Nature and autonomy: an organizational view of social and neurobiological aspects of self-regulation in behavior and development

The concepts of self-regulation and autonomy are examined within an organizational framework. We begin by retracing the historical origins of the organizational viewpoint in early debates within the field of biology between vitalists and reductionists, from which the construct of self-regulation emerged. We then consider human autonomy as an evolved behavioral, developmental, and experiential phenomenon that operates at both neurobiological and psychological levels and requires very specific supports within higher order social organizations. We contrast autonomy or true self-regulation with controlling regulation (a nonautonomous form of intentional behavior) in phenomenological and functional terms, and we relate the forms of regulation to the developmental processes of intrinsic motivation and internalization. Subsequently, we describe how self-regulation versus control may be characterized by distinct neurobiological underpinnings, and we speculate about some of the adaptive advantages that may underlie the evolution of autonomy. Throughout, we argue that disturbances of autonomy, which have both biological and psychological etiologies, are central to many forms of psychopathology and social alienation.     

Brain imaging and cognitive neuroscience: Toward strong inference in attributing function to structure.

While research in cognitive neuroscience combines many levels of neuroscientific and psychological analyses, modern imaging techniques that monitor brain activity during behavioral or cognitive operations have significantly contributed to the emergence of this discipline. The conclusions deduced from these studies are inherently localizationistic in nature; in other words, they describe cognitive functions as being localized in focal brain regions (brain activity in a defined brain region, Φ, is involved in specific cognitive function, Ψ). A broad discussion about the virtues and limitations of such conclusions may help avoid the emergence of a mentalistic localizationism (i.e., the attribution of mentalistic concepts such as happiness, morality, or consciousness to brain structure) and illustrates the importance of a convergence with information generated by different research strategies (such as, for example, evidence generated by studies in which the effects of experimental manipulations of local neuronal processes on cognitive functions are assessed. A conceptual framework to advance the interpretation of data describing the relationships between cognitive phenomena and brain structure activity is provided. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Tapestry of memory.

In this essay, I have elaborated on the ideas and experiments that have guided my research career. First, I present my early research history and my involvement in determining the neurobiological basis of the consolidation process based primarily on the consolidation paradigm. Based on a series of experiments and a new interest in cognitive psychology, I then developed a cognitive and neurobiologically based model of memory. This model represents a comprehensive view of memory organization based on multiple processes and multiple forms of memory representation and is based on the neurobiology of a multiple attribute, multiple process, tripartite system model of memory. I present some detailed evidence in terms of the neural foundations, specific attributes, and processes of operation for the event-based, knowledge-based, and rule-based memory systems. In addition, I present a set of experiments to demonstrate that there might be parallel processing of mnemonic information in rats and humans. Finally, I recognize that ideas can be generated by reading the extant literature, interaction with colleagues at meetings, and exchange of ideas with students to design and execute hopefully meaningful experiments. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Determination of famotidine in human plasma by high performance liquid chromatography with column switching

While functional magnetic resonance imaging (fMRI) is now used widely for demonstrating neural activity-related signals associated with perceptual, motor, and cognitive processes in humans, to date this technique has not been developed for use with nonhuman primates. fMRI in monkeys offers a potentially valuable experimental approach for investigating brain function, which will complement and aid existing techniques such as electrophysiology and the behavioral analysis of the effects of brain lesions. There are, however, a number of significant technical challenges involved in using fMRI with monkeys. Here, we describe the procedures by which we have overcome these challenges to carry out successful fMRI experiments in an alert monkey, and we present the first evidence of activity-related fMRI signals from monkey cerebral cortex.     

Chronic ethanol consumption: from neuroadaptation to neurodegeneration

In this review first we evaluate evidence on the role of the neurobiological alterations induced by chronic ethanol consumption in the development of ethanol tolerance, dependence and withdrawal. Secondly, we describe the neuropathological consequences of chronic ethanol on cognitive functions and on brain structures. Chronic alcohol consumption can induce alterations in the function and morphology of most if not all brain systems and structures. While tolerance mechanisms are unlikely to contribute to the neuroadaptive changes associated with ethanol dependence, it is otherwise clear that repeated high, intoxicating doses of ethanol trigger those neuroadaptive processes that lead to dependence and contribute to the manifestation of the abstinence syndrome upon withdrawal. An unbalance between inhibitory and excitatory neurotransmission is the most prominent neuroadaptive process induced by chronic ethanol consumption. Due to the diffuse glutamatergic innervation to all brain structures, the neuroadaptive alterations in excitatory neurotransmission can affect the function of most if not all of neurotransmitter systems. The expression of the withdrawal syndrome is the major causal factor for the onset and development of the neuropathological alterations. This suggests a link between the neuroadaptive mechanisms underlying the development of ethanol dependence and those underlying the functional and structural alterations induced by chronic ethanol. In animals and humans, specific alterations occur in the function and morphology of the diencephalon, medial temporal lobe structures, basal forebrain, frontal cortex and cerebellum, while other subcortical structures, such as the caudate nucleus, seem to be relatively spared. The neuropathological alterations in the function of mesencephalic and cortical structures are correlated with impairments in cognitive processes. In the brain of alcoholics, the prefrontal cortex and its subterritories seem particularly vulnerable to chronic ethanol, whether Korsakoff's syndrome is present or not. Due to the role of these cortical structures in cognitive functions and in the control of motivated behavior, functional alterations in this brain area may play an important role in the onset and development of alcoholism.     

Is there a postinfection fatigue syndrome?

Prolonged fatigue syndromes are common in general practice. Most of these syndromes are secondary to other common medical or psychological disorders. It appears, however, that some specific infectious illnesses are associated with prolonged recovery. Theories as to the mechanisms for such post infection fatigue syndromes include a range of immunological, psychological and neurobiological processes. Current evidence suggests disruption of fundamental central nervous system mechanisms, such as the sleep-wake cycle and the hypothalamic-pituitary-adrenal axis, may underpin the clinical features of this disorder. Treatment should focus on the provision of continuous medical care, physical rehabilitation and adjunctive psychological therapies.     

Aesthetics and the environment.

This article presents a framework for understanding aesthetic experience, with special reference to the natural environment. The framework entails 2 broad perspectives. First, from a functional perspective, aesthetic experiences are analyzed in terms of biological, sociocultural, and psychological systems of behavior; succinctly stated, objects are experienced aesthetically if they activate cognitive representations of response patterns that do or did contribute to the survival or enhancement of the species, society, or the self. Second, from the perspective of mediating mechanisms, the cognitive processes that enable aesthetic experiences are examined. The mechanisms discussed range from simple sensory processes to the activation and transformation of complex schemes. To the extent that cognitive representations of behavioral systems are flexible and subject to elaboration and refinement, aesthetic experience is a creative, skillful act. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Seeing meaning in action: A bidirectional link between visual perspective and action identification level.

Actions do not have inherent meaning but rather can be interpreted in many ways. The interpretation a person adopts has important effects on a range of higher order cognitive processes. One dimension on which interpretations can vary is the extent to which actions are identified abstractly—in relation to broader goals, personal characteristics, or consequences—versus concretely, in terms of component processes. The present research investigated how visual perspective (own 1st-person vs. observer’s 3rd-person) in action imagery is related to action identification level. A series of experiments measured and manipulated visual perspective in mental and photographic images to test the connection with action identification level. Results revealed a bidirectional causal relationship linking 3rd-person images and abstract action identifications. These findings highlight the functional role of visual imagery and have implications for understanding how perspective is involved in action perception at the social, cognitive, and neural levels. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Neural correlates of attention and arousal: insights from electrophysiology, functional neuroimaging and psychopharmacology

Attention and arousal are multi-dimensional psychological processes, which interact closely with one another. The neural substrates of attention, as well as the interaction between arousal and attention, are discussed in this review. After a brief discussion of psychological and neuropsychological theories of attention, event-related potential correlates of attention are discussed. Essentially, attention acts to modulate stimulus-induced electrical potentials (N100/P100, P300, N400), rather than generating any unique potentials of its own. Functional neuroimaging studies of attentional orienting, selective attention, divided attention and sustained attention (and its inter-dependence on underlying levels of arousal) are then reviewed. A distinction is drawn between the brain areas which are crucially involved in the top-down modulation of attention (the 'sources' of attention) and those sensory-association areas whose activity is modulated by attention (the 'sites' of attentional expression). Frontal and parietal (usually right-lateralised) cortices and thalamus are most often associated with the source of attentional modulation. Also, the use of functional neuroimaging to test explicit hypotheses about psychological theories of attention is emphasised. These experimental paradigms form the basis for a 'new generation' of functional imaging studies which exploit the dynamic aspect of imaging and demonstrate how it can be used as more than just a 'brain mapping' device. Finally, a review of psychopharmacological studies in healthy human volunteers outlines the contributions of the noradrenergic, cholinergic and dopaminergic neurotransmitter systems to the neurochemical modulation of human attention and arousal. While, noradrenergic and cholinergic systems are involved in 'low-level' aspects of attention (e.g. attentional orienting), the dopaminergic system is associated with more 'executive' aspects of attention such as attentional set-shifting or working memory.     

A neuropsychological theory of motor skill learning

This article describes a neuropsychological theory of motor skill learning that is based on the idea that learning grows directly out of motor control processes. Three motor control processes may be tuned to specific tasks, thereby improving performance: selecting spatial targets for movement, sequencing these targets, and transforming them into muscle commands. These processes operate outside of awareness. A 4th, conscious process can improve performance in either of 2 ways: by selecting more effective goals of what should be changed in the environment or by selecting and sequencing spatial targets. The theory accounts for patterns of impairment of motor skill learning in patient populations and for learning-related changes in activity in functional imaging studies. It also makes a number of predictions about the purely cognitive, including accounts of mental practice, the representation of motor skill, and the interaction of conscious and unconscious processes in motor skill learning.     

Serotonin in aging, late-life depression, and Alzheimer's disease: the emerging role of functional imaging

Serotonin (5-HT) neuron and neurotransmitter loss in normal aging and neuropsychiatric diseases of late life may contribute to behavioral changes commonly observed in the elderly population. Extensive evidence implicates a deficit in serotonergic neurotransmission in the development of major depression. It has been further suggested that the age-related changes in 5-HT neurons may predispose the elderly to develop depression. There is also increasing evidence that a combination of disturbances in cholinergic and serotonergic function may play a role in cognitive impairment in Alzheimer's disease (AD), with serotonergic dysfunction potentially responsible for a significant portion of the behavioral aspects of the disease. This implication of the 5-HT system in aging and age-related cognitive and mood disorders rests in large part on post mortem studies and animal models, which are limited in their capacity to predict dynamic human biochemical-behavior relationships or to accurately model the living human brain. Initial applications of functional brain imaging with positron emission tomography (PET) in the in vivo study of the brain in aging depression, and dementia focused on characterizing alterations in physiological measurements of cerebral metabolism and perfusion. However, recent advances in PET radiochemistry, instrumentation, and image processing have paved the way for noninvasive means to test specific hypotheses regarding the direct involvement of 5-HT neurons in the behavioral features of aging and to define and monitor therapeutic regimens for neuropsychiatric conditions of late life. Coupling of clinical trials in well-characterized subject populations with PET imaging using ligands specific for 5-HT receptor subtypes and transporter proteins promises to increase our understanding of the role of the 5-HT system in affective and cognitive aspects of treatment response. Longitudinal studies in aging, late-life depression, and AD are also needed to evaluate the complex interplay between neurodegenerative processes and serotonergic neurotransmission.     

Rats and humans paying attention: Cross-species task development for translational research.

Substantial gains have been made on the neurobiology of attention from systems neuroscience work in animal models and human cognitive neuroscience. However, the integration of rodent-based research on the specific neurotransmitter systems that subserve attention with the results from human behavioral and neuroimaging studies has been hampered by the lack of tasks that validly assess attention in both species. To address this issue, an operant sustained attention task that has been extensively used in research on the neurobiology of attention in rats was redesigned and validated for use in humans. Although humans showed better performance overall, the two species showed similar effects of several attention-related variables, including the introduction of distractor-related challenge. This task provides a useful tool for integrative, cross-species research and may help to determine how specific neurotransmitter systems contribute to the hemodynamic changes observed in human functional neuroimaging experiments. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Multinomial modeling and the measurement of cognitive processes.

This article presents a detailed discussion and application of a methodology, called multinomial modeling, that can be used to measure and study cognitive processes. Multinomial modeling is a statistically based technique that involves estimating hypothetical parameters that represent the probabilities of unobservable cognitive events. Models in this class provide a statistical methodology that is compatible with computational theories of cognition. Multinomial models are relatively uncomplicated, do not require advanced mathematical techniques, and have certain advantages over other, more traditional methods for studying cognitive processes. The statistical methodology behind multinomial modeling is briefly discussed, including procedures for data collection, model development, parameter estimation, and hypothesis testing. Three substantive examples of multinomial modeling are presented. Each example, taken from a different area within the field of human memory, involves the development of a multinomial model and its application to a specific experiment. It is shown how multinomial models facilitate the interpretation of the experiments. The conclusion discusses the general advantages of multinomial models and their potential application as research tools for the study of cognitive processes. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Sensitive periods in development: Structural characteristics and causal interpretations.

The presence or absence of a particular experience at a particular time in the life cycle may exert an extraordinary and dramatic influence over structure or function well beyond that point in development. Such sensitive periods are thought to be widespread in animal and in human neurobiology and psychology. A comprehensive treatment of the sensitive period needs minimally to include information about its structural characteristics as well as an interpretation of its causes, including why the sensitive period arises in terms of the natural history of the species and how the sensitive period is regulated in terms of physical, physiological, and psychological processes. This article provides a framework for research and theory concerning specific sensitive periods and the sensitive period generally conceived. The framework delimits four sets of parameters, which encompass 14 structural characteristics that define sensitive periods, and two levels of causal interpretation that guide research and theory into sensitive periods however they may be manifested. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Brain imaging and age-related changes in cognition

Although there is currently some debate as to the degree of structural changes in the brain that occur with age, there is little doubt that such changes occur. There also are physiological changes in many areas that could have implications for cognitive function in the elderly. One way to study the impact of these age-related changes in the brain on cognition is to use neuroimaging techniques to examine brain activity during the performance of various tasks, and determine how this activity differs between young and older individuals. This approach has been used to study functions such as memory, perception, and attention, and it has generally been found that older individuals utilize different areas of the brain than do young subjects when carrying out the same cognitive task. This has led some researchers to suggest that older persons utilize different functional brain networks, perhaps to compensate for reductions of efficiency in some brain areas. The areas of the brain most often found to be more active during cognitive tasks in the elderly are the frontal lobes. Studies that have directly examined the functional networks utilized during cognition have found that older people do indeed have different functional interactions involving the frontal lobes, and therefore, utilize different functional networks. In some cases this differential activity has been accompanied by cognitive performance in the older participants that is equivalent to that seen in the young, suggesting that greater reliance on this brain region is related in some way to the maintained ability of the older individuals to perform the task. However, data collected to date on this issue are still limited, so although the evidence is intriguing, the definitive interpretation of these findings must await further experiments.     

Imaging neuroscience: principles or maps?

This article reviews some recent trends in imaging neuroscience. A distinction is made between making maps of functional responses in the brain and discerning the rules or principles that underlie their organization. After considering developments in the characterization of brain imaging data, several examples are presented that highlight the context-sensitive nature of neuronal responses that we measure. These contexts can be endogenous and physiological, reflecting the fact that each cortical area, or neuronal population, expresses its dynamics in the context of interactions with other areas. Conversely, these contexts can be experimental or psychological and can have a profound effect on the regional effects elicited. In this review we consider experimental designs and analytic strategies that go beyond cognitive subtraction and speculate on how functional imaging can be used to address both the details and principles underlying functional integration and specialization in the brain.     

High-frequency brain activity: its possible role in attention, perception and language processing

Coherent high-frequency neuronal activity has been proposed as a physiological indicator of perceptual and higher cognitive processes. Some of these processes can only be investigated in humans and the use of non-invasive recording techniques appears to be a prerequisite for investigating their physiological substrate in the healthy human brain. After addressing methodological issues in the non-invasive recording of high-frequency responses, we summarize studies indicating co-occurrence of neuronal synchrony of single cells exhibiting rhythmic activity at high frequencies, oscillations in the local field potential and dynamics in high frequencies recorded using high-resolution electroencephalography (EEG) and magnetoencephalography (MEG). We then review EEG and MEG studies of attention, perception, and language processing in humans indicating that dynamics in the high-frequency range > 20 Hz reflect specific cognitive processes. Types of high-frequency (HF) activity can be distinguished according to their latency after stimulus onset, stimulus-locking, cortical topography and frequency. There appears to be a systematic relationship between specific cognitive processes and types of HF activity. The findings are related to recent theories about the generation of HF activity and their possible role in binding of stimulus features. Dynamics of HF cortical activity reflecting higher cognitive processes can be accounted for based on the assumption that the elements of cognitive processing, e.g. visual objects and words, are organized in the brain as distributed neuronal assemblies with defined cortical topographies generating well-timed spatio-temporal activity patterns.     

Stimulus- and motivation-specific sensitization and redirection of aggression in the three-spined stickleback (Gasterosteus aculeatus).

Studied 50 male 3-spined sticklebacks to examine the incremental processes of sensitization-habituation. Findings indicate that the incremental processes are analogous to those postulated by a dual-process theory of habituation based on acute neurobiological preparations. Sensitization appears to have both stimulus- and motivation-specific components and appears to sensitize over repeated experiences. Sensitization may serve to maintain behavior during the presence of the eliciting stimulus while the inhibitory component (habituation) is consolidating independently. Finally, the motivation-specific component may explain the increased aggression, during stimulus presentation, directed to neighbors to which the S fish had already habituated. (18 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Inferring psychological significance from physiological signals.

Since the publication of William James's (1890) Principles of Psychology, most of James's questions about the relation between physiological events and molar psychological or behavioral processes remain unanswered. The slow progress in using physiological signals (PSs) to address general psychological questions is due in part to problems in quantifying PSs in humans and to the way in which investigators have been thinking about the relation between PSs and psychological operations. A framework is provided to foster analysis of psychological phenomena based on PSs. Psychological operations and physiological responses are defined in terms of configural and temporal properties, and psychophysiological relations are conceptualized in terms of their specificity (e.g., one-to-one vs many-to-one) and their generality (e.g., situation or person specific vs cross-situational and pancultural). This model yields 4 classes of psychophysiological relations: (a) outcomes, (b) concomitants, (c) markers, and (d) invariants. The model specifies how to determine whether a psychophysiological relation is an outcome, concomitant, marker, or invariant, and it describes limitations in inferences of psychological significance based on PSs when dealing with each. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Household behaviour in response to earthquake risk: an assessment of alternative theories

Households response to earthquake risk in different ways. The main theories explaining human behaviour under threat of earthquakes are reviewed. A survey of households' responses in Tehran and Rasht in Iran to earthquake risks is used to assess the validity of psychological, 'need', socio-cultural and economic theories in explaining behaviour. More support of cognitive and cultural theories is found rather than economic and 'need' theories of earthquake safety measures; this suggests that positive adoption of mitigation measures can be encouraged in terms of cognitive processes through information and education.