Actinobacillus and Streptococcus: producers of isoschizomers of the restriction endonucleases R.HphI, R.SauI, R.NheI, R.MboI and R.SwaI

New restriction endonucleases have been found in microorganisms isolated from the microflora of human teeth. The strain-producers are Actinobacillus suis and Streptococcus milleri. The new enzymes are isoschizomers of the prototypes as follows: AsuHPI - HphI; AsuSAI - SauI; AsuNHI - NheI; AsuMBI and SmiMBI - MboI; SmiI - rare-cutter SwaI.     

Ataxia-telangiectasia in the Japanese population: identification of R1917X, W2491R, R2909G, IVS33+2T-->A, and 7883del5, the latter two being relatively common mutations

Postmenopausal uterine bleeding is an indication to sample the endometrium for diagnostic purposes. The endometrial brush cytologies of 20 advanced postmenopausal women collected at the time of hysterectomy in order to benchmark the expected morphology of postmenopausal endometrial brushings were reviewed. No women had symptoms or gross findings of primary endomyometrial disease. Endometrium was collected at the surgical pathology laboratory using the Tao Brush and CytoRich Fixative System. After formalin fixation of the uterus, the entire endometrium was embedded for routine histology. Sixteen endometrial brushings and matched endometrial sections showed endometrial atrophy, one brushing showed many ciliated epithelial cells, and three brushings showed focal (less than 10%) epithelial-cell atypia. In two atypias, abnormal endometrial epithelial-cell sheets contained enlarged, clear nuclei with nuclear notches and grooves resembling papillary thyroid cancer. One case showed no histological counterpart to this finding. The other case showed thickening of the pericornual fundic endometrium with cystic glands. The third case with epithelial atypia showed abnormal endometrial-cell sheets with nuclei resembling atypical hyperplasia or type I endometrial adenocarcinoma; corresponding endometrial tissue sections showed rare, irregular glands and back-to-back gland clusters with equivalent nuclear features. Atypical epithelium may be found in atrophic uteri in the absence of gross endometrial thickening. This may be a common event related either to de novo intraepithelial dysplasia in a noncycling endometrium or to hyperplasia that has partly regressed with estradiol withdrawal. This study shows that, in addition to endometrial intraepithelial carcinoma (EIC), isolated atypical glands with morphological and immunohistochemical features of atypical hyperplasia or type I endometrial adenocarcinoma may be found in grossly normal advanced postmenopausal endometrium of asymptomatic patients. This atypical epithelium is readily apparent in endometrial brush preparations, but requires serial sectioning of the endometrium to be demonstrated histologically. We have not established the natural history of this lesion, and in the absence of EIC or gross endometrial thickening indicative of atypical hyperplasia, we do not know whether this degree of epithelial atypia should be an indication for hysterectomy.     

Validity and usefulness of WAIS—R, WISC—R, and WPPSI short forms: A critical review.

Reviews the short-form studies that have been conducted on the Wechsler Adult Intelligence Scale—Revised (WAIS—R), the Wechsler Intelligence Scale for Children—Revised (WISC—R), and the Wechsler Preschool and Primary Scale of Intelligence (WPPSI). Results show that none of the abbreviated forms were considered to be valid as a short-form IQ measure but that they could be useful as screening instruments. It is concluded that when developing a screening instrument, the more items that are used and the more widely the items are distributed among the subtests, the more effective the screening instrument will generally be. (61 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

手性碳原子R,S构型确定法

对映异构体用R，S来标记手性碳原子的空间构型．以IUPAC规定的R，S构型表示方法为基础，文章提供了用手螺旋法和由投影式直接判定手性碳原子R，S构型的两种直观、简便方法，并对环状化合物中手性碳原子R，S的标记做了解释说明，同时对次序规则进行了总结与补充．     

Rare Earth Metals in Light Alloys

ＲａｒｅＥａｒｔｈＭｅｔａｌｓｉｎＬｉｇｈｔＡｌｏｙｓＦｅｒｏＲ，ＳａｃｃｏｎｅＡ，ＢｏｒｚｏｎｅＧ（ＤｉｖｉｓｉｏｎｏｆＧｅｎｅｒａｌａｎｄＩｎｏｒｇａｎｉｃＣｈｅｍｉｓｔｒｙａｎｄＭｅｔａｌｕｒｇｙ，ＤｅｐａｒｔｍｅｎｔｏｆＣｈｅｍｉｓｔｒｙ，Ｕ...