Multiple jeopardy: risk and protective factors among addicted mothers' offspring

Objectives of this study were to ascertain risk and protective factors in the adjustment of 78 school-age and teenage offspring of opioid- and cocaine-abusing mothers. Using a multimethod, multiinformant approach, child outcomes were operationalized via lifetime psychiatric diagnoses and everyday social competence (each based on both mother and child reports), and dimensional assessments of symptoms (mother report). Risk/protective factors examined included the child sociodemographic attributes of gender, age, and ethnicity, aspects of maternal psychopathology, and both mother's and children's cognitive functioning. Results revealed that greater child maladjustment was linked with increasing age, Caucasian (as opposed to African American) ethnicity, severity of maternal psychiatric disturbance, higher maternal cognitive abilities (among African Americans) and lower child cognitive abilities (among Caucasians). Limitations of the study are discussed, as are implications of findings for future research.     

Validity of the 1994 Strong Interest Inventory with racial and ethnic groups in the United States.

During the revision of the 1994 Strong Interest Inventory (SII; Harmon, Hansen, Borgen & Hammer, 1994), information was obtained about the race–ethnicity and careers of over 55,000 employed adults in 50 different occupations. The national norm group, the general reference sample, contains 18,789 individuals who identified their race–ethnicity in the following manner: 378 African Americans; 363 Asian Americans; 17,365 Caucasian Americans; 349 Hispanic Americans/Latinos (Latinas); and 77 Native Americans/American Indians. Concurrent validity across racial–ethnic groups was examined by typing their 50 occupations into the appropriate Holland (1997) job family. Then the General Occupational Themes, the SII scales corresponding to Holland's (1997) 6 vocational personality types, were examined for their ability to predict Holland (1997) job family in similar ways for the different racial–ethnic groups. Results generally showed comparable validity and interpretive counseling implications in using the SII with these racial–ethnic groups. Some interesting trends and important limitations were also noted. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Linoleate impairs collagen synthesis in primary cultures of avian chondrocytes

Several extended major histocompatability complex (MHC) haplotypes are associated with susceptibility to autoimmune disease in Caucasian populations. It is known that African Americans and Afro-Caribbeans are ethnic groups descended from west, central and southern black African populations which are admixed with Caucasians. To examine the possible association of some marker of Caucasian MHC genes and susceptibility to rheumatoid arthritis (RA) in African Americans, we studied extended MHC haplotypes (HLA-B, complement and DR) in a sample of 18 African American and Afro-Caribbean probands with RA, their first degree relatives and in 15 non-RA families. We defined 36 disease-associated RA haplotypes among the probands and 96 normal haplotypes in normal individuals. To obtain the most conservative estimate, we excluded recognized Caucasian, DR4-bearing, extended MHC haplotypes from the analysis. Admixture proportions for non-HLA-DR4 extended MHC haplotypes of known Caucasian origin among RA-associated and normal haplotypes were computed (0.40 versus 0.163 respectively). When we compared the difference in proportions between RA and normal haplotypes, the proportion of extended MHC haplotypes of known Caucasian origin was significantly increased among RA-associated haplotypes (Z = 3.16, p (one sided) < 0.001, p (adjusted) < 0.008). Our results suggest that racial admixture with Caucasian MHC genes may augment RA susceptibility and thus may be one mechanism to explain the higher prevalence of RA in African Americans and Afro-Caribbeans than in black African populations.     

Recruitment and retention of African American patients for clinical research: An exploration of response rates in an urban psychiatric hospital.

The issues related to recruiting African American psychiatric inpatients are discussed in the context of a study on the influence of ethnicity on psychiatric diagnosis. Ethnically diverse psychiatric residents interviewed 960 Black and White inpatients in 2 urban psychiatric hospitals. Despite the obstacles cited in the literature about recruiting and retaining African Americans into research, 78% of this sample were African American. In addition, interview completion and refusal rates did not differ by patient ethnicity. Results suggest that matching interviewer and patient ethnicity did not influence African Americans' likelihood of participating in or of refusing an interview. This article summarizes a number of guidelines that others may find useful in conducting clinical research with African Americans, ranging from the formation of academic-public liaisons to interviewer training. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Chronic stress burden, discrimination, and subclinical carotid artery disease in African American and Caucasian women.

This study examined the association between a composite index of stress that included measures of life events, ongoing stress, discrimination, and economic hardship and subclinical carotid disease among 109 African American and 225 Caucasian premenopausal women. African Americans reported more chronic stress and had higher carotid intima-media thickness (IMT) as compared with Caucasians. Among African Americans only, the composite stress index and unfair treatment were associated with higher IMT. These effects were partially mediated by biological risk factors. African Americans who reported experiencing racial discrimination had marginally more carotid plaque than did those who did not report experiencing racial discrimination. The results suggest that African Americans may be particularly vulnerable to the burden of chronic stress. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Childhood socioeconomic status is associated with psychosocial resources in African Americans: The Pittsburgh Healthy Heart Project.

Objective: To determine whether lower childhood socioeconomic status (SES) was associated with fewer psychosocial resources independent of adult SES, and whether these associations differed by race/ethnicity. Method: Cross-sectional study of 342 middle-aged (M = 60.5 ± 4.7) African American (n = 49) and Caucasian (n = 293) adults. Childhood SES and adult SES were assessed via highest parental education and participant education, respectively. Participants completed: (a) 6 days of ecological momentary assessment via electronic diaries to assess social support and the number of social interactions and (b) self-report measures of social support, social network diversity, and coping—specifically, active, planning, and emotion focused coping. Results: The interaction term for childhood SES and race/ethnicity significantly predicted several psychosocial resources. Lower childhood SES was associated with less perceived social support in daily life, a less diverse social network, and more limited use of proactive coping strategies in adulthood among African Americans, regardless of adult SES. Comparable associations were not observed among Caucasians. Conclusions: Childhood SES is associated with psychosocial resources in adulthood among African Americans, independent of SES in adulthood. Given emerging associations between childhood SES and health in adulthood, future studies to disentangle the role of psychosocial resources as a mediating pathway and to further examine racial/ethnic variations across these associations are warranted. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Rethinking individualism and collectivism: Evaluation of theoretical assumptions and meta-analyses.

Are Americans more individualistic and less collectivistic than members of other groups? The authors summarize plausible psychological implications of individualism-collectivism (IND-COL), meta-analyze cross-national and within-United States IND-COL differences, and review evidence for effects of IND-COL on self-concept, well-being, cognition, and relationality. European Americans were found to be both more individualistic--valuing personal independence more--and less collectivistic--feeling duty to in-groups less--than others. However, European Americans were not more individualistic than African Americans, or Latinos, and not less collectivistic than Japanese or Koreans. Among Asians, only Chinese showed large effects, being both less individualistic and more collectivistic. Moderate IND-COL effects were found on self-concept and relationality, and large effects were found on attribution and cognitive style. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Age and education effects on relationships of cognitive test scores with brain structure in demographically diverse older persons.

This study examined how age and education influence the relationship between neuropsychological test scores and brain structure in demographically diverse older adults spanning the range from normal cognition to dementia. A sample of 351 African Americans, 410 Hispanics, and 458 Whites underwent neuropsychological testing. Volumetric magnetic resonance imaging (MRI) measures of total brain, white matter hyperintensity, and hippocampus were available for 79 African Americans, 102 Hispanics, and 134 Whites. The authors used latent variable modeling to examine effects of age, education, and brain volumes on test scores and determine how much variance brain volumes explained in unadjusted and age- and education-adjusted scores. Age adjustment resulted in weaker relationships of test scores with MRI variables; adjustment for ethnicity yielded stronger relationships. Education adjustment increased relationships with MRI variables in the combined sample and Hispanics, made no difference in Whites, but decreased some associations in African Americans. Results suggest that demographic adjustment is beneficial when demographic variables are strongly related to test scores independent of measures of brain structure, but adjustment has negative consequences when effects of demographic characteristics are mediated by brain structure. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A multicultural assessment of adolescent connectedness: Testing measurement invariance across gender and ethnicity.

Counselors, psychologists, and evaluators of intervention programs for youth increasingly view the promotion of connectedness as an important intervention outcome. When evaluating these programs, researchers frequently test whether the treatment effects differ across gender and ethnic or racial groups. Doing so necessitates the availability of culturally and gender-invariant measures. We used the Hemingway: Measure of Adolescent Connectedness to estimate the factor structure invariance and equality of means across gender and 3 racial/ethnic groups with a large sample of middle school adolescents. From a practical perspective, the 10-scale model suggested factor structure invariance across gender and racial or ethnic (i.e., African American, Caucasian, and Latina/o) groups of adolescents. However, tests for partial invariance revealed some group difference on the factor loadings and intercepts between gender and ethnic/racial groups. When testing for mean equivalence, girls reported higher connectedness to friends, siblings, school, peers, teachers, and reading but lower connectedness to their neighborhoods. Caucasians reported higher connectedness to their neighborhoods and friends but lower connectedness to siblings than African Americans and Latinos. African Americans reported the highest connectedness to self (present and future) but lowest connectedness to teachers. Latinos reported the lowest connectedness to reading, self-in-the-present, and self-in-the-future. Overall, this study reveals racial/ethnic and gender mean differences on several connectedness subscales and suggests the Hemingway subscales are, from a practical perspective, invariant across gender and ethnicity and therefore appropriate for most assessment and evaluation purposes. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Unfair treatment is associated with poor sleep in African American and Caucasian adults: Pittsburgh SleepSCORE project.

Objective: To test the association between self-reported unfair treatment and objective and self-reported sleep characteristics in African American and Caucasian adults. Design: Cross-sectional study of 97 African American and 113 Caucasian middle-aged adults. Main Outcome Measures: Participants completed: (a) two-night in-home, polysomnography (PSG) sleep study, (b) sleep diaries and actigraph assessments across 9 days and nights, and (c) self-report measures of sleep quality in the past month, and daytime sleepiness in the past 2 weeks. Results: Greater unfair treatment was associated with reports of poorer self-reported sleep quality and greater daytime sleepiness, shorter sleep duration, and lower sleep efficiency as measured by actigraphy and PSG, and a smaller proportion of rapid eye movement (REM) sleep. Racial/ethnic differences were few. Exploratory analyses showed that nightly worry partially mediated the associations of unfair treatment with sleep quality, daytime sleepiness, sleep efficiency (actigraphy), and proportion of REM sleep. Conclusion: Perceptions of unfair treatment are associated with sleep disturbances in both African American and Caucasian adults. Future studies are needed to identify the pathways that account for the association between unfair treatment and sleep. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

The role of familism in stress and coping processes among African American and White dementia caregivers: Effects on mental and physical health.

Objective: To explore how familism, burden, and coping styles mediate the relationships between ethnicity and the mental and physical health of caregivers. Design: A probability sample of 65 White and 95 African Americans respondents caring for an older family member with dementia was used to test hypotheses from a sociocultural stress and coping model using path analysis. Main outcome measures: Measures of caregivers' health included subjective health, self-reported diseases, blood pressure, and heart rate. Mental health measures included self-reported depression and psychological symptoms. Results: Contrary to the hypothesis, familism had an adverse effect on outcomes and was related to low education levels rather than to African American ethnicity. A buffering effect of active coping between being African American and diastolic blood pressure was found even after controlling for levels of education. Conclusions: Findings supported a core stress and coping model in which more behavior problems of care recipients were associated with poorer mental health of caregivers via greater burden and more use of avoidant coping. Results also demonstrate that this core model can be extended to physical health. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Severity of homelessness and adverse birth outcomes.

Predictors and the prevalence of adverse birth outcomes among 237 homeless women interviewed at 78 shelters and meal programs in Los Angeles in 1997 were assessed. It was hypothesized that they would report worse outcomes than national norms, that African Americans would report the worst outcomes because of their greater risk in the general population, and that homelessness severity would independently predict poorer outcomes beyond its association with other adverse conditions. Other predictors included reproductive history, behavioral and health-related variables, psychological trauma and distress, ethnicity, and income. African Americans and Hispanics reported worse outcomes than are found nationally, and African Americans reported the worst outcomes. In a predictive structural equation model, severity of homelessness significantly predicted low birth weight and preterm births beyond its relationship with prenatal care and other risk factors. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Exposure of hepatic sinusoidal mononuclear cells to UW solution in situ but not ex vivo induces apoptosis

OBJECTIVES: To determine the influence of race or ethnicity on serum prostate-specific antigen (PSA) levels and PSA density (PSAD) in a population of healthy men without clinically evident prostate cancer. METHODS: This retrospective study was conducted between January 1988 and January 1993. The serum PSA levels were measured in 859 men (586 African Americans, 142 whites, and 131 Hispanics) who were participants in a prostate cancer screening program or had urinary symptoms suggestive of prostate gland pathology. All men underwent a detailed clinical examination, including digital rectal examination, serum PSA determination, and transrectal ultrasound (TRUS). None of the subjects included had clinical or TRUS evidence of prostate cancer (furthermore, 283 men were pathologically proved to be cancer-free by prostate biopsies). Serum PSA levels and PSA densities as a function of each individual's ethnic background were determined. RESULTS: The mean serum PSA level in African Americans was 2.1 ng/mL, which was significantly higher than that of whites (mean PSA of 1.53 ng/mL) and Hispanics (mean PSA of 1.83 ng/mL) (P = 0.003). Similar differences among the three groups were observed in PSA density (the mean PSAD was 0.078, 0.057, and 0.065 for African Americans, whites, and Hispanics, respectively). A separate analysis for the biopsy-negative men was performed, and the findings were consistent with the observations for the entire study group. After adjustment for age and prostate volume, the differences remained statistically significant. CONCLUSIONS: Among men without evidence of prostate cancer, African Americans have higher serum PSA levels and PSA densities than do whites or Hispanics. Race or ethnicity was an independent factor that affected serum PSA levels even after adjustment for age and prostate volume.     

Cultural differences in optimism, pessimism, and coping: Predictors of subsequent adjustment in Asian American and Caucasian American college students.

Cultural differences were examined between 111 Asian American and 111 Caucasian American students matched on age and sex in a prospective design study. Using separate optimism and pessimism scores, Asian Americans were found to be more pessimistic than Caucasian Americans. Asian Americans were also found to use more problem avoidance and social withdrawal coping strategies than Caucasian Americans. When health outcomes were assessed 6 weeks later, Asian Americans were found to report more depressive and psychological symptoms, but not more physical symptoms, than Caucasian Americans. Results of separate regression analyses for each ethnic group indicated that along with different coping strategies, lack of optimism predicted all 3 health outcomes for Asian Americans, whereas pessimism predicted 2 of the 3 health outcomes for Caucasian Americans. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Fat distribution and insulin response in prepubertal African American and white children

Ethnic differences in obesity-related disease prevalence may relate to differences in fat distribution or metabolism. We conducted a study in 73 African American and white children to examine the relation between fat distribution and insulin and to determine whether ethnic differences in fat distribution or in adiposity-insulin relations contribute to differences in insulin concentrations. Fasting and postchallenge insulin concentrations were determined by oral-glucose-tolerance test, total body fat by dual-energy X-ray absorptiometry, and subcutaneous abdominal (SAAT) and intraabdominal (IAAT) adipose tissue by computerized tomography. African Americans had greater fasting insulin (x +/- SD: 79 +/- 37 compared with 55 +/- 23 pmol/L, P < 0.01), incremental 30-min insulin (567 +/- 438 compared with 300 +/- 304 pmol/L, P < 0.001), and incremental area under the insulin curve (AUC; 262 +/- 209 compared with 164 +/- 156 pmol/L, P < 0.01). In multiple linear regression, fasting insulin was independently related to total fat within both ethnic groups (model R2 = 0.42 and 0.52 for African Americans and whites, respectively), incremental 30-min insulin to total fat and IAAT in whites only (model R2 = 0.71), and AUC to SAAT in African Americans only (model R2 = 0.49). Adjusting insulin indexes for adiposity did not eliminate the significant effect of ethnicity. In general, relations between adiposity and insulin were stronger in whites than in African Americans. African American children had higher insulin concentrations than white children after total body fat, IAAT, and SAAT were controlled for. However, strong relations between adiposity (total and abdominal) and insulin in both groups suggest that obesity may contribute to disease risk regardless of ethnicity.     

Psychiatric symptomatology among alcoholics: Comparisons between African Americans and Caucasians.

Using data collected on 190 patients in a hospital-based substance abuse treatment center in a large midwestern city, this study compared psychiatric symptomatology between 39 African-American and 151 Caucasian adults. Although the groups were equivalent in consumption and frequency of usage, African-American alcoholics used significantly more substances (beyond alcohol) than did Caucasians. With regard to psychiatric symptomatology, African Americans reported higher levels of somatization, obsessive–compulsive behavior, depression, hostility, paranoid ideation, and psychoticism, and an overall higher degree of stress. Although the overall level of alcoholic self-reported severity did not distinguish the 2 groups, African Americans exhibited lower levels of global functioning as assessed by trained clinical staff. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Angiotensin II type I receptor polymorphism in African Americans lower frequency of the C1166 variant

The C1166 variant, an A to C substitution polymorphism at the 1166 position of the angiotensin II type I (AT1) receptor, has been previously associated with hypertension in Caucasians. This study determines the frequency of the C1166 variant in an African American population. Normotensive African American (n = 99) and Caucasian (n = 100) subjects were genotyped to determine the frequency of the C1166 variant. This study establishes the frequency of the C1166 variant in African Americans (0.05 +/- 0.01) and demonstrates a significantly lower frequency in African Americans compared with Caucasians (0.05 vs. 0.25, respectively, chi 2 = 30.7, p < < 0.001, 1 df).     

Clinical practices with African Americans: Juxtaposition of standard clinical practices and Africentricism.

Rapidly changing demographics necessitate increased awareness of the impact of race, ethnicity, and levels of acculturation on treatment efficacy and differential diagnosis of ethnic minorities. Increasingly, psychologists are in a position of providing treatment for clients whose cultural background differs from their own. Because African Americans have historically underutilized mental health services, sensitivity to the cultural variables represented by this group is a growing concern. An integrated approach to conceptualizing, evaluating, and diagnosing African Americans from a culturally sensitive, Africentric perspective is provided. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Self-stereotyping in the context of multiple social identities.

This research examines self-stereotyping in the context of multiple social identities and shows that self-stereotyping is a function of stereotyped expectancies held in particular relationships. Participants reported how others evaluated their math and verbal ability and how they viewed their own ability when their gender or ethnicity was salient. Asian American women (Experiment 1) and European Americans (Experiment 2) exhibited knowledge of stereotyped social expectancies and corresponding self-stereotyping associated with their more salient identity. African Americans (Experiment 3) exhibited some knowledge of stereotyped social expectancies but no corresponding self-stereotyping. Correlational evidence and a 4th experiment suggest that self-stereotyping is mediated by the degree to which close others are perceived to endorse stereotypes as applicable to the self. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

HLA gene and haplotype frequencies in the North American population: the National Marrow Donor Program Donor Registry

BACKGROUND: As of May 1, 1995, the National Marrow Donor Program had a donor registry consisting of over 1.35 million HLA-typed volunteers recruited from most major cities and states in the United States. This registry represents the largest single HLA-typed pool of normal individuals in the world. METHODS: We analyzed the HLA-A, -B, -DR locus phenotypes of the National Marrow Donor Program donors in order to estimate gene and haplotype frequencies for major racial groups of the United States: Caucasian American, Asian American, African American, Latin American, and Native American. The large size of the database allowed us to calculate the frequencies of relatively rare antigens and haplotypes with more accuracy than previous studies. RESULTS: We observed 89,522 distinguishable HLA-A, -B phenotypes in 1,351,260 HLA-A, -B-typed donors and 302,867 distinguishable HLA-A, -B, -DR phenotypes in 406,503 HLA-A, -B, -DR-typed donors. Gene and haplotype frequencies differed remarkably among the five racial groups, with African Americans and Asian Americans having a large number of haplotypes that were specific to their racial groups, whereas Caucasian Americans, Latin Americans, and Native Americans shared a number of common haplotypes. CONCLUSIONS: These data represent an important resource for investigators in the fields of transplantation and population genetics. The gene and haplotype frequencies can be used to aid clinicians in advising patients about the probability of finding a match within a specific ethnic group, or to determine donor recruitment goals and strategies. The information is also a valuable resource for individuals who are interested in population genetics, selection and evolution of polymorphic human genes, and HLA-disease association.