Urinary N-acetyl-beta-glucosaminidase as an indicator of renal dysfunction in electroplating workers

OBJECTIVES: To investigate chromium-induced renal dysfunction in electroplating workers. METHODS: A cross-sectional study was used to evaluate four biochemical markers of renal function. A total of 178 workers were divided into 3 comparable groups consisting of 34 hard-chrome plating workers, 98 nickel-chrome electroplating workers. and 46 aluminum anode-oxidation workers, who represented the reference group. Ambient and biological monitoring of urinary chromium were performed to measure exposure concentrations. RESULTS: Overall, urinary chromium concentrations were highest among hard-chrome plating workers (geometric mean 2.44 microg/g creatinine), followed by nickel-chrome electroplating workers (0.31 microg/g creatinine) and aluminum workers (0.09 microg/g creatinine). Airborne chromium concentrations were also highest in the hard-chrome plating area (geometric mean 4.20 microg/m3), followed by the nickel-chrome electroplating area (0.58 microg/m3) and the aluminum area (0.43 microg/m3). A positive correlation was found between urinary chromium and airborne concentrations (r=0.54, P < 0.01). Urinary concentrations of N-acetyl-beta-D-glucosaminidase (NAG) were also highest among hard-chrome plating workers (geometric mean 4.9 IU/g creatinine), followed by nickel-chrome workers (3.4 IU/g creatinine) and aluminum workers (2.9 IU/g creatinine). The prevalence of "elevated" NAG (>7 IU/g creatinine) was significantly highest among hard-chrome plating workers (23.5%), then among nickel-chrome workers (7.1%) and aluminum workers (8.7%). Differences in beta2-microglobulin, total protein, and microalbumin were not significant. CONCLUSION: The author's evidence indicates that NAG is an early indicator of renal dysfunction in hard-chrome plating workers.     

Prosocial development in early adulthood: A longitudinal study.

Consistency of measures of a prosocial personality and prosocial moral judgment over time, and the interrelations among them, were examined. Participants' and friends' reports of prosocial characteristics were obtained at ages 21-22, 23-24, and 25-26 yrs. In addition, participants' prosocial judgment was assessed with interviews and with an objective measure of prosocial moral reasoning at several ages. Reports of prosocial behavior and empathy-related responding in childhood and observations of prosocial behavior in preschool also were obtained. There was interindividual consistency in prosocial dispositions, and prosocial dispositions in adulthood related to empathy/sympathy and prosocial behavior at much younger ages. Interview and objective measures of moral reasoning were substantially interrelated in late adolescence/early adulthood and correlated with participants' and friends' reports of a prosocial disposition. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A longitudinal study on the early development of leader-member exchanges.

Investigated the 1st 6 mo that 166 newly hired employees and their immediate supervisors worked together. Expectations, perceived similarity, liking, demographic similarity, and performance were examined as determinants of leader–member exchanges (LMXs). Leader and member expectations of each other assessed in the 1st 5 days in the life of the dyad predicted LMXs at 2 wks and at 6 wks following the 1st day of the dyads' existence. Member expectations of leaders also predicted LMXs at 6 mo. Following nearly the same pattern, perceived similarity and liking from both the leaders' and members' perspectives predicted LMXs at most time periods. Demographic similarity between leaders and members had no significant effects on LMX development, and subordinate performance ratings were relatively less important in predicting LMX than were affective variables. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A prospective study of early pregnancy loss

The New York State Early Pregnancy Detection Study was a prospective study of early pregnancy loss, between implantation and menses, in 217 women attempting to become pregnant during 1989-1992. Women collected urine samples on three consecutive mornings during the late luteal phase of their menstrual cycle, for up to 12 cycles, contributing samples for 1253 menstrual cycles. Urinary human chorionic gonadotrophin (HCG), measured using an immunoradiometric assay, was the biomarker for pregnancy. We observed a range of early pregnancy loss (EPL) rates, from a low estimate of 11.0% to a high estimate of 26.9%, depending on the definition used and the subgroup analysed. Based on a definition of 3 days of HCG concentration > or = 4.00 pmol/l, 2 days > or = 5.33 pmol/l or the last day of HCG > or = 6.67 pmol/l, we identified 115 positive cycles; 95 cycles were clinically confirmed pregnancies and 20 cycles were EPL, giving an EPL rate of 17.4% [95% confidence interval (CI) 11.0-25.6]. In addition, we observed an EPL rate of 19.5% (95% CI 11.3-30.1) for samples collected within a 15 day window around menses, and a rate of 20.3% (95% CI 11.3-32.2) for samples limited to the first three menstrual cycles. Because studies use urine collection schemes other than daily sampling, the definition of pregnancy will be crucial in defining EPL.     

A short-term longitudinal study of memorial development during early grade school.

Analyzed the overt-rehearsal and free-recall memorial performance of 18 children longitudinally in 2 experimental testing sessions initially conducted when Ss were 7 yrs old and again 2 yrs later when they were 9 yrs old. Measures of short- and long-term memory recall and 2 measures of input processing, rehearsal frequency, and rehearsal-set size were obtained for both sessions. Results show that mean performance levels were consistent with past cross-sectional research; significant increases between age levels were exhibited by all variables except short-term memory. Stability coefficients showed all memorial characteristics observed to be stable during the developmental period sampled. At both developmental levels, correlational evidence supported the hypothesis that long-term memory recall is related to rehearsal-set size and not rehearsal frequency. For short-term memory recall, however, reverse relationships with the 2 rehearsal variables were apparent in the 2nd testing session. (13 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A pilot study using the first cervical vertebra as an indicator of race

The articular surfaces and vertebral foramen of the first cervical vertebra can be used to estimate race from complete and fragmentary specimens. Eight measurements taken from 200 vertebrae from the Terry and Hamann-Todd collections (Smithsonian Institution and Cleveland Museum of Natural History, respectively) were used to construct 13 discriminant functions that predict race with 76-60% accuracy.     

Ploidy disturbances as an early indicator of intrinsic malignancy in endometrial carcinoma

Ursodeoxycholic acid is an efficient treatment for putatively immune-mediated liver diseases, but its mechanism of action is unknown. We studied human mononuclear cell proliferation as an in vitro model for cell-mediated immunity in the presence of ursodeoxycholic acid, its glycoconjugate and tauroconjugate and chenodeoxycholic acid at concentrations of 5, 25 and 50 mumol/L. Proliferation was inhibited in a dose-dependent manner compared with control values (15% to 54% depending on the bile acid, concentration and mitogen used), except at 5 mumol/L where inhibition was significant with only one mitogenic stimulus of the three used. With one mitogen (phorbolester) the inhibition was additive with that of cyclosporine. The number of cell-surface receptors studied was not modified by bile acids. Interleukin-2 production was decreased 35% to 60% by ursodeoxycholic acid and its conjugates. The proliferation of the interleukin-2-dependent cell line CTLL-2 was also inhibited. The immunosuppression was reversible except at a chenodeoxycholic acid concentration of 50 mumol/L. Because bile acids are able to partition into membranes and change their properties, we speculate that this allows them to interact with cell-surface receptors or signaling systems within the membrane or on its inner face, thus impairing their function. This would inhibit the numerous extracellular messages that lymphocytes need to proliferate.     

Skin potential as an indicator of emotion.

Monitored the skin-potential responses of 6 college students while each was seen for 10 counseling sessions. Results indicate that the nature of a S's skin-potential wave was generally a reliable indicator of the way the S was managing or experiencing his feelings, as reported on the Mood Adjective Check List during the sessions. Negative skin-potential responses were accompanied by feelings described as pleasant and released; positive responses were associated with unpleasant and inhibited feelings, and neutral responses were often associated with unpleasant and inhibited feelings but also tended to coincide with thoughtful moods. (17 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A longitudinal study of emotion expression and personality relations in early development.

To investigate emotion expression and personality relations, the authors coded infants' full-face and component positive and negative expressions during Episodes 4 through 8 of the strange situation procedure at age 18 months and obtained maternal ratings of the 5-factor model of personality when children were 3.5 years old. Full-face negative expression was directly related to Neuroticism and inversely related to Agreeableness and Conscientiousness. By contrast, component positive expression showed the exact opposite pattern of relations. Full-face positive expression was positively correlated with Extraversion and Openness to Experience. These findings indicate that full-face and component expressions may index different intensities of emotions. Emotion expression and personality relations were not mediated by the security of attachment continuum or the emotional reactivity dichotomy derived from the attachment subclassifications. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Remodeling of neuronal membranes as an early response to deafferentation. A freeze-fracture study

The early effects of deafferentation on the postsynaptic membrane beneath the end bulb of Held in the anteroventral cochlear nucleus (AVCN) were studied with the freeze-fracture technique. Three distinct responses were seen on the external membrane leaflet after cochlear ablation. Within 12 h the number of nonaggregate particles increased 147% by the addition of new particles to the membrane. The increase in number of nonaggregate particles continued until 4 days after cochlear ablation. The other responses occurred later, after degenerative changes were present in the end bulb. Between 1 and 2 days after cochlear ablation, the number of perisynaptic aggregates surrounding the postsynaptic active zone decreased to 10% of normal numbers. By 4 days, all perisynaptic aggregates had disappeared from the membrane. Coated vesicles may be involved in removing these aggregates. Between 1 and 3 days, the number of junctional aggregates decreased, but the size of the aggregates increased, apparently as a result of coalescence of nearby junctional aggregates. The total number of particles in junctional aggregates in the membrane was not altered during the first 6 days after cochlear ablation. The three separate responses suggest the existence of at least three different types of intramembranous particles on the external leaflet of the principal cell membrane, with each type dependent upon different cues for its maintenance in the membrane.     

Individual differences in reactions to noise: A longitudinal study in a college dormitory.

Investigated differences among individuals in their initial reactions to noise and in their ability to adapt to noise over a longer period of time. 155 college freshmen completed a self-report measure of noise sensitivity before they arrived on campus. Two subgroups were constructed from students whose noise-sensitivity scores fell within either the top or bottom 30% of this group. Each had nearly equal numbers of males and females. Self-reports of dormitory noise disturbance were obtained from the noise-sensitive and noise-insensitive groups (24 and 31 Ss respectively) early in the school year and again 7 mo later. As predicted, noise-sensitive students were much more bothered by dormitory noise. Noise-sensitive students became increasingly disturbed during the year; noise-insensitive students showed no change. Correlations of the noise-sensitivity scale with academic test data and personality inventories suggested that noise-sensitive students were lower in scholastic ability, felt less secure in social interactions, and had a greater desire for privacy than their less noise-sensitive peers. (33 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Impact of early socialization on union commitment and participation: A longitudinal study.

New members of a union (N?=?305) were surveyed twice over a 1-year period to assess the effects of institutional and individual socialization practices on union commitment and participation. Whereas individual socialization practices were found to impact on both affective and behavioral involvement in the union, institutional socialization practices were shown to be ineffective at best and counterproductive at worst. The theoretical and practical implications of the findings are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Alumni ratings as an indicator of departmental quality.

University alumni and enrolled students from 22 departments responded to 11 satisfaction items concerning instructional, curricular, advising, and operational aspects of their major departments. Factor structures for the 2 groups were nearly identical and included 2 factors: General Satisfaction With Major and Satisfaction With Mentorship. Comparisons of department means showed differences between alumni and enrolled students on many items, particularly vocational guidance. Alumni ratings were relatively uninfluenced by job-related variables. It is concluded that they are an important source of information in assessing departmental quality. (12 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The intergenerational continuity of observed early parenting: A prospective, longitudinal study.

The authors report the results from a prospective, longitudinal study of cross-generational parenting quality in a lower socioeconomic status sample of moderate ethnic diversity (N = 61). The study extends previous research on intergenerational continuity of parenting in several significant ways: (a) Assessments in both generations were based on direct observation, (b) assessments were made at the same age (24 months) in both generations, (c) there were controls for later parenting in the first generation, and (d) there were controls for critical background factors (stress, socioeconomic status, child and parent IQ). An observed parenting-quality composite showed moderate stability (r = .43) across generations, and findings held after controlling for all other factors. A possible special role for early parenting experience and the extensive research needed to demonstrate it are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Pain and depression in injured workers and their return to work: A longitudinal study.

This study investigated the long-term relationships between depression, pain, and return to work in injured workers with chronic pain. Clients (N = 185) completing the Pain Disability Prevention Program were evaluated for pain and depression at three points in time: on admission to the treatment program, at mid-treatment, and at the end of treatment. The return to work (RTW) was assessed at four weeks after the intervention ended. Correlation and logistic regression analyses showed that depression and pain were significantly associated over time, and that depression and affective pain were the most significant variables for predicting RTW regardless of the time of assessment. An initial cluster analysis divided the sample into four groups reflecting fluctuations of depression and pain over time. Chi-square results indicated that individuals with severe or moderate depression and high levels of affective pain were less likely to RTW (from 18% to 21%) compared to individuals with mild depression or normal emotional "ups and downs" and lower affective pain scores (from 61% to 85%). These results highlighted the importance of considering the clinical symptoms profiles over time when determining the probability of RTW. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Seven-year longitudinal study of the early prediction of reading achievement.

Investigated how well a broad, comprehensive battery of tests administered in kindergarten to 286 Ss (aged 5.0–7.1 yrs) predicted reading achievement in Grades 1–6. The test variables were reduced to 6 predictive factors by factor analysis that, together with the S's sex and the parent's language, had multiple correlations with reading achievement of .58 (Grade 1), .65 (Grade 2), .70 (Grade 3), .66 (Grade 6), and .71 (across all reading achievement tests). Path analysis showed that characteristics measured in kindergarten directly influenced reading in early primary grades and that early reading achievement was the primary determinant of later reading performance. It is concluded that the use of a 2-stage testing procedure, a preliminary screening device followed by the full test battery for selected Ss, substantially reduced testing time and resources, but it had almost no effect on the accuracy of predictions in the present study. (41 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Principle requirements of an electromechanical transducer for implantable hearing aids in inner hearing hearing loss. II: Clinical aspects]

In this retrospective study, 13 patients with subtle Lisfranc joint injuries were examined after a mean period of 23 months using clinical assessment, radiography and dynamic pedographic gait analysis. The aims were to identify the factors leading to a mobile flatfoot deformity, evaluate the functional and clinical outcome of these injuries, and draw practical conclusions for initial management and subsequent intervention. All patients showed a mobile flatfoot deformity, increased motion in the subtalar joint, increased load on the hindfoot, decreased load on the forefoot, and a prolonged contact phase during the stance phase. Radiographs revealed progressive osteoarthrosis in the joint and a residual displacement of the medial Lisfranc joint. An unstable medial Lisfranc joint results in the development of a mobile flatfoot. Initial treatment of a subtly displaced Lisfranc joint should consist of exact anatomical reduction and additional maintenance of the longitudinal arch of the foot. After failed initial treatment, early arthrodesis of the midfoot is recommended as a salvage procedure for the foot.