共查询到20条相似文献,搜索用时 15 毫秒
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Jonas Croissant Arnaud Chaix Olivier Mongin Miao Wang Sébastien Clément Laurence Raehm Jean‐Olivier Durand Vincent Hugues Mireille Blanchard‐Desce Marie Maynadier Audrey Gallud Magali Gary‐Bobo Marcel Garcia Jie Lu Fuyuhiko Tamanoi Daniel P. Ferris Derrick Tarn Jeffrey I. Zink 《Small (Weinheim an der Bergstrasse, Germany)》2014,10(9):1752-1755
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Rumi Khandelia Amit Jaiswal Siddhartha Sankar Ghosh Arun Chattopadhyay 《Small (Weinheim an der Bergstrasse, Germany)》2013,9(20):3494-3505
The fabrication of a versatile nanocarrier based on agglomerated structures of gold nanoparticle (Au NP)–lysozyme (Lyz) in aqueous medium is reported. The carriers exhibit efficient loading capacities for both hydrophilic (doxorubicin) and hydrophobic (pyrene) molecules. The nanocarriers are finally coated with an albumin layer to render them stable and also facilitate their uptake by cancer cells. The interaction between agglomerated structures and the payloads is non‐covalent. Cell viability assay in vitro showed that the nanocarriers by themselves are non‐cytotoxic, whereas the doxorubicin‐loaded ones are cytotoxic, with efficiencies higher than that of the free drug. Transmission electron microscopy and fluorescence microscopy along with flow cytometry analysis confirm the uptake of the drug‐loaded nanocarriers by a human cervical cancer HeLa cell line. Field‐emission scanning electron microscopy reveals the formation of apoptotic bodies leading to cell death, confirming the release of the payloads from the nanocarriers into the cell. Overall, the findings suggest the fabrication of novel Au NP–protein agglomerate‐based nanocarriers with efficient drug‐loading and ‐releasing capabilities, enabling them to act as multimodal drug‐delivery vehicles. 相似文献
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Dong Xiao Hui‐Zhen Jia Jing Zhang Chen‐Wei Liu Ren‐Xi Zhuo Xian‐Zheng Zhang 《Small (Weinheim an der Bergstrasse, Germany)》2014,10(3):591-598
A novel pH‐ and redox‐ dual‐responsive tumor‐triggered targeting mesoporous silica nanoparticle (TTTMSN) is designed as a drug carrier. The peptide RGDFFFFC is anchored on the surface of mesoporous silica nanoparticles via disulfide bonds, which are redox‐responsive, as a gatekeeper as well as a tumor‐targeting ligand. PEGylated technology is employed to protect the anchored peptide ligands. The peptide and monomethoxypolyethylene glycol (MPEG) with benzoic‐imine bond, which is pH‐sensitive, are then connected via “click” chemistry to obtain TTTMSN. In vitro cell research demonstrates that the targeting property of TTTMSN is switched off in normal tissues with neutral pH condition, and switched on in tumor tissues with acidic pH condition after removing the MPEG segment by hydrolysis of benzoic‐imine bond under acidic conditions. After deshielding of the MPEG segment, the drug‐loaded nanoparticles are easily taken up by tumor cells due to the exposed peptide targeting ligand, and subsequently the redox signal glutathione in tumor cells induces rapid drug release intracellularly after the cleavage of disulfide bond. This novel intelligent TTTMSN drug delivery system has great potential for cancer therapy. 相似文献
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Near‐Infrared‐Triggered Azobenzene‐Liposome/Upconversion Nanoparticle Hybrid Vesicles for Remotely Controlled Drug Delivery to Overcome Cancer Multidrug Resistance 下载免费PDF全文
Chi Yao Peiyuan Wang Xiaomin Li Xiaoyu Hu Junli Hou Leyong Wang Fan Zhang 《Advanced materials (Deerfield Beach, Fla.)》2016,28(42):9341-9348
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Juan L. Vivero‐Escoto Igor I. Slowing Brian G. Trewyn Victor S.‐Y. Lin 《Small (Weinheim an der Bergstrasse, Germany)》2010,6(18):1952-1967
The application of nanotechnology in the field of drug delivery has attracted much attention in the latest decades. Recent breakthroughs on the morphology control and surface functionalization of inorganic‐based delivery vehicles, such as mesoporous silica nanoparticles (MSNs), have brought new possibilities to this burgeoning area of research. The ability to functionalize the surface of mesoporous‐silica‐based nanocarriers with stimuli‐responsive groups, nanoparticles, polymers, and proteins that work as caps and gatekeepers for controlled release of various cargos is just one of the exciting results reported in the literature that highlights MSNs as a promising platform for various biotechnological and biomedical applications. This review focuses on the most recent progresses in the application of MSNs for intracellular drug delivery. The latest research on the pathways of entry into live mammalian and plant cells together with intracellular trafficking are described. One of the main areas of interest in this field is the development of site‐specific drug delivery vehicles; the contribution of MSNs toward this topic is also summarized. In addition, the current research progress on the biocompatibility of this material in vitro and in vivo is discussed. Finally, the latest breakthroughs for intracellular controlled drug release using stimuli‐responsive mesoporous‐silica‐based systems are described. 相似文献
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Anticancer Therapy: Light‐Activated Hypoxia‐Responsive Nanocarriers for Enhanced Anticancer Therapy (Adv. Mater. 17/2016) 下载免费PDF全文
Chenggen Qian Jicheng Yu Yulei Chen Quanyin Hu Xuanzhong Xiao Wujin Sun Chao Wang Peijian Feng Qun‐Dong Shen Zhen Gu 《Advanced materials (Deerfield Beach, Fla.)》2016,28(17):3226-3226
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Chung Yen Ang Si Yu Tan Cathleen Teh Jia Min Lee Mun Fei Eddy Wong Qiuyu Qu Li Qing Poh Menghuan Li Yuanyuan Zhang Vladimir Korzh Yanli Zhao 《Small (Weinheim an der Bergstrasse, Germany)》2017,13(7)
Responsive nanomaterials have emerged as promising candidates as drug delivery vehicles in order to address biomedical diseases such as cancer. In this work, polymer‐based responsive nanoparticles prepared by a supramolecular approach are loaded with doxorubicin (DOX) for the cancer therapy. The nanoparticles contain disulfide bonds within the polymer network, allowing the release of the DOX payload in a reducing environment within the endoplasm of cancer cells. In addition, the loaded drug can also be released under acidic environment. In vitro anticancer studies using redox and pH dual responsive nanoparticles show excellent performance in inducing cell death and apoptosis. Zebrafish larvae treated with DOX‐loaded nanoparticles exhibit an improved viability as compared with the cases treated with free DOX by the end of a 3 d treatment. Confocal imaging is utilized to provide the daily assessment of tumor size on zebrafish larva models treated with DOX‐loaded nanoparticles, presenting sustainable reduction of tumor. This work demonstrates the development of functional nanoparticles with dual responsive properties for both in vitro and in vivo drug delivery in the cancer therapy. 相似文献
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Zibiao Li Enyi Ye David Rajamani Lakshminarayanan Xian Jun Loh 《Small (Weinheim an der Bergstrasse, Germany)》2016,12(35):4782-4806
The development of hybrid biomaterials has been attracting great attention in the design of materials for biomedicine. The nanosized level of inorganic and organic or even bioactive components can be combined into a single material by this approach, which has created entirely new advanced compositions with truly unique properties for drug delivery. The recent advances in using hybrid nanovehicles as remotely controlled therapeutic delivery carriers are summarized with respect to different nanostructures, including hybrid host–guest nanoconjugates, micelles, nanogels, core–shell nanoparticles, liposomes, mesoporous silica, and hollow nanoconstructions. In addition, the controlled release of guest molecules from these hybrid nanovehicles in response to various remote stimuli such as alternating magnetic field, near infrared, or ultrasound triggers is further summarized to introduce the different mechanisms of remotely triggered release behavior. Through proper chemical functionalization, the hybrid nanovehicle system can be further endowed with many new properties toward specific biomedical applications. 相似文献
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Multifunctional Hybrid Nanoparticles for Traceable Drug Delivery and Intracellular Microenvironment‐Controlled Multistage Drug‐Release in Neurons 下载免费PDF全文
Bingyang Shi Xin Du Jian Chen Libing Fu Marco Morsch Albert Lee Yong Liu Nicholas Cole Roger Chung 《Small (Weinheim an der Bergstrasse, Germany)》2017,13(20)
Innovative nanoparticles hold promising potential for disease therapy as drug delivery systems. For brain‐disease therapy, a drug delivery system that can sustainably control drug‐release and monitor fluorescence of the drug cargos is highly desirable. In this study, a light‐traceable and intracellular microenvironment‐responsive drug delivery system was developed based on the combination of glutathione‐responsive autoflurescent nanogel, dendrimer‐like mesoporous silica nanoparticles, and gold nanoparticles. The resulting hybrid nanoparticles represent a new class of delivery system that can efficiently load, transport, and control multistage‐release of sulfydryl‐containing drugs into neurons, with light‐traceable monitoring for future brain‐disease therapy. 相似文献
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Drug Delivery: Thrombin‐Responsive Transcutaneous Patch for Auto‐Anticoagulant Regulation (Adv. Mater. 4/2017) 下载免费PDF全文
Yuqi Zhang Jicheng Yu Jinqiang Wang Nicholas J. Hanne Zheng Cui Chenggen Qian Chao Wang Hongliang Xin Jacqueline H. Cole Caterina M. Gallippi Yong Zhu Zhen Gu 《Advanced materials (Deerfield Beach, Fla.)》2017,29(4)
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Silicon Drug Nanocarriers: Highly Fluorescent,Photostable, and Ultrasmall Silicon Drug Nanocarriers for Long‐Term Tumor Cell Tracking and In‐Vivo Cancer Therapy (Adv. Mater. 6/2015) 下载免费PDF全文
Xiaoyuan Ji Fei Peng Yiling Zhong Yuanyuan Su Xiangxu Jiang Chongxi Song Liu Yang Binbin Chu Shuit‐Tong Lee Yao He 《Advanced materials (Deerfield Beach, Fla.)》2015,27(6):1131-1131