Adverse effects on offspring of maternal alcohol abuse during pregnancy

To evaluate the risk of offspring of heavy drinking during pregnancy, we administered a questionnaire to 633 women at the first prenatal visit. Nutritional status, smoking, drug and alcohol use were determined. Women were classified into three groups: abstinent and rare drinkers; moderate drinkers; and heavy drinkers. After delivery, detailed pediatric, neurologic and developmental examinations were administered by a physician without prior knowledge of any history. Infants born to heavy drinkers had twice the risk of abnormality of those born to abstinent or moderate drinkers (P less than 0.001). Thirty-two per cent of infants born to heavy drinkers demonstrated congenital anomalies, as compared to 9 per cent in the abstinent and 14 per cent in the moderate group (P less than 0.001). Microcephaly and multiple congenital anomalies were much more frequent in this group (P less than 0.001). Heavy drinking during pregnancy increases the risk to offspring.     

Social influences on drinking during pregnancy.

The influence of social networks on the drinking practices of pregnant women was examined. Pregnant women (n?=?153) were classified according lo whether they were heavy or light drinkers just before pregnancy and whether they reduced their alcohol risk status after pregnancy recognition. Failure to reduce alcohol risk status following pregnancy recognition among initially heavy drinkers was associated with reporting drinking as a social activity and difficulty in resisting social pressure to drink. There was also evidence that failure to reduce drinking was associated with greater approval for drinking during pregnancy and more frequent serving of alcohol among the social network. Findings suggest that interventions designed to reduce drinking among pregnant women help them to find alternative social activities and to develop strategies for resisting pressure to drink (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The impact of maternal depression on adolescent adjustment: The role of expressed emotion.

The present study evaluated the role of expressed emotion (EE) as a predictor of child symptomatology and functional impairment in a sample of nearly 800 adolescent children of mothers with varying histories of depression or who were nondepressed. Structural equation modeling was used to test the hypothesized associations in half of the sample, and all models were cross-validated on the other half of the study sample. Results indicated that EE criticism and degree of maternal depression both had independent predictive associations with youths' externalizing symptoms and functional impairment. In addition, high EE criticism served as an intervening variable between maternal depression and child functioning (externalizing symptoms and functional impairment). Results are discussed in terms of the mutual effects of depressed mothers and dysfunctional youths on each other. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The impact of maternal personality on individuation during adolescence.

The role of the mother in the resolution of the rapprochement crisis as it continues into adolescence is examined through the analyses of a 14-year-old boy and his mother. The symptoms of the adolescent were anxiety, poor school performance, and drug abuse. The mother sought treatment for intense anxiety and overwhelming dread when contemplating her future and that of her son. The dynamics of the mother, the nature of the symbiotic bond, and their impact on the inability of the adolescent to effectively disengage from anaclitic parental ties are discussed. The importance of understanding parental dynamics in the analysis of adolescents is stressed from theoretical and clinical viewpoints. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Some models and mechanisms for explaining the impact of maternal and adolescent characteristics on adolescent stage of drug use.

Examined the impact of interrelationship models and interactive mechanisms involving maternal and adolescent variables on the adolescent's stage of drug use in 356 mothers and their youngsters (aged 13–18 yrs). Ss completed questionnaires assessing maternal personality attributes, mother–child relationship, adolescent personality attributes, and stage of drug use. Results indicate that domains (i.e., sets of related variables) of adolescent personality and mother–child relationship variables each had an independent impact on drug use. Thus, conventional adolescents with strong mutual attachments to mothers were at lower drug stages. The maternal personality domain had an indirect impact on drug use via the other 2 domains. A psychologically stable and conventional mother was associated with a positive mother–child relationship and conventionality in the adolescent, which led to lower drug stages. The interactive effects on drug stage of individual maternal and adolescent measures were also examined. Results show that the impact on drug use of maternal risk (drug-prone) and protective (non-drug prone) characteristics could be altered by certain adolescent traits. (42 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Smoking during pregnancy: Long-term effects on offspring.

241 children (approximately 10 yrs old) of 233 mothers who did or did not smoke during pregnancy were compared on 4 classes of variables: physical, intellectual, affective, and personal and social functioning. No statistically significant differences were found between the offspring of smokers and nonsmokers on these variables. (13 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Parental drinking problems and adolescent offspring substance use: Moderating effects of demographic and familial factors.

Examined the moderating effects of background and demographic factors and current family situation on the relationship between parental drinking problems and adolescent offspring substance use. Face-to-face interviews were conducted with a random sample of 818 Black and White adolescents (aged 13–17 yrs) and telephone interviews were completed with 1 primary caregiver. Results revealed that neither paternal nor maternal drinking problems consistently predicted substance use among adolescent offspring; however, chaotic and unsupportive family situations were strongly predictive. Hypothesized moderating effects also were found for gender, age, co-occurring parental psychiatric problems, extended family history of drinking problems, current family structure, and caregiver support. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The effects of maternal alcohol consumption and cigarette smoking during pregnancy on acoustic cry analysis

During the last trimester of pregnancy, 127 primiparous Irish mothers were interviewed to ascertain their history of alcohol and tobacco use. Confounding effects due to other drugs were not a factor in this sample. Mothers consumed an average of .21 ounces absolute alcohol (AA) per day, with 62% classified as moderate drinkers, 10.6% as heavy drinkers, and 26% as nondrinkers. Neurobehavioral status was measured using acoustic characteristics of the infant's cry, collected on the third day of life. Multiple regression analysis showed that more ounces AA per day was related to more dysphonation and higher first formant, while more cigarette smoking was related to higher pitch, higher second formant, and more variability in the second formant. Analysis of variance comparisons of these 3 alcohol groups demonstrated significant cry effects on infants of heavy drinking mothers.     

Peer and parental influences on male adolescent drinking

Using data from males aged 16-19 in Buffalo, NY, the present study examines two social mechanisms by which parents and peers influence adolescent drinking--behavioral and attitudinal transmission--and compares the patterns of behavioral and attitudinal transmission for parents and for peers. The study also assesses the relative importance of parents and peers in accounting for adolescent alcohol behavior. The findings indicate that both alcohol behavior and attitudes of parents and peers are significant predictors of adolescent drinking. However, the prediction patterns are reversed. Parental attitudes are more important than parental alcohol behavior, while peer alcohol behavior is more important than peer attitudes. Overall, peers have more influence on adolescent drinking than parents. There is a significant interaction of parental alcohol-related attitudes and age, which indicates that parental alcohol-related attitudes exert a greater effect on younger (i.e., age 16-17) males' alcohol use.     

Perinatal events associated with maternal smoking during pregnancy

To identify components of smoking-related increased perinatal mortality, detailed analyses of data from the Ontario Perinatal Mortality Study (50,000 births, 1,300 deaths, 1960-1961) measured the relationship of maternal smoking to birth weight, gestation, placental complications, and perinatal mortality. Cross-tabulations with other factors and multiple adjustment showed increases with amount smoked of birth weights less than 2500 gm, gestations less than 38 weeks, placenta previa, abruptio placentae, and perinatal mortality. These significant, smoking-related increases were independent of mother's height, weight, hospital status, age-parity group, birthplace, previous pregnancy history, weight gain, time of registration, and sex of child. Maternal smoking had the strongest effect on birthweight in the 8 factor regression, and birth less than 2500 gm increased directly with smoking level from 20% to 340% in 37 data subgroups. Births less than 38 weeks increased 20% and 50% and perinatal mortality increased 20% and 35% for less than 1 pack and 1 + pack smokers, respectively, adjusted for 7 other factors. Placental complications increased consistently with smoking level in all of 37 subgroups except for primiparous less than 1 pack smokers. Adjusted rates increased 25% and 92% for placenta previa, 23% and 86% for abruptions among smokers of less than 1 pack and 1 + packs, respectively. These complications carry high perinatal mortality risk, and account for one-third to one-half of the perinatal deaths attributable to maternal smoking.     

Effect of pregnancy on maternal oxygen saturation values: use of reflectance pulse oximetry during pregnancy

Our objective was to evaluate the usefulness of pulse oximetry monitoring in a large population of pregnant patients. We designed our study to measure pulse oximetry saturation in a cross section of 952 obstetric inpatients and outpatients. A group of 366 patients identified as normal were compared with abnormal subgroups. A subgroup of 64 patients with saturation measurements less than 96% were further evaluated. Our results indicated that oxygen saturation values did not change appreciably during the course of pregnancy in normal patients. Hypoxemia (saturation measurement less than 96%) was associated with smoking, and hypoxemia with preterm labor occurred more frequently in patients who smoked. Obesity and magnesium sulfate use appeared to be synergistic in the presence of hypoxemia. We concluded that the routine use of pulse oximetry during pregnancy may not be justified. Smoking, obesity, and magnesium sulfate use have some effect on oximetry in pregnant patients.     

More on adolescent pregnancy.

Responds to L. Silka's (see record 1982-30189-001) and P. Williams's (see record 1982-30129-001) comments on D. Baumrind's (see record 1982-01029-001) article concerning teenage sexual activity, pregnancy, and birthrate. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Models of parenting and adolescent drinking.

Comments on the A. W. Collins et al article (see record 2000-13816-002) which discusses behavioral genetics and the parenting theory. The current author points out that Collins et al made little mention of the influence of parenting on adolescent drinking behavior. Selected studies on this topic are reviewed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Using alcohol expectancies to predict adolescent drinking behavior after one year.

An accumulating literature has shown the influence of childhood experiences associated with alcohol use on later drinking practices. Recent studies have suggested that alcohol-related expectancy may serve as an intervening variable to connect these early experiences with the later, proximal decision to drink when opportunities for actual alcohol consumption arise. Those studies, however, have collected expectancy and drinking data concurrently, whereas the present study for the first time reports on the power of expectancies measured in early adolescents (seventh and eighth grades) to predict self-reported drinking onset and drinking behavior measured a full year later. Results show that five of seven expectancy scores readily discriminated between nonproblem drinkers and those subsequently beginning problem drinking and accounted for a large portion of the variance in a continuous quantity/frequency index and a problem drinking index. The strength of these time-lagged relations strengthens the case for inferring that expectancies have causal power on drinking behavior and suggests prevention strategies. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Impact of pregnancy on maternal AIDS

OBJECTIVE: To assess the impact of pregnancy on maternal acquired immunodeficiency syndrome (AIDS) among tribal women in India. STUDY DESIGN: From February 1992 to February 1996, 71 tribal women from Manipur, India, with AIDS (Centers for Disease Control stage iii/iv), matched for age, parity, CD4 lymphocyte count and demographic characteristics, were recruited into a prospective study. Thirty-two (49%) of these women were pregnant (8-10 weeks) (group A) and 38 (51%) nonpregnant (group B). RESULTS: Pneumocystis carinii pneumonia followed by miliary tuberculosis and wasting disease were the most common AIDS-defining illness and cause of maternal death in both groups. A total of 28 (39%) women died as a direct result of their AIDS-defining illness; 10 (27%) of them were among the nonpregnant women as compared to 18 (56%) deaths among the pregnant women (P = .17, odds ratio 3.7285, 95% confidence interval 1.23, 11.58). Three (16%) of these 18 deaths occurred within 14 weeks of an uneventful first-trimester medical termination of pregnancy. Thirteen women (41%) died undelivered at 30-34 weeks' gestation, and two died within 3 weeks of delivery. Fourteen (44%) women vaginally delivered 14 preterm infants, between 28 and 35 weeks' gestation. Eleven of these infants died within six weeks; nine deaths were a direct result of prematurity and clinical diagnosis of an AIDS-defining illness. The mean survival time was 9.72 months for the pregnant women and 22.6 months for the nonpregnant women (P = .066). CONCLUSION: Pregnancy increased maternal and fetal mortality in these AIDS-infected women.     

Circulating iodide concentrations during and after pregnancy

Early, indirect studies suggested that an important aspect of thyroid economy during pregnancy was a decline in plasma or serum inorganic iodide (PII) concentrations, but there is little information concerning circulating iodide concentrations as assessed by direct measurement. The present study was undertaken to determine the relationship between gestation and serum iodide concentrations as assessed by direct measurement of PII. PII concentrations, urinary iodide levels, and other parameters of thyroid economy were measured during the first, second, and third trimesters and after delivery in 16 women. Mean serum T4 concentrations were significantly higher in all 3 trimesters than those after delivery. Serum free T4 index concentrations were significantly higher in the first trimester than during later periods of gestation or after delivery, but serum TSH concentrations were not depressed in the first trimester. Serum thyroglobulin concentrations were similar during pregnancy and after delivery. There was wide variability in PII and urinary iodide concentrations during and after pregnancy, but there was no trend for PII concentrations to be depressed during pregnancy. Pregnancy, at least in iodine-sufficient regions, does not have an important influence on circulating concentrations of iodide.     

The influence of the maternal thyroid hormone environment during pregnancy on the ontogenesis of brain and placental ornithine decarboxylase activity in the rat

The influence of maternal hypothyroxinaemia on early brain and placental development was examined in a partially thyroidectomized (parathyroid-spared; TX) rat dam model. Ornithine decarboxylase (ODC) specific activity, along with more general indices of cell growth, were determined in prenatal whole brain (at 15, 19 and 22 days of gestation), postnatal brain regions (at 5, 10 and 14 days) and placenta. Maternal hypothyroxinaemia resulted in reductions in fetal body weight, brain weight, brain DNA content and brain total protein content at 15 days of gestation; the latter effect persisting until 19 days of gestation. Further changes in brain cell growth were observed near term, when an increase in the DNA concentration was accompanied by a decrease in the total protein:DNA ratio. Growth of the postnatal brain regions appeared normal, with the exception of an isolated increase in the protein content of the cerebellum at postnatal day 5. Determination of the specific activity of brain ODC revealed a complex pattern of change in the progeny of TX dams, superimposed upon the normal ontogenetic decline. In the fetal brain, activity was initially deficient at 15 days of gestation but was increased at 22 days of gestation relative to controls. The compromise extended into the postnatal period; ODC specific activity being transiently reduced in the brainstem, the subcortex and the cerebral cortex. Placental development was less consistently affected; wet weight, gross indices of cell growth (DNA content, DNA concentration, total protein:DNA ratio) and ODC specific activity were all normal in the TX dam. However, cytosolic and total protein concentrations were reduced at 15 and 19 days of gestation respectively.(ABSTRACT TRUNCATED AT 250 WORDS)     

The relationship between maternal problem-solving style and adolescent social adjustment.

Examined the relationship between social functioning in adolescents and their mothers' conflict-handling style, categorized according to 5 conflict-handling styles identified by M. A. Rahim (see record 1983-27060-001). 89 adolescents (aged 11–17 yrs) and their mothers participated. Mothers completed a measure assessing their style of handling conflict, mothers and fathers completed measures of the adolescents' social functioning, and behavioral observations of the mothers and adolescents were conducted. Results indicate that mothers who scored high on the integrating style (a style using exchange of information and examination of differences to come to a mutually acceptable, often creative, solution) measure had adolescents who were better socially adjusted according to mother, father, and behavioral observation. (PsycINFO Database Record (c) 2010 APA, all rights reserved)