共查询到20条相似文献,搜索用时 62 毫秒
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采用分子杂交策略,设计合成15个氨基酸结构的磺酰胺衍生物进行抗菌活性评价。首先,苯磺酰氯与氨基酸反应制得苯磺酰氨基酸(中间体Ⅰ),然后,以芳香醛、亚磷酸酯、乙酸铵和三氟甲磺酸铝为原料,一锅法制得α-氨基膦酸酯(中间体Ⅱ),最后,中间体Ⅰ与Ⅱ缩合,制得目标物,经1H NMR 、13C NMR和MS确认结构。结果表明,该类化合物对大肠杆菌(E. coli)和耐氟喹诺酮大肠杆菌(FREC)活性最为显著。其中,化合物Ⅲb〔{(2-氟苯基) [2-(苯基磺酰氨基)苯丙酰氨基]甲基}膦酸二乙酯〕、Ⅲc〔{(2-氟苯基) [2-(苯基磺酰氨基)苯丙酰氨基]甲基}膦酸二乙酯〕、Ⅲh〔{(2-氟苯基) [2-(苯基磺酰基氨)异戊酰氨基]甲基}膦酸二乙酯〕和Ⅲm〔{(苯基) [2-(苯基磺酰基氨)乙酰氨基]甲基}膦酸二乙酯〕对E. coli的MIC(Minimum Inhibitory Concentration)均为16 μg/mL,化合物Ⅲn〔{(2-氟苯基) [2-(苯基磺酰氨基)乙酰氨基]甲基}膦酸二乙酯〕对E. coli的MIC为8 μg/mL,抗菌活性不低于对照药苯唑西林;化合物Ⅲb、Ⅲh、Ⅲm和Ⅲn对FREC的MIC分别为32、32、32和16 μg/mL,优于对照药苯唑西林和诺氟沙星。 相似文献
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酰胺类化合物作为有机化合物中重要且常见的一类化合物,在药物研发、生产中扮演着重要的角色,对于其合成方法的研究在医药研发、应用领域中有着积极的现实意义。在酰胺类化合物的传统合成方法中,通常主要采用羧酸类衍生物同胺类直接偶联进行,往往在安全性、经济性、绿色性方面应用受限。随着社会经济的快速发展,科学技术的不断进步,不断涌现出一些新的方法、技术,应用于酰胺类化合物的合成中,极大地丰富了酰胺键构建方法。本文总结以往酰胺类化合物合成方法的相关报道,以期为今后酰胺类化合物合成的有效进行提供一定依据。 相似文献
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以氯虫苯甲酰胺为先导化合物,通过在其吡唑环上引入氯原子,合成了1 1个吡唑酰胺类新化合物。所有化合物通过~1HNMR、元素分析进行了结构表征,并初步测定了化合物对二化螟的杀虫活性。在0.1 mg/L质量浓度下,部分新化合物对二化螟的生物活性显著高于氯虫苯甲酰胺。 相似文献
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A novel method for preparing anion exchangers based on crosslinked polystyrene is proposed which comprises first acetylation of crosslinked polystyrene by Friedel-Crafts reaction, then reductive amination of acetylated products by Leuckart reaction. Aminated products, if desired, are readily converted to corresponding tertiary amino anion exchangers or optionally quaternized to form corresponding strong base, quaternary ammonium anion exchangers. The new method, overcome the toxic problem of classic chloromethylation process, is safe, economical and convenient. Received: 29 September 1997/Revised version: 4 November 1997/Accepted: 12 November 1997 相似文献
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《Ceramics International》2019,45(15):18931-18936
The physio-chemical properties of natural bone are significantly determined by the biological environment. Thus, it is desirable to prepare advanced bone tissue engineered scaffold by mimicking nature bone formation process. In this study, we proposed a new simple method (physio-chemical mixing) to prepare a hybrid hydroxyapatite (HA) scaffolds mimicking nature bone. Nano powder phases constitution was studied by SEM, XRD, and TEM. The results founded that the simple method could affect the physio-chemical properties (i.e., compositions and morphologies) of HA scaffolds. Moreover, the scaffolds prepared could have mimicked the nature bone. 相似文献
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Poly(ε-caprolactone)-block-poly[2-(dimethylamino)ethyl methacrylate] (PCL-b-PDMAEMA) block copolymers were applied to fabricate elongated polymer platelets with axial length of 5–20 μm and thickness of ca. 10 nm by crystallization-driven self-assembly (CDSA). The block copolymer platelets composed of a crystallized PCL layer sandwiched between two PDMAEMA layers were obtained spontaneously by adding methanol, a selective solvent of PDMAEMA, into the block copolymer solution of THF at 25 °C. Therefore, this is a facile approach to generate lamellar nanoobjects of block copolymers. Effects of the block copolymer compositions on the morphologies of platelets were investigated. The presence of PDMAEMA segments along the lamellar surfaces was further confirmed by loading gold nanoparticles. Moreover, PEO-b-PCL-b-PDMAEMA triblock terpolymer could form spindle platelets by this approach. The crystalline platelets were characterized by the transmission electron microscopy (TEM), scanning electron microscopy (SEM), atomic force microscopy (AFM), small-angle X-ray scattering (SAXS) and wide-angle X-ray diffraction (WAXD). 相似文献
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《Carbon》2013
We report a simple approach to prepare the nitrogen-modified few-layer graphene (FLG) directly from graphite flakes. With the aid of melamine, graphite flakes can be directly ultrasonicated into FLG in acetone. The subsequent annealing process further transforms the melamine absorbed on the surface of graphene into melon (C6N9H3)x, which is one type of condensation product of melamine, and simultaneously dopes the graphene with nitrogen. When tested as a supercapacitor electrode, the nitrogen-modified FLG shows a much higher specific capacitance (e.g., 227 F/g at 1A/g) than that of reduced graphene oxide (rGO) (e.g., 133 F/g at 1A/g). 相似文献
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Lifeng Yan 《应用聚合物科学杂志》2005,98(3):1412-1417
A novel, simple method was developed to prepare conjugated polymer array in a large scale by using a spinodal dewetting technique. Mica, silicon, and glass were selected as substrates. The results show that with a suitable concentration of poly(9,9‐dihexylfluorene) (PF) in volatile organic solvent the polymer forms different sizes of array on the substrates. Atomic force microscopy measured the three‐dimensional structure of the arrays, and the relative FFT and PSD analyses reveal the detail information of the dewetting process and the array formation mechanism. The size of spots in the arrays is controlled by the evaporation speed of solvent and concentration of the PF solutions. The photoluminescence of PF arrays were also measured. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 98: 1412–1417, 2005 相似文献
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简便测定L-半胱氨酸含量的方法 总被引:1,自引:0,他引:1
目前有22种氨基酸可由发酵法制得,只有胱氨酸和L-半胱氨酸不能用发酵法生产.而L-半胱氨酸可由胱氨酸还原而来,其化学反应式为: 相似文献