A review of computer assisted detection/diagnosis (CAD) in breast thermography for breast cancer detection

Breast cancer is the leading type of cancer diagnosed in women. For years human limitations in interpreting the thermograms possessed a considerable challenge, but with the introduction of computer assisted detection/diagnosis (CAD), this problem has been addressed. This review paper compares different approaches based on neural networks and fuzzy systems which have been implemented in different CAD designs. The greatest improvement in CAD systems was achieved with a combination of fuzzy logic and artificial neural networks in the form of FALCON-AART complementary learning fuzzy neural network (CLFNN). With a CAD design based on FALCON-AART, it was possible to achieve an overall accuracy of near 90%. This confirms that CAD systems are indeed a valuable addition to the efforts for the diagnosis of breast cancer. Lower cost and high performance of new infrared systems combined with accurate CAD designs can promote the use of thermography in many breast cancer centres worldwide.     

A systematic survey of deep learning in breast cancer

In recent years, we witnessed a speeding development of deep learning in computer vision fields like categorization, detection, and semantic segmentation. Within several years after the emergence of AlexNet, the performance of deep neural networks has already surpassed human being experts in certain areas and showed great potential in applications such as medical image analysis. The development of automated breast cancer detection systems that integrate deep learning has received wide attention from the community. Breast cancer, a major killer of females that results in millions of deaths, can be controlled even be cured given that it is detected at an early stage with sophisticated systems. In this paper, we reviewed breast cancer diagnosis, detection, and segmentation computer-aided (CAD) systems based on state-of-the-art deep convolutional neural networks. The available data sets also indirectly determine CAD systems' performance, so we introduced and discussed the details of public data sets. The challenges remaining in CAD systems for breast cancer are discussed at the end of this paper. The highlights of this survey mainly come from three following aspects. First, we covered a wide range of the basics of breast cancer from imaging modalities to popular databases in the community; Second, we presented the key elements in deep learning to form the compactness for methods mentioned in reviewed papers; Third and lastly, the summative details in each reviewed paper are provided so that interested readers can have a refined version of these works without referring to original papers. Therefore, this systematic survey suits readers with varied backgrounds and will be beneficial to them.     

Detection of mitotic cells in breast cancer histopathological images using deep versus handcrafted features

One of the most important processes in the diagnosis of breast cancer, which is the leading mortality rate in women, is the detection of the mitosis stage at the cellular level. In literature, many studies have been proposed on the computer-aided diagnosis (CAD) system for detecting mitotic cells in breast cancer histopathological images. In this study, comparative evaluation of conventional and deep learning based feature extraction methods for automatic detection of mitosis in histopathological images are focused. While various handcrafted features are extracted with textural/spatial, statistical and shape-based methods in conventional approach, the convolutional neural network structure proposed on the deep learning approach aims to create an architecture that extracts the features of small cellular structures such as mitotic cells. Mitosis detection/counting is an important process that helps us assess how aggressive or malignant the cancer’s spread is. In the proposed study, approximately 180,000 non-mitotic and 748 mitotic cells are extracted for the evaluations. It is obvious that the classification stage cannot be performed properly due to the imbalanced numbers of mitotic and non-mitotic cells extracted from histopathological images. Hence, the random under-sampling boosting (RUSBoost) method is exploited to overcome this problem. The proposed framework is tested on mitosis detection in breast cancer histopathological images dataset provided from the International Conference on Pattern Recognition (ICPR) 2014 contest. In the results obtained with the deep learning approach, 79.42% recall, 96.78% precision and 86.97% F-measure values are achieved more successfully than handcrafted methods. A client/server-based framework has also been developed as a secondary decision support system for use by pathologists in hospitals. Thus, it is aimed that pathologists will be able to detect mitotic cells in various histopathological images more easily through necessary interfaces.

     

Automated breast cancer detection and classification using ultrasound images: A survey

Breast cancer is the second leading cause of death for women all over the world. Since the cause of the disease remains unknown, early detection and diagnosis is the key for breast cancer control, and it can increase the success of treatment, save lives and reduce cost. Ultrasound imaging is one of the most frequently used diagnosis tools to detect and classify abnormalities of the breast. In order to eliminate the operator dependency and improve the diagnostic accuracy, computer-aided diagnosis (CAD) system is a valuable and beneficial means for breast cancer detection and classification. Generally, a CAD system consists of four stages: preprocessing, segmentation, feature extraction and selection, and classification. In this paper, the approaches used in these stages are summarized and their advantages and disadvantages are discussed. The performance evaluation of CAD system is investigated as well.     

Computer-aided detection and classification of microcalcifications in mammograms: a survey

Breast cancer continues to be a significant public health problem in the world. Approximately, 182,000 new cases of breast cancer are diagnosed and 46,000 women die of breast cancer each year in the United States. Even more disturbing is the fact that one out of eight women in US will develop breast cancer at some point during her lifetime. Primary prevention seems impossible since the causes of this disease still remain unknown. Early detection is the key to improving breast cancer prognosis. Mammography is one of the reliable methods for early detection of breast carcinomas. There are some limitations of human observers, and it is difficult for radiologists to provide both accurate and uniform evaluation for the enormous number of mammograms generated in widespread screening. The presence of microcalcification clusters (MCCs) is an important sign for the detection of early breast carcinoma. An early sign of 30–50% of breast cancer detected mammographically is the appearance of clusters of fine, granular microcalcification, and 60–80% of breast carcinomas reveal MCCs upon histological examinations. The high correlation between the appearance of the microcalcification clusters and the diseases show that the CAD (computer aided diagnosis) systems for automated detection/classification of MCCs will be very useful and helpful for breast cancer control. In this survey paper, we summarize and compare the methods used in various stages of the computer-aided detection systems (CAD). In particular, the enhancement and segmentation algorithms, mammographic features, classifiers and their performances are studied and compared. Remaining challenges and future research directions are also discussed.     

面向乳腺超声计算机辅助诊断的两阶段深度迁移学习

目的 为了提升基于单模态B型超声（B超）的乳腺癌计算机辅助诊断（computer-aided diagnosis,CAD）模型性能,提出一种基于两阶段深度迁移学习（two-stage deep transfer learning,TSDTL）的乳腺超声CAD算法,将超声弹性图像中的有效信息迁移至基于B超的乳腺癌CAD模型之中,进一步提升该CAD模型的性能。方法 在第1阶段的深度迁移学习中,提出将双模态超声图像重建任务作为一种自监督学习任务,训练一个关联多模态深度卷积神经网络模型,实现B超图像和超声弹性图像之间的信息交互迁移;在第2阶段的深度迁移学习中,基于隐式的特权信息学习（learning using privilaged information,LUPI）范式,进行基于双模态超声图像的乳腺肿瘤分类任务,通过标签信息引导下的分类进一步加强两个模态之间的特征融合与信息交互;采用单模态B超数据对所对应通道的分类网络进行微调,实现最终的乳腺癌B超图像分类模型。结果 实验在一个乳腺肿瘤双模超声数据集上进行算法性能验证。实验结果表明,通过迁移超声弹性图像的信息,TSDTL在基于B超的乳腺癌诊断任务中取得的平均分类准确率为87.84±2.08%、平均敏感度为88.89±3.70%、平均特异度为86.71±2.21%、平均约登指数为75.60±4.07%,优于直接基于单模态B超训练的分类模型以及多种典型迁移学习算法。结论 提出的TSDTL算法通过两阶段的深度迁移学习,将超声弹性图像的信息有效迁移至基于B超的乳腺癌CAD模型,提升了模型的诊断性能,具备潜在的应用可行性。     

改进的稀疏深度置信网络

深度学习作为近年热门研究领域,具有极大的应用前景,但存在过拟合、欠拟合、隐藏层数和节点数选取等诸多问题。针对深度置信网络存在的过拟合问题,借鉴压缩感知理论和零范数的数学性质,构建了一种基于无均值高斯分布函数的稀疏深度置信网络。通过在预训练阶段添加稀疏正则项,进一步改进深度置信网络训练过程的方法加以解决过拟合问题。利用ORL和MINIST两种公开数据集上对该改进方案进行验证分析,结果表明其比现有的改进方案在稀疏性和准确性上有较大提升。     

Automatic nipple detection in breast thermograms

Breast cancer is one of the most dangerous diseases for women. Detecting breast cancer in its early stage may lead to a reduction in mortality. Although the study of mammographies is the most common method to detect breast cancer, it is outperformed by the analysis of thermographies in dense tissue (breasts of young women). In the last two decades, several computer-aided diagnosis (CAD) systems for the early detection of breast cancer have been proposed. Breast cancer CAD systems consist of many steps, such as segmentation of the region of interest, feature extraction, classification and nipple detection. Indeed, the nipple is an important anatomical landmark in thermograms. The location of the nipple is invaluable in the analysis of medical images because it can be used in several applications, such as image registration and modality fusion. This paper proposes an unsupervised, automatic, accurate, simple and fast method to detect nipples in thermograms. The main stages of the proposed method are: human body segmentation, determination of nipple candidates using adaptive thresholding and detection of the nipples using a novel selection algorithm. Experiments have been carried out on a thermograms dataset to validate the proposed method, achieving accurate nipple detection results in real-time. We also show an application of the proposed method, breast cancer classification in dynamic images, where the new nipple detection technique is used to segment the region of the two breasts from the infrared image. A dataset of dynamic thermograms has been used to validate this application, achieving good results.     

Implementing automated diagnostic systems for breast cancer detection

This paper intends to an integrated view of implementing automated diagnostic systems for breast cancer detection. The major objective of the paper is to be a guide for the readers, who want to develop an automated decision support system for detection of breast cancer. Because of the importance of making the right decision, better classification procedures for breast cancer have been searched. The classification accuracies of different classifiers, namely multilayer perceptron neural network (MLPNN), combined neural network (CNN), probabilistic neural network (PNN), recurrent neural network (RNN) and support vector machine (SVM), which were trained on the attributes of each record in the Wisconsin breast cancer database, were compared. The purpose was to determine an optimum classification scheme with high diagnostic accuracy for this problem. This research demonstrated that the SVM achieved diagnostic accuracies which were higher than that of the other automated diagnostic systems.     

Implementing automated diagnostic systems for breast cancer detection

This paper intends to an integrated view of implementing automated diagnostic systems for breast cancer detection. The major objective of the paper is to be a guide for the readers, who want to develop an automated decision support system for detection of breast cancer. Because of the importance of making the right decision, better classification procedures for breast cancer have been searched. The classification accuracies of different classifiers, namely multilayer perceptron neural network (MLPNN), combined neural network (CNN), probabilistic neural network (PNN), recurrent neural network (RNN) and support vector machine (SVM), which were trained on the attributes of each record in the Wisconsin breast cancer database, were compared. The purpose was to determine an optimum classification scheme with high diagnostic accuracy for this problem. This research demonstrated that the SVM achieved diagnostic accuracies which were higher than that of the other automated diagnostic systems.     

Using deep belief network to construct the agricultural information system based on Internet of Things

To study the impact of the agricultural information system based on the Internet of Things (IoT) on the income of agricultural products, an agricultural information system was constructed based on the agricultural IoT technology, and its impact on the income of agricultural products was discussed through the deep belief network. First, the relevant theories of agricultural IoT were introduced. Then, an agricultural information system based on agricultural IoT technology was constructed, and a deep belief network model was proposed. The vegetable prices and influencing factors were collected. The data were distributed in the range of 0–1 after normalization. The collinearity between the data was eliminated through principal component analysis. Then, the principal component analysis of vegetable prices and influencing factors from 2015 to 2019 was performed. A total of 96 sample data of calibration set and 24 sample data of test machine were collected. The optimal number of hidden layers of the deep belief network model and the number of nodes contained in the hidden layer were obtained through experiments. The results show that the first, second, and third hidden layers have 8, 6, and 10 nodes, respectively; the prediction accuracy of the deep belief network model is more accurate than that of the BP neural network and wavelet neural network. Besides, the absolute value of the prediction error of the deep belief model is within 0.1, which has good prediction accuracy. In short, the deep belief model has a good development prospect in agricultural product price forecasting, and it can provide relevant reference for the establishment and research of other agricultural product price forecasting models.

     

Early diagnosis of breast cancer by gene expression profiles

Breast cancer is the second leading cause of cancer death in women worldwide. Nevertheless, there is evidence that early detection and treatment can increase the survival rate of breast cancer patients. This paper presents an intelligent decision support system (IDSS) for breast cancer diagnosis by using gene expression profiles. The proposed system first extracts significant features from the input patterns by using information gain and then employs deep genetic algorithm for feature reduction as well as for breast cancer diagnosis. The proposed system is evaluated by considering a benchmark microarray dataset and compared with the most recent systems. The results show that the proposed IDSS outperforms other systems in terms of diagnosis time and accuracy. The proposed system produces 100 % classification accuracy. In addition, the proposed system reduces the required memory space.     

Deep feature extraction and classification of breast ultrasound images

Controlled despeckling (structure/edges/feature preservation with smoothing the homogeneous areas) is a desired pre-processing step for the design of computer-aided diagnostic (CAD) systems using ultrasound images as the presence of speckle noise masks diagnostically important information making interpretation difficult even for experienced radiologist. For efficiently classifying the breast tumors, the conventional CAD system designs use hand-crafted features. However, these features are not robust to the variations in size, shape and orientation of the tumors resulting in lower sensitivity. Thus deep feature extraction and classification of breast ultrasound images have recently gained attention from research community. The deep networks come with an advantage of directly learning the representative features from the images. However, these networks are difficult to train from scratch if the representative training data is small in size. Therefore transfer learning approach for deep feature extraction and classification of medical images has been widely used. In the present work the performance of four pre-trained convolutional neural networks VGG-19, SqueezeNet, ResNet-18 and GoogLeNet has been evaluated for differentiating between benign and malignant tumor types. From the results of the experiments, it is noted that CAD system design using GoogLeNet architecture for deep feature extraction followed by correlation based feature selection and fuzzy feature selection using ANFC-LH yields highest accuracy of 98.0% with individual class accuracy value of 100% and 96% for benign and malignant classes respectively. For differentiating between the breast tumors, the proposed CAD system design can be utilized in routine clinical environment.

     

乳腺X线图像计算机辅助诊断技术综述

近年来,乳腺癌严重威胁全球女性的身体健康,乳腺X线摄影是乳腺癌筛查的有效影像检查手段.乳腺X线图像计算机辅助诊断(computer aided diagnosis,CAD)运用计算机视觉、图像处理、机器学习等人工智能先进技术,自动分析处理乳腺X线图像,可为医生在临床中提供重要的诊断参考.主要面向肿块和微钙化病变检测、分...     

A deep ensemble network model for classifying and predicting breast cancer

Breast cancer is one of the leading causes of death among women worldwide. In most cases, the misinterpretation of medical diagnosis plays a vital role in increased fatality rates due to breast cancer. Breast cancer can be diagnosed by classifying tumors. There are two different types of tumors, such as malignant and benign tumors. Identifying the type of tumor is a tedious task, even for experts. Hence, an automated diagnosis is necessary. The role of machine learning in medical diagnosis is eminent as it provides more accurate results in classifying and predicting diseases. In this paper, we propose a deep ensemble network (DEN) method for classifying and predicting breast cancer. This method uses a stacked convolutional neural network, artificial neural network and recurrent neural network as the base classifiers in the ensemble. The random forest algorithm is used as the meta-learner for providing the final prediction. Experimental results show that the proposed DEN technique outperforms all the existing approaches in terms of accuracy, sensitivity, specificity, F-score and area under the curve (AUC) measures. The analysis of variance test proves that the proposed DEN model is statistically more significant than the other existing classification models; thus, the proposed approach may aid in the early detection and diagnosis of breast cancer in women, hence aiding in the development of early treatment techniques to increase survival rate.     

Computer aided detection system for micro calcifications in digital mammograms

Breast cancer continues to be a significant public health problem in the world. Early detection is the key for improving breast cancer prognosis. Mammogram breast X-ray is considered the most reliable method in early detection of breast cancer. However, it is difficult for radiologists to provide both accurate and uniform evaluation for the enormous mammograms generated in widespread screening. Micro calcification clusters (MCCs) and masses are the two most important signs for the breast cancer, and their automated detection is very valuable for early breast cancer diagnosis. The main objective is to discuss the computer-aided detection system that has been proposed to assist the radiologists in detecting the specific abnormalities and improving the diagnostic accuracy in making the diagnostic decisions by applying techniques splits into three-steps procedure beginning with enhancement by using Histogram equalization (HE) and Morphological Enhancement, followed by segmentation based on Otsu's threshold the region of interest for the identification of micro calcifications and mass lesions, and at last classification stage, which classify between normal and micro calcifications ‘patterns and then classify between benign and malignant micro calcifications. In classification stage; three methods were used, the voting K-Nearest Neighbor classifier (K-NN) with prediction accuracy of 73%, Support Vector Machine classifier (SVM) with prediction accuracy of 83%, and Artificial Neural Network classifier (ANN) with prediction accuracy of 77%.     

A Real-Time and Ubiquitous Network Attack Detection Based on Deep Belief Network and Support Vector Machine

In recent years, network traffic data have become larger and more complex, leading to higher possibilities of network intrusion. Traditional intrusion detection methods face difficulty in processing high-speed network data and cannot detect currently unknown attacks. Therefore, this paper proposes a network attack detection method combining a flow calculation and deep learning. The method consists of two parts: a real-time detection algorithm based on flow calculations and frequent patterns and a classification algorithm based on the deep belief network and support vector machine (DBN-SVM). Sliding window (SW) stream data processing enables real-time detection, and the DBN-SVM algorithm can improve classification accuracy. Finally, to verify the proposed method, a system is implemented. Based on the CICIDS2017 open source data set, a series of comparative experiments are conducted. The method’s real-time detection efficiency is higher than that of traditional machine learning algorithms. The attack classification accuracy is 0.7 percentage points higher than that of a DBN, which is 2 percentage points higher than that of the integrated algorithm boosting and bagging methods. Hence, it is suitable for the real-time detection of high-speed network intrusions.      

经典YOLO系列目标检测算法及其在乳腺癌检测中的应用

目前乳腺癌已取代肺癌成为年发病率最高的癌症, 基于深度学习的目标检测技术可对乳腺X线、乳腺超声和乳腺核磁共振等非侵入式成像进行自动病变检测, 已成为乳腺癌辅助诊断的首选途径. YOLO (you only look once)系列算法是基于深度学习的目标检测算法, 经典YOLO算法在速度和精准度具有优势, 被广泛应用于计算机视觉各领域, 最新YOLO算法是计算机视觉领域的SOTA (state of the art)模型, 如何利用YOLO系列算法提高乳腺癌检测速度和准确率, 已经成为研究者关注的焦点之一. 基于此, 本文介绍经典YOLO系列算法的原理, 梳理经典YOLO系列算法在乳腺癌图像检测中的应用现状, 并归纳总结现存问题, 同时对YOLO系列算法在乳腺癌检测的进一步应用进行展望.     

基于深度学习的早期火灾预警算法

传统火灾预警方法存在检测精度低、未发生火灾时不能及时预警的问题,提出一种基于深度学习的早期火灾预警算法.首先,使用红外热像仪采集特定场景中的红外图像,构建数据集;其次,使用改进的YOLOv4算法进行训练得到网络权重,在主干网络的3个输出特征层后引入卷积注意力模块,提升网络对关键信息的提取能力;在主干网络和路径聚合网络中增加卷积层,提高特征提取的能力;最后,使用提出的智能火灾检测(intelligent fire detection, IFD)算法对预测图像处理并根据得分评估火灾隐患.实验结果表明,改进YOLOv4算法在数据集上的mAP达到98.31%,比原始YOLOv4算法的mAP提高了2.7%, FPS达到37.1 f/s, IFD算法精确度为93%,误检率为3.2%.提出的早期火灾预警算法具有检测精度高,未形成火灾时及时预警的优点.     

应用于CT图像肺结节检测的深度学习方法综述

肺癌是世界上死亡率最高的癌症，通过胸部CT影像检测肺结节对肺癌早期诊断和治疗意义重大。为了减轻放射科医生的工作量以及同时减少误诊率和漏诊率，研究人员提出了计算机辅助检测（CAD）系统辅助放射科医生检测和诊断肺结节。目前，研究人员正在尝试不同的深度学习技术，以提高计算机辅助诊断系统在基于CT图像的肺癌筛查中的性能。这项工作回顾了作为肺癌检测的CAD系统目前典型的深度学习的算法和框架，主要从数据集介绍、2D深度学习方法、3D深度学习方法、数据不平衡问题的处理、模型训练方法以及模型可解释性这六个方面进行介绍。最后，对各个方法的主要特点和算法性能进行了综合比较分析，并对如何提高结节检测性能进行了展望。