spectra (MTR_asym) in selected regions of interest in knee cartilage was calculated. Differences in MTR_asym between different regions were evaluated using ANOVA and the Bonferroni corrected post hoc test.

Results

The improvement of the saturation scheme reduced the influence of field inhomogeneities, resulted in more uniform saturation, and allowed for good reproducibility in a reasonable measurement time (19 min), as demonstrated by an intraclass correlation coefficient of 0.77. Improved fixation helped to reduce motion artifacts. Whereas similar MTR_asym values were found for weight-bearing and non-weight-bearing femoral cartilage, lower values were observed in the trochlear groove (p = 0.028), patellar (p = 0.015) and tibial cartilage (p < 0.001) when compared to non-weight-bearing femoral cartilage.

Conclusion

Reasonable reproducibility and sensitivity to regional differences in GAG content suggests that the improved gagCEST protocol might be useful for assessing the biochemical changes in articular cartilage that are associated with early stages of cartilage degeneration.

     

Sequential whole-body PET/MR scanner: concept, clinical use, and optimisation after two years in the clinic. The manufacturer’s perspective

PET and MRI are established clinical tools which provide complementary information, but clinical workflow limits widespread clinical application of both modalities in combination. The two modalities are usually situated in different hospital departments and operated and reported independently, and patients are referred for both scans, often consecutively. With the advent of PET/MR as a new hybrid imaging modality there is now a possibility of addressing these concerns. There are two different design philosophies for integrated PET/MR imaging—positioning PET inside the MRI magnet or in tandem, similar to PET/CT. The Ingenuity TF PET/MR by Philips Healthcare is a sequential PET/MR tomograph combining state-of-the-art time-of-flight PET and high-field MRI with parallel transmission capabilities. In this review article we describe the technology implemented in the system, for example RF and magnetic shielding, MR-based attenuation correction, peculiarities in scatter correction, MR system optimisation, and the philosophy behind its design. Furthermore, we provide an overview of how the system has been used during the last two years, and expectations of how the use of PET/MR may continue in the years to come. On the basis of these observations and experiences we discuss the utility of the system, clinical workflow and acquisition times, and possible ways of optimization.     

Solving the problems concerned with modernization of power unit monitoring and control systems using the distributed facilities and technologies available in the sargon computerized automation system. Part 1: Tools of PTC “sargon” for distributed systems

The first part of this article describes the tools intended to construct distributed automated process control systems for the main thermal power equipment of power stations that are available in the SARGON computerized automation system.