0Cr18Ni9不锈钢冷轧卷碱洗工艺参数的正交试验

 首次选用CIE1976 L*a*b*色空间中的总色差ΔE*作为0Cr18Ni9不锈钢冷轧卷碱洗工艺后表面质量的评价指标。在简述表色系统CIE1976 L*a*b*色空间及色差公式测量原理和测量方法的基础上,用TC PⅡG全自动测色色差计测量了不锈钢板表面颜色。并对碱洗工艺参数进行了正交试验和方差分析,通过F检验判定出各工艺参数的显著性及其顺序,最后给出了碱洗工艺参数的最佳结果。碱洗最佳工艺条件为：碱洗配方80%NaOH+20%NaNO3、碱洗温度550 ℃、碱洗时间25 s。因子显著性顺序为：碱洗温度>碱洗配方>碱洗时间。碱洗时间因子不显著,可作为连续生产线调控参数,依据生产线速度和碱洗槽长度设置碱洗时间。     

Photography and densitometry to measure skin pigmentation caused by ultraviolet exposure

This was a project that a final year physiotherapy student was undertaking. Part of the project required the measurement of skin pigmentation before and after treatment with a standard E2 UV dose. The measurement of skin redness was undertaken using an erythema meter, and it was necessary to use photographic and densitometric techniques to measure skin pigmentation. The results of this experiment proved to be consistent with other published papers on the way that skin types react on exposure to standard UV doses. This paper describes the photographic method and procedures that were used and the way the raw data was treated so that it could be used for statistical analysis by the physiotherapy student.     

Ethnic stratification in northwest China: occupational differences between Han Chinese and national minorities in Xinjiang, 1982-1990

Skin color of free flaps can represent their vascular conditions after reconstructive surgery. Thus far, however, surgeons have subjectively inspected flap color changes. More precise and objective measurement is necessary for early detection of vascular insufficiency. In order to evaluate color changes of flaps we used a portable non-contact type colorimeter with a L*a*b* color space (L* is brightness and a*, b* are chromaticness) recommended by the CIE (Commission Internationale d'Eclairage). Initially, we successfully performed objective evaluation of flap color changes in rats with or without a tied femoral artery or vein. Vein failure showed a decrease in a* and b* soon after surgery, while the artery failure appeared as b* and L* after 12 and 24 hours, respectively. Then, the color differences between sites of clinical free flaps were examined and considered to be relatively negligible against the time-dependent changes using delta a*, delta b*, delta L*, which represents the difference in color of an objective point from a control point. Next, we demonstrated that the color of abdominal skin did not significantly differ from that of forearm skin using delta a*, delta b*, delta L*. The clinical free flaps were measured with these parameters pre- and post-operatively and their normal course of color changes was revealed. The findings showed that a* changed with characteristic ups and downs before and after elevation due to congestion.     

MR image-guided portal verification for brain treatment field

PURPOSE: To investigate a method for the generation of digitally reconstructed radiographs directly from MR images (DRR-MRI) to guide a computerized portal verification procedure. METHODS AND MATERIALS: Several major steps were developed to perform an MR image-guided portal verification procedure. Initially, a wavelet-based multiresolution adaptive thresholding method was used to segment the skin slice-by-slice in MR brain axial images. Some selected anatomical structures, such as target volume and critical organs, were then manually identified and were reassigned to relatively higher intensities. Interslice information was interpolated with a directional method to achieve comparable display resolution in three dimensions. Next, a ray-tracing method was used to generate a DRR-MRI image at the planned treatment position, and the ray tracing was simply performed on summation of voxels along the ray. The skin and its relative positions were also projected to the DRR-MRI and were used to guide the search of similar features in the portal image. A Canny edge detector was used to enhance the brain contour in both portal and simulation images. The skin in the brain portal image was then extracted using a knowledge-based searching technique. Finally, a Chamfer matching technique was used to correlate features between DRR-MRI and portal image. RESULTS: The MR image-guided portal verification method was evaluated using a brain phantom case and a clinical patient case. Both DRR-CT and DRR-MRI were generated using CT and MR phantom images with the same beam orientation and then compared. The matching result indicated that the maximum deviation of internal structures was less than 1 mm. The segmented results for brain MR slice images indicated that a wavelet-based image segmentation technique provided a reasonable estimation for the brain skin. For the clinical patient case with a given portal field, the MR image-guided verification method provided an excellent match between features in both DRR-MRI and portal image. Moreover, target volume could be accurately visualized in the DRR-MRI and mapped over to the corresponding portal image for treatment verification. The accuracy of DRR-MRI was also examined by comparing it to the corresponding simulation image. The matching results indicated that the maximum deviation of anatomical features was less than 2.5 mm. CONCLUSION: A method for MR image-guided portal verification of brain treatment field was developed. Although the radiographic appearance in the DRR-MRI is different from that in the portal image, DRR-MRI provides essential anatomical features (landmarks and target volume) as well as their relative locations to be used as references for computerized portal verification.     

Measurement of skin color: practical application and theoretical considerations

Quantification of erythema and/or pigmentation is important for in vivo assessment of skin reactions to external stimuli such as ultraviolet radiation. Measurement of lesional color is also useful for quantitative evaluation of the efficacy of therapies for skin lesions. Several types of portable optoelectronic instruments have recently become available for these purposes and have been applied to research in dermatology, physiology, pharmacology, and cosmetic science. As color is not a genuine physical quantity but a sensory perception based on color vision, any colorimetric data obtained for the skin should be interpreted carefully. Erythema and melanin indices derived from skin reflectance data should also be evaluated in relation to the optical properties of the skin to avoid misuse. In this article, various methods for quantifying skin color and related parameters are reviewed and the characteristics of each method are discussed theoretically using an optical model of the skin.     

联合多种边缘检测算子的无参考质量评价算法

提出了一种联合多种边缘检测算子的无参考质量评价算法,同时考虑一阶和二阶边缘算子,避免了单一算子的局限性.该方法首先将彩色图像转换为灰度图像,然后计算灰度图像的梯度,相对梯度以及LOG特征.本文所使用的特征分为两部分,一部分提取相对梯度方向的标准差,另一部分利用条件熵来量化不同特征之间的相似性和相互关系,并且考虑到人眼特性进行多尺度计算,最后使用自适应增强（AdaBoost）神经网络进行训练和预测.在公共数据库LIVE和TID2008上进行实验,结果表明新方法对失真图像的预测评分与主观评分有较高的一致性,能很好地反映图像质量的视觉感知效果,仅使用10维特征,性能优于现有的主流无参考质量评价算法.      

Concrete Column Recognition in Images and Videos

The automated detection of structural elements (e.g., columns and beams) from visual data can be used to facilitate many construction and maintenance applications. The research in this area is under initial investigation. The existing methods solely rely on color and texture information, which makes them unable to identify each structural element if these elements connect each other and are made of the same material. The paper presents a novel method of automated concrete column detection from visual data. The method overcomes the limitation by combining columns’ boundary information with their color and texture cues. It starts from recognizing long vertical lines in an image/video frame through edge detection and Hough transform. The bounding rectangle for each pair of lines is then constructed. When the rectangle resembles the shape of a column and the color and texture contained in the pair of lines are matched with one of the concrete samples in knowledge base, a concrete column surface is assumed to be located. This way, one concrete column in images/videos is detected. The method was tested using real images/videos. The results are compared with the manual detection ones to indicate the method’s validity.     

Relationship between the amount of propranolol permeating through the stratum corneum of guinea pig skin after application of propranolol adhesive patches and skin irritation

In the present study we evaluated the relationship between the cumulative amount of propranolol permeating through the stratum corneum and the formation of erythema, a skin irritation reaction, after transdermal application of adhesive patches containing propranolol to the skin of guinea pigs. The intensity of erythema was expressed in terms of a* values measured with a chromameter. The a* values increased in guinea pigs after application of the adhesive patches containing 0.4 mg/cm2 of propranolol to the skin. Since the adhesive patches showed good adhesion to the skin (propranolol content is less than the saturated concentration in the adhesive base) and the cumulative amount of propranolol permeating through the stratum corneum is small, the development of erythema was considered to be mainly due to physical factors such as peeling. Even in adhesive patches containing 0.8 mg/cm2 or 1.2 mg/cm2 of propranolol, a* values increased, although adhesion to the skin is low because of crystallization of propranolol in the adhesive base. On the other hand, in these two adhesive patches, the cumulative amount of propranolol permeating through the stratum corneum increased up to 24 h after application. These findings suggest that the skin irritation reaction is due to propranolol mainly absorbed transdermally, because there is a high correlation between the cumulative amount of propranolol permeating through the stratum corneum and the a* values (r = 0.928).     

Central mechanism of an extensive analgesic effect due to strong electroacupuncture of acupoint on spinal dorsal horn neurons]

Experiments were performed on male rats. The responses of dorsal horn convergent neurons in spinal cord (T12-L1) to noxious stimulation of hind paw were recorded extracellularly with glass microelectrode. When low intensity (2 V) electroacupuncture (EA) was used, the nociceptive responses of convergent neurons were inhibited by EA at "Zusanli" near noxious stimulation area, but not at "Xiaguan" far from the area. When intensity (18 V) high than the threshold of C fibers EA was applied at the far acupoint "Xiaguan", obvious analgesic effects on convergent neurons were also produced, showing an extensive analgesic effect of strong EA at acupoint. This extensive analgesic effect was abdicated by lesion of nucleus raphe magnus (NRM), but still persisted to some extent by EA at the same segment acupoint "Zusanli" with 18 V or 2 V intensity. The results suggest that, the extensive analgesia of strong EA at far segment acupoint may be mainly mediated by noxious stimulation through NRM, a negative feedback mechanism modulating pain of supraspinal cord. The analgesia due to 2 V EA at the same segment acupoint may be mainly produced by gate control in spinal cord, but also to some extend by supraspinal cord mechanism.     

Radiosurgery and microsurgery for AVMs

We developed a method of velocity-coded color MR angiography using a color code from the data obtained from velocity-phase images of phase-contrast MR angiography in order to add flow direction information to MR angiograms. Phase-contrast MR angiography with reconstruction of velocity-phase images was performed in 30 patients. Two projection images from velocity-phase images of each phase-contrast MR angiogram were obtained and assigned color according to flow direction. We then superimposed the two color images onto the maximum intensity projection image of the MR angiogram. The velocity-coded color MR angiogram clearly showed flow direction from the data on the phase-contrast MR angiogram of the neck. Veins were readily distinguishable from arteries, and flow changes, such as a subclavian steal, were also identified.     

Retinal vessels before and after photocoagulation in diabetic retinopathy. Determining the diameter using digitized color fundus slides

BACKGROUND: Retinal vessel diameter is an important parameter in blood flow analysis. Despite modern digital image technology, most clinical studies investigate diameters subjectively using projected fundus slides or negatives. In the present study we used a technique to examine vessel diameters by digital image analysis of color fundus slides. We investigated in a retrospective manner diameter changes in twenty diabetic patients before and after panretinal laser coagulation. MATERIAL AND METHODS: Color fundus slides were digitized by a new high resolution scanning device. The resulting images consisted in three channels (red, green, blue). Since vessel contrast was the highest in the green channel, we assessed grey value profiles perpendicular to the vessels in the green channel. Diameters were measured at the half-height of the profile. RESULTS: After panretinal laser coagulation, average venous diameter was decreased, whereas arterial diameter remained unchanged. There was no significant relation between the diameter change and the number of laser burns or the presence of neovascularization. CONCLUSIONS: Splitting digitized images into color planes enables objective measurements of retinal diameters in conventional color slides.     

The contribution of color to visual memory in X-chromosome-linked dichromats

We used a recognition memory paradigm to assess the visual memory of X-chromosome-linked dichromats for color images of natural scenes. The performance of 17 protanopes and 14 deuteranopes, who lack the second (red-green opponent) subsystem of color vision, but retain the primordial (yellow-blue opponent) subsystem, was compared with that of 36 color normal observers. During the presentation phase, 48 images of natural scenes were displayed on a CRT for durations between 50 and 1000 msec. Each image was followed by a random noise mask. Half of the images were presented in color and half in black and white. In the subsequent query phase, the same 48 images were intermixed with 48 new images and the subjects had to indicate which of the images they had already seen during the presentation phase. We find that the performance of the color normal observers increases with exposure duration. However, they perform 5-10% better for colored than for black and white images, even at exposure durations as short as 50 msec. Surprisingly, performance is not impaired for the dichromats, whose recognition performance is also better for colored than for black and white images. We conclude either that X-chromosome-linked dichromats may be able to compensate for their reduced chromatic information range when viewing complex natural scenes or that the chromatic information in most natural scenes, for the durations tested, is sufficiently represented by the surviving primordial color subsystem.     

A novel MR angiography technique: SPEED acquisition using half-Fourier RARE

A novel MR angiography (MRA) method, swap phase encode extended data (SPEED), was developed. Two one-shot images with the phase-encode directions swapped were collected within a single breath-hold period and processed with a maximum intensity projection (MIP) to obtain an image. In this study, a long echo train two-dimensional rapid acquisition with relaxation enhancement (RARE) sequence with half-Fourier (half-RARE) was used to obtain the pulmonary MRA images. The MIP image obtained using the SPEED technique presented promising results for pulmonary vessels.     

Hemostatic efficacy of a fibrin sealant dressing in an animal model of kidney injury

Arterial spin tagging techniques have been used to image tissue perfusion in MR without contrast injection or ionizing radiation. Currently, spin tagging studies are performed primarily using single-slice imaging sequences, which are time consuming. This note reports a multislice echo-planar arterial spin tagging technique (Simultaneous Multislice Acquisition with aRterial-flow Tagging, or "SMART"). Multiband RF encoding (Hadamard) is used to provide simultaneous multislice acquisition capability for spin tagging techniques (such as echo planar imaging signal targeting with alternating radio frequency and flow-sensitive alternative inversion recovery). The method is illustrated with a two-slice pulse sequence that was implemented using the FAIR technique to generate two perfusion weighted images simultaneously. Compared with single-slice sequences, this two-slice sequence provided similar image quality, signal-to-noise ratio, and twice the spatial coverage compared with the single-slice technique within the same scan time.     

Functional MRI study of thalamic and cortical activations evoked by cutaneous heat, cold, and tactile stimuli

Positron emission tomography studies have provided evidence for the involvement of the thalamus and cortex in pain and temperature perception. However, the involvement of these structures in pain and temperature perception of individual subjects has not been studied in detail with high spatial resolution imaging. As a first step toward this goal, we have used functional magnetic resonance imaging (fMRI) to locate discrete regions of the thalamus, insula, and second somatosensory cortex (S2) modulated during innocuous and noxious thermal stimulation. Results were compared with those obtained during tactile stimulation of the palm. High resolution functional images were acquired on a 1.5 T echospeed GE MR system with an in-plane resolution of 1.7 mm. A modified peltier-type thermal stimulator was used to deliver innocuous cool and warm and noxious cold and hot stimuli for 40-60 s to the thenar eminence of normal male and female volunteers. Experimental paradigms consisted of four repetitions of interleaved control and task stimuli. A pixel by pixel statistical analysis of images obtained during each task versus control (e.g., noxious heat vs. warm, warm vs. neutral temperature, etc.) was used to determine task-related activations. Painful thermal stimuli activated discrete regions within the lateral and medial thalamus, and insula, predominantly in the anterior insula in most subjects, and the contralateral S2 in 50% of subjects. The innocuous thermal stimuli did not activate the S2 in any of the subjects but activated the thalamus and posterior insula in 50% of subjects. By comparison, innocuous tactile stimulation consistently activated S2 bilaterally and the contralateral lateral thalamus. These data also demonstrate that noxious thermal and innocuous tactile-related activations overlap in S2. The data also suggest that innocuous and noxious-related activations may overlap within the thalamus but may be located in different regions of the insula. Therefore, we provide support for a role of the anterior insula, S2, and thalamus in the perception of pain; whereas the posterior insula appears to be involved in tactile and innocuous temperature perception. These data demonstrate the feasibility of using fMRI for studies of pain, temperature, and mechanical stimuli in individual subjects, even in small regions such as thalamic nuclei. However, the intersubject variability should be considered in future single subject imaging studies and studies that rely on averaged group responses.     

Two-dimensional blood flow determinations in allergic reactions using laser Doppler scanning

The new technique of laser Doppler scanning (LDS) provides a 2-dimensional pattern of cutaneous microcirculation, which offers a visual image and can quantify the intensity and expansion of perfusion. With the help of this technique, we examined the microcirculatory pattern of Type IV reactions to recall antigens, which were applied using a test stamp (Multitest Merieux). The measurements were performed before application of the test stamp as well as 10 min, 24, 48 and 72 h afterwards. The inflammatory hyperemia was evaluated using LDS and unidimensional laser Doppler fluxmetry. The diameter of the inflammatory infiltrate was quantified by means of palpation, the thickness by means of high-resolution 20 MHz sonography. The clinically visible erythema was measured planimetrically. An unspecific hyperemia resulting from the trauma of the stamp revealed no evident infiltrate under sonography 10 min after the test application. Depending of the individual reaction, the mean flux and the expansion of the hyperemia were at their peak after 48 h. The flux values were at a maximum in the center of the inflammatory reaction and dropped continuously toward the periphery. The area of the hyperemia seen in the LDS image was significantly larger than the expansion of the erythema measured planimetrically, but there was a significant correlation. The perfusion correlated significantly with the infiltration diameter (24 h, 48 h, 72 h) and the infiltration thickness 48 h after testing. All in all, it was possible to measure directly and without touching the skin and to quantify a subclinical pattern of skin perfusion as a response to and inflammatory reaction on a 2-dimensional display.     

Basic principles and historical consideration of MR cholangiopancreatography

Basic principle of MR cholangiopancreatography (MRCP) is heavily T2-weighted imaging (hydrography) to use bile and pancreatic juice as "natural contrast medium". Firstly developed sequence for MRCP was a CE-FAST sequence, which employed time-reversed FID signal. The current most popular sequences for MRCP are single-shot fast spin-echo sequences, which are divided into three types (2D single slice, 2D mutiple slice and 3D methods). The advantage of 2D single slice method is conveniently obtained projection imaging within a few seconds of examination time. Both 2D multiple slice and 3D methods consists of a MIP image and a series of source images. The MIP image creates global images of pancreatico-biliary system. The source images provide detailed evaluation of various anatomical structures and abnormalities. By using these sequences properly, MRCP can yield valuable informations of pancreatico-biliary diseases non-invasively.     

Anesthetic depth defined using multiple noxious stimuli during isoflurane/oxygen anesthesia. I. Motor reactions

BACKGROUND: Potency of inhaled anesthetics usually is defined by determining the minimal alveolar concentration (MAC) that prevents movement in 50% of patients in response to skin incision. Skin incision, however, is usually only a single event and, thus, determination of potency cannot be repeated in one patient. Traditional MACskin incision cannot be used to predict response to other noxious stimuli. The aim of this study was to investigate the effects of other noxious stimulation patterns and then compare these to MACskin incision measuring the end-tidal isoflurane concentrations with the corresponding arterial concentrations. METHODS: In 26 patients, the end-tidal and corresponding arterial isoflurane concentrations needed to suppress eye opening to verbal command and motor response after trapezius squeeze, 50 Hz electric tetanic stimulation, laryngoscopy, skin incision, and tracheal intubation in 50% of all patients were determined. RESULTS: The end-tidal (equivalent arterial) isoflurane concentrations (mean +/- SE, adjusted to sea level) expressed in vol% (to allow comparison) increased in the following order (mean +/- SE): vocal command 0.37 +/- 0.09 (0.36 +/- 0.09); trapezius squeeze 0.84 +/- 0.07 (0.65 +/- 0.07); laryngoscopy 1.00 +/- 0.12 (0.78 +/- 0.09); tetanic stimulation 1.03 +/- 0.09 (0.80 +/- 0.06); skin incision 1.16 +/- 0.10 (0.97 +/- 0.17); and intubation 1.76 +/- 0.13 (1.32 +/- 0.11). CONCLUSIONS: Different stimuli require different isoflurane concentrations to suppress motor responses. Tetanic stimulation and, to some extent, trapezius squeeze are reproducible and noninvasive stimulation patterns that can be used as an alternative to skin incision when evaluating potency of an anesthetic agent. In contrast to skin incision, they can be repeated.     

Simultaneous face lifting and skin resurfacing

Although face lifting and skin resurfacing both produce dramatic facial rejuvenations, the simultaneous combination has never been popularized. The development of new methods of lifting and resurfacing may now allow a reevaluation of this combination. The objective was to evaluate the safety and efficacy of this combined face lift and skin resurfacing. The facial skin was resurfaced with a trichloroacetic acid peel or a "short-pulse" CO2 laser and, then, lifted after liposuction and superficial musculoaponeurotic system tightening. A dramatic rejuvenation was produced in these 25 cases. There were no incidents of persistent erythema, pigmentation, hyperpigmentation, or full-thickness flap necrosis. Side effects were the usual sequelae of edema and ecchymoses. The small areas of "dusky" erythema of the skin flaps were no more significant than those after a face lift alone. By following the guidelines developed in this report, the combination of controlled skin resurfacing with face lifting is safe and effective. Other procedures, such as blepharoplasties, can also be added. After one recovery period of 6 to 8 weeks, these patients reported that they looked 15 to 20 years younger. The complexion continued to improve during the 1-year follow-up period.     

"Anatometabolic" tumor imaging: fusion of FDG PET with CT or MRI to localize foci of increased activity

Positron emission tomographic (PET) images of visceral cancers are commonly visualized as "hot spots" of increased activity with relatively little normal anatomy discernable, when 2-[18F]-fluoro-2-deoxy-D-glucose (FDG) is used as the tracer. We describe a method by which computed tomography or magnetic resonance anatomic images can be digitally fused in three dimensions, using a rigid rotate-translate scale model with PET "metabolic" images, to simultaneously display registered anatomic and metabolic information. Such "anatometabolic" fusion images were produced in 10 patients with a variety of visceral cancers. External fiducial markers placed during both the anatomic and the metabolic study, as well as internal anatomic fiducials defined from landmarks observed on reconstructed transmission images, were used to achieve image fusion. The mean error magnitude +/- s.e.m. of fiducial registration in the nine patients with successful realignments was 5.0 +/- 0.8 mm. The mean accuracy in realignment between known anatomic structures seen on both the anatomic study and on the emission PET scan (but not used in realignment) was 6.3 +/- 0.8 mm. Localization of foci of increased FDG uptake to specific anatomic structures was achieved by this method, which represented an enhancement over the rudimentary anatomy available from the emission images alone. Anatometabolic fusion images made using this reasonably simple method should prove useful in the management of patients with cancer and other diseases.