Cytological criteria for assessing the evolution of herpetic keratitis

There were studied 33 patients admitted with clinical diagnosis of superficial herpetic keratitis, typical form of dendritic ulcer. In all these cases there were performed smears from the level of cornea and conjunctiva, that were stained with rapid blue polycrome tanin Dragan staining method. Smears were performed before and during the evolution of the disease, in patients specifically treated with antiviral drugs and also in cases treated unspecifically. There are described some cytological particularities which have a relative specificity for the diagnosis: a high number of lymphocytes with cytoplasmic blebs, giant multinucleated cells, and epithelial cells with degenerative lesions (nucleocytoplasmic inclusions, vacuoles, chromophobe halo around nucleus). Such lesions were not observed in patients with non herpetic keratitis. Modifications noticed in epithelial corneal cells could suggest the diagnosis, which can be associated with clinical examination, in order to administer a specific therapy. Dynamic cytological evolution shows early regression of specific cellular modifications in patients treated by Acyclovir.     

Characterization of the excitable gap in human type I atrial flutter

OBJECTIVES: We sought to characterize the excitable gap of the reentrant circuit in atrial flutter. BACKGROUND: The electrophysiologic substrate of typical atrial flutter has not been well characterized. Specifically, it is not known whether the properties of the tricuspid valve isthmus differ from those of the remainder of the circuit. METHODS: Resetting was performed from two sites within the circuit: proximal (site A) and distal (site B) to the isthmus in 14 patients with type I atrial flutter. Resetting response patterns and the location where interval-dependent conduction slowing occurred were assessed. RESULTS: Some duration of a flat resetting response (mean +/- SD 40.1 +/- 20.9 ms, 16 +/- 8% of the cycle length) was observed in 13 of 14 patients; 1 patient had a purely increasing response. During the increasing portion of the resetting curve, interval-dependent conduction delay most commonly occurred in the isthmus. In most cases, the resetting response was similar at both sites. In three patients, the resetting response differed significantly between the two sites; this finding suggests that paced beats may transiently change conduction within the circuit or the circuit path, or both. CONCLUSIONS: Some duration of a flat resetting response was observed in most cases of type I atrial flutter, signifying a fully excitable gap in all portions of the circuit. The isthmus represents the portion of the circuit most vulnerable to interval-dependent conduction delay at short coupling intervals.     

The problems of internal validation without a theoretical context: The different conceptual underpinnings of psychopathy and the disruptive behavior disorder criteria.

G. Burns (see record 2001-17304-012) has concluded that the Psychopathy Screening Device's content is limited because it contains items that overlap with criteria for several disorders in the Diagnostic and Statistical Manual of Mental Disorders. The problem with Burn's analysis is that it was conducted without an adequate understanding or specification of the conceptual underpinnings of either the construct of psychopathy or the constructs assessed by the DSM criteria. This reply attempts to clarify these conceptual frameworks to illustrate that to judge the adequacy of the content of a measure of psychopathy by comparing it with DSM criteria is inconsistent with the differing theoretical frameworks underlying these classification systems. Forcing measures of psychopathy to be designed around DSM criteria leads to inadequate measures of psychopathy and can limit advances both in our understanding of developmental precursors to psychopathy and in the classification of DSM disorders. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The type A behavior pattern, physical fitness, and psychophysiological reactivity.

Examined joint effects of the Type A (coronary prone) behavior pattern and aerobic fitness with regard to heart rate (HR) and blood pressure (BP) changes elicited by laboratory challenges. 61 male college students were classified as Type A or Type B (noncoronary prone) using R. H. Rosenman's (1978) structured interview (SI), and as physically fit or sedentary using self-reports of activity level and estimated VO?max values obtained on a step test. Ss were challenged with the SI, presentation of a snake, mental arithmetic, a cold pressor task, and 2 competitive card games. Significant A-B differences were found only on the SI and the card games: During the SI, (a) Type A's displayed significantly greater BP increases than B's; (b) sedentary Ss showed greater BP increases than fit Ss; and (c) sedentary A's revealed greater BP increases than either fit A's, fit B's, or sedentary B's. In contrast, during the competitive games, physically fit A's showed reliably greater BP increases than either sedentary A's, sedentary B's, or fit B's. Since the physically fit Ss were almost exclusively varsity athletes and the sedentary Ss were college students who reported following a sedentary lifestyle, the differences between sedentary and fit groups may have been due to differences in aerobic fitness or to the improved ability of competitive athletes or those engaged in fitness training to match arousal level to task requirements. (47 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Comparison of procedures for the assessment of psychopathy.

Compared clinical-behavioral and self-report measures of psychopathy in 274 male prison inmates (mean age 29.8 yrs). Assessment procedures included global clinical ratings, a 22-item checklist, DSM-III criteria for antisocial personality disorder, and self-report version of the 22-item checklist, the Socialization scale of the California Psychological Inventory, and the MMPI. Agreement among the various assessment procedures was evaluated with correlational analyses, discriminant function analyses, and kappa coefficients of diagnostic agreement. Results indicate that there was stronger agreement among the clinical-behavioral measures (ratings, checklist, and DSM-III) than among the self-report measures. Agreement between these 2 measurement domains was, with few exceptions, poor. Findings suggest that caution should be exercised when comparisons are made among studies in which different assessment procedures for psychopathy are used. (27 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Vocal affect recognition and psychopathy: Converging findings across traditional and cluster analytic approaches to assessing the construct.

Deficits in emotion processing have been widely reported to be central to psychopathy. However, few prior studies have examined vocal affect recognition in psychopaths, and these studies suffer from significant methodological limitations. Moreover, prior studies have yielded conflicting findings regarding the specificity of psychopaths’ affect recognition deficits. This study examined vocal affect recognition in 107 male inmates under conditions requiring isolated prosodic vs. semantic analysis of affective cues and compared subgroups of offenders identified via cluster analysis on vocal affect recognition. Psychopaths demonstrated deficits in vocal affect recognition under conditions requiring use of semantic cues and conditions requiring use of prosodic cues. Moreover, both primary and secondary psychopaths exhibited relatively similar emotional deficits in the semantic analysis condition compared to nonpsychopathic control participants. This study demonstrates that psychopaths’ vocal affect recognition deficits are not due to methodological limitations of previous studies and provides preliminary evidence that primary and secondary psychopaths exhibit generally similar deficits in vocal affect recognition. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The psychophysiological mechanisms of awareness: the hypothesis of self-identification

A hypothesis is advanced concerning the neurophysiological mechanisms underlying the mental process of self-identification. It is assumed that a specific excitation pattern produced by a stimulus in one of several cortical areas is transmitted back to the neurons of the same cortical areas via massive parallel feedback pathways. The coincident (identical) excitation patterns--those produced by the stimulus and relayed by backward projections add together in the same neuronal structures thus inducing their intensive firing. This cyclic process amplifies the specificity and intensifies a representation of the stimulus thus creating the most favorable conditions for its categorization by distributed long-term memory. The result of categorization, a symbol or an image, is physiologically expressed by a pattern of neuronal activity, which is also included in the cycle of self-identification. This process underlies representation of subjective meaning of sensory characteristics of the stimulus. Symbolic representation of the stimulus signifies the transition of the perception process from the physiological (objective) to the mental (subjective) level. Theoretical analysis and experimental data show that the cyclic processes of self-identification and symbolic interpretation of sensory signals are likely to produce the phenomenon of awareness.     

Generalizability of a checklist for assessment of psychopathy.

Suggests that there are problems associated with assessments of psychopathy in prison populations that use self-report inventories and global diagnostic procedures. In response to these problems, the authors developed a behavioral checklist for psychopathy. The psychometric qualities of the checklist were evaluated using generalizability theory and classical test score indices of reliability. In each of 5 yrs, 2 raters (usually different each year) rated prison inmates (N?=?301; mean age 26.9 yrs) on 22 items. The generalizability coefficients were .85, .86, and .89 for the years 1977–1981, respectively. The generalizability coefficient for a test–retest study was .89. Classical indices of reliability (alpha coefficients and inter- and intrarater reliability) ranged from .82 to .93. Results indicate that the checklist is a highly reliable and generalizable instrument when used with prison populations. It is highly correlated with global ratings of psychopathy and criteria from the DSM-III for antisocial personality disorder. (14 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The biological role of carnosine in excitable tissues

We provide a general framework for the development of model-free methods for the linkage analysis of multivariate phenotypic data. It is possible within this framework to test both for linkage of a set of phenotypes to one or more markers and for the presence of structural relations among the phenotypes themselves. This report presents the general model, paying special attention to the assumptions that enter its formulation, and outlines the estimation procedures that may be used.     

Judging creativity: A method for assessing how and by what criteria it is done.

In 2 experiments with a total of 90 undergraduates, Ss evaluated fictitious protocols that varied in the number and uniqueness of the answers. In Exp I, Ss were instructed to use criteria for creativity; in Exp II, judgments were made according to creativity, intelligence, or gender. Productivity influenced the ratings under all 3 criteria with the largest effect being on intelligence, followed by creativity. Uniqueness had an independent influence on judgments of creativity, a borderline effect on intelligence, and no significant effect on gender. Protocols which had more answers were judged more "masculine." Results indicate that laymen share the same definition of creativity used by psychometricians and that intelligence is semantically different from creativity. It is concluded that the method offers an unobtrusive but objective way of assessing factors that enter into conceptual judgments. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The millennium criteria for the diagnosis of atopic dermatitis

Atopic dermatitis forms an active area of basic and clinical research, where important new knowledge about genetics and immunopathogenesis has surfaced over the past years, and where simultaneous development of new and innovative therapies is under way. However, the inclusion of any patient in an atopic dermatitis study, whether it is on its genetics, pathogenesis or therapy, requires a diagnosis which is irrefutable. Since there is no simple and also no complicated laboratory procedure to reach a diagnosis of atopic dermatitis, different sets of clinical criteria have been developed for the purpose of making the diagnosis uniformly in different studies as well as in different study centers. The most commonly used are Hanifin and Rajka's set of diagnostic features, which have major and minor clinical criteria to be fulfilled in order to establish a diagnosis of atopic dermatitis. Recent developments in the immunology of atopy have clearly established the major abnormality in this syndrome, the preferential production of allergen-specific IgE. In this contribution, it is suggested that the presence of such antibodies in a given patient should be a mandatory criterium for the diagnosis of atopic dermatitis. Such a diagnostic test however establishes a diagnosis of atopic syndrome, not atopic dermatitis. Thus, for atopic dermatitis we have to rely, for the time being, on additional clinical criteria. The clinical features described in the literature are critically evaluated, and it is suggested that in addition to the mandatory presence of allergen-specific IgE, 2 of 3 principal criteria (pruritus, typical morphology and distribution, chronic or chronically relapsing) should be present for such a diagnosis. Finally, the minor features originally described by Hanifin and Rajka and later evaluated by others are revised and divided over 4 subcategories; a) related to subclinical eczema; b) related to dry skin; c) extra skin folds; and d) ophthalmological pathology. They are suggested to be used as additional criteria only, needed when clinical suspicion is high but the new mandatory and principal diagnostic criteria described here are inconclusive. For study purposes, we suggest that the mandatory and principal criteria are sufficient. They are now evaluated and validated in ongoing atopic dermatitis treatment studies.     

The content validity of juvenile psychopathy: An empirical examination.

This study examined the content validity of a juvenile psychopathy measure, the Childhood Psychopathy Scale (CPS; D. R. Lynam, 1997), based on a downward translation of an adult instrument, the Hare Psychopathy Checklist-Revised (PCL-R; R. D. Hare, 1991). The CPS was compared with two other indices of juvenile psychopathy: (a) an index derived from expert ratings and (b) an empirical index based on correlations with adult psychopathy. The 100 items of the Common Language Q-Sort (CLQ; A. Caspi et al., 1992) provided a common metric for the comparison. Psychopathy and personality were assessed at age 13 years with the mother-reported CPS and the CLQ. Psychopathy was assessed at age 24 years with the interviewer-rated Psychopathy Checklist: Screening Version (PCL:SV; S. D. Hart, D. N. Cox, & R. D. Hare, 1995). Data from over 250 participants of the middle sample of the Pittsburgh Youth Study were used to examine these relations. Item content analyses demonstrated considerable overlap among the three indices, indicating that the downward translation utilizes criteria similar to those of experts and the empirically-derived measure. In addition, these indices, even after removing overlapping items, demonstrated considerable convergence, also supporting the content validity of the downward translation. These results suggest that the downward translation method is adequate for understanding the juvenile psychopathy construct. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The dependence of the flight training of students on their individual psychophysiological traits

A correlation between individual properties of the higher nervous activity, parameters of complex motor-coordination acts and success of flying training of military students has been established. Equations of multiple correlation-regression analysis are described as such that may be useful for prediction flying training.     

The history of evaluation criteria for CAP surveys

I summarize the evolution of target-value assignment methods and laboratory performance assessment (evaluation) within the College of American Pathologists Interlaboratory Survey Programs and review the importance of, and longstanding interest in, medical relevance criteria in setting analytical goals.     

A taxometric analysis of the latent structure of psychopathy: Evidence for dimensionality.

The taxonomic status of psychopathy is controversial. Whereas some studies have found evidence that psychopathy, at least its antisocial component, is distributed as a taxon, others have found that both major components of psychopathy-callousness/unemotionality and impulsivity/antisocial behavior-appear to distribute as dimensions and show little evidence of taxonicity. In the present study, recent advances in taxometric analysis were added to P. Meehl's (1995) multiple consistency tests strategy for assessing taxonicity, and they were applied to Psychopathy Checklist-Revised (R. D. Hare, 2003) ratings of 4,865 offenders sampled from multiple forensic settings. The results indicated that both the individual components of psychopathy and their interface are distributed dimensionally. Both the implications of these results for research in psychopathy and the integration of these findings with previous taxometric studies of psychopathy are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The effects of steroid hormones on electrical activity of excitable cells

BACKGROUND/AIM OF STUDY: Laser therapy is effective in relieving malignant dysphagia, but repeated treatments at 4 to 6 week intervals are usually required. This prospective randomised trial is designed to determine if addition of brachytherapy offers any advantages over laser therapy alone. METHODS: Patients with inoperable carcinoma of the oesophagus were randomised to receive either endoscopic Nd:YAG laser therapy alone, or laser followed by brachytherapy. Patients who developed worsening dysphagia during follow-up were offered further treatment as appropriate. RESULTS: Fourteen patients were randomised to receive laser only, and 12 to receive laser followed by brachytherapy. Of these 12, one was lost to follow-up and four did not receive brachytherapy because they were unfit, had extension into the cardia or had mainly extrinsic compression. These 4 are included on an 'intention-to-treat' basis. The mean therapeutic interval for the brachytherapy group was significantly longer, 83 days compared to 36 days for the laser group (p = 0.026). There were no differences in the degree of dysphagia relief, number of endoscopic procedures or survival times. CONCLUSION: The preliminary results of this trial suggest that brachytherapy in addition to laser therapy prolongs the first therapeutic interval. However, no long-term advantages have been shown.