In order to meet the requirement of electric vehicles (EVs), hybrid electric vehicles (HEVs) and smart grids, effective energy storage devices will become imperative in the future energy technologies. However, it is necessary to further improve the energy density, rate performance and cycle performance of the energy storage devices. Zeolitic imidazolate framework-8 (ZIF-8) is a kind of porous materials that has attracted enormous attention due to its high surface areas, controllable structures and tunable pore sizes. Besides the applications in gas storage and separation, catalysis, sensor, and drug delivery, ZIF-8 is receiving increasing research interest in the field of electrochemical energy storage due to the advantage of synthetic method, such as simplicity and safety. By focusing on recent advances, we summarize the applications of ZIF-8 in electrical energy storage devices, such as rechargeable batteries and supercapacitors. We also list the current problems in applications and give the future study direction. 相似文献
Metal-organic framework (MOF) nanoparticles have recently emerged as a promising vehicle for drug delivery with high porosity and feasibility. However, employing a MOF-based drug delivery system remains a challenge due to the difficulty in controlling interfaces of particles in a biological environment. In this paper, protein corona-blocked Zr6-based MOF (PCN-224) nanoparticles are presented for targeted cancer therapy with high efficiency. The unmodified PCN-224 surface is precoated with glutathione transferase (GST)-fused targetable affibody (GST-Afb) proteins via simple mixing conjugations instead of chemical modifications that can induce the impairment of proteins. GST-Afb proteins are shown to stably protect the surface of PCN-224 particles in a specific orientation with GST adsorbed onto the porous surface and the GST-linked Afb posed outward, minimizing the unwanted interfacial interactions of particles with external biological proteins. The Afb-directed cell-specific targeting ability of particles and consequent induction of cell death is demonstrated both in vitro and in vivo by using two kinds of Afb, which targets the surface membrane receptor, human epidermal growth factor receptor 2 (HER2) or epidermal growth factor receptor (EGFR). This study provides insight into the way of regulating the protein-adhesive surface of MOF nanoparticles and designing a more effective MOF-hosted targeted delivery system. 相似文献
Hybrid solid-state electrolytes (HSSEs) provide new opportunities and inspiration for the realization of safer, higher energy-density metal batteries. The innovative application of 3‑dimensional printing in the electrochemical field, especially in solid-state electrolytes, endows energy storage devices with fascinating characteristics. In this paper, effective dendrite-inhibited PEO/MOFs HSSEs is innovatively developed through universal room-temperature 3‑dimensional printing (RT-3DP) strategy. The prepared HSSEs display enhanced dendrite inhibition due to the porous MOF filler promoting homogeneity of lithium deposition and the formation of C-OCO3Li, ROLi, LiF mesophases, which further improve the migration of Li+ in PEO chain and comprehensive performances. This universal strategy realizes the fabrication of different slurry components (PEO with ZIF-67, MOF-74, UIO-66, ZIF-8 fillers) HSSEs at RT environment, providing new inspirations for the exploration of next-generation advanced solid-state batteries. 相似文献
As an emerging strategy for the synthesis of metal-organic frameworks (MOFs), a microdroplet-based spray method holds merits of improved heat and mass transfer rates, which allows the formation of MOF crystals in a much faster manner. To optimize the spray route for the MOF synthesis, further exploration is needed to understand the dominant variables controlling the quality of the products. With a series of experiments and advanced computational analysis, we present here general guidance for the synthesis of representative zeolitic imidazolate frameworks (i.e., ZIF-8 and ZIF-67) using the spray route. 相似文献
Metal–organic frameworks (MOFs) have attracted a special attention due to outstanding porosity, adjustable pore sizes, and huge opportunities in varying organic–inorganic compositions. Enormous studies conducted so far on MOFs indicate their high potential in catalysis, gas adsorption, drug delivery, water treatment, energy storage, among others. However, mass production of MOFs is still limited mainly due to the non-economic, non-green and complex synthesis methods. Mechanochemistry is an alternative solution for efficient and environmentally friendly syntheses of various MOFs. Fast and solvent-free or solvent-less mechanosynthesis seems to be a very powerful versatile method for obtaining these advanced porous materials. The mechanochemical concept was used for the preparation of various MOFs including the most popular structures: MOF-5, ZIF-8, HKUST-1, MIL-101, UiO-66. These MOFs feature high specific surface areas, comparable to those prepared by conventional solvent-based methods. Furthermore, mechanochemistry was successfully used for the synthesis of non-conventional multimetallic MOFs and previously unreported solid phases. This review shows the recent developments, challenges and perspectives of green synthesis of diverse MOF structures using mechanochemistry. Besides describing the mechanochemical synthesis of MOFs, some achievements in green applications are also summarized. Importantly, current trends in research suggests for further development of these fields i.e., harmful gas adsorption, water treatment, and energy storage. 相似文献
Recently, sodium‐ion batteries (SIBs) are extensively explored and are regarded as one of the most promising alternatives to lithium‐ion batteries for electrochemical energy conversion and storage, owing to the abundant raw material resources, low cost, and similar electrochemical behavior of elemental sodium compared to lithium. Metal–organic frameworks (MOFs) have attracted enormous attention due to their high surface areas, tunable structures, and diverse applications in drug delivery, gas storage, and catalysis. Recently, there has been an escalating interest in exploiting MOF‐derived materials as anodes for sodium energy storage due to their fast mass transport resulting from their highly porous structures and relatively simple preparation methods originating from in situ thermal treatment processes. In this Review, the recent progress of the sodium‐ion storage performances of MOF‐derived materials, including MOF‐derived porous carbons, metal oxides, metal oxide/carbon nanocomposites, and other materials (e.g., metal phosphides, metal sulfides, and metal selenides), as SIB anodes is systematically and completely presented and discussed. Moreover, the current challenges and perspectives of MOF‐derived materials in electrochemical energy storage are discussed. 相似文献
Smart drug delivery nanocarriers with high drug loading capacity are of great importance in the treatment of diseases, and can improve therapeutic effectiveness as well as alleviate side effects in patients. In this work, a pH and H2O2-responsive drug delivery platform with high doxorubicin (DOX) loading capacity has been established through coordination interaction between DOX and phenylboronic acid containing block polymer. A composited drug nanocarrier is further fabricated by growing a zeolitic imidazolate framework 8 (ZIF-8) on the surface of drug-loaded polymer micelles. The study verifies that ZIF-8 shell can act as intelligent “switch” to prevent DOX leaking from core–shell nanoparticles upon H2O2 stimulus. However, a burst drug release is detected upon pH and H2O2 stimuli due to the further disassociation of ZIF-8 in acid solution. Moreover, the in vitro anti-cancer experiments demonstrate that the DOX-loaded core–shell nanoparticles provide effective treatment towards cancer cells but have negligible effect on normal cells, which results from the high concentration of H2O2 and low pH in the microenvironment of tumor cells. 相似文献
Transdermal drug delivery system (TDDS) was prepared with temperature-responsive hydrogel. The graphite was oxidized and incorporated into hydrogel matrix to improve the thermal response of hydrogel. The micro heater was fabricated to control the temperature precisely by adopting a joule heating method. The drug in hydrogel was delivered through a hairless mouse skin by controlling temperature. The efficiency of drug delivery was improved obviously by incorporation of graphite oxide due to the excellent thermal conductivity and the increased interfacial affinity between graphite oxide and hydrogel matrix. The fabricated micro heater was effective in controlling the temperature over lower critical solution temperature of hydrogel precisely with a small voltage less than 1 V. The cell viability test on graphite oxide composite hydrogel showed enough safety for using as a transdermal drug delivery patch. The performance of TDDS could be improved noticeably based on temperature-responsive hydrogel, thermally conductive graphite oxide, and efficient micro heater. 相似文献
Type II porous liquids are demonstrated to be promise porous materials. However, the category of porous hosts is very limited. Here, a porous host metal–organic polyhedra (MOP‐18) is reported to construct type II porous liquids. MOP‐18 is dissolved into 15‐crown‐5 as an individual cage (5 nm). Both the molecular dynamics simulations and experimental gravimetric CO2 solubility test indicate that the inner cavity of MOP‐18 in porous liquids is unoccupied by 15‐crown‐5 and is accessible to CO2. Thus, the prepared porous liquids show enhanced gas solubility. Furthermore, the prepared porous liquid is encapsulated into graphene oxide (GO) nanoslits to form a GO‐supported porous liquid membrane (GO‐SPLM). Owing to the empty cavity of MOP‐18 unit cages in porous liquids that reduces the gas diffusion barrier, GO‐SPLM significantly enhances the permeability of gas. 相似文献
To improve the aqueous solubility and cancer targeting of the photosensitizers in photodynamic therapy (PDT), we encapsulated the photosensitizer in a biocompatibility and pH-sensitive drug delivery system, zeolitic imidazolate frameworks-8 (ZIF-8) nanospheres. Powder X-ray diffraction and electron microscopy show that our nanospheres are uniform and single-crystalline particles. Owing to the cleavage of zinc–ligand coordination bonds, more ZnPc–COOH were released much faster in the mild acidic conditions (pH 5.0 and 6.0) in comparison with physiological environment (pH 7.4). By incorporating ZnPc–COOH in ZIF-8, our nanospheres exhibited high singlet oxygen quantum yield and intracellular ROS generation. Cell viability experiments toward HepG2 cells demonstrated the low toxicity of ZIF-8 and the good anticancer efficacy of the nanospheres with low IC50 values (4.2–4.9 μg/mL) under light illumination (670 nm, 1.5 J/cm2). Collectively, these results suggested that our nanospheres are the promising pH-responsive drug delivery systems for PDT. 相似文献
Pancreatic cancer is one of the most devastating cancers with poor prognosis and no significant change in the survival rate over the past decades. Localized targeted drug delivery through interventional endoscopic ultrasonography-guided fine-needle injection (EUS-FNI) is an attractive and minimally invasive strategy for inoperable pancreatic cancer. An injectable in-situ formed long-lasting drug delivery system is a promising alternative for the localized treatment of pancreatic cancer via EUS-FNI. Here, a biodegradable thermo-sensitive copolymer hydrogel for the co-delivery of anticancer agents gemcitabine (GEM) and cis-platinum (DDP) was developed. This hydrogel is a free flowable liquid at room temperature that changes into a semi-solid hydrogel following injection in response to the physiological temperature. Both in vitro and in vivo drug release behaviors indicate sustained drug release of this delivery system. Synergistic cellular proliferation inhibition and desirable apoptosis promotion have been found when pancreatic cancer Bxpc-3 cells were co-cultured with this GEM-DDP/hydrogel system. After a single intratumoral injection, the dual-drug loaded hydrogel formulation exhibited superior anti-tumor efficacy and minimized systemic side effect on pancreatic cancer xenograft mouse model in comparison to the intravenously injected free GEM and DDP combination. In addition, a strong synergistic therapeutic effect of the GEM-DDP/hydrogel system against pancreatic cancer has been found in vitro and in vivo compared to the single-drug loaded hydrogel composites. The obtained findings suggest this developed thermo-sensitive copolymer hydrogel system as a potential universal carrier for the localized targeted delivery of multi-drugs, for use in a variety of inoperable solid tumors.
The interplay of physical and chemical properties at the nanometer scale provides porous nanoparticles with unique sorption and interaction capabilities. These properties have aroused great interest toward this class of materials for application ranging from chemical and biological sensing to separation and drug delivery. However, so far the preferential uptake of different components of mixed solvents by porous nanoparticles is not measured due to a lack of methods capable of detecting the resulting change in physical properties. Here, a new method, nanomechanical mass correlation spectroscopy, is used to reveal an unexpected dependence of the effective mass density of porous metal–organic framework (MOF) nanoparticles on the chemistry of the solvent system and on the chemical functionalization of the MOF's internal surface. Interestingly, the pore size of the nanoparticles is much too large for the exclusion of small solvent molecules by steric hindrance. The variation of effective density of the nanoparticles with the solvent composition indicates that a complex solvent environment can form within or around the nanoparticles, which may substantially differ from the solvent composition. 相似文献
A chiral nanoporous metal-organic framework (MOF) with high porosity is obtained based on nontoxic zinc and achiral hexadentate ligand. It shows high drug loading and slow release of the proportion of the loaded drug with a complete delivery time of about one week when used as a material for adsorption and delivery of anticancer 5-fluorouracil. 相似文献
As one of the most promising localized drug delivery systems for enhancing therapeutic efficacy and reducing systemic toxicity, supramolecular hydrogels self-assembled from natural products have recently attracted tremendous attention. However, the intricate drug loading process, limited drug entrapment efficacy, and lack of stimulus responsiveness considerably impede their potential for biological applications and raise the need for advanced hydrogel-based delivery systems. Therefore, the development of updated materials that integrate localized delivery and drug activity into a single system is extremely desired and has great potential to overcome the aforementioned shortcomings. In this study, a pH-responsive dual-functional isoG-based supramolecular hydrogel with both localized delivery and anti-cancer activity in one molecule is successfully developed in one pot by following a simple and green procedure. The isoguanosine-phenylboronic-guanosine (isoGPBG) hydrogel exhibits exceptional stability (more than one year), outstanding pH-responsiveness and excellent sustained release capability. Both in vitro and in vivo experiments demonstrate that the isoGPBG hydrogel not only shows acceptable biocompatibility and biodegradability but also significantly inhibit tumor growth (approximately 60% inhibition of tumor growth) and improve overall survival, especially in preclinical patient-derived xenograft (PDX) model of oral squamous cell carcinoma (OSCC). Therefore, the isoGPBG hydrogel, to the best of our knowledge, is the first example of pH-responsive dual-functional isoG-based supramolecular hydrogel integrating localized delivery and anti-cancer activity in one molecule. It is implied that the isoGPBG hydrogel could act as a smart dual-functional localized delivery system in the future for clinical cancer therapy. 相似文献
Metal‐organic frameworks (MOFs) represent a new class of hybrid organic‐inorganic supramolecular materials comprised of ordered networks formed from organic electron donor linkers and metal cations. They can exhibit extremely high surface areas, as well as tunable pore size and functionality, and can act as hosts for a variety of guest molecules. Since their discovery, MOFs have enjoyed extensive exploration, with applications ranging from gas storage to drug delivery to sensing. This review covers advances in the MOF field from the past three years, focusing on applications, including gas separation, catalysis, drug delivery, optical and electronic applications, and sensing. We also summarize recent work on methods for MOF synthesis and computational modeling. 相似文献