纳米羟基磷灰石应用研究进展

羟基磷灰石是人体和动物骨骼的主要无机矿物成分,当羟基磷灰石的尺寸达到纳米级时将表现出一系列的独特性能。纳米羟基磷灰石具有良好的生物相容性和生物活性,是较好的生物材料,被广泛应用于骨组织的修复与替代技术,在生物医学领域具有非常广阔的应用前景。文章综述了纳米羟基磷灰石的应用研究,指出了目前纳米羟基磷灰石材料中存在的主要问题,并对纳米羟基磷灰石的发展前景进行了展望。     

纳米HAP粉末的制备技术及其研究进展

羟基磷灰石具有重要的医学价值,简要介绍了羟基磷灰石的结构和性质,并综述了目前国内外制备纳米羟基磷灰石的技术及其进展情况,通过对这些制备技术的概括比较,提出了纳米羟基磷灰石在制备、应用等方面的未来发展方向.     

纳米羟基磷灰石及其复合材料技术进展

介绍了纳米羟基磷灰石制备和掺杂技术,以及纳米羟基磷灰石复合材料,包括它们在组织工程支架材料、缓控释药物载体、靶向药物传递及环境功能材料等方面的制备技术和应用,显示纳米羟基磷灰石及其复合材料在生物医学领域将会有良好发展前景。     

纳米羟基磷灰石/聚合物骨修复材料的研究进展

纳米羟基磷灰石因其具有良好的生物相容性和生物活性,被广泛应用于骨组织的修复与替代材料.但由于磷灰石本身力学性能较差限制了其应用范围,因此,提高及制备综合性能优越的纳米羟基磷灰石/聚合物复合生物材料是当今研究的热门领域.本文综述了近年来n-HA/聚合物复合材料的国内外研究进展情况,并对此类材料存在的问题进行了分析,探讨了n-HA骨修复材料的发展方向.     

掺锶羟基磷灰石及其在口腔保健领域中的应用

主要综述了掺锶羟基磷灰石的生物特性和制备方法,以金属锶元素取代羟基磷灰石中的部分钙元素进行改性,可得到掺锶羟基磷灰石,掺锶后改善和提高了羟基磷灰石的结晶性、溶解性、降解性和机械性能,并增强生物相容性。详细讨论了掺锶羟基磷灰石在口腔保健领域中的功效及作用,指出了掺锶羟基磷灰石在口腔保健用品中具有广阔的应用前景。     

纳米羟基磷灰石的制备、性能及在牙膏中的应用

介绍了纳米羟基磷灰石的制备方法，纳米羟基磷灰石在牙齿再矿化、牙齿脱敏和牙齿美白方面的性能及纳米羟基磷灰石在牙膏中的应用。     

羟基磷灰石骨修复复合材料的研究进展

纳米羟基磷灰石是一种具有良好生物相容性和生物活性的材料,常用来用做骨替代材料,本文概述了当前羟基磷灰石及其复合材料在骨修复领域的研究进展。     

纳米掺锶羟基磷灰石及其在牙膏中的应用研究

采用化学沉淀法以金属锶元素取代纳米羟基磷灰石中的部分钙元素。可制得纳米掺锶羟基磷灰石；通过XRD、FTIR、TEM等手段，对纳米掺锶羟基磷灰石进行了结构分析；掺锶后提高了纳米掺锶羟基磷灰石的生物性能和使用性能，将其应用于牙膏，可以提高牙膏的使用功效作用，具有广阔的应用前景。     

纳米羟基磷灰石在生物医学领域中的应用研究

综合近年来国内外有关纳米羟基磷灰石的研究报道,对纳米羟基磷灰石在在生物医学领域的研究进展进行综述。     

羟基磷灰石骨组织工程材料研究进展

近年来,骨组织工程的迅速发展为骨缺损修复提供了新的策略和思路。羟基磷灰石具有良好的韧性、生物活性、生物相容性、骨诱导性及骨传导性,对人体硬组织表现出很强的亲和力,与异体骨移植和人工合成替代物相比,其与人体硬组织的化学结合使其在临床中具有更大的应用和优势,是理想的骨组织工程支架材料,在生物医疗领域有着广泛的应用。本文简述了羟基磷灰石的结构与性能,介绍了纳米羟基磷灰石骨组织工程材料研究进展。     

Hydrothermal synthesis of hierarchical hydroxyapatite: Preparation, growth mechanism and drug release property

Hydroxyapatite (HAP) hierarchical microspheres were synthesized by a facile hydrothermal method using calcium nitrate and ammonium dihydrogen phosphate through controlling complexing agents. The influences of two kinds of complexing agents (potassium sodium tartrate tetrahydrate and trisodium citrate) and reaction time on the morphology of HAP crystals have been investigated. These results indicate that complexing agents have a great influence on the morphology of HAP. When potassium sodium tartrate tetrahydrate was used as complexing agent, HAP flowers were composed of the network of nanosheet building blocks. Well-crystallized HAP dandelions with nanorods radiating from the center can be obtained by the introduction of trisodium citrate. Broader XRD diffraction peaks imply a nanometer scale size. Based on XRD and SEM results, the formation mechanism of HAP crystals has been discussed. The hierarchically structured HAP microspheres were explored as drug carriers. The results indicate that HAP flowers and dandelions showed a favorable sustained release property for ibuprofen; thus, they are very promising for application in drug delivery.     

羟基磷灰石湿法制备技术及应用研究进展

羟基磷灰石（HAP）较强的离子交换能力、独特的多吸附位点及可调变的酸碱性质使其在处理含重金属离子废水和废气治理等方面备受瞩目;HAP规整的立体化学结构和良好的生物相容性及生物活性使其在药物载体、生物支架等领域具有广阔的应用前景。综述了HAP的湿法制备技术及其在环境治理、生物医学等领域的研究进展。     

Novel interconnected nanochannel hydroxyapatite ceramics: synthesis,microstructure, and permeability

Uniform interconnected micro/nanoporous ceramics with good mechanical properties hold universal applications in biomedical and engineering fields. Herein, using hydroxyapatite (HAP) microtubes as the raw material instead of traditional particles, a novel interconnected nanochannel hydroxyapatite ceramic was fabricated successfully through one-step microwave sintering method without the addition of pore generators. The tubular structure of the HAP microtubes remains even after microwave sintering, which endows the ceramic with uniform interconnected nanochannels and 3-D porous structure. The HAP microtube nanochannel ceramic has a narrow pore size distribution from 400 nm to 600 nm, and exhibits well permeability, high adsorption/desorption ability. The porosity is about 30%, the HAP microtube nanochannel ceramic can be totally dyed by methylene blue within several minutes, and the blue dye can be desorbed completely in 45 min by ultrasonic vibration. In addition, due to the one-dimensional structure of the HAP microtubes, the HAP microtube nanochannel ceramic has smaller shrinkage, bigger porosity, and better toughness than the control sample fabricated by nanoparticles. Base on the uniform interconnected nanochannel structure, well permeability, high adsorption/desorption ability, the HAP microtube nanochannel ceramic fabricated here may be a promising candidate for many applications in biomedical engineering, environmental engineering, and energy engineering.     

Pore-forming agent induced microstructure evolution of freeze casted hydroxyapatite

There were interconnected small lamellar pores, big spherical pores and ceramic walls in the hydroxyapatite (HAP) ceramics fabricated by a freeze casting/pore-former method. As keeping the content of polymethyl methacrylate (PMMA) constant and decreasing the size of PMMA, the size of spherical pores and length of ceramic wall both decreased, and the compressive strength increased. As keeping the size of PMMA and decreasing the content of PMMA, the open porosity decreased and compressive strength increased. The shapes of pores caused by ice crystals were reticular, lamellar and treelike, in turn. The HAP ceramics with the spherical pores of 150-250 μm, open porosity of 62.13% and compressive strength of 7.01 MPa are prospective to have biomedical application.     

Hydroxyapatite nanorod-assembled hierarchical microflowers: rapid synthesis via microwave hydrothermal transformation of CaHPO4 and their application in protein/drug delivery

Hydroxyapatite (HAP) nanostructured materials have attracted much attention due to their excellent biocompatibility and promising applications in various biomedical fields. In this study, a facile method has been developed to synthesize HAP with flower-like hierarchical nanostructures. The flower-like CaHPO₄ precursor is firstly synthesized using triethyl phosphate (TEP) as the organic phosphorus source by the solvothermal method. The HAP hierarchical microflowers constructed with nanorods are then fabricated through rapid microwave hydrothermal transformation of the CaHPO₄ precursor in NaOH aqueous solution. The as-prepared HAP nanorod-assembled hierarchical microflowers are explored to study the protein/drug loading and release properties using hemoglobin (Hb) and ibuprofen (IBU) as a model protein and drug, respectively. The experimental results indicate that the as-prepared HAP nanorod-assembled hierarchical microflowers have relatively large specific surface area, high biocompatibility, high protein/drug loading capacity and pH-dependent sustained release properties. Thus, the as-prepared HAP nanorod-assembled hierarchical microflowers are promising for the applications in protein/drug delivery.     

Rapid synthesis of citrate-zinc substituted hydroxyapatite using the ultrasonication-microwave method

Bio-inspired citrate-hydroxyapatite (HAP) nanoparticles doped with zinc ions were prepared from mussel shells via a rapid method of ultrasonication and microwave irradiation. It was found that zinc ions can interact with citrate ions in the crystallization process of HAP. The growth of nanocrystals in citrate solution was slower than that in HCl solution. The addition of zinc ions reduced the residue of citrate in the products and increased the crystallinity of HAP. Furthermore, mineral platelets with the length of 29 ± 7 nm and the thickness of 3–5 nm were obtained for Zn/(Zn+Ca) = 5 mol%, which displayed similar morphology with HAP platelets in bone. Moreover, the obtained HAP nanoparticles are promising for use as bone graft materials in biomedical applications.     

高纯度羟基磷灰石纳米功能材料的制备工艺

本文利用碳酸钙高温分解得到的氧化钙和磷酸为原料，通过湿式法制备医用生物活性陶瓷羟基磷灰石(HAP)。用X射线衍射(XRD)、傅立叶变换红外光谱(FTIR)等技术对陶瓷材料的组织结构和化学组成进行分析。结果表明在适当工艺条件下。得到的钙磷陶瓷产物为高纯度的羟基磷灰石纳米材料。该方法容易操作，重复性好，适于大批量工业生产，是制备高纯度羟基磷灰石纳米功能材料的理想方法。     

Hybrid Nanocomposites of Hydroxyapatite,Eu2O3, Graphene Oxide Via Ultrasonic Power: Microstructure,Morphology Design and Antibacterial for Biomedical Applications

Post-implantation infections are regarded as a major issue in the biomedical field. Further, many investigations are continuous towards developing antibacterial biocompatible materials. In this regard, hydroxyapatite (HAP), erbium oxide (Eu₂O₃), and graphene oxide (GO) were introduced in nanocomposites combinations, including single, dual, and triple constituents. The nanoparticles of HAP, Eu₂O₃, and nanosheets of GO are synthesized separately, while dispersed in the nanocomposites simultaneously. The morphological investigation showed that HAP was configured in a rod-like shape while the nano ellipsoidal shape of Eu₂O₃ was confirmed. The particle size of the ternary nanocomposite containing HAP/Eu₂O₃/GO reached the length of 40 nm for the rods of HAP and around 28 nm for the length axis of ellipsoidal Eu₂O₃ nanoparticles. The roughness average increased to be about 54.7 nm for HAP/GO and decreased to 37.9 nm for the ternary nanocomposite. Furthermore, the maximum valley depth (R_v) increased from HAP to the ternary nanocomposite from 188.9 to 189.8 nm. Moreover, the antibacterial activity was measured, whereas the inhibition zone of HAP/Eu₂O₃/GO reached 13.2?±?1.1 mm for Escherichia coli and 11.4?±?0.8 mm for Staphylococcus aureus. The cell viability of the human osteoblast cell lines was evaluated to be 98.5?±?3% for the ternary composition from 96.8?±?4% for the pure HAP. The existence of antibacterial activity without showing cytotoxicity against mammalian cells indicates the compatibility of nanocomposites with biomedical applications.

     

电泳沉积羟基磷灰石生物陶瓷涂层的研究进展

羟基磷灰石(hydroxyapatite，HAP)生物陶瓷涂层被认为是目前最好的用于替代人体硬组织的一种生物医用材料。电泳沉积是一种全新的涂层制备方法，它可以解决传统HAP生物陶瓷涂层制备工艺上的各种不足。文中综合介绍了国内外有关电泳沉积HAP生物陶瓷涂层的研究报道，概述了电泳沉积的工艺流程和工艺参数，并对各种影响因素全面地进行了详细的探讨，进而提出了相应的设想和展望。