共查询到20条相似文献,搜索用时 78 毫秒
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Xu Li Taflove A. Backman V. 《IEEE journal of selected topics in quantum electronics》2005,11(4):759-765
An emerging research area in biophotonics with potentially near-term clinical applications in early stage cancer detection involves the investigation of possible correlations of the elastic light scattering properties of tissues with alterations in their cellular composition and nanostructure. Until recently, exploring these correlations has been impeded by a lack of robust and accurate mathematical models of the light scattering properties of complex structures. In this paper, we review recent progress in this area. Topics include: 1) development of accurate reduced-order expressions for the total scattering cross section spectra of a wide range of nonspherical and inhomogeneous particles; 2) rigorous finite-difference time-domain modeling results showing how the backscattering of light can be sensitive to nanometer scale features embedded within micrometer-scale particles; and 3) development of accurate reduced-order expressions for the backscattering depolarization properties of a wide range of inhomogeneous particles. These advances provide an improved science base for cellular level biophotonics, and have promise to accelerate the development of novel corresponding clinical technologies. 相似文献
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针对过渡层较大的感应淬火零件用超声法测量淬硬层深度时,极限硬度点难以准确定位的问题,开展35MnB合金淬硬件的淬硬层深度超声测量实验。用小波多分辨率分析(MRA)研究信号在不同分解尺度下的时频特征,分析信号在各频带的能量分布,并探求提取背散射信号的趋势特征计算淬硬层深度的方法。结果表明,背散射信号中的高频振动成分明显,分布无规律且能量较低;趋势特征项随信号振动幅值包络缓慢变化,能量占比高达96.73%,显著高于其他分解项,高尺度分解下的MRA过程实质上滤除了多数与淬硬层深度信息无关的杂波噪声项。基于趋势特征项的实测结果最大平均误差为0.123 mm,最大重复误差为6.24%,测量精度以及重复可靠性均显著高于常规超声测量模型,相比于金相法和显微硬度法具有更高效、无损等优势,在工程机械零件的实际测量中具有较好的应用前景。 相似文献
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Lee M.R. Izatt J.A. Swanson E.A. Huang D. Schumun J.S. Lin C.P. Puliafito C.A. Fujimoto J.G. 《IEEE engineering in medicine and biology magazine》1995,14(1):67-76
The authors have developed a new technique for micron scale resolution cross-sectional imaging of ocular and other biological tissue, called optical coherence tomography (OCT). OCT is similar to B-scan ultrasonic imaging, except that image contrast relies on differences in optical rather than acoustic backscattering characteristics of tissue. In contrast to ultrasound and nonlinear optical gating techniques, low-coherence interferometry is used to resolve the position of reflective or optical backscattering sites within a sample. Two-dimensional tomographic images of a thin, optical slice of tissue may be obtained with 10 μm longitudinal and lateral resolution. Optical heterodyne detection and the application of noise-reduction techniques originally developed for optical communication achieve sensitivity to reflected light as small as 10-10 of the incident optical power. OCT is non-contact, non-invasive, and has superior resolution to conventional clinical ultrasound. Unlike scanning laser ophthalmoscopy and scanning laser tomography, the optical sectioning capability of OCT is not limited by the pupil aperture and ocular aberrations. OCT may be implemented in a compact, low-cost, fiber-optic based interferometer that is easily coupled to existing ophthalmic instrumentation. Here, the authors demonstrate high-speed in vivo OCT imaging in both the anterior and posterior eye, and highlight the system's potential usefulness for the early diagnosis and quantitative monitoring of a variety of ocular diseases and treatments 相似文献
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Collier T. Arifler D. Malpica A. Follen M. Richards-Kortum R. 《IEEE journal of selected topics in quantum electronics》2003,9(2):307-313
Most models of light propagation through tissue assume the scattering properties of the various tissue layers are the same. The authors present evidence that the scattering coefficient of normal cervical epithelium is significantly lower than values previously reported for bulk epithelial tissue. They estimated the scattering coefficient of normal and precancerous cervical epithelium using measurements of the reflectance as a function of depth from confocal images. Reflectance measurements were taken from ex vivo cervical biopsies and fit to an exponential function based upon Beer's law attenuation. The mean scattering coefficients derived were 22 cm/sup -1/ for normal tissue and 69 cm/sup -1/ for precancerous tissue. These values are significantly lower than previously reported for bulk epithelial tissues and suggest that scattering of bulk tissue is dominated by the stroma. They also suggest that computational models to describe light propagation in epithelial tissue must incorporate different scattering coefficients for the epithelium and stroma. Further, the lower scattering of the epithelium suggests greater probing depths for fiber optic probes used by optical diagnostic devices which measure reflectance and fluorescence in epithelial tissue. The difference in scattering between normal and precancerous tissue is attributed to increased nuclear size, optical density, and chromatin texture. The scattering coefficients measured here are consistent with predictions of numerical solutions to Maxwell's equations for epithelial cell scattering. 相似文献
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Three-dimensional computation of light scattering from cells 总被引:2,自引:0,他引:2
Dunn A. Richards-Kortum R. 《IEEE journal of selected topics in quantum electronics》1996,2(4):898-905
Using the finite-difference time-domain method, three-dimensional scattering patterns are computed for cells containing multiple organelles. The scattering cross section and average cosine of the scattering angle are computed for cells as a function of volume fraction of melanin granules and mitochondria. Results show that small organelles play a significant role in light scattering from cells, and the volume fraction of organelles affects both the total amount of scattered light and the angular distribution of scattered light 相似文献
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《Intelligent Transportation Systems, IEEE Transactions on》2009,10(4):639-648
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为了实现对精密光学元件表面疵病的高精度测量,提出了一种基于多光谱图像融合的光学元件表面疵病检测方法。通过使用不同波长的光源入射到光学表面,在显微暗场成像系统中获得了450nm,532nm,650nm单波长光源照明时光学表面疵病的检测结果,并将采集到的图片通过加权平均法、拉普拉斯金字塔变换法和小波变换法三种方法进行图像融合后,再进行图像处理获取疵病尺寸信息。由实验结果对比可知,相较于单波长原始图像的疵病检测结果,多光谱融合图像的检测结果更加精确,并且通过对比三种融合方法结果,其中以拉普拉斯金字塔变换融合的效果最佳。 相似文献
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Nima Dehdashti Akhavan Isabelle Ferain Ran Yu Pedram Razavi Jean-Pierre Colinge 《Journal of Computational Electronics》2012,11(3):249-265
In this paper we study the influence of emission/absorption processes due to optical phonons on the electrical properties of multigate silicon nanowire transistors. We show that low-energy phonons reduce drain current through backscattering of carriers by emission/absorption processes while high-energy phonons redistribute the current energy spectrum along the nanowire channel through phonon emission without significantly reducing the drain current drive. The influence of emission/absorption is investigated in different multigate silicon FET structures with uniform channel, single impurity, random doping atom distribution and oxide tunnel barriers. A three-dimensional quantum mechanical device simulator based on the NEGF formalism in coupled mode-space approach is used to model electron transport in the presence of optical phonon scattering mechanism. Electron-phonon scattering is accounted for by adopting the self-consistent Born approximation and using the deformation potential theory. 相似文献
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Constantinou P. Nicklee T. Hedley D.W. Damaskinos S. Wilson B.C. 《IEEE journal of selected topics in quantum electronics》2005,11(4):766-777
Recent advances in imaging technology have contributed greatly to biological science. Confocal fluorescence microscopes can acquire two-dimensional and three-dimensional images of biological samples such as live or fixed cells and tissues. Specimens that are large (e.g., a 10 mm/spl times/10 mm tissue section) and overfill the field of view (FOV) of typical microscope objectives require the use of image tiling to cover the entire specimen. This can be time consuming and cause artifacts in the composite image. The MACROscope system (Biomedical Photometrics Inc., Waterloo, ON, Canada) is a confocal device with a 22 mm/spl times/70 mm FOV designed for imaging large tissue sections in a single frame. The prototype demonstrated here can obtain images in reflected, transmitted, fluorescence, phase contrast, and hyperspectral modes. The new spectral imaging mode is characterized with a series of test targets, and sampled spectra are compared to a commercial spectrometer. Fluorescence images of human SiHa tumor xenografts stained with CD31-Cy3, showing blood vessel location, and EF5-Cy5, showing areas of tissue hypoxia, were collected. Differential phase contrast images of the same section, as well as human epithelial cells, were recorded to assess the phase contrast mode. Additionally, fluorescence images of Cytokeratin-Cy3 stained squamous cell carcinoma tissue sections were captured. Finally, red, green, blue transmitted light images of human tongue were obtained. This new device avoids the need for image tiling and provides simultaneous imaging of multiple fluorescently labeled tissue-specific markers in large biological samples. This enables time- and cost-efficient imaging of (immuno)histopathological samples. This device may also serve in the imaging of high-throughput DNA and tissue arrays. 相似文献
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ABSTRACTNanowire is an important low dimensional semiconductor nano-material which can be used in field effect transistors, photovoltaic cells, field emission nanodevices, and chemical and gas sensors. In this paper, CuO nanowires are synthesized by heating copper substrates in air, and the CuO nanowire is assembled on two opposite microelectrodes to fabricate a single CuO nanowire nanodevice by dielectrophoresis (DEP). In experiment, suitable parameters are chosen, such as concentration of the CuO nanowire solution, applied voltage and frequency on the microelectrodes, time of DEP duration, to assemble a single CuO nanowire on the microelectrode. Using this single nanowire nanodevice, this paper measured FET effect and photoconductivity of the single CuO nanowire. The results show that the single CuO nanowire nanodevice can work as a FET and it also has novel sensitivity to light intensity. 相似文献
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在基于后向散射原理的大气能见度测量过程中,大气消光系数边界值的选取对反演精度具有较大影响。提出一种基于弦截法的大气消光系数边界值的确定方法,并利用迭代的思想对边界值的选取结果进行修正。通过理论仿真和实地测量对本方法的可行性进行验证,结果表明,弦截法具有较快的收敛速度,且迭代次数较少,经过比对迭代修正之后的消光系数边界值可以更准确的反演出大气消光系数,进而实现大气能见度的高精度测量,具有较强的实际应用价值。 相似文献
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Masaru Higaki 《Electrical Engineering in Japan》1996,117(6):53-62
Optical voltage and current measurement generally necessitates the compensation of light intensity variation which occurs in the optical measuring system, because it is possible the light intensity variation may give rise to a measuring error. Therefore, such compensation methods as dividing the ac component by the dc component of the light intensity are usefully introduced in optical ac voltage and current measurement, but those methods are not useful exactly for the optical measurement of the quantities including dc components. This paper deals with a new useful compensation method for light intensity variation in the optical dc current measurement. Linearly polarized light passes through two kinds of Faraday sensors, in which one detects dc magnetic field caused by dc current and the other detects externally applied constant ac magnetic field. Then, the compensation of the light intensity variation is carried out by measuring the dc and ac components of the beam. The principle of the compensation method using the ac component is described in the paper. Experimental results of this method using flint glass as the Faraday effect cells are reported and it is clarified that this method can decrease the measuring error of the modulation depth for dc current and compensate light intensity variation validity. 相似文献
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Lirong Zheng Yiqing Chen Chenglu Lin Weigen Luo Shichang Zou 《Integrated ferroelectrics》2013,141(1-3):69-74
Abstract Pb(Zr,Ti)O3 thin films were prepared by ArF excimer laser deposition on silicon and Pt-coated silicon substrates, and then were treated by rapid thermal annealing. The dependence of perovskite/pyrochlore phase formation on annealing conditions was investigated. The results show that the formation of perovskite phase or pyrochlore phase in the films was not only dependent on the heat treatment temperature, but also dependent on the heat treatment time. A wide range operational window of heat treatment time and temperature for obtaining single phase perovskite Pb(Zr,Ti)O3 thin films was given, and the films were analyzed by Rutherford backscattering spectroscopy to explain this phase transition. 相似文献