Genetic abnormalities and male infertility. A comprehensive review

We have previously observed that ciliary neurotrophic factor (CNTF) can prevent the degeneration of androgen-sensitive perineal motoneurons and their target muscles, the bulbocavernosus and levator ani (BC/LA), in perinatal female rats. Response to CNTF is dependent on the expression of the alpha component of the CNTF receptor (CNTFRalpha). In the present study, we examined the developmental profile and androgen regulation of CNTFRalpha gene expression in BC/LA muscle, thigh muscle, and lumbosacral spinal cord. CNTFRalpha mRNA was abundantly expressed in the BC/LA and thigh around the time of birth; expression declined progressively after birth and remained low into adulthood. In contrast, CNTFRalpha message remained high in the lumbosacral spinal cord throughout development. Androgen regulation of CNTFRalpha expression was examined in prenatal animals by administering the androgen receptor blocker hydroxyflutamide from embryonic days E18 through E21. Four days of androgen deprivation caused a significant up-regulation of CNTFRalpha mRNA in the BC/LA, thigh, and spinal cord of male fetuses. After castration in adulthood, CNTFRalpha expression in the BC/LA transiently increased, then decreased below control levels. Expression of CNTFRalpha in thigh muscles and the lumbosacral spinal cord was not affected by adult castration. Thus, the perineal muscles and motoneurons are potential sites of direct CNTF action, and expression of the CNTFRalpha gene is modulated by androgen, especially in the androgen-sensitive perineal muscles. Transient up-regulation of CNTFRalpha following castration or androgen receptor blockade may represent a protective response designed to counteract the muscle atrophy normally induced by androgen withdrawal.     

Executive coaching: A comprehensive review of the literature.

[Correction Notice: An erratum for this article was reported in Vol 60(1) of Consulting Psychology Journal: Practice and Research (see record 2009-06606-001). The author would like to indicate that unfortunately, Peterson’s (1993) dissertation on executive coaching outcomes was excluded from the original literature review conducted by Kampa-Kokesch and Anderson (2001). Later, Kampa and White (2002) stated that Peterson’s (1993) dissertation was excluded due to the programmatic nature of the coaching conducted in the study. Specifically, it was written, “this research did not investigate executive coaching as practiced by consultants in the field,” (p. 145). However, all of the coaches in Peterson’s study were field-based PDI consultants and the individuals being coached did receive individual coaching from those consultants. In the future, Peterson’s research, which was a well-designed long-term outcome study of 370 coaching participants, should be reviewed when considering executive coaching outcomes.] Executive coaching as a consultation intervention has received increased attention in the literature within the past decade. Executive coaching has been proposed as an intervention aimed toward helping executives improve their performance and consequently the performance of the overall organization (R. R. Kilburg, 1996c). Whether or not it does what it proposes, however, remains largely unknown because of the lack of empirical studies. Some also question whether executive coaching is just another fad in the long list of fads that have occurred in consultation and business. To explore these issues and the place of executive coaching in consulting practice, this article critically examines the literature on executive coaching. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A comprehensive review of sedative and analgesic agents

Transforming growth factor-beta proteins are key regulators of cellular growth and differentiation. To understand the role of TGF-beta in colonic tumour progression, 47 paraffin embedded samples from colonic tumours (13 adenomas, and 34 adenocarcinomas) were studied. Gene mutations in the region coding for the active protein were studied by PCR SSCP analysis of exons 5, 6, and 7. TGF-beta1 mRNA expression and localization were studied by NISH using cDNA probes generated by RT-PCR. Protein distribution was investigated by immunohistochemistry using antibodies against both intracellular and extracellular forms. Three mutations were found: one in exon 5 (Dukes C) and two in exon 7 (Dukes C and A). TGF-beta1 mRNA was observed in 9 (69%) of 13 adenomas and in 30 (88%) of 34 adenocarcinomas. Levels of TGF-beta1 mRNA and proteins were higher in colorectal carcinomas than in colorectal adenomas. Tubular adenomas associated with dysplasia showed greater expression of TGF-beta1 than adenomas without dysplasia and than non-neoplastic colonic mucosa. In dysplasia and cancer, epithelial neoplastic cells and stromal cells were positive for TGF-beta1. In normal tissue endothelial cells and granulocytes sporadically showed immunoreactivity for TGF-beta1, whereas epithelial cells were all negative. The three mutations in TGF-beta1 exons 5, 6 and 7 found in colorectal adenocarcinomas suggest that TGF-beta1 mutation may play a role in colorectal carcinogenesis and that the presence of the mutant form contributes to the transformed state. Our two other findings, the loss of staining gradient in normal colonic mucosa and the higher levels of TGF-beta1 mRNA and proteins in colorectal carcinomas than in colorectal adenomas, indicate that the de-regulation of TGF-beta1 expression may occur as an early event in colorectal carcinogenesis. Although TGF-beta1 expression is generally a reflection of cellular differentiation, tumour grade is not associated with TGF-beta1 mRNA expression. Beside being present in the epithelial cells of the colonic tumours, TGF-beta1 mRNA also occurred in the stroma: its localization in the macrophages adjacent to tumour strongly suggests that TGF-beta1 could be secreted by macrophages. This hypothesis should lead to new therapeutic strategies for colorectal carcinoma.     

The effectiveness of psychotherapeutic interventions for bereaved persons: A comprehensive quantitative review.

Previous quantitative reviews of research on psychotherapeutic interventions for bereaved persons have yielded divergent findings and have not included many of the available controlled outcome studies. This meta-analysis summarizes results from 61 controlled studies to offer a more comprehensive integration of this literature. This review examined (a) the absolute effectiveness of bereavement interventions immediately following intervention and at follow-up assessments, (b) several of the clinically and theoretically relevant moderators of outcome, and (c) change over time among recipients of the interventions and individuals in no-intervention control groups. Overall, analyses showed that interventions had a small effect at posttreatment but no statistically significant benefit at follow-up. However, interventions that exclusively targeted grievers displaying marked difficulties adapting to loss had outcomes that compare favorably with psychotherapies for other difficulties. Other evidence suggested that the discouraging results for studies failing to screen for indications of distress could be attributed to a tendency among controls to improve naturally over time. The findings of the review underscore the importance of attending to the targeted population in the practice and study of psychotherapeutic interventions for bereaved persons. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Differential validity of employment tests by race: A comprehensive review and analysis.

Examined 866 Black–White employment test validity pairs from 39 studies for evidence of differential validity beyond that which would be expected on the basis of chance plus various statistical artifacts. The data in this study, unlike those in previous studies of differential validity, were free of Type I bias induced by data preselection. Results support the hypothesis that findings of apparent differential validity in samples are produced by the operation of chance and a number of statistical artifacts and indicate that true differential validity probably does not exist. (51 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Rare earth-based conversion coatings under scrutiny:A comprehensive review

Extensive research efforts have been dedicated to enhancing the corrosion resistance properties and mitigating the reactivity of metals.Various surface modification techniques,including anodizing,electrochemical deposition,non-electric current-based coating,ion implantation,conversion coatings,and organic coatings,have been explored for these objectives.Among these surface modification methodologies,conversion coatings have garnered substantial attention due to their capacity of depositing onto metal surfaces uniformly,enhancing adhesion for subsequent layers,facilitating ease of application,and offering cost-effectiveness.Different coatings,each possessing distinct properties,have been employed for diverse metals.Nonetheless,in light of hexavalent chromium compounds' elevated toxicity and carcinogenic nature,environmentally compatible conversion coatings are actively sought as viable alternatives.The deposition of conversion coatings is an intricate process influenced by several variables.Consequently,laboratory optimization of conditions is imperative for commercializing specialized conversion coatings.Further research endeavors are warranted to expand the standards and requisite characteristics for specific applications.Composite conversion coatings,formulated with rare earth elements and innovative mineral and organic transformative agents,hold promise as a subject of investigation.Advanced studies in theoretical research and computer modeling about the mechanism of crack prevention in rare earth element-based co nversion coatings devoid of defects will yield valuable insights.The present work furnishes a comprehensive review of this subject,marking its inaugural examination.     

Psychotherapy for the treatment of depression: A comprehensive review of controlled outcome research.

Previous quantitative reviews of research on the efficacy of psychotherapy for depression have included only a subset of the available research or limited their focus to a single outcome measure. The present review offers a more comprehensive quantitative integration of this literature. Using studies that compared psychotherapy with either no treatment or another form of treatment, this article assesses (1) the overall effectiveness of psychotherapy for depressed clients, (2) its effectiveness relative to pharmacotherapy, and (3) the clinical significance of treatment outcomes. Findings from the review confirm that depressed clients benefit substantially from psychotherapy, and these gains appear comparable to those observed with pharmacotherapy. Initial analysis suggested some differences in the efficacy of various types of treatment; however, once the influence of investigator allegiance was removed, there remained no evidence for the relative superiority of any 1 approach. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Cerebral palsy: a comprehensive review

Cerebral palsy is a broad range of static, nonprogressive motor disabilities that present from birth or early childhood as a result of injury to neuromotor components of the central nervous system. Motor performance is normally coordinated via communication between the cerebral cortex, thalamus, basal ganglia, brain stem, cerebellum, spinal cord, and communicating sensori-motor pathways. This complex network lends itself to injury at many different levels. Etiologies are numerous and can occur during the prenatal, perinatal, and postnatal periods. The severity of the neurologic deficit and the clinical manifestations are varied depending on the time, location and nature of the original injury. In order to approach cerebral palsy systematically, the primary health care practitioner must be prepared to recognize neuromotor deficits, diagnose and classify the type of disorder, and implement a methodical treatment plan. The purpose of this article is to review the etiology, pathophysiology, diagnostic classification (Swedish system), clinical manifestations, and therapeutic management of cerebral palsy and prepare the advanced practice nurse to care for the individual and family.     

Anal adenocarcinoma: a comprehensive review

In the past decade there has been an increasing use of high dose of chemo-radiotherapy in the treatment of poor prognosis solid tumors of childhood. The autologous bone marrow transplantation is the most used technique for circumventing the infectious and haemorrhagic complications occurring in the prolonged period of myelotoxicity. The faster recovery assured by the peripheral blood progenitor cells (PBPC) makes this procedure an attractive alternative. The advent of new apheretic modalities and the use of combinations of active antineoplastic drugs with various growth factors, such as G-CSF, GM-CSF and IL-3, has allowed to collect and concentrate the mononuclear fraction of peripheral blood leukocytes. The optimal timing for the collection is a crucial point and the utilization of flow cytometry for the determinations of circulating CD34+ cells in the peripheral blood is so far the best indicator for successful apheresis. The authors describe their experience in 16 children affected by poor prognosis neuroblastoma who had undergone high dose chemotherapy followed by G-CSF administration and PBPC collection. The details of apheretic techniques and the characteristics of conditioning regimen and haematologic recovery after PBPC reinfusion are also presented.     

The Burch procedure: a comprehensive review

The relationship of timing of early parental separation to psychosocial development of daughters was examined in 77 girls, 6-9 years of age over a four-year period. Disruptive behavior across contexts was prevalent in girls separated between birth and two years of age. Girls separated between three and five years of age showed more externalizing behavior problems, but only in school. Results suggest that early parental separation has more pervasive and stable negative effects on psychosocial adjustment of girls in this age group in single-parent families. Implications of the findings and directions for research are discussed.     

A comprehensive set of counselor competencies.

75 experienced counselors or therapists from a variety of work settings contributed statements of those competencies they believed necessary for effective face-to-face counseling. The contributed competency statements were edited and compiled into a set of 132 competencies. Each of the 132 competencies was rated for importance by 376 experienced counselors and therapists. 12 dimensions of counselor competency were defined by factor analysis of the ratings. A number of significant differences in importance were found between the ratings of 9 of the 12 dimensions by raters of different work settings, theoretical orientations, majors or degrees, years of experience, and other background categories. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The 90-kDa molecular chaperone family: structure, function, and clinical applications. A comprehensive review

The 90-kDa molecular chaperone family (which comprises, among other proteins, the 90-kDa heat-shock protein, hsp90 and the 94-kDa glucose-regulated protein, grp94, major molecular chaperones of the cytosol and of the endoplasmic reticulum, respectively) has become an increasingly active subject of research in the past couple of years. These ubiquitous, well-conserved proteins account for 1-2% of all cellular proteins in most cells. However, their precise function is still far from being elucidated. Their involvement in the aetiology of several autoimmune diseases, in various infections, in recognition of malignant cells, and in antigen-presentation already demonstrates the essential role they likely will play in clinical practice of the next decade. The present review summarizes our current knowledge about the cellular functions, expression, and clinical implications of the 90-kDa molecular chaperone family and some approaches for future research.     

Examination of ethnicity in controlled treatment outcome studies involving adolescent substance abusers: A comprehensive literature review.

The extent to which adolescent drug treatment outcome studies address ethnicity was systematically examined. Reliability coefficients were calculated for both the search methodology used to obtain these outcome studies and the extent to which ethnicity was addressed along several dimensions. The resulting coefficients were highly reliable. Findings indicated that although investigators of 94% of the outcome studies considered ethnicity to some extent, only 28% of these studies incorporated ethnicity into their design, and only 6% of studies involved statistical analyses to examine differential response to treatment or moderating effects of ethnicity with a sufficient number of ethnic minority participants. Overall, results indicated that there is much work to do regarding the examination of ethnicity in controlled treatment outcome studies involving adolescent substance abusers. Indeed, modifications were rarely made to the treatment components to accommodate ethnicity-related variables. Future recommendations are presented in light of these findings. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A comprehensive review of effect size reporting and interpreting practices in academic journals in education and psychology.

Null hypothesis significance testing has dominated quantitative research in education and psychology. However, the statistical significance of a test as indicated by a p-value does not speak to the practical significance of the study. Thus, reporting effect size to supplement p-value is highly recommended by scholars, journal editors, and academic associations. As a measure of practical significance, effect size quantifies the size of mean differences or strength of associations and directly answers the research questions. Furthermore, a comparison of effect sizes across studies facilitates meta-analytic assessment of the effect size and accumulation of knowledge. In the current comprehensive review, we investigated the most recent effect size reporting and interpreting practices in 1,243 articles published in 14 academic journals from 2005 to 2007. Overall, 49% of the articles reported effect size—57% of which interpreted effect size. As an empirical study for the sake of good research methodology in education and psychology, in the present study we provide an illustrative example of reporting and interpreting effect size in a published study. Furthermore, a 7-step guideline for quantitative researchers is also summarized along with some recommended resources on how to understand and interpret effect size. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A modified direct lateral approach in total hip arthroplasty: a comprehensive review

A retrospective review of 770 consecutive primary total hip arthroplasties was conducted to determine the complications and utility of a modified direct lateral approach, which involves elevation of the anterior one-third of the gluteus medius and vastus lateralis in continuity. In 640 patients, 712 total hip arthroplasties were followed up for a minimum of 2 years (maximum 6.5 years, average 3.6 years). Two prosthetic dislocations occurred in the follow-up period, for a prevalence of instability of 0.3%. A moderate or severe limp was present in 10% of all patients at 2-year follow-up and in 4% of a subgroup of patients with only unilateral osteoarthritis of the hip (Charnley A). Severe heterotopic ossification (Brooker grade III or IV) developed in fewer than 3% of hips and was functionally limiting in only seven patients. Four sciatic nerve palsies occurred. Surgical exposure has been excellent through this approach, without the need for extensile measures, such as a trochanteric osteotomy. The duration of surgery has been considered acceptable, and the position of the components considered excellent while using this approach. From this review, it was concluded that this modified direct lateral approach has greatly diminished the potentially devastating complication of postoperative instability and is associated with an acceptable level and severity of limp and heterotopic ossification. The approach provides excellent exposure in primary total hip arthroplasty to allow accurate placement of components in an efficient manner.     

Bioresorbable fracture fixation in orthopedics: a comprehensive review. Part II. Clinical studies

Bioresorbable materials overcome two major disadvantages of the metal alloys most commonly used in fracture-fixation devices: their extreme stiffness, which causes stress shielding of the underlying bone, and the necessity, in a significant number of cases, of removing metallic implants after fracture healing is complete. The orthopedic surgeon now has the use of polylactic acid, polyglycolic acid, and polydioxanone implants for the fixation of small cancellous bone fractures. The currently available bioresorbable materials lack strength and stiffness and are associated with inflammatory reactions and osteolysis in a significant number of cases. Surgeons should use the available pins and screws with extreme care and attention to the characteristics of each individual injury, particularly its healing characteristics, as well as to the material's initial mechanical properties, degradation rates, and associated complications.     

Extracorporeal shock wave lithotripsy: a comprehensive review

Extracorporeal shock wave lithotripsy (ESWL) has revolutionized treatment of urolithiasis since its introduction in the 1980s. The great majority of renal and ureteral stones can be successfully treated with ESWL. Complications can be minimized with maximal efficacy if patient selection is optimum.