HIFU focusing efficiency and a twin annular array source for prostate treatment

A measure of focusing efficiency is introduced for high-intensity, focused ultrasound (HIFU). The measure consists of the fraction of the total acoustic power emitted that linearly propagates through a circle located at the focus. The medium is absorption-free water, and power is computed using pressure and the normal component of velocity. 3 MHz phased-array designs involving different element layouts and curvatures are placed in square apertures of length 2.2 cm. The acoustic fields of these devices then are propagated to on-axis foci. The resulting focal efficiencies then are calculated using a two wavelength (0.1 cm) radius circle. Among these array designs, an annular array with 27 wavelength-wide rings then is extended to be the basis of a twin phased-array device for prostate hyperthermia treatment. The two annular arrays are attached to door-like hinges to allow for joint two-dimensional focusing. The focusing efficiency of this device then is compared to rectangular element-array devices with the same 5.4 by 2.2 cm source extent. With the addition of absorption and finite-amplitude distortion, the heating rate and temperature rise produced by the twin annular device in prostate tissue is considered. As a final look at the potential of annular array-based designs, three larger 2 MHz devices are briefly considered for abdominal treatment.     

Forward-viewing CMUT arrays for medical imaging

This paper reports the design and testing of forward-viewing annular arrays fabricated using capacitive micromachined ultrasonic transducer (CMUT) technology. Recent research studies have shown that CMUTs have broad frequency bandwidth and high-transduction efficiency. One- and two-dimensional CMUT arrays of various sizes already have been fabricated, and their viability for medical imaging applications has been demonstrated. We fabricated 64-element, forward-viewing annular arrays using the standard CMUT fabrication process and carried out experiments to measure the operating frequency, bandwidth, and transmit/receive efficiency of the array elements. The annular array elements, designed for imaging applications in the 20 MHz range, had a resonance frequency of 13.5 MHz in air. The immersion pulse-echo data collected from a plane reflector showed that the devices operate in the 5-26 MHz range with a fractional bandwidth of 135%. The output pressure at the surface of the transducer was measured to be 24 kPa/V. These values translate into a dynamic range of 131.5 dB for 1-V excitation in 1-Hz bandwidth with a commercial low noise receiving circuitry. The designed, forward-viewing annular CMUT array is suitable for mounting on the front surface of a cylindrical catheter probe and can provide Doppler information for measurement of blood flow and guiding information for navigation through blood vessels in intravascular ultrasound imaging.     

Focusing properties of a novel plasmonic lens allowing for circularly polarized illumination

We propose a novel plasmonic lens (PLs) that is composed of a gold film with an annular array of nanoholes surrounded by two concentric grooves. The proposed PLs has the advantages of enabling the illumination of a circularly polarized light. Through numerical calculation and analysis, the relationship between the groove positions and the phase difference between the light radiating from the grooves and nanoholes is determined. The finite-difference time-domain method is used to compute the light field and confirms that the proposed PLs can achieve super-resolution, long depth of focus and strong central axisymmetric focusing. The PLs arrays are also studied; it is found that owing to the focusing interaction of the adjacent plasmonic lenses, the focusing performance could be further improved. Our study helps design the easy-to-fabricate PLs and facilitates applications of plasmonic devices.     

A theoretical assessment of the relative performance of spherical phased arrays for ultrasound surgery

Computer modeling of spherical-section phased arrays for ultrasound surgery (tissue ablation) is described. The influence on performance of the number of circular elements (68 to 1024), their diameter (2.5 to 10 mm), frequency (1 to 2 MHz), and degree of sparseness in the array is investigated for elements distributed randomly or in square, annular, and hexagonal patterns on a spherical shell (radius of curvature, 120 mm). Criteria for evaluating the quality of the intensity distributions obtained when focusing the arrays both on and away from their center of curvature, and in both single focus and simultaneous multiple foci modes, are proposed. Of the arrays studied, the most favorable performance, for both modes, is predicted for 256 5-mm diameter, randomly distributed elements. For the single focus mode, this performed better than regular arrays of 255 to 1024 elements and, for the case of nine simultaneous foci produced on a coplanar 3x3 grid with 4-mm spacing, better than square, hexagonal, or annular distributed arrays with a comparable number of elements. Randomization improved performance by suppressing grating lobes significantly. For single focus mode, a several-fold decrease in the number of elements could be made without degrading the quality of the intensity distribution.     

Piezoelectrically actuated flextensional micromachined ultrasound transducers--II: fabrication and experiments

This paper presents novel micromachined two-dimensional array piezoelectrically actuated flextensional transducers that can be used to generate sound in air or water. Micromachining techniques to fabricate these devices are also presented. Individual unimorph array elements consist of a thin piezoelectric annular disk and a thin, fully clamped, circular plate. We manufacture the transducer in two-dimensional arrays using planar silicon micromachining and demonstrate ultrasound transmission in air at 2.85 MHz with 0.15 μm/V peak displacement. The devices have a range of operating resonance frequencies starting from 450 kHz to 4.5 MHz. Such an array could be combined with on-board driving and addressing circuitry for different applications     

Sparse random ultrasound phased array for focal surgery

Ultrasound phased arrays offer several advantages over single focused transducer technology, enabling electronically programmable synthesis of focal size and shape, as well as position. While phased arrays have been employed for medical diagnostic and therapeutic (hyperthermia) applications, there remain fundamental problems associated with their use for surgery. These problems stem largely from the small size of each array element dictated by the wavelength employed at surgical application frequencies (2-4 MHz), the array aperture size required for the desired focal characteristics, and the number of array elements and electronic drive channels required to provide RF energy to the entire array. The present work involves the theoretical and experimental examination of novel ultrasound phased arrays consisting of array elements larger than one wavelength, minimizing the number of elements in an aperture through a combination of geometric focusing, directive beams, and sparse random placement of array elements, for tissue ablation applications. A hexagonally packed array consisting of 108 8-mm-diameter circular elements mounted on a spherical shell was modeled theoretically and a prototype array was constructed to examine the feasibility of sparse random array configurations for focal surgery. A randomly selected subset of elements of the prototype test array (64 of 108 available channels) was driven at 2.1 MHz with a 64-channel digitally controlled RF drive system. The performance of the prototype array was evaluated by comparing field data obtained from theoretical modeling to that obtained experimentally via hydrophone scanning. The results of that comparison, along with total acoustic power measurements, suggest that the use of sparse random phased arrays for focal surgery is feasible, and that the nature of array packing is an important determinant to observed performance     

The progressive focusing correction technique for ultrasound beamforming

This work presents a novel method for digital ultrasound beamforming based on programmable table look-ups, in which vectors containing coded focusing information are efficiently stored, achieving an information density of a fraction of bit per acquired sample. Timing errors at the foci are within half the period of a master clock of arbitrarily high frequency to improve imaging quality with low resource requirements. The technique is applicable with conventional as well as with deltasigma converters. The bit-width of the focusing code and the number of samples per focus can be defined to improve both memory size and F# with controlled timing errors. In the static mode, the number of samples per focus is fixed, and in the dynamic approach that figure grows progressively, taking advantage of the increasing depth of focus. Furthermore, the latter has the lowest memory requirements. The technique is well suited for research purposes as well as for real-world applications, offering a degree of freedom not available with other approaches. It allows, for example, modifying the sampling instants to phase aberration correction, beamforming in layered structures, etc. The described modular and scalable prototype has been built using low-cost field programmable gate arrays (FPGAs). Experimental measurements are in good agreement with the theoretically expected errors.     

The production of intense atomic beams

Methods of producing multichannel capillary arrays in various materials for use as atomic beam forming devices are reviewed. The advantages of gas focusing arrays are considered. The theories of the flow of gas through a cylindrical tube are discussed. Completely general numerical and graphical results derived from Zugenmaier's theory are presented. Their use in designing gas beam systems is described. Data are presented in a convenient form for the experimentalist. Comparison of the numerical results with published experimental data is made. It is shown that, for most purposes, a capillary is best operated at an input pressure giving a mean free path which is less than 10% of the tube length. In an array, it is an advantage to have tubes of small diameter. With a focusing array, beam densities of up to 10¹⁴ atoms cm^?3 are predicted when the beam half width is 1°.     

High frequency ultrasound imaging using an active optical detector

Optical detection of ultrasound has numerous advantages over traditional piezoelectric methods. These systems offer noncontact inspection, rapid scanning capabilities, fine spatial sampling, and large bandwidths. In addition, difficulties associated with conventional ultrasound imaging systems such as cross-talk between elements, electrical connections, and electromechanical resonances are greatly reduced or even eliminated. Because of this, high frequency phased arrays for ultrasound detection can be emulated by accurately positioning and focusing optical beams on a suitable surface, which defines array elements. However, optical systems have lower sensitivity than their piezoelectric counterparts, limiting their widespread use in ultrasound imaging. Active optical detection offers a solution. An active ultrasound detector consisting of a neodymium-doped glass waveguide laser with an optical demodulation system, was built demonstrating enhanced sensitivity while preserving the benefits of traditional passive optical detection.     

Low temperature fabrication of immersion capacitive micromachined ultrasonic transducers on silicon and dielectric substrates

A maximum processing temperature of 250/spl deg/C is used to fabricate capacitive micromachined ultrasonic transducers (CMUTs) on silicon and quartz substrates for immersion applications. Fabrication on silicon provides a means for electronics integration via post-complementary metal oxide semiconductor (CMOS) processing without sacrificing device performance. Fabrication on quartz reduces parasitic capacitance and allows the use of optical displacement detection methods for CMUTs. The simple, low-temperature process uses metals both as the sacrificial layer for improved dimensional control, and as the bottom electrode for good electrical conductivity and optical reflectivity. This, combined with local sealing of the vacuum cavity by plasma-enhanced chemical-vapor deposition of silicon nitride, provides excellent control of lateral and vertical dimensions of the CMUTs for optimal device performance. In this paper, the fabrication process is described in detail, including process recipes and material characterization results. The CMUTs fabricated for intravascular ultrasound (IVUS) imaging in the 10-20 MHz range and interdigital CMUTs for microfluidic applications in the 5-20 MHz range are presented as device examples. Intra-array and wafer-to-wafer process uniformity is evaluated via electrical impedance measurements on 64-element ring annular IVUS imaging arrays fabricated on silicon and quartz wafers. The resonance frequency in air and collapse voltage variations are measured to be within 1% and 5%, respectively, for both cases. Acoustic pressure and pulse echo measurements also have been performed on 128 /spl mu/m/spl times/32 /spl mu/m IVUS array elements in water, which reveal a performance suitable for forward-looking IVUS imaging at about 16 MHz.     

Beam steering with segmented annular arrays

Two-dimensional (2-D) arrays of squared matrix have maximum periodicity in their main directions; consequently, they require half wavelength (lambda/2), interelement spacing to avoid grating lobes. This condition gives rise to well-known problems derived from the huge number of array elements and from their small size. In contrast, 2-D arrays with curvilinear configuration produce lower grating lobes and, therefore, allow the element size to be increased beyond lambda/2. Using larger elements, these arrays have the advantage of reducing the number of elements and of increasing the signal-to-noise ratio (SNR). In this paper, the beamforming properties of segmented annular phased arrays are theoretically analyzed and compared with the equivalent squared matrix array. In the first part, point-like elements are considered in order to facilitate the field analysis with respect to the array structure. Afterward, the effect of the element size on the steered beam properties also is presented. In the examples, it is shown that the segmented annular array has notably lower grating lobes than the equivalent squared matrix array and that it is possible to design segmented annular arrays with interelement distance higher than lambda whose beam characteristics are perfectly valid for volumetric imaging applications.     

High-frequency ultrasound annular array imaging. Part II: digital beamformer design and imaging

This is the second part of a two-paper series reporting a recent effort in the development of a high-frequency annular array ultrasound imaging system. In this paper an imaging system composed of a six-element, 43 MHz annular array transducer, a six-channel analog front-end, a field programmable gate array (FPGA)-based beamformer, and a digital signal processor (DSP) microprocessor-based scan converter will be described. A computer is used as the interface for image display. The beamformer that applies delays to the echoes for each channel is implemented with the strategy of combining the coarse and fine delays. The coarse delays that are integer multiples of the clock periods are achieved by using a first-in-first-out (FIFO) structure, and the fine delays are obtained with a fractional delay (FD) filter. Using this principle, dynamic receiving focusing is achieved. The image from a wire phantom obtained with the imaging system was compared to that from a prototype ultrasonic backscatter microscope with a 45 MHz single-element transducer. The improved lateral resolution and depth of field from the wire phantom image were observed. Images from an excised rabbit eye sample also were obtained, and fine anatomical structures were discerned.     

Coded excitation system for improving the penetration of real-time phased-array imaging systems

Based on an analysis of the inherent signal-to-noise ratio (SNR) in medical ultrasound imaging, SNR improvements of 15-20 dB are theoretically possible for real-time phased-array imagers using coded excitation. A very simple coded excitation for phased arrays based on the principles of ;pseudochirp' excitation and equalization filtering is described. This system is capable of SNR improvements of about 15 dB with range sidelobe levels acceptable for many medical imaging applications. Such improvements permit increased operating frequencies, and hence enhanced spatial resolution, for real-time array imagers. Both simulations and measurements are used to demonstrate the efficacy of the method.     

A single FPGA-based portable ultrasound imaging system for point-of-care applications

We present a cost-effective portable ultrasound system based on a single field-programmable gate array (FPGA) for point-of-care applications. In the portable ultrasound system developed, all the ultrasound signal and image processing modules, including an effective 32-channel receive beamformer with pseudo-dynamic focusing, are embedded in an FPGA chip. For overall system control, a mobile processor running Linux at 667 MHz is used. The scan-converted ultrasound image data from the FPGA are directly transferred to the system controller via external direct memory access without a video processing unit. The potable ultrasound system developed can provide real-time B-mode imaging with a maximum frame rate of 30, and it has a battery life of approximately 1.5 h. These results indicate that the single FPGA-based portable ultrasound system developed is able to meet the processing requirements in medical ultrasound imaging while providing improved flexibility for adapting to emerging POC applications.     

Polymer-based flexible microlens arrays with hermaphroditic focusing properties

Polymer microlens arrays with hermaphroditic focusing behaviors are demonstrated. Each microlens in an arrays exhibits either converging or diverging focus, depending on the polarization direction of the incident light. A polymer film with patterned microlens arrays is flexible, lightweight, and ultrathin (approximately 50 microm). Details of the lens structure, device fabrication, and lens performance are described.     

Circular Dammann grating under high numerical aperture focusing

Circular Dammann grating (CDG) under high numerical aperture (NA) focusing is described based on Richards-Wolf vectorial diffraction theory in this paper. Several CDGs are presented under the condition of NA=0.9 with the illumination of circularly polarized plane-wave laser beams. Numerical results show that the sizes of these circular patterns with equal-intensity are in the wavelength scale, and doughnut-shaped central spots and dark rings are in the subwavelength width. To verify this kind of CDG, a binary pure-phase three-order CDG is fabricated to produce a dark center pattern surrounded by three concentric bright rings. The corresponding intensity distribution of the pattern on the focal plane of a high-NA objective (NA=0.9) is measured, and the results agree well with theoretical simulations. This kind of CDG with annular patterns of equal-intensity in the wavelength scale should be highly interesting for its potential applications in optical trapping, stimulated emission depletion (STED) microscopy, and the study of singular optics, as well as annular array illumination.     

Reduction of cavitation using pseudorandom signals [therapeutic US]

It is known that the scattering of ultrasound by cavitation bubbles reduces the efficiency of treatment by high-intensity focused ultrasound. In the authors' experiments striving to reduce grating lobe levels of annular arrays they observed less microbubble formation at the focus of the transducer when pseudorandom phase-modulated CW signals were used rather than single-frequency CW signals. To confirm this unexpected result, the authors performed an experiment in a solution of luminol which is known to be a cavitation detector. A 5-cm diameter spherical transducer (1.1 MHz center frequency and 0.6 MHz bandwidth), focused at 197 mm was used. The ratio of the sonoluminescence intensity produced by a single-frequency signal to that produced by a pseudorandom phase-modulated signal increased with the intensity of the applied held and attained a value of nearly 50 for an intensity of 4.6 W cm^-2      

A model to predict the transient radiation from segmented annularapertures radiating into solid media

An approach to predict the compressional wave transient radiation in solid load media from elements and arrays comprised of segmented annular apertures is described. The model may also be applied to the simulation of the transient radiation from circular, rectangular, and annular apertures by suitable parameter manipulation. The approach is based on the method developed by Stepanishen to model propagation in a fluid medium. A suitable angular weighting factor, that of Miller and Pursey, is included to account for the multimode nature of solids, A number of experimental results, including single-element and phased array operation, obtained from a prototype segmented annular array system are presented. These results demonstrate good agreement when compared with those obtained from the theoretical model     

Fabrication and characterization of piezoelectric micromachined ultrasonic transducers with thick composite PZT films

Ferroelectric microelectromechanical systems (MEMS) has been a growing area of research in past decades, in which ferroelectric films are combined with silicon technology for a variety of applications, such as piezo-electric micromachined ultrasonic transducers (pMUTs), which represent a new approach to ultrasound detection and generation. For ultrasound-radiating applications, thicker PZT films are preferred because generative force and response speed of the diaphragm-type transducers increase with increasing film thickness. However, integration of 4- to 20-microm thick PZT films on silicon wafer, either the deposition or the patterning, is still a bottleneck in the micromachining process. This paper reports on a diaphragm-type pMUT. A composite coating technique based on chemical solution deposition and high-energy ball milled powder has been used to fabricate thick PZT films. Micromachining of the pMUTs using such thick films has been investigated. The fabricated pMUT with crack-free PZT films up to 7-microm thick was evaluated as an ultrasonic transmitter. The generated sound pressure level of up to 120 dB indicates that the fabricated pMUT has very good ultrasound-radiating performance and, therefore, can be used to compose pMUT arrays for generating ultrasound beam with high directivity in numerous applications. The pMUT arrays also have been demonstrated.