Dietary behavior during obesity

Human alimentary behavior deals with a threefold need: energetic, hedonic and sociocultural. Among the clinical constellation offered by obese patients it could be worthwile to distinguish: 1. Some constitutional and organic obesities, pathogenesis of which does not imply an abnormality of alimentary behavior; 2. Conversely, in some other cases, psychological induced behavioral abnormalities are able to lead to an overstepping of the so called "normal" weight; 3. In other instances, the alimentary behavior reflects the elevation of the set point for weight. All these mechanisms are mutally reinforcing and could act simultaneously or successively accounting for the great variability of the individual situations. In any case environmental conditions are operating and play a pathogenic role more especially as the anatomic, physiologic and psychologic background is predisposed.     

Dietary carbohydrate and atherosclerosis

Epidemiologic evidence indicated a relationship between refined sugar intake and increased serum cholesterol levels and atherosclerotic heart disease, which resulted in a series of human and animal experiments examining this relationship. Sucrose and fructose were found to be more atherogenic in rabbits and baboons when fed as part of a semipurified diet. However, serum lipid levels were not always elevated when more severe atherosclerosis was present. Human studies generally observed increases in serum triglycerides and, less consistently, serum cholesterol in response to substitution of sucrose for starch or glucose. These differences in lipid levels and experimental atherosclerosis are thought to arise from 1) increased endogenous triglyceride synthesis, present in serum as very low-density lipoproteins; 2) impaired clearance of these lipoproteins; 3) slowed turnover of cholesterol into bile acids; and 4) possible changes in aortic connective tissue metabolism.     

Dietary fat and body composition

Vascular endothelial growth factor (VEGF) is a cytokine that induces angiogenesis. Angiogenesis is a prominent histologic component of the luteinization process. Luteinization is also characterized by granulosa cell progesterone secretion in response to the luteinizing hormone (LH) surge. Local VEGF production in human pre-ovulatory follicles, induced by LH, was postulated to be a luteinization mediator in women. To investigate this hypothesis, serum and fluid from the dominant follicle of 31 healthy regularly cycling multiparous women undergoing laparoscopic sterilization were obtained. VEGF was measured by enzyme-linked immunosorbent assay, and LH and progesterone were measured by radioimmunoassay. Follicle aspiration was performed at a median of 13 days from the last menstrual period (range 11-17 days). The median pre-ovulatory follicle diameter was 16 mm (range 11-23 mm). Follicle fluid VEGF concentrations (mean 6900 pg/ml, range 1200-17 100 pg/ml) were correlated positively with follicle fluid progesterone concentrations (mean 10 176 nmol/l, range 636-66780 nmol/l, r=0.62, P=0.002). This correlation was even tighter (r=0.87, P < 0.0001) when only samples from the 22 women in the earliest stages of follicle luteinization were considered. In these women serum LH concentrations were also correlated with follicle fluid VEGF concentrations (r=0.51, P=0.02). Our findings demonstrate the close dynamic relationship between VEGF production and early luteinization in human follicles during normal non-stimulated cycles.     

Dietary modulation of avian coccidiosis

During the past several years, our laboratory has been investigating the anticoccidial activities of various natural products that have potential use as dietary supplements for coccidiosis control. Sources of fats containing high concentrations of n-3 fatty acids such as menhaden oil and flaxseed oil and flaxseed, when added to starter rations and fed to chicks from one day of age, effectively reduce lesions caused by the caecal parasite Eimeria tenella, but not lesions caused by Eimeria maxima. Our results are consistent with reports of effects of diets high in n-3 fatty acids on other protozoan parasites which suggest that the state of oxidative stress induced by these diets in the cells of both host and parasites is responsible for their parasitic actions. Artemisinin, a naturally occurring (Artemisia annua) endoperoxide and effective antimalarial significantly lowers lesions from E. tenella when given at low levels as a feed additive. The mechanism of its action is also considered to involve induction of oxidative stress. Diets supplemented with 8 p.p.m. gamma-tocopherol (abundant in flaxseeds) or with 1% of the spice tumeric, reduce mid-small intestinal lesion scores and improve weight gains during E. maxima infections. These compounds may exert their anticoccidial activity because they are effective antioxidants. Betaine, a choline analogue found in high concentrations in sugar beets, improves nutrient utilisation by animals under stress. When provided as a dietary supplement at a level of 0.15% it has enhanced the anticoccidial activity of the ionophore, salinomycin. Betaine may act as an osmoprotectant whereby it improves the integrity and function of the infected intestinal mucosa. In in vivo studies, betaine plus salinomycin significantly inhibit invasion of both E. tenella and E. acervulina. However, subsequent development of E. acervulina is inhibited more effectively with this combination treatment than development of E. tenella.     

Dietary L-arginine in renal disease

The amino acid L-arginine is a substrate for at least three products involved extensively in tissue injury and fibrosis. L-arginine is metabolized to L-proline, a major constituent of the collagen that makes up fibrotic extracellular matrix. L-arginine is a precursor for polyamines, which are required for proliferative responses characteristic of many renal disease. L-arginine is also the sole substrate for generation of nitric oxide (NO) which, produced in large quantities by macrophages, has been implicated in tissue injury. On the other hand, NO produced in small quantities by endothelium is a critical vasodilator. Given the importance of elevated intraglomerular pressure in renal injury, it is perhaps not surprising that dietary L-arginine supplementation increase NO generation and is beneficial in reducing intraglomerular pressure and subsequent disease. Other data, based on the therapeutic effects of low protein diets, have suggested that L-arginine restriction limits NO-mediated glomerular injury and greatly reduces matrix accumulation, consistent with the idea that limitation of substrate effectively diminishes injurious NO levels, polyamine synthesis, and collagen production.     

Dietary interventions of human carcinogenesis

The diet is a complex mixture that is associated with approximately 30% of human cancer in the U.S. Extensive laboratory studies indicate that the diet is composed of many mutagens/carcinogens as well as antimutagens/anticarcinogens. Overwhelming evidence from epidemiological studies indicates that a diverse diet that is high in fruits and vegetables and low in certain fats, along with moderate caloric intake and exercise, is most closely associated with reduced cancer risk. Dietary intervention studies using complex food items (fruits, vegetables, and fats) support these epidemiological observations; dietary interventions using single compounds (vitamins, antioxidants, etc.) have generally not. Estimates suggest that appropriate dietary changes could reduce the percentage of deaths due to prostate, colorectal, pancreatic, and breast cancer by >/=50%.     

Dietary self-selection by animals.

A growing awareness of the biological context of learning and revelations of long-delay learning in the feeding system have stimulated psychologists' interests in the areas of poison avoidance and food aversion. However, relatively little attention has been given to the intimately related area of dietary self-selection. This review covers the literature on dietary selection from various fields including psychology, nutrition, physiology, and agriculture. It is organized methodologically along 2 lines: the method of diet presentation and the method of inducing a nutritional need. The bulk of the existing literature consists of demonstrations of dietary selection. Future studies should proceed beyond simple demonstration to elucidation of underlying mechanisms and factors effecting food selection by animals. Suggestions are made for research on dietary selection by psychologists from such areas as comparative, perceptual, and physiological psychology. (51/2 p ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Dietary fatty acids and blood coagulation

Factor VII coagulant activity (VIIc) is a risk factor for coronary heart disease (CHD). Plasma VIIc is positively associated with dietary fat intake, suggesting that fat-rich diets are accompanied by a hypercoagulable state. Reduction in total fat consumption is followed by a decrease in VIIc within 24 h. In adults taking diets rich in long-chain saturated fatty acids, a postprandial increase in VIIc occurs after a fatty meal irrespective of its fat composition. This effect has dose-response characteristics, persists for several hours, and is due to activation of factor VII. There is no acute effect of dietary fat on factor VII antigen (VIIag) concentration, but VIIag is positively related to dietary fat intake. More studies are needed on the effects of dietary fat composition on fasting and postprandial factor VII. Dietary fat appears to influence both the atherosclerotic and thrombogenic components of CHD.