共查询到17条相似文献,搜索用时 140 毫秒
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羟基磷灰石生物医用陶瓷材料的研究与发展 总被引:8,自引:0,他引:8
自然骨的主要无机矿物成分为纳米羟基磷灰石[Ca10(PO4)6(OH)2,HAP]针状晶体。人工合成的羟基磷灰石材料具有与自然矿物相似的结构,形态,成分,表现出良好的生物相容性和生物活性,广泛应用于医药和牙科领域。对近年来羟基磷灰石生物材料的制备和应用进行了综述。 相似文献
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羟基磷灰石生物材料具有良好的生物活性和生物相溶性,是一种比较好的骨修复或替代材料。本文主要阐述了羟基磷灰石的结构、性能及制备方法的研究进展概况。 相似文献
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高分子复合生物材料的研究进展 总被引:2,自引:0,他引:2
本文综述了近年来用于骨修复的各类高分子复合生物材料的研究状况,并从力学性能的改善和降解速率的可调性等角度,总结了高分子复合生物材料与单一组分的材料相比在生物医用领域应用中所表现出的综合使用性能的优越性,提出将与人骨中磷灰石微晶类似的无机纳米粒子与具有降解性能的有机生物材料进行复合,能够得到具有优越骨修复性能的新型骨生物材料。 相似文献
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羟基磷灰石/壳聚糖复合材料研究进展 总被引:13,自引:2,他引:11
综述了羟基磷灰石/壳聚糖复合材料的研究现状,对其制备、特点、性能进行了探讨,羟基磷灰石基人工骨作为最有前途的生物硬组织替代材料之一,在生物医用材料和医学研究领域有着广泛的应用前景。主要从化学的角度对材料复合、表征、应用进行了阐述。进而对壳聚糖/羟基磷灰石复合材料的研究发展前景予以展望。 相似文献
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Yang YU Hong ZHANG Hong SUN Dandan XING Fanglian YAO 《Frontiers of Chemical Science and Engineering》2013,7(4):388
With the excellent biocompatibility and osteoconductivity, nano-hydroxyapatite (nHA) has shown significant prospect in the biomedical applications. Controlling the size, crystallinity and surface properties of nHA crystals is a critical challenge in the design of HA based biomaterials. With the graft copolymer of chitosan and poly(N -isopropylacrylamide) in coil and globule states as a template respectively, a novel composite from chitosan-g-poly(N -isopropylacrylamide) and nano-hydroxyapatite (CS-g-PNIPAM/nHA) was prepared via co-precipitation. Zeta potential analysis, thermogravimetric analysis and X-ray diffraction were used to identify the formation mechanism of the CS-g-PNIPAM/nHA composite and its morphology was observed by transmission electron microscopy. The results suggested that the physical aggregation states of the template polymer could induce or control the size, crystallinity and morphology of HA crystals in the CS-g-PNIPAM/nHA composite. The CS-g-PNIPAM/nHA composite was then introduced to chitosan-gelatin (CS-Gel) polyelectronic complex and the cytocompatibility of the resulting CS-Gel/composite hybrid film was evaluated. This hybrid film was proved to be favorable for the proliferation of MC 3T3-E1 cells. Therefore, the CS-g-PNIPAM/nHA composite is a potential biomaterial in bone tissue engineering. 相似文献
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Gardin C Chiara G Ferroni L Letizia F Favero L Lorenzo F Stellini E Edoardo S Stomaci D Diego S Sivolella S Stefano S Bressan E Eriberto B Zavan B Barbara Z 《International journal of molecular sciences》2012,13(1):737-757
Bone tissue engineering strategies are emerging as attractive alternatives to autografts and allografts in bone tissue reconstruction, in particular thanks to their association with nanotechnologies. Nanostructured biomaterials, indeed, mimic the extracellular matrix (ECM) of the natural bone, creating an artificial microenvironment that promotes cell adhesion, proliferation and differentiation. At the same time, the possibility to easily isolate mesenchymal stem cells (MSCs) from different adult tissues together with their multi-lineage differentiation potential makes them an interesting tool in the field of bone tissue engineering. This review gives an overview of the most promising nanostructured biomaterials, used alone or in combination with MSCs, which could in future be employed as bone substitutes. Recent works indicate that composite scaffolds made of ceramics/metals or ceramics/polymers are undoubtedly more effective than the single counterparts in terms of osteoconductivity, osteogenicity and osteoinductivity. A better understanding of the interactions between MSCs and nanostructured biomaterials will surely contribute to the progress of bone tissue engineering. 相似文献
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Bone defects are very common, and there has been a great deal of research in the field of orthopedics to find ideal materials to repair such defects. Nanohydroxyapatite is a good bone substitute material; it has a number of structural similarities to natural bone, can promote new bone formation, is noncytotoxic, and has good biodegradability and biocompatibility. The use of composite and polymeric biomaterials can overcome the problems associated with the brittleness and weak mechanical properties of nanohydroxyapatite. Nanohydroxyapatite and its composite biomaterials were confirmed to play important roles in bone defect repair. This review presents a comparison of research regarding use of nanohydroxyapatite and its composite biomaterials in repairing bone defects. The goal is to identify the artificial bone substitute materials with the best biocompatibility and clinical repairing effects for various individuals and clinical situations. 相似文献
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Composite biomaterials, which consist of a polymer matrix and a particulate bioactive phase and are hence analogous to bone microstructure, have been developed for human hard tissue substitution. In this investigation, a manufacturing route employing injection moulding was established for producing bone analogue biomaterials. Using this manufacturing technology, a potential bone replacement material, hydroxyapatite (HA) reinforced polypropylene (PP) composite (HA/PP), was made, with the HA volume percentage being up to 25%. The characteristics of the HA/PP composite were studied using various techniques including scanning electron microscopy (SEM), differential scanning calorimetry (DSC), tensile testing, microhardness testing, and dynamic mechanical analysis (DMA). It was demonstrated that with the use of the established manufacturing route, HA particles were well dispersed and homogeneously distributed in the PP matrix. Properties of the composite were affected by the amount of HA incorporated in the composite. The melting temperature and crystallisation temperature of the composite were slightly affected by the addition of HA particles, and the crystallinity of the PP matrix polymer was decreased with an increase in HA content. Young's modulus, microhardness, and storage modulus increased when the HA volume percentage was increased from 10 to 25%, with corresponding decreases in tensile strength, elongation at fracture and loss tangent. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 2007 相似文献
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BACKGROUND: Polymer/hydroxyapatite (HA) nanocomposites have emerged in recent years as a new class of biomaterials that can be used as artificial bone. Compared to pure HA or HA‐based bioceramics, and metallic implants, they exhibit good plasticity, improved toughness and good mechanical compatibility with natural bone. Compared to their microcomposite counterparts and the pristine polymer matrix, they show increased tensile strength and modulus, and enhanced bioactivity. RESULTS: In this study, polyamide 6 (PA6)/nanoscale HA (n‐HA) nanocomposites were prepared via in situ hydrolytic ring‐opening polymerization of ε‐caprolactam in the presence of newly synthesized n‐HA aqueous slurry. The synthesized n‐HA, which is similar to bone apatite in chemical composition, microscopic morphology and phase composition, dispersed uniformly in the composites even if its loading was up to 60 wt%. The PA6/n‐HA composites show a similarity to natural bone in chemical composition to a certain extent. Mechanical tests show that the composites are reinforced considerably by the incorporation of needle‐like n‐HA, and the composites have mechanical properties near to those of natural bone. CONCLUSION: The PA6/n‐HA nanocomposite with high n‐HA content shows a similarity to natural bone in terms of chemistry and mechanical properties. This makes it a possible candidate for biomaterials suitable for bone repair or fixation. Copyright © 2008 Society of Chemical Industry 相似文献
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《Ceramics International》2019,45(11):14029-14038
In order to promote bone healing, new generations of biomaterials are under development. These biomaterials should demonstrate proper biological and mechanical properties preferably similar to the natural bone tissue. In this research, 3D-printed barium strontium titanate (BST)/β-tricalcium phosphate (β-TCP) composite scaffolds have been synthesized as an alternative strategy for bone regeneration to not only induce appropriate bioactive characteristics but also piezoelectric behavior. The physical, chemical and biological performance of the scaffolds have been examined in terms of mechanical, dielectric properties, apatite-forming ability, Alizarin Red Staining (ARS), Alkaline Phosphatase activity (ALP), and cytotoxicity. The samples composed of 60% BST and 40% β-TCP showed the highest compressive strength, bending module, elastic modulus and the Young's modulus. The dielectric constant increased with further addition of the BST phase in the constructs. Scanning Electron Microscope (SEM) and energy dispersive X-ray (EDX) analyses showed that 60% BST/40% β-TCP sample had the highest amount of bone-like apatite formation after 28 days in simulated body fluid (SBF). Moreover, the results of ARS proved that 60% BST/40% β-TCP composite could present higher quantities of mineral deposition. The ALP activity of osteosarcoma cells on 60% BST/40% β-TCP sample showed higher activities compare with the other composites. None of the samples demonstrated any sign of toxicity using MTT test. It can be suggested that BST/β-TCP composite scaffolds can be potentially used as the next generation of bone tissue engineering scaffold materials. 相似文献
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Ceramic/polymer composites and hollow ceramic microspheres are receiving attention as biomaterials as a bone/tissue substitute and cancer remedy. This article describes the advantages of the use of enzymes as "controllable precipitant supplier" in the processing of such biomaterials. It has been demonstrated that hydroxyapatite (HA)/polymer composites and hollow microspheres of Y2 O3 , Fe3 O4 , and HA may be fabricated in a shorter time and using a simpler operation. 相似文献