An efficient diagnosis system for detection of Parkinson’s disease using fuzzy k-nearest neighbor approach

In this paper, we present an effective and efficient diagnosis system using fuzzy k-nearest neighbor (FKNN) for Parkinson’s disease (PD) diagnosis. The proposed FKNN-based system is compared with the support vector machines (SVM) based approaches. In order to further improve the diagnosis accuracy for detection of PD, the principle component analysis was employed to construct the most discriminative new feature sets on which the optimal FKNN model was constructed. The effectiveness of the proposed system has been rigorously estimated on a PD data set in terms of classification accuracy, sensitivity, specificity and the area under the receiver operating characteristic (ROC) curve (AUC). Experimental results have demonstrated that the FKNN-based system greatly outperforms SVM-based approaches and other methods in the literature. The best classification accuracy (96.07%) obtained by the FKNN-based system using a 10-fold cross validation method can ensure a reliable diagnostic model for detection of PD. Promisingly, the proposed system might serve as a new candidate of powerful tools for diagnosing PD with excellent performance.     

Machine learning technique for early detection of Alzheimer’s disease

Microsystem Technologies - Alzheimer’s disease (AD) is non-repairable brain disorder which impacts a person’s thinking along with shrinking the size of the brain, ultimately resulting...     

Machine learning Ensemble for the Parkinson’s disease using protein sequences

Multimedia Tools and Applications - The most challenging issue in diagnosing and treating neurological disorders is gene identification that causes the disease. Classification of the genes that...     

Speech-based solution to Parkinson’s disease management

Parkinson’s disease (PD) is a neurological disorder marked by decreased dopamine levels in the brain. Persons suffering from PD, exhibits vocal symptoms such as dysphonia and dysarthria. Speech impairments in PD are grouped together and called as hypokinetic dysarthria. Traditional PD management is based on a patient’s clinical history and through physical examination as there are currently no known biomarkers for its diagnosis. Automatic analysis techniques aid clinicians in diagnosis and monitoring patients using speech and provide frequent, cost effective and objective assessment. This paper presents pilot experiment to detect presence of dysarthria in speech and detect level of severity based on deep learning approach. Automated feature extraction and classification using convolutional neural network shows 77.48% accuracy on test samples of TORGO database with five fold validation. Using transfer learning, system performance is further analyzed for gender specific performance as well as in detection of severity of disease.

     

User interface design guidelines for smartphone applications for people with Parkinson’s disease

Parkinson’s disease (PD) is often responsible for difficulties in interacting with smartphones; however, research has not yet addressed these issues and how these challenge people with Parkinson’s (PwP). This paper specifically investigates the symptoms and characteristics of PD that may influence the interaction with smartphones to then contribute in this direction. The research was based on a literature review of PD symptoms, eight semi-structured interviews with healthcare professionals and observations of PwP, and usability experiments with 39 PwP. Contributions include a list of PD symptoms that may influence the interaction with smartphones, a set of experimental results that evaluated the performance of four gestures tap, swipe, multiple-tap, and drag and 12 user interface design guidelines for creating smartphone user interfaces for PwP. Findings contribute to the work of researchers and practitioners’ alike engaged in designing user interfaces for PwP or the broader area of inclusive design.     

Statistical methods for analysis of Parkinson’s disease gait pattern and classification

Multimedia Tools and Applications - Understanding the human gait and extracting intrinsic feature helps to classify walking patterns of Parkinson disease patients. The measurement of time series...     

Cloud based framework for Parkinson’s disease diagnosis and monitoring system for remote healthcare applications

Speech signal processing and its recognition system have gained a lot of attention from last few years due to its widespread application. In this paper, a novel approach is proposed for diagnosis and monitoring the Parkinson’s Disease (PD) which is the second most severe neurological disease in the world. PD is a neurodegenerative disease which impairs person’s balance, motor skills, speech, and other characteristics such as decision making process, emotions, and sensation. Here, we proposed a cloud based framework for detecting and monitoring Parkinson patients that will enable healthcare service in low resource setting. In the developing countries, where most of the people do not get proper healthcare services and are not well aware of Parkinson’s disease, let alone detecting and getting healthcare for PD, this system can be very practical and useful. For this system, the patients of rural areas, patients from the regions where doctors are not available, can communicate to the doctors only if they have internet connections in their smart phones to access the cloud. Doctors can check and detect patient’s PD by checking their voice disorders or Dysphonia over cloud. With this system, a PD patient can be easily detected and diagnosed by giving their voice samples through their phones, regardless of their location. Based on the evaluation, our proposed systems are avail to achieve 96.6% accuracy in the cloud environment for detecting PD. It is expected that the proposed framework will have great potential to enable healthcare service for PD patients, who live in remote areas, especially in developing countries.     

A novel PBL-McRBFN-RFE approach for identification of critical brain regions responsible for Parkinson’s disease

In this paper, we present a novel approach for the identification of critical brain regions responsible for Parkinson’s disease (PD) based on magnetic resonance images (MRI) using meta-cognitive radial basis function network (McRBFN) classifier with Recursive Feature Elimination (RFE). The McRBFN classifier uses voxel based morphometric (VBM) features extracted from MRI and employs a projection based learning (PBL) algorithm. The meta-cognitive learning present in PBL-McRBFN helps in selecting proper samples to learn based on its current knowledge and evolve the architecture automatically. Since, the classifier developed using PBL-McRBFN is efficient, we propose recursive feature elimination approach (called PBL-McRBFN-RFE) to identify most relevant brain regions responsible for PD prediction.The study has been conducted using the Parkinson’s Progression Markers Initiative (PPMI) data set. First, we conducted the study on PD prediction using the PBL-McRBFN classifier on the PPMI data set. We have also compared the results of the PBL-McRBFN classifier with the support vector machine (SVM) classifier. The study results clearly show that the PBL-McRBFN classifier produces better generalization performance on PD prediction. Finally, we use RFE approach with PBL-McRBFN to identify the brain regions responsible for PD. The PBL-McRBFN-RFE selected features indicate that the loss of gray matter in the superior temporal gyrus region may be responsible for the onset of PD, and is consistent with the earlier findings from medical research studies.     

Multiclass classification of Parkinson’s disease using cepstral analysis

This paper addressees the problem of an early diagnosis of PD (Parkinson’s disease) by the classification of characteristic features of person’s voice knowing that 90% of the people with PD suffer from speech disorders. We collected 375 voice samples from healthy and people suffer from PD. We extracted from each voice sample features using the MFCC and PLP Cepstral techniques. All the features are analyzed and selected by feature selection algorithms to classify the subjects in 4 classes according to UPDRS (unified Parkinson’s disease Rating Scale) score. The advantage of our approach is the resulting and the simplicity of the technique used, so it could also extended for other voice pathologies. We used as classifier the discriminant analysis for the results obtained in previous multiclass classification works. We obtained accuracy up to 87.6% for discrimination between PD patients in 3 different stages and healthy control using MFCC along with the LLBFS algorithm.     

Analysis of multiple types of voice recordings in cepstral domain using MFCC for discriminating between patients with Parkinson’s disease and healthy people

In this study, we wanted to discriminate between two groups of people. The database used in this study contains 20 patients with Parkinson’s disease (PD) and 20 healthy people. Three types of sustained vowels (/a/, /o/ and /u/) were recorded from each participant and then the analyses were done on these voice samples. The technique used in this study is to extract voiceprint from each voice samples by using mel frequency cepstral coefficients (MFCCs). The extracted MFCC were compressed by calculating their average value in order to extract the voiceprint from each voice recording. Subsequently, a classification method was performed using leave one subject out (LOSO) validation scheme along with support vector machines (SVMs). We also used an independent test to validate our results by using another database which contains 28 PD patients. Based on the research result, the best obtained classification accuracy using LOSO on the first dataset was 82.50 % using MLP kernel of SVM on sustained vowel /u/. And the maximum classification accuracy using the independent test was 100 % using sustained vowel /a/ with polynomial kernel of the SVM and with MLP kernel of the SVM. This result was also achieved using sustained vowel /o/ with polynomial kernel of the SVM.     

Analysis of vertical eye movements in Parkinson’s disease and its potential for diagnosis

Applied Intelligence - It is well known that eye movements are highly affected by Parkinson’s disease. The majority of studies related to effects of Parkinson’s disease on eye movements...     

An efficient classification approach for detection of Alzheimer’s disease from biomedical imaging modalities

Multimedia Tools and Applications - The complex patterns of the neuroimaging data are analyzed successfully with bio-medical imaging applications. The patients with/without AD can be discriminated...     

Automatic classification and prediction models for early Parkinson’s disease diagnosis from SPECT imaging

Early and accurate diagnosis of Parkinson’s disease (PD) is important for early management, proper prognostication and for initiating neuroprotective therapies once they become available. Recent neuroimaging techniques such as dopaminergic imaging using single photon emission computed tomography (SPECT) with ¹²³I-Ioflupane (DaTSCAN) have shown to detect even early stages of the disease. In this paper, we use the striatal binding ratio (SBR) values that are calculated from the ¹²³I-Ioflupane SPECT scans (as obtained from the Parkinson’s progression markers initiative (PPMI) database) for developing automatic classification and prediction/prognostic models for early PD. We used support vector machine (SVM) and logistic regression in the model building process. We observe that the SVM classifier with RBF kernel produced a high accuracy of more than 96% in classifying subjects into early PD and healthy normal; and the logistic model for estimating the risk of PD also produced high degree of fitting with statistical significance indicating its usefulness in PD risk estimation. Hence, we infer that such models have the potential to aid the clinicians in the PD diagnostic process.     

Analysis of medications change in Parkinson’s disease progression data

Parkinson’s disease is a neurodegenerative disorder that affects people worldwide. Careful management of patient’s condition is crucial to ensure the patient’s independence and quality of life. This is achieved by personalized treatment based on individual patient’s symptoms and medical history. The aim of this study is to determine patient groups with similar disease progression patterns coupled with patterns of medications change that lead to the improvement or decline of patients’ quality of life symptoms. To this end, this paper proposes a new methodology for clustering of short time series of patients’ symptoms and prescribed medications data, and time sequence data analysis using skip-grams to monitor disease progression. The results demonstrate that motor and autonomic symptoms are the most informative for evaluating the quality of life of Parkinson’s disease patients. We show that Parkinson’s disease patients can be divided into clusters ordered in accordance with the severity of their symptoms. By following the evolution of symptoms for each patient separately, we were able to determine patterns of medications change which can lead to the improvement or worsening of the patients’ quality of life.     

Insight into an unsupervised two-step sparse transfer learning algorithm for speech diagnosis of Parkinson’s disease

Neural Computing and Applications - Speech diagnosis of Parkinson’s disease (PD) as a non-invasive and simple diagnosis method is particularly worth exploring. However, the number of samples...     

Fuzzy approach for intrusion detection based on user’s commands

The article concerns the problem of detecting masqueraders in computer systems. A masquerader in a computer system is an intruder who pretends to be a legitimate user in order to gain access to protected resources. The article presents an intrusion detection method based on a fuzzy approach. Two types of user’s activity profiles are proposed along with the corresponding data structures. The solution analyzes the activity of the computer user in a relatively short period of time, building a user’s profile. The profile is based on the most recent activity of the user, therefore, it is named the local profile. Further analysis involves creating a more general structure based on a defined number of local profiles of one user, called the fuzzy profile. It represents a generalized behavior of the computer system user. The fuzzy profiles are used directly to detect abnormalities in users’ behavior, and thus possible intrusions. The proposed solution is prepared to be able to create user’s profiles based on any countable features derived from user’s actions in computer system (i.e., used commands, mouse and keyboard data, requested network resources). The presented method was tested using one of the commonly available standard intrusion data sets containing command names executed by users of a Unix system. Therefore, the obtained results can be compared with other approaches. The results of the experiments have shown that the method presented in this article is comparable with the best intrusion detection methods, tested with the same data set, in the matter of the obtained results. The proposed solution is characterized by a very low computational complexity, which has been confirmed by experimental results.     

CRIM’s content-based audio copy detection system for TRECVID 2009

We report results on audio copy detection for TRECVID 2009 copy detection task. This task involves searching for transformed audio queries in over 385?h of test audio. The queries were transformed in seven different ways, three of them involved mixing unrelated speech to the original query, making it a much more difficult task. We give results with two different audio fingerprints and show that mapping each test frame to the nearest query frame (nearest-neighbor fingerprint) results in robust audio copy detection. The most difficult task in TRECVID 2009 was to detect audio copies using predetermined thresholds computed from 2008 data. We show that the nearest-neighbor fingerprints were robust to even this task and gave actual minimal normalized detection cost rate (NDCR) of around 0.06 for all the transformations. These results are close to those obtained by using the optimal threshold for each transform. This result shows the robustness of the nearest-neighbor fingerprints. These nearest-neighbor fingerprints can be efficiently computed on a graphics processing unit, leading to a very fast search.