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1.
《Drug development and industrial pharmacy》2013,39(12):1874-1880
To improve physical properties and modulate the mucoadhesive hydrogel formulation via cross-linking by radiation, hydrogels were prepared using thermoreversible polymer Pluronic F127 (PF127) and mucoadhesive polymer carbopol 934P (C934P). As a model drug, naproxen was loaded in the hydrogel formulation. Sol-gel transition temperatures of hydrogels were measured by the tube-inversion method. The mucoadhesive potential of each formulation was determined by measuring the force required to detach the formulation from oral mucosal tissue. To strengthen the mechanical properties, the formulations were irradiated using an electronic beam. Drug release from the hydrogels and the cytotoxicity of each formulation were investigated. Sol-gel transition temperatures of the formulations were decreased by the addition of carbopol and were close to body temperature. The mucoadhesive force of the PF127 formulation was increased by addition of carbopol. In vitro release was sustained and the release rate was reduced by the addition of carbopol. After irradiation, the mucoadhesive force was increased about five-fold especially in the case of PF127 23% (9.7 kPa) and in vitro release was not sustained further. In conclusion, the use of a PF127 formulation incorporating a mucoadhesive polymer could effectively and safely improve oral residence time and absorption of naproxen. Irradiated formulations showed permanent cross-linking and improved properties. 相似文献
2.
Chao Lin Peng Zhao Fang Li Fangfang Guo Zhuoquan Li Xuejun Wen 《Materials science & engineering. C, Materials for biological applications》2010,30(8):1236-1244
A thiolated dextran (Dex-SH) with a degree of substitution of 10 was synthesized and used for in situ hydrogel formation via Michael-type addition using vinyl sulfone functionalized Pluronic 127 (PL-VS) or acrylated Pluronic 127 (PL-Ar). Dextran/Pluronic hydrogels were rapidly formed in situ under physiological conditions upon mixing the solutions of Dex-SH and PL-VS or PL-Ar at a PL concentration of 10 or 20 w/v%. Rheological studies showed that these hydrogels with a broad range of storage moduli of 0.3 to 80 kPa could be obtained by varying PL concentration from 5% to 20 w/v%. Moreover, the hydrogels at a PL concentration of 10% or 20 w/v% revealed thermosensitive property with a temperature increase from 10 to 37 °C. Dex-SH/PL-Ar hydrogels were degradable under physiological conditions and had lower cytotoxicity than Dex-SH/PL-VS hydrogels. These thermosensitive injectable hydrogels show promise for biomedical applications. 相似文献
3.
Zhu CH Hai ZB Cui CH Li HH Chen JF Yu SH 《Small (Weinheim an der Bergstrasse, Germany)》2012,8(6):930-936
Thermosensitive poly(N‐isopropylacrylamide) (PNIPAM)/Au nanoparticle (NP) nanocomposite hydrogels are synthesized by in situ γ‐radiation‐assisted polymerization of N‐isopropylacrylamide monomer aqueous solution in the presence of HAuCl4·4H2O. In this reaction, the PNIPAM hydrogels and the Au NPs are formed simultaneously, thus demonstrating an easy and straightforward synthetic strategy for the preparation of a uniform nanocomposite. The results suggest that increasing the monomer content during the preparation of nanocomposite materials can increase the sizes of Au NPs. The effects of irradiation dose and concentration of HAuCl4·4H2O on the optical and thermal properties of the hydrogel are also investigated. The PNIPAM/Au nanocomposite hydrogels act as an excellent catalyst for the conversion of o‐nitroaniline to 1,2‐benzenediamine, and the catalytic activity of the composite hydrogel can be tuned by the volume transition of PNIPAM. The in situ polymerization of monomer and reduction of metal ions initiated by a “clean” and “green” γ‐radiation technique can be extended to the efficient synthesis of other nanocomposite materials. 相似文献
4.
Xiao Wen Kun Xi Yu Tang Jie Bian Yu Qin Wanshu Xiao Tingzheng Pan Xiaoming Cheng Zili Ge Wenguo Cui 《Small (Weinheim an der Bergstrasse, Germany)》2023,19(15):2207030
The “double-edged sword” effect of macrophages under the influence of different microenvironments determines the outcome and prognosis of tissue injury. Accurate and stable reprogramming macrophages (Mφ) are the key to rapid wound healing. In this study, an immunized microsphere-engineered GelMA hydrogel membrane is constructed for oral mucosa treatment. The nanoporous poly(lactide-co-glycolide) (PLGA) microsphere drug delivery system combined with the photo-cross-linkable hydrogel is used to release the soybean lecithin (SL)and IL-4 complexes (SL/IL-4) sustainedly. In this way, it is realized effective wound fit, improvement of drug encapsulation, and stable triphasic release of interleukin-4 (IL-4). In both in vivo and in vitro experiments, it is demonstrated that the hydrogel membrane can reprogram macrophages in the microenvironment into M2Mφ anti-inflammatory types, thereby inhibiting the local excessive inflammatory response. Meanwhile, high levels of platelet-derived growth factor (PDGF) secreted by M2Mφ macrophages enhanced neovascular maturation by 5.7-fold, which assisted in achieving rapid healing of oral mucosa. These findings suggest that the immuno-engineered hydrogel membrane system can re-modulating the biological effects of Mφ, and potentiating the maturation of neovascularization, ultimately achieving the rapid repair of mucosal tissue. This new strategy is expected to be a safe and promising immunomodulatory biomimetic material for clinical translation. 相似文献
5.
Zhenhai Zhang Changchang Cui Fang Wei Huixia Lv 《Drug development and industrial pharmacy》2017,43(8):1276-1282
The aim of this study was to develop a novel mix micelles system composing of two biocompatible copolymers of Soluplus® and Pluronic F127 to improve the solubility, oral bioavailability of insoluble drug apigenin (AP) as model drug. The AP-loaded mixed micelles (AP-M) were prepared by ethanol thin-film hydration method. The formed optimal formulation of AP-M were provided with small size (178.5?nm) and spherical shape at ratio of 4:1 (Soluplus®:Pluronic F127), as well as increasing solubility of to 5.61?mg/mL in water which was about 3442-fold compared to that of free AP. The entrapment efficiency and drug loading of AP-M were 95.72 and 5.32%, respectively, and a sustained release of AP-M was obtained as in vitro release study indicated. Transcellular transport study showed that the cell uptake of AP was increased in Caco-2 cell transport models. The oral bioavailability of AP-M was 4.03-fold of free AP in SD rats, indicating the mixed micelles of Soluplus® and Pluronic F127 is an industrially feasible drug delivery system to promote insoluble drug oral absorption in the gastrointestinal tract. 相似文献
6.
Rafael Vercelino Thiago Mattar Cunha Elisa Silva Ferreira Fernando Q. Cunha Sérgio H. Ferreira Marcelo G. de Oliveira 《Journal of materials science. Materials in medicine》2013,24(9):2157-2169
New approaches based on topical treatments are needed for treating pain and impaired dermal blood flow. We used a topical Pluronic F127 hydrogel containing S-nitrosoglutathione (GSNO) as a prodrug to generate free NO, an effector molecule that exerts both dermal vasodilation and antinociceptive effects. GSNO-containing hydrogels underwent gelation above 12 °C and released free NO at rates that were directly dependent on the GSNO concentration in the range of 50–150 mM. The topical application of this material led to dose–response dermal vasodilation in healthy volunteers and to a reduction of up to 50 % of the hypernociception intensity in Wistar rats that were subjected to inflammatory pain. Mechanistic investigations indicated that the antinociceptive effect of the topical F127/GSNO hydrogels is produced by the local activation of the cGMP/PKG/KATP channel-signaling pathway, which was stimulated by the free NO that diffused through the skin. These results expand the scope of the biomedical applications of this material and may represent a new approach for the topical treatment of inflammatory pain. 相似文献
7.
Hariharasudhan D. Chirra Tejal A. Desai 《Small (Weinheim an der Bergstrasse, Germany)》2012,8(24):3839-3846
A variety of oral administrative systems such as enterically coated tablets, capsules, particles, and liposomes have been developed to improve oral bioavailability of drugs. However, they suffer from poor intestinal localization and therapeutic efficacy due to the various physiological conditions and high shear fluid flow. Fabrication of novel microdevices combined with the introduction of controlled release, improved adhesion, selective targeting, and tissue permeation may overcome these issues and potentially diminish the toxicity and high frequency of conventional oral administration. Herein, thin, asymmetric, poly(methyl methacrylate) (PMMA) microdevices are fabricated with multiple reservoirs using photolithography and reactive ion etching. They are loaded with different individual model drug in each reservoir. Enhanced bioadhesion of the microdevices is observed in the presence of a conjugated of targeting protein (tomato lectin) to the PMMA surface. As compared to drug encompassing hydrogels, an increase in drug permeation across the caco‐2 monolayer is noticed in the presence of a microdevice loaded with the same drug–hydrogel system. Also, the release of multiple drugs from their respective reservoirs is found to be independent from each other. The use of different hydrogel systems in each reservoir shows differences in the controlled release of the respective drugs over the same release period. These results suggest that, in the future, microfabricated unidirectional multi‐drug releasing devices will have an impact on the oral administration of a broad range of therapeutics. 相似文献
8.
A nanocomposite (NC) hydrogel was prepared by incorporating the nanoclay (Laponite (Lap) XLS) into a poly(acrylamide) (PAAm) hydrogel by the in situ polymerization method without any organic cross-linker. The parameters pertaining to the swelling (Q) and diffusion (D) of water for the PAAm/Lap NC hydrogels were estimated. The crystal violet (CV) dye adsorption properties of the PAAm/Lap NC hydrogels were investigated. The adsorption of CV dye by the hydrogel increases as the concentration of the dye increases. The cationic dye adsorption ability of the NC hydrogel increased with increasing clay content in the NC hydrogel. The NC hydrogels containing CV dye were characterized by FT-IR. A sigmoidal type of adsorption isotherm was observed for the CV-NC hydrogels. The effects of heat treatment on the dye adsorption behavior of the NC hydrogels were studied. 相似文献
9.
Self‐Assembly of Enzyme‐Like Nanofibrous G‐Molecular Hydrogel for Printed Flexible Electrochemical Sensors
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Ruibo Zhong Qian Tang Shaopeng Wang Hongbo Zhang Feng Zhang Mingshu Xiao Tiantian Man Xiangmeng Qu Li Li Weijia Zhang Hao Pei 《Advanced materials (Deerfield Beach, Fla.)》2018,30(12)
Conducting hydrogels provide great potential for creating designer shape‐morphing architectures for biomedical applications owing to their unique solid–liquid interface and ease of processability. Here, a novel nanofibrous hydrogel with significant enzyme‐like activity that can be used as “ink” to print flexible electrochemical devices is developed. The nanofibrous hydrogel is self‐assembled from guanosine (G) and KB(OH)4 with simultaneous incorporation of hemin into the G‐quartet scaffold, giving rise to significant enzyme‐like activity. The rapid switching between the sol and gel states responsive to shear stress enables free‐form fabrication of different patterns. Furthermore, the replication of the G‐quartet wires into a conductive matrix by in situ catalytic deposition of polyaniline on nanofibers is demonstrated, which can be directly printed into a flexible electrochemical electrode. By loading glucose oxidase into this novel hydrogel, a flexible glucose biosensor is developed. This study sheds new light on developing artificial enzymes with new functionalities and on fabrication of flexible bioelectronics. 相似文献
10.
Qingsong Zhang Li Chen Youyu Dong Si Lu 《Materials science & engineering. C, Materials for biological applications》2013,33(3):1616-1622
The structure, morphology, thermal behaviors and cytotoxicity of novel hydrogels, composed of poly(N-isopropylacrylamide)(PNIPAM) and biodegradable polyester poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) under nanoclay hectorite “Laponite XLG” severed as physical cross-linker, were characterized by X-ray diffraction, scanning electron microscopy, gravimetric method, differential scanning calorimetry, and cell culture experiments. It was found that, due to the introduction of hydrophobic PHBV, the homogeneity of interior pore in the pure PNIPAM nanocomposite hydrogel was disrupted, the transparency and swelling degree gradually decreased. Although the weight ratio between PHBV and NIPAM increased from 5 to 40 wt.%, the volume phase transition temperature (VPTTs) of hydrogel were not altered compared with the pure PNIPAM nanocomposite hydrogel. No matter what PHBV content, the PHBV/PNIPAM/Hectorite hydrogels always exhibit good stimuli-responsibility. In addition, human hepatoma cells(HepG2) adhesion and spreading on the surface of PHBV-based hydrogels was greatly improved than that of pure PNIPAM nanocomposite hydrogel at 37 °C due to the introduction of PHBV. 相似文献
11.
Mar Diez Vera A. Schulte Filippo Stefanoni Carlo F. Natale Francesco Mollica Claudia M. Cesa Jingyu Chen Martin Möller Paolo A. Netti Maurizio Ventre Marga C. Lensen 《Advanced Engineering Materials》2011,13(10):B395-B404
We present an innovative and simple, soft UV lithographic method “FIll‐Molding In Capillaries” (FIMIC) that combines soft lithography with capillary force driven filling of micro‐channels to create smooth hydrogel substrates with a 2D micro‐pattern on the surface. The lithographic procedure involves the molding of a polymer; in our case a bulk PEG‐based hydrogel, via UV‐curing from a microfabricated silicon master. The grooves of the created regular line pattern are consequently filled with a second hydrogel by capillary action. As a result, a smooth surface is obtained with a well‐defined pattern design of the two different polymers on its surface. The FIMIC method is very versatile; the only prerequisite is that the second material is liquid before curing in order to enable the filling process. In this specific case we present the proof of principle of this method by applying two hydrogels which differ in their crosslinking density and therefore in their elasticity. Preliminary cell culture studies on the fabricated elasticity patterned hydrogels indicate the preferred adhesion of the cells to the stiffer regions of the substrates, which implies that the novel substrates are a very useful platform for systematic cell migration studies, e.g. more fundamental investigation of the concept of “durotaxis”. 相似文献
12.
Riku Takahashi Tao Lin Sun Yoshiyuki Saruwatari Takayuki Kurokawa Daniel R. King Jian Ping Gong 《Advanced materials (Deerfield Beach, Fla.)》2018,30(16)
Reinforcing hydrogels with a rigid scaffold is a promising method to greatly expand the mechanical and physical properties of hydrogels. One of the challenges of creating hydrogel composites is the significant stress that occurs due to swelling mismatch between the water‐swollen hydrogel matrix and the rigid skeleton in aqueous media. This stress can cause physical deformation (wrinkling, buckling, or fracture), preventing the fabrication of robust composites. Here, a simple yet versatile method is introduced to create “macroscale” hydrogel composites, by utilizing a rigid reinforcing phase that can relieve stress‐induced deformation. A low‐melting‐point alloy that can transform from a load‐bearing solid state to a free‐deformable liquid state at relatively low temperature is used as a reinforcing skeleton, which enables the release of any swelling mismatch, regardless of the matrix swelling degree in liquid media. This design can generally provide hydrogels with hybridized functions, including excellent mechanical properties, shape memory, and thermal healing, which are often difficult or impossible to achieve with single‐component hydrogel systems. Furthermore, this technique enables controlled electrochemical reactions and channel‐structure templating in hydrogel matrices. This work may play an important role in the future design of soft robots, wearable electronics, and biocompatible functional materials. 相似文献
13.
Man Yang Xizi Wan Mingqian Liu Zhao Wang Lanxin Jia Feilong Zhang Shutao Wang 《Small (Weinheim an der Bergstrasse, Germany)》2023,19(21):2208157
Anti-dehydration hydrogels have attracted considerable attention due to their promising applications in stretchable sensors, flexible electronics, and soft robots. However, anti-dehydration hydrogels prepared by conventional strategies inevitably depend on additional chemicals or suffer from cumbersome preparation processes. Here, inspired by the succulent Fenestraria aurantiaca a one-step wetting-enabled three-dimensional interfacial polymerization (WET-DIP) strategy for constructing organogel-sealed anti-dehydration hydrogels is developed. By virtue of the preferential wetting on the hydrophobic-oleophilic substrate surfaces, the organogel precursor solution can spread on the three-dimensional (3D) surface and encapsulate the hydrogel precursor solution, forming anti-dehydration hydrogel with 3D shape after in situ interfacial polymerization. The WET-DIP strategy is simple and ingenious, and accessible to discretionary 3D-shaped anti-dehydration hydrogels with a controllable thickness of the organogel outer layer. Strain sensors based on this anti-dehydration hydrogel also exhibit long-term stability in signal monitoring. This WET-DIP strategy shows great potentialities for constructing hydrogel-based devices with long-term stability. 相似文献
14.
通过可逆加成-断裂链转移聚合(RAFT)反应制备了一种亲水性两嵌段聚合物——聚乙二醇/聚N-异丙基丙烯酰胺(PEG-PNIPAM),利用α-环糊精(α-CD)与其中PEG链段的选择性包合形成了一种独特的主客体胶束,这种胶束由于具备中空结构,可对亲水性药物起到很好的负载作用。其对神经生长因子的包载率为经典普朗尼克F127胶束的2倍。进一步利用主客体胶束为大分子交联剂制备丙烯酰胺水凝胶,可赋予水凝胶优异的力学性能,拉伸伸长率为化学交联对照组5倍,并且强度高于对照组2倍以上。循环拉伸测试表明,该水凝胶具有良好的应力耗散机制。 相似文献
15.
Chengyan Wang Jiani Xie Xinghua Dong Linqiang Mei Maoru Zhao Zhengwei Leng Houxiang Hu Lele Li Zhanjun Gu Yuliang Zhao 《Small (Weinheim an der Bergstrasse, Germany)》2020,16(16)
The exploration of an old drug for new biomedical applications has an absolute predominance in shortening the clinical conversion time of drugs for clinical application. In this work, carbon nanoparticles suspension injection (CNSI), the first clinically approved carbon nanoparticles in China, is explored as a new nano‐radioprotective agent for potent intestinal radioprotection. CNSI shows powerful radioprotective performance in the intestine under oral administration, including efficient free radical scavenging ability, good biosafety, high chemical stability, and relatively long retention time. For example, CNSI shows high reactive oxygen species (ROS) scavenging activities, which effectively alleviates the mitochondrial dysfunction and DNA double‐strand breaks to protect the cells against radiation‐induced damage. Most importantly, this efficient ROS scavenging ability greatly helps restrain the apoptosis of the small intestinal epithelial and crypt stem cells, which decreases the damage of the mechanical barrier and thus relieves radiation enteritis. Moreover, CNSI helps remove the free radicals in the intestinal microenvironment and thus maintain the balance of intestinal flora so as to mitigate the radiation enteritis. The finding suggests a new application of clinically approved carbon nanoparticles, which not only promotes the development of new intestinal radioprotector, but also has a great potential for clinical transformation. 相似文献
16.
Vivian Rachel Feig Helen Tran Minah Lee Kathy Liu Zhuojun Huang Levent Beker David G. Mackanic Zhenan Bao 《Advanced materials (Deerfield Beach, Fla.)》2019,31(39)
Due to their high water content and macroscopic connectivity, hydrogels made from the conducting polymer PEDOT:PSS are a promising platform from which to fabricate a wide range of porous conductive materials that are increasingly of interest in applications as varied as bioelectronics, regenerative medicine, and energy storage. Despite the promising properties of PEDOT:PSS‐based porous materials, the ability to pattern PEDOT:PSS hydrogels is still required to enable their integration with multifunctional and multichannel electronic devices. In this work, a novel electrochemical gelation (“electrogelation”) method is presented for rapidly patterning PEDOT:PSS hydrogels on any conductive template, including curved and 3D surfaces. High spatial resolution is achieved through use of a sacrificial metal layer to generate the hydrogel pattern, thereby enabling high‐performance conducting hydrogels and aerogels with desirable material properties to be introduced into increasingly complex device architectures. 相似文献
17.
Novel superabsorbent chitin/carboxymethylcellulose (CMC) hydrogels were successfully prepared from mixture of CMC and chitin solution dissolved in 8 wt% NaOH/4 wt% urea aqueous system at low temperature by crosslinking with epichlorohydrin. The morphology and structure of the resultant composite hydrogels were investigated by scanning electron microscope, thermogravimetry, and Fourier transform infrared spectroscopy. The results indicated that the stiff chains of chitin are as a strong backbone in the hydrogel to support the pore wall, whereas the CMC contributed to water absorption. The maximum swelling ratio in water reached an exciting level of 1300 as the hydrogels still kept an intact appearance. Moreover, the hydrogels exhibited smart swelling and shrinking behaviors in NaCl and CaCl2 aqueous solution, showing salt-responsive adsorption behaviors in different media. This work provided a “green” pathway to prepare chitin-based superabsorbent hydrogels, which would be potential for the application in the biodegradable water-absorbent material field. 相似文献
18.
Huijuan Liao Hanwei Zhang Weiliam Chen 《Journal of materials science. Materials in medicine》2009,20(6):1263-1271
Marine derived gelatin is not known to associate with any communicable diseases to mammals and could be a reasonable substitute
for gelatin derived from either bovine or porcine sources. The low melting point of marine gelatin (8°C) also offers greater
formulation flexibility than mammalian derived gelatins. However, the sub-optimal physical properties of marine gelatin generally
limit the interest to further develop it for biomedical applications. This study aimed at investigating the feasibility of
using oxidized alginate (Oalg) as a high activity macromolecular crosslinker of marine gelatin to formulate in situ gelable
hydrogels with the goal of enhancing the latter’s physical properties. The performance of Oalg/marine gelatin hydrogel was
compared to Oalg/porcine gelatin hydrogel; in general, the physicomechanical properties of both hydrogels were comparable,
with the hydrogels containing porcine gelatin exhibiting moderately higher mechanical strengths with shorter gelation times,
smaller size pores, and higher swelling ratios. On the contrary, the biological performances of the two hydrogels were significantly
difference. Cells cultured in the marine gelatin derived hydrogel grew significantly faster, with greater than 60% more cells
by 7 days and they exhibited more spread-out conformations as compared those cultured in the porcine derived hydrogel. Production
of ECM by cells cultured in the Oalg/marine gelatin hydrogel was up to 2.4 times greater than that of in the Oalg/porcine
gelatin hydrogel. The biodegradation rate of the hydrogel formulated from marine gelatin was greater than its counterpart
prepared from porcine gelatin. These differences have important implications in the biomedical applications of the two hydrogels.
Huijuan Liao and Hanwei Zhang are the first authors. 相似文献
19.
Bae WK Lee JH Lee SJ Park MS Hwang JE Shim HJ Cho SH Guo DD Cho CS Park IK Chung IJ 《Journal of nanoscience and nanotechnology》2011,11(2):1425-1428
Conjugated linoleic acid-coupled Pluronic F127 (Plu-CLA) is an effective drug delivery system with numerous advantages and anti-cancer activity. 5-FU administered in Plu-CLA hydrogel (P-FU) led to the significant enhancement of tumor growth suppression and cellular apoptosis. Moreover, growth of hepatic and intraperitoneal metastases in vivo was significantly reduced in mice treated with P-FU. Therefore, Plu-CLA could be a potential intraperitoneal carrier for hydrophilic 5-FU for the effective treatment of metastatic colon cancer. 相似文献