超细粉碎技术在制药工业中的应用

超细粉体技术是近几十年发展起来的一门新技术 ,在制药工业中有着广泛的发展前景。尤其是药物超细颗粒在外用药、内服药及悬浊液针剂中的使用 ,可进一步提高药物在体内的吸收 ,增强药物的疗效。目前 ,市场对微粉化固体药物的需求量正逐年增长。在制药过程中 ,一般通过以下两种途径获得超细粉体药物。微粉结晶 :通过控制结晶工艺条件 ,制得超细颗粒晶体 ,再通过过滤、洗涤、抽干、烘干而获得 ;超细粉碎 :将大颗粒结晶获得的晶体颗粒经过超细粉碎处理而获得。用微粉结晶法制取超细粉体药物 ,由于晶体小 ,不仅难以进行过滤、洗涤、抽干、烘干 ,…     

酶解胶原蛋白研究进展

阐述了近年来国内外关于酶法水解胶原蛋白所做的研究工作,并对胶原多肽的应用前景进行了分析。     

Kalrez全氟弹性体在制药工业中的应用

介绍了制药工业中对于密封材料的特殊要求。Kalrez 6230和6221具有宽域的耐化学介质性能、高度洁净性能、良好的耐热和耐压缩永久变形性能,可为制药工业提供完整有效的密封功能。     

表面活性剂在制药工业中的应用

论述了表面活性剂在药物制剂中做药剂辅料、在药物合成中做相转移催化剂以及在药物荧光分析中做增溶增敏剂的应用原理及现状,介绍了表面活性剂在制药工业中应用研究的新进展,提出了在制药工业中应用表面活性剂的展望。     

酶解技术在中药提取中的应用进展

简要介绍了酶解技术在中药提取分离中的原理以及最新应用进展.纤维素酶、果胶酶、木瓜蛋白酶等酶能够分解植物细胞壁、果胶质和蛋白质等,加速药用有效成分的溶出,提高药用有效成分的提取率.酶解技术在中药有效成分提取分离的应用有着广阔的发展前景,同时也能促进中药研究的现代化.     

酶催化工艺用于制药工业的研究进展

论述了酶催化工艺应用与制药工业的研究和发展,并介绍了在医药领域中酶催化工艺的运用。     

酶解木质素的研究进展及其在橡胶工业中的应用

酶解木质素是利用酶解生物质原料制备能源酒精的残渣中分离得到的木质素,具有纯度高、化学活性强等特点。介绍了酶解木质素的制备及其研究进展,并着重阐述了酶解木质素及其衍生物在橡胶工业中的应用情况。     

绿色化学技术在制药工业中的应用

绿色化学是当今国际化学研究的前沿，是21世纪的科学，并将成为各化学基础学科和应用技术研究的热点。本文综述了几种绿色化学技术在制药工业中的应用及进展．并指出了绿色化学是我国制药工业可持续发展的必由之路。     

纳滤技术在食品及制药工业中的应用（上）

介绍了纳滤膜的制备方法和分离机理,并综述了纳滤技术在食品工业和制药工业中的应用。     

清洗技术在食品产业中的应用

随着工业的发展,食品加工技术得到迅速提高.食品加工业运用清洗、杀菌、消毒等清洗技术显得越来越重要.概述了食品工业中各领域清洁、清洗技术的广泛应用及特点.     

渗透汽化膜技术在医药化工中的应用

渗透汽化膜技术在医药化工方面的应用前景和市场非常广阔,它是一种新型的分离技术,与其他分离技术相比具有自身独特的优势。介绍了渗透汽化膜技术的原理、过程特点、优越性及其在医药化工中的应用和发展现状。     

功能化离子液体及其在食品工业中的应用

介绍了功能化离子液体的制备,综述了功能化离子液体在食品工业领域的最新应用进展,重点讨论了功能化离子液体在食品工业的原料合成、分析提纯和生物技术方面的应用进展,分析了功能化离子液体在食品工业应用中存在的问题,提出了功能化离子液体在食品工业中的发展方向.     

食品级、医药级磷酸三钙生产工艺

采用改进的固相反应法，以碳酸钙和工业磷酸为原料，制备食品级、医药级磷酸三钙(TCP)产品，研究了CaO与P2O5物质量的比、助剂加入量、反应温度对产物化学组成结构的影响；用X射线衍射(XRD)研究了产品的物相结构。提出了该工艺的反应机理，并确定了在技术上、经济上可行的工艺路线。分析结果表明，可以得到高品质磷酸三钙，产品质量指标符合FCC、USP和EP标准。     

The application and prospects of cyclodextrin inclusion complexes and polymers in the food industry: a review

Cyclodextrin is an odorless and tasteless cyclic oligosaccharide widely used in various fields such as food, medicine and the environment. Cyclodextrin can improve solubility and stability, and can mask the bad taste of specific substances. Cyclodextrins and their polymers primarily act by forming complexes in foods, and can be applied in food packing, food analysis, enhancing the properties of antioxidants, antibacterials, for stability and so on. The challenges and opportunities facing this area are reviewed. It is hoped that the review will provide useful information for future applications of cyclodextrin in the food industry. © 2020 Society of Chemical Industry     

Applications of the crystallization process in the pharmaceutical industry

The applications of the crystallization technique in the pharmaceutical industry as a purification and separation process for the isolation and synthesis of pure active pharmaceutical ingredients (API), co-crystals, controlled release pulmonary drug delivery, and separation of chiral isomers are briefly discussed using a few case studies. The effect of process variables and solvent on the polymorphism and morphology of stavudine is discussed. The implementation of external control in the form of feedback and real-time optimal control using cooling and antisolvent crystallization of paracetamol in water-isopropyl alcohol is introduced. Two methods to prepare micronsized drug particles, namely, micro-crystallization and polymer-coated API-loaded magnetic nanoparticles for pulmonary drug delivery, are discussed. The significance of co-crystals in drug administration is highlighted using the theophylline-nicotinamide co-crystal system. Resolution of chloromandelic acid derivatives, a racemic compound, is achieved using direct crystallization and diastereomeric salts crystallization. The crystal structures of diastereomeric salts of chloromandelic acid and phenylethylamine are determined. The structure comparison between the less soluble and more soluble salts shows that weak interactions such as CH/π interactions and van der Waals forces contribute to chiral recognition when the hydrogen bonding patterns are similar.     

Applications of the crystallization process in the pharmaceutical industry

The applications of the crystallization technique in the pharmaceutical industry as a purification and separation process for the isolation and synthesis of pure active pharmaceutical ingredients (API), co-crystals, controlled release pulmonary drug delivery, and separation of chiral isomers are briefly discussed using a few case studies. The effect of process variables and solvent on the polymorphism and morphology of stavudine is discussed. The implementation of external control in the form of feedback and real-time optimal control using cooling and antisolvent crystallization of paracetamol in water-isopropyl alcohol is introduced. Two methods to prepare micron-sized drug particles, namely, micro-crystallization and polymer-coated API-loaded magnetic nanoparticles for pulmonary drug delivery, are discussed. The significance of co-crystals in drug administration is highlighted using the theophylline-nicotinamide co-crystal system. Resolution of chloromandelic acid derivatives, a racemic compound, is achieved using direct crystallization and diastereomeric salts crystallization. The crystal structures of diastereomeric salts of chloromandelic acid and phenylethylamine are determined. The structure comparison between the less soluble and more soluble salts shows that weak interactions such as CH/π interactions and van der Waals forces contribute to chiral recognition when the hydrogen bonding patterns are similar.     

Specific energy consumption in electrochemical treatment of food industry wastewaters

BACKGROUND: Specific energy consumption (SEC) is an important factor in electrochemical treatment of wastewaters. SEC during electrochemical treatment of food industry wastewaters, specifically deproteinated whey wastewater (DWW), simulated sugar beet factory wastewater (SFW) and fruit juice factory wastewater (FJW), were investigated in this study. The effects of operational parameters applied voltage, and electrolyte and wastewater concentrations on SEC were assessed and optimized. RESULTS: SEC values were found in the range of 0.27–148.65, 0.94–375.76 and 0.20–636.40 kWh (kg COD)^?1 for DWW, SFW and FJW, respectively, after 8 h of reaction. Operational parameters were optimized at 25 °C through response surface methodology (RSM) where applied voltage was kept in the range (2–12 V), wastewater concentration and COD removal percent were maximized electrolyte concentration and SEC were minimized. Optimum conditions were estimated as 7.73 V applied voltage and 100% wastewater concentration in the presence of 27.11 g L^?1 supporting electrolyte concentration to achieve 25.02, 67.74 and 43.10% COD removal for DWW, SFW and FJW with corresponding SEC values of 17.85, 22.79 and 80.47 kWh (kg COD)^?1, respectively. CONCLUSIONS: Providing further research on the reduction of SEC values, application of electrochemical treatment to food industry wastewaters with non‐biodegradable components may become an alternative to conventional methods. Copyright © 2012 Society of Chemical Industry     

高浓度制药发酵废水处理工程技术

制药发酵废水具有有机物浓度高、成分复杂等特点.采用PW膜法处理高浓度制药发酵废水,解决了污染问题.经过多年的运行表明,其处理效果好、运行性能稳定、操作和维护管理方便且运行费用低廉,具有较高的推广价值.     

青霉素菌丝中蛋白质酶法水解工艺

采用碱热法溶解青霉素菌丝,研究酶法催化水解菌丝溶解液中蛋白质转化为氨基酸的过程.考察酶种类、溶解液pH值、酶与蛋白质质量比、反应温度和时间等因素对蛋白质水解度的影响,建立最佳水解工艺.结果 表明,酶种类、酶与蛋白质之比、pH、温度和时间均对蛋白质水解过程产生影响.以单酶为催化剂,碱性蛋白酶催化水解效果最好,蛋白质水解度...