Investigating the TEPC radiation quality factor response for low energy accelerator based clinical applications

The use of a tissue equivalent proportional counter (TEPC) filled with propane based tissue equivalent gas simulating a 2 microm diameter tissue sphere has been investigated to estimate the radiation quality factor of the neutron fields used in in vivo neutron activation measurements at the McMaster University 3 MV Van de Graaff accelerator. The counter response to estimate the effective quality factor based on the definitions of Q(L) provided in ICRP 26 and 60 as a function of neutron energy has been examined experimentally using monoenergetic and continuous neutron spectra in the energy range of 35 to 600 keV. In agreement with other studies, the counter failed to provide a flat R(Q) response and showed a sharp drop below 200 keV neutron energy. Development of an algorithm to evaluate the quality factors using measured dose-mean lineal energy, yD, and comparison of the algorithm with other reported algorithms and analytical methods developed for the improvement in TEPC dose equivalent response has been reported.     

A chamber for determining the conventionally true value of Hp(10) and H*(10) needed by calibration laboratories

A secondary standard chamber for photon radiation developed for measuring directly the conventionally true value of the personal dose equivalent, Hp(10), in a slab phantom is now commercially available. In addition, this chamber can be used for determining the true value of the ambient dose equivalent, H*(10), in monodirectional radiation fields; for example, photon fields generated by X ray facilities. Once the chamber has been calibrated at the facility of the calibration laboratory, the true value of Hp(10) or H*(10) can be measured at other facilities without applying any conversion coefficients. For low energy photon fields the conversion coefficients are strongly dependent on the spectral distribution. For nominally the same radiation quality small spectral differences, caused, for example, by use of different X ray facilities, may lead to differences between the spectrum-averaged conversion coefficients from Ka to Hp(10) and H*(10), respectively, of up to several tens per cent. For this reason, tabulated conversion coefficients for low energy radiation fields cannot be used for calibration purposes, if the standard uncertainty is to be 2-5%. Direct measurement by the secondary standard chamber overcomes this problem.     

The use of TEPC for reference dosimetry.

The radiation fields on board aircraft are quite complex and cover an energy range that is unusual in ordinary radiation protection work. Usually dosemeters measure only one radiation quality and the mixture found on board makes measurements complicated. There is also some doubt when it comes to the best choice of quantity for this application and no radiation standards exist for this kind of radiation field. For those reasons there is a need to find a standard measurement procedure that could serve as a reference for other, maybe simpler, measurements or for calculations of route doses. The only direct reading dosemeter that both measures the absorbed dose to tissue and the radiation quality (in terms of lineal energy) is the tissue-equivalent proportional counter (TEPC). The instrument was originally developed for scientific purposes and is still used as such. The detector consists of a gas filled cavity surrounded by a few mm thick wall. Both wall and gas consists of tissue-like material. The measurement principles are explained. Results observed with TEPC instruments are demonstrated. A preliminary collection of data reported by different groups from measurements on board aircraft will be shown. The results agree within +/- 20%. The conclusion is that TEPC instruments have the capacity of serving as reference instruments.     

Measurement and simulation of lineal energy distribution at the CERN high energy facility with a tissue equivalent proportional counter

The response of a tissue equivalent proportional counter (TEPC) in a mixed radiation field with a neutron energy distribution similar to the radiation field at commercial flight altitudes has been studied. The measurements have been done at the CERN-EU High-Energy Reference Field (CERF) facility where a well-characterised radiation field is available for intercomparison. The TEPC instrument used by the ARC Seibersdorf Research is filled with pure propane gas at low pressure and can be used to determine the lineal energy distribution of the energy deposition in a mass of gas equivalent to a 2 mum diameter volume of unit density tissue, of similar size to the nuclei of biological cells. The linearity of the detector response was checked both in term of dose and dose rate. The effect of dead-time has been corrected. The influence of the detector exposure location and orientation in the radiation field on the dose distribution was also studied as a function of the total dose. The microdosimetric distribution of the absorbed dose as a function of the lineal energy has been obtained and compared with the same distribution simulated with the FLUKA Monte Carlo transport code. The dose equivalent was calculated by folding this distribution with the quality factor as a function of linear energy transfer. The comparison between the measured and simulated distributions show that they are in good agreement. As a result of this study the detector is well characterised, thanks also to the numerical simulations the instrument response is well understood, and it's currently being used onboard the aircrafts to evaluate the dose to aircraft crew caused by cosmic radiation.     

FLUKA simulation of TEPC response to cosmic radiation

The aircrew exposure to cosmic radiation can be assessed by calculation with codes validated by measurements. However, the relationship between doses in the free atmosphere, as calculated by the codes and from results of measurements performed within the aircraft, is still unclear. The response of a tissue-equivalent proportional counter (TEPC) has already been simulated successfully by the Monte Carlo transport code FLUKA. Absorbed dose rate and ambient dose equivalent rate distributions as functions of lineal energy have been simulated for several reference sources and mixed radiation fields. The agreement between simulation and measurements has been well demonstrated. In order to evaluate the influence of aircraft structures on aircrew exposure assessment, the response of TEPC in the free atmosphere and on-board is now simulated. The calculated results are discussed and compared with other calculations and measurements.     

Performance of a cylindrical tissue-equivalent proportional counter for use in neutron monitoring

Tissue-equivalent proportional counters (TEPC) allow the measurements of the absorbed dose and the ambient dose equivalent for neutron fields. A device based on this approach, called NAUSICAA((1,2)), has already been developed by IRSN to be used in high energy neutron fields for space applications. The response of this detector underestimates significantly the dose equivalent at low energies (several hundred keV) which represent the major component of neutron fields at workplaces in the nuclear industry. A counter with a similar geometry (cylindrical detector) and a lower gas pressure was studied in order to simulate a 1 microm biological site. In 2003, the performance of the device was further improved by adding a small amount of 3He to the tissue-equivalent gas (propane based) in order to increase the response for the lower energies of neutrons. Three amplification circuits were used to cover lineal energy range from 10(-1) to 10(4) keV microm(-1). Tests were performed in monoenergetic neutron and source fields. This paper presents the experimental results obtained with this change.     

Response investigations of a TEPC in high energy proton and neutron beams using the variance method

Results from measurements in proton and neutron beams between 68 and 174 MeV at the T. Svedberg Laboratory in Uppsala are presented. The result indicate that a TEPC might underestimate the high-energy contribution to H*(10) in cosmic radiation applications such as measurements onboard aircraft.     

Radiation exposure measurement onboard civil aircraft

The active dosemeter DOSTEL based on two silicon planar detectors was flown on civil aircraft flights to study the radiation exposure of air crew members. The altitude and latitude dependence of count and dose rates as well as long-term variations are measured. After calibration of the DOSTEL response against measurements of a TEPC instrument, total dose-equivalent values for various flights are compared with H*(10) calculations by EPCARD yielding a ratio of 1.02 +/- 0.09 (standard variation).     

A tissue equivalent proportional counter filled with a mixture of tissue equivalent gas and 3He for neutron monitoring

Tissue equivalent proportional counters (TEPC) allow the measurement of the ambient dose equivalent H(*)(10) in mixed fields. IRSN has been studying the design and the response of a TEPC in terms of neutron H(*)(10). First, a cylindrical counter was filled with propane gas at a low pressure. H(*)(10) measured in monoenergetic neutron fields underestimated the reference (>50%) at low energies (< 500 keV). A small amount of (3)He was then added to the gas in order to increase the response. The underestimation observed decreased but the results (> 40%) were not totally complying with the objectives (< 20%). Finally the choice was made to improve the analysis of the microdosimetric spectra y.d(y) in order to identify the energy of the incident neutrons. The analysis allows a better estimate of H(*)(10). The aim of this article is to describe the TEPC and the effect of these methods of optimisation.     

Optimisation of a secondary standard chamber for the measurement of the ambient dose equivalent, H*(10), for low photon energies

A secondary standard ionisation chamber for photon radiation for measuring an ionisation current, which is directly proportional to the conventionally true value of the ambient dose equivalent, H*(10), was optimised. The chamber was developed in the Austrian Research Centers Seibersdorf and is used successfully worldwide by dosimetry laboratories. The chamber response with respect to H*(10) for photon energies from 40 to 1,250 keV is nearly constant. For lower photon energies the response is strongly energy-dependent and does not fulfil the requirements concerning the quality of a secondary standard given in ISO 4,037-2, i.e. for energies for which the determination of the conventionally true value of H*(10) is very difficult. Considering the dose limits defined in the Directive 96/29/Euratom, in the case of whole-body irradiation the knowledge of the personal dose equivalent is of importance down to energies of approximately 12 keV. For area dosimetry, this means that the knowledge of H*(10) for energies approximately >or=12 keV is necessary. To get one secondary standard chamber for H*(10) for the whole photon energy range and to close the gap for low energies in the dissemination of the conventionally true value of H*(10), the chamber was optimised for a flat response for energies from approximately 12 to 1,250 keV.     

The results of cosmic radiation in-flight TEPC measurements during the CAATER flight campaign and comparison with simulation

The European-Commission-supported project DOSMAX (Dosimetry of Aircrew Exposure to Radiation During Solar Maximum) was aimed at measuring aircrew exposure to cosmic radiation on-board the aircraft during solar maximum. During a dedicated international comparison mission (Co-ordinated Access to Aircraft for Transnational Environmental Research; CAATER) different measurement techniques have been compared by six European institutes (Results of the CAATER Mission, DOSMAX Meeting, Dublin, June 2004). In this paper, we present the tissue-equivalent proportional counter (TEPC) measurements carried out by ARC Seibersdorf research (ARCS), Austria, and Institut de Radioprotection et de S?reté Nucléaire (IRSN), France, together with a comparison with simulation results under the same conditions. The whole flight campaign consists of four different in-flight investigations performed at two different geographical positions at 12.2 km (FL 400) and 9.8 km (FL 320). One location was chosen above Rome (42 degrees North, 12 degrees East), Italy, for high cut-off rigidity (6.4 GV) and the second above Aalborg (57 degrees North, 10 degrees East), Denmark, for low cut-off rigidity (1.8 GV). The TEPC measurements are presented in terms of absorbed dose and ambient dose equivalent as well as microdosimetric spectra as a function of lineal energy. For the same conditions of the CAATER flights the response of the TEPC has also been simulated by using the Monte Carlo Transport Code FLUKA (version 2003). The results from simulations are compared with measurements and they show a reasonable agreement.     

Use of energy deposition spectrometer Liulin for individual monitoring of aircrew

Silicon energy deposition spectrometer Liulin was primarily developed for cosmic radiation monitoring onboard spacecrafts. Nowadays, Liulin type detectors are also used to characterise radiation field on board aircraft, at alpine observatories and behind the shielding of heavy ion accelerators. In this work, experiments and calibrations performed in these radiation fields are presented and the method developed for calculation of ambient dose equivalent H*(10) on board aircraft is described. Since 2001, a simple method employing the energy deposition spectra had been used to determine H*(10) on board aircraft but, in 2004, it became clear that the resulting values were strongly biased at locations close to Earth's equator. An improved method for the determination of H*(10) on board aircraft using the Liulin detector was developed. It took into account the composition of the radiation field via the ratio of absorbed doses D(low) and D(neut) reflecting the contributions from low-LET particles and neutrons, respectively. It resulted in much better agreement with the EPCARD computer code for all aircraft locations; relative differences were within 11 % for low-LET and 20 % for neutron components of H*(10).     

Measurement of neutron dose with an organic liquid scintillator coupled with a spectrum weight function

A dose evaluation method for neutrons in the energy range of a few MeV to 100 MeV has been developed using a spectrum weight function (G-function), which is applied to an organic liquid scintillator of 12.7 cm in diameter and 12.7 cm in length. The G-function that converts the pulse height spectrum of the scintillator into the ambient dose equivalent, H*(10), was calculated by an unfolding method using successive approximation of the response function of the scintillator and the ambient dose equivalent per unit neutron fluence (H*(10) conversion coefficients) of ICRP 74. To verify the response function of the scintillator and the value of H*(10) evaluated by the G-function. pulse height spectra of the scintillator were measured in some different neutron fields, which have continuous energy, monoenergetic and quasi-monoenergetic spectra. Values of H*(10) estimated using the G-function and pulse height spectra of the scintillator were compared with those calculated using neutron energy spectra. These doses agreed with each other. From the results, it was concluded that H*(10) can be evaluated directly from the pulse height spectrum of the scintillator by applying the G-function proposed in this study.     

Dosimetric considerations on TEPC fluka-simulation and measurements

The response of a tissue equivalent proportional counter (TEPC) has been simulated with the Monte Carlo transport code FLUKA. The absorbed dose distribution of lineal energy y has been determined for several monoenergetic photon and neutron sources. The agreement between the calculated results and the measurements carried out with different well-known sources is well demonstrated. Work is in progress in order to evaluate the response of the instrument in the cosmic ray environment.     

Application of TEPC microdosimetry to boron neutron capture therapy

Boron neutron capture therapy (BNCT) is a bimodal radiation therapy used primarily for highly malignant gliomas. Tissue-equivalent proportional counter (TEPC) microdosimetry has proven an ideal dosimetry technique for BNCT, facilitating accurate separation of the photon and neutron absorbed dose components, assessment of radiation quality and measurement of the BNC dose. A miniature dual-TEPC system has been constructed to facilitate microdosimetry measurements with excellent spatial resolution in high-flux clinical neutron capture therapy beams. A 10B-loaded TEPC allows direct measurement of the secondary charged particle spectrum resulting from the BNC reaction. A matching TEPC fabricated from brain-tissue-equivalent plastic allows evaluation of secondary charged particle spectra from photon and neutron interactions in normal brain tissue. Microdosimetric measurements performed in clinical BNCT beams using these novel miniature TEPCs are presented, and the advantages of this technique for such applications are discussed.     

A measuring system with a recombination chamber for neutron dosimetry around medical accelerators

A measuring system for dosimetry of neutrons generated around medical electron accelerators is proposed. The system consists of an in-phantom tissue-equivalent recombination chamber and associated electronics for automated control and data acquisition. A second ionization chamber serves as a monitor of photon radiation. Two quantities are determined by the recombination chamber--the total absorbed dose and the recombination index of radiation quality. The ambient dose equivalent, H*(10), or neutron absorbed dose in an appropriate phantom, can be then derived from the measured values. Tests of the system showed that a 0.5% dose contribution of neutrons to the absorbed dose of photons could be detected and estimated under laboratory conditions. Preliminary tests at the 15 MV Varian Clinac 2300C/D medical accelerator confirmed that the measuring system could be used under clinical conditions. The H*(10) of the mixed radiation was determined with an accuracy of approximately 10%.     

Galactic and solar radiation exposure to aircrew during a solar cycle

An on-going investigation using a tissue-equivalent proportional counter (TEPC) has been carried out to measure the ambient dose equivalent rate of the cosmic radiation exposure of aircrew during a solar cycle. A semi-empirical model has been derived from these data to allow for the interpolation of the dose rate for any global position. The model has been extended to an altitude of up to 32 km with further measurements made on board aircraft and several balloon flights. The effects of changing solar modulation during the solar cycle are characterised by correlating the dose rate data to different solar potential models. Through integration of the dose-rate function over a great circle flight path or between given waypoints, a Predictive Code for Aircrew Radiation Exposure (PCAIRE) has been further developed for estimation of the route dose from galactic cosmic radiation exposure. This estimate is provided in units of ambient dose equivalent as well as effective dose, based on E/H x (10) scaling functions as determined from transport code calculations with LUIN and FLUKA. This experimentally based treatment has also been compared with the CARI-6 and EPCARD codes that are derived solely from theoretical transport calculations. Using TEPC measurements taken aboard the International Space Station, ground based neutron monitoring, GOES satellite data and transport code analysis, an empirical model has been further proposed for estimation of aircrew exposure during solar particle events. This model has been compared to results obtained during recent solar flare events.     

Design of a multi-element TEPC for neutron monitoring

Tissue-equivalent proportional counters (TEPCs) have long been considered suitable candidate instruments for more accurate neutron monitors in nuclear power plants. It has also been recognised that the production of truly light-weight devices based on TEPCs requires further effort directed towards increasing their sensitivity and decreasing their physical size. This paper deals with the construction of a multi-element TEPC (METEPC) designed to have the sensitivity of a 12.7-cm (5-in.) diameter spherical TEPC, but with approximately one-tenth of its physical size. Construction of the METEPC is achieved by machining 61 elongated cylindrical cavities in a single block of A150 TE plastic. Comparative measurements carried out in neutron fields with mean energies ranging from 34 to 354 keV demonstrate that the METEPC constructed does match the sensitivity of a 5-in. spherical TEPC and that microdosimetric lineal energy spectra measured with both detectors have the same features and show the same changes with neutron radiation quality.     

Field calibration studies for ionisation chambers in mixed high-energy radiation fields

The monitoring of ambient doses at work places around high-energy accelerators is a challenging task due the complexity of the mixed stray radiation fields encountered. At CERN, mainly Centronics IG5 high-pressure ionisation chambers are used to monitor radiation exposure in mixed fields. The monitors are calibrated in the operational quantity ambient dose equivalent H*(10) using standard, source-generated photon- and neutron fields. However, the relationship between ionisation chamber reading and ambient dose equivalent in a mixed high-energy radiation field can only be assessed if the spectral response to every component and the field composition is known. Therefore, comprehensive studies were performed at the CERN-EU high-energy reference field facility where the spectral fluence for each particle type has been assessed with Monte Carlo simulations. Moreover, studies have been performed in an accessible controlled radiation area in the vicinity of a beam loss point of CERN's proton synchrotron. The comparison of measurements and calculations has shown reasonable agreement for most exposure conditions. The results indicate that conventionally calibrated ionisation chambers can give satisfactory response in terms of ambient dose equivalent in stray radiation fields at high-energy accelerators in many cases. These studies are one step towards establishing a method of 'field calibration' of radiation protection instruments in which Monte Carlo simulations will be used to establish a correct correlation between the response of specific detectors to a given high-energy radiation field.     

The response of the sievert instrument in neutron beams up to 180 MeV

Measurements with a tissue-equivalent proportional counter (TEPC) using the variance-covariance method have been performed in neutron beams between 71 keV and 180 MeV and in the cosmic radiation reference field (CERF) at CERN. The results show that with appropriate linear QD(yD) relations, the ambient dose equivalent can be determined within about 55% in these beams. Build-up measurements show that wall thickness is not crucial for H* determinations at 60 and 180 MeV.