Sodium taste detectability in rats is dependent of anion size: The psychophysical characteristics of the transcellular sodium taste transduction pathway.

There are two known sodium transduction pathways in the rat gustatory system. The transcellular pathway is blocked by amiloride, and the paracellular pathway is limited by the anion gluconate. The contribution of each pathway to sodium detection was assessed. Sodium gluconate (NaGlu) and NaCl thresholds did not differ, implying that the paracellular pathway is not necessary for normal sodium detection. Adding 100 μM amiloride raised both NaCl and NaGlu thresholds but did not abolish all performance to NaGlu, indicating that some chemical cue was present at high concentrations. Rats were also exposed to one of three NaCl diets (0.12%. 1.0%, or 6.0% NaCl) through maternal and ad lib intake from Embryonic Day 1 through testing in adulthood. No differences across dietary groups were found for NaCl or NaGlu threshold with or without amiloride. Thus, this developmental dietary treatment does not appear to affect taste sensitivity to sodium subserved through either transduction pathway. Collectively, these data suggest that the transcellular transduction pathway is both necessary and sufficient for normal sodium detection. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The encephalus of the pond-loach, Misgurnus fossilis (L.), 1758 (fish, teleosts, Cobitidae). An example of sexual dimorphism]

The brain of the Pond-loach (Misgurnus fossilis) is very closely related to that of Cyprinidae. In the Medulla oblongata, the facial lobe-in relation with the skin taste buds, especially on the barbels-is bigger than the vagal lobes-which are related with the mouth taste buds. The intraspecific relations between brainweight and bodyweight or various body lengths show a real sexual dimorphism (brain dimegaly). The interspecific brain-bodyweight relationship shows an allometric coefficient of 0.505 in males and 0.485 in females, very close to that of the Rainbow trout. The encephalization index (63) is very close to that of the Tench, and a little lower than that of the Cyprinidae as a whole.     

Viewing time and stereoscopic threshold with random-dot stereograms

The effect of viewing time on the threshold for depth and form discrimination using random-dot stereograms has been investigated. For 12 subjects the relation between logarithm of threshold disparity and logarithm of viewing time was linear for both depth and form discrimination, but the threshold for form discrimination was approximately twice the threshold for depth discrimination. Stereo thresholds determined with random-dot stereograms were not significantly related to stereo thresholds measured with a Howard-Dolman apparatus.     

Effects of Selective Lingual Gustatory Deafferentation on Suprathreshold Taste Intensity Discrimination of NaCl in Rats.

In rats, chorda tympani nerve transection (CTX) greatly increases the detection threshold of sodium chloride (NaCl) and severely disrupts salt discriminability. Here it is shown that CTX has surprisingly little effect, if any, on suprathreshold intensity discrimination. Glossopharyngeal nerve transection (GLX), which has no reported effect on salt sensibility, also did not affect performance. Rats were tested in a 2-response, operant taste intensity discrimination task. Difference thresholds for CTX rats were only slightly higher (-0.15 log/10 unit) than those for GLX and sham-transected rats, when 0.05 M served as the standard, and did not significantly differ when 0.1 M NaCl was the standard. Although the perceived intensity of NaCl might be reduced by CTX, input from remaining taste nerves sufficiently maintains the relative discriminability of suprathreshold NaCl concentrations. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

NaCl thresholds in man: Thresholds for water taste or NaCl taste?

Notes that water is not tasteless to humans, but rather can produce any of the 4 basic taste qualities if it is preceded by adaptation to an appropriate substance. After adaptation to the NaCl in saliva, water tastes predominantly bitter. Results of detection threshold experiments with 9 male undergraduates and the author as Ss demonstrate that this bitter water taste can be confused with solute tastes so that some detection thresholds for NaCl may actually represent water thresholds instead. Water also appears to have a taste after adaptation to saliva in the rat. Just as with humans, some apparently low thresholds for NaCl detection in rat may be water-taste thresholds. The apparently high preference threshold for NaCl in rat may be a true NaCl threshold based on adaptation to saliva. (116 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Propylthiouracil tasting: determination of underlying threshold distributions using maximum likelihood

The ability to taste low concentrations of propylthiouracil (PROP) and related bitter compounds is heritable. The current analysis determines whether the distribution of PROP taste thresholds is consistent with an additive or a dominant mode of Mendelian transmission. To that end, the lowest concentration of PROP detectable was determined for 1015 subjects and models of bi- or tri-modal distributions of PROP taste thresholds were tested. The model with the greatest likelihood had three distributions and followed an additive model of PROP taste sensitivity if the variances associated with the distributions were assumed to be equal. However, if the taste thresholds were transformed to remove skewness, or if the variances were unequal, then three- or two-distribution models were equally likely. Resolution of the mode of inheritance for bitter taste perception awaits additional family studies and the characterization of the molecular basis of taste perception for these bitter compounds.     

Gustation and ingestive behavior in the rat.

Studied the contribution of taste to the quantitative control of intake and body weight in 15 male Wistar rats. Gustatory deafferentation was produced by combined bilateral section of the chorda tympani and glossopharyngeal nerves and the pharyngeal branch of the vagus nerve. The procedure did not affect the condition of the mouth, impair orientation to sensory stimuli, or severely disrupt the consummatory sequence. Nevertheless, deafferented Ss showed reduced responsiveness to food and water, elevated quinine HCl aversion thresholds, and impaired feeding efficiency. Food and water intake and body weight remained below control levels for at least 40–50 days postoperatively. Food intake deficits were not observed when Ss were offered ad lib pablum, a result suggesting that increased palatability could compensate for decreased gustatory input. The order of recovery of food intake through different diet types suggests a heightened responsiveness to taste stimuli. The effects of gustatory deafferentation are compared with those seen after section of trigeminal orosensory nerves, and the differential contributions of oral taste and oral touch are discussed. (42 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Depressive symptoms and alterations in sucrose taste perception: Cognitive bias or a true change in sensitivity?

Examined whether changes in response bias and/or sucrose detection thresholds were associated with symptoms of depression. Ss were 49 18–34 yr old undergraduates and 1 52-yr-old outpatient who had been diagnosed with major depressive episode. Sucrose detection thresholds were measured (1) in Ss with high and low Hamilton Depression Rating Scale (HAM-D) scores who did not meet standard criteria for current Major Depressive Episode (MDE); and (2) in Ss who did fulfill standard criteria for MDE. Ss with low HAM-D scores produced significantly more false alarms than the other 2 groups but taste sensitivity did not vary significantly across groups. Results suggest that changes in response bias underlie previously reported increases in sucrose taste thresholds in depressed Ss. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Some principles of sensory analysis.

Proposes 2 principles of sensory analysis concerning sensory discrimination and small, near-threshold stimuli that are incorporated into a simple model that is applied to the discrimination of differences in luminance. The phenomena surveyed include signal-detection operating characteristics, psychometric functions, and thresholds both for discriminations between 2 separate stimuli and for the detection of increments superimposed on a uniform luminance. The wide variety of phenomena that can be related to each of the 2 principles is discussed, including the Craik-Cornsweet Illusion, modulation transfer functions for sinusoidal gratings, negative masking, and the pedestal effect. (37 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Spatial and temporal integration of signals in foveal line orientation

The discrimination of the orientation of a line improves with line length, reaching an optimum when a foveal line is approximately 0.5 degrees long. We studied the effect of eliminating sections of the line, of displacing them out of alignment, and of delaying them. Orientation discrimination thresholds are only a little elevated when a 25-arcmin line is replaced by three equally spaced collinear 5-arcmin segments. Two collinear 5-arcmin segments show better thresholds than a single one when they are separated by as much as 20 arcmin. But thresholds are impaired by bringing line segments out of collinearity by as little as 1 arcmin. Asynchrony of up to 50 ms can be tolerated, but when the middle segment of a three-line pattern is delayed by approximately 100 ms there is active inhibition, thresholds being now higher than when the middle segment is absent. It is concluded that for signals to address the orientation discrimination mechanism optimally, they have to be contained inside a narrow spatial corridor and be presented within a time window of approximatley 50 ms, but that some spatial summation can take place over a length of > or = 0.5 degrees in the fovea. Because short lines made of black and white collinear segments do not have good orientation thresholds, whereas longer and interrupted lines do, it is concluded that what is involved is potentiating interaction between collinearly arranged neurons with identical orientation selectivity rather than summation of signals within the receptive fields of single neurons.     

Sex and species differences in mouse and rat forebrain commissures depend on the method of adjusting for brain size

Sex differences in the forebrain commissures (corpus callosum, hippocampal commissure, and anterior commissure) were examined in B6D2F2 hybrid mice and Sprague-Dawley rats. Twenty-four male-female littermate pairs of mice were perfused at each of 21, 42 and 63 days of age and the midsagittal area of the commissures was measured from en bloc stained tissue. Twenty-two male-female littermate pairs of rats were examined at 110 days of age using the same methods. Male mice had larger bodies than females but no sex differences were found for mouse brain weight or commissure areas. In contrast, a significant sex difference was found for rat body, brain, corpus callosum and hippocampal commissure sizes. Four methods were used to adjust for differences in brain size (ratio, geometric, linear regression, and allometric). When the two species were analysed separately, neither mice nor rats showed significant sex differences in commissure areas relative to brain size if regression or allometric adjustments were made. Even when data from mice and rats were combined into one large group with a wide range of values, no species or sex differences were apparent after adjustments were made for brain size with either the regression or allometric methods. The use of ratios to adjust for differences in overall size is not recommended, especially because this method does not effectively remove the influence of brain size from commissure size; a substantial correlation is often present between the ratio and brain size.     

Relationship between dietary restraint, energy intake, physical activity, and body weight: A prospective analysis.

Dietary, activity, and body weight differences in high- and low-restrained eaters and the independent impact of dietary restraint on body weight change were evaluated in 287 adults (141 men, 146 women) followed over a 1-yr period. Analyses of measures of energy intake, physical activity, and dietary restraint indicated that high-restraint eaters did not differ in physical activity compared to low-restrained eaters at baseline but were ingesting significantly fewer kcal/lb and a higher percentage of the diet from fat. Body mass was significantly greater in both high-restrained men and high-restrained women than in their low-restrained counterparts. Regression modeling procedures revealed that weight and body mass at baseline were related to weight gain in men. In contrast, weight gain in women was predicted by baseline weight and higher restraint scores. Results indicate that dietary restraint is associated with weight gain in women but not in men. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Comparison of the stimulus properties of ethanol and the Ca2+ channel antagonist nimodipine in rats

A variety of L-type Ca2+ channel antagonists, including the dihydropyridine derivative nimodipine, have been shown to be effective in reducing ethanol intake and preference in animal models of alcoholism. The behavioral mechanism involved in the anti-alcohol effects of nimodipine are, however, not clear yet. The aim of the present study was to investigate the possibility that the effects of nimodipine on ethanol intake are based on stimulus substitution. Therefore, rats were trained to discriminate ethanol (12.5% w/v, 1000 mg/kg i.p.) from saline in a two-lever food-reinforced drug discrimination procedure (dose range of ethanol tested: 125-1000 mg/kg i.p., ED50 value: 488 mg/kg). In cross-generalization tests with nimodipine (0.15-15 mg/kg i.p.), stimulus substitution was not noted. In addition, a cross-familiarization conditioned taste aversion paradigm was utilized. In rats, 1000 mg/kg i.p. ethanol was used as the reference drug producing a conditioned taste aversion. Effects of preexposure to ethanol (500-1500 mg/kg i.p.) and nimodipine (7.5-30 mg/kg i.p.) on the magnitude of the ethanol-induced conditioned taste aversion were investigated as an index for stimulus similarity between preexposure and reference drug. Preexposure to both ethanol and nimodipine prevented the development of a conditioned taste aversion. Contrary to the drug discrimination results, these latter findings suggest that there may be similarities between the stimulus properties of nimodipine and ethanol. Moreover, the apparent discrepancy between the results obtained in drug discrimination and cross-familiarization conditioned taste aversion suggests that different stimulus properties of ethanol control behavior in both procedures. The finding that, under particular conditions, ethanol and nimodipine appear to share common stimulus properties needs to be further evaluated, as this may be related to the reported anti-alcohol effects of nimodipine and other Ca2+ channel antagonists.     

The stereoscopic anisotropy: Individual differences and underlying mechanisms.

Observers are more sensitive to variations in the depth of stereoscopic surfaces in a vertical than in a horizontal direction; however, there are large individual differences in this anisotropy. The authors measured discrimination thresholds for surfaces slanted about a vertical axis or inclined about a horizontal axis for 50 observers. Orientation and spatial frequency discrimination thresholds were also measured. For most observers, thresholds were lower for inclination than for slant and lower for orientation than for spatial frequency. There was a positive correlation between the 2 anisotropies, resulting from positive correlations between (a) orientation and inclination thresholds and (b) spatial frequency and slant thresholds. These results support the notion that surface inclination and slant perception is in part limited by the sensitivity of orientation and spatial frequency mechanisms. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Amiloride-insensitive units of the chorda tympani nerve are necessary for normal ammonium chloride detectability in the rat.

In spite of its common use as a standard stimulus in peripheral nerve recordings, relatively little is known about the psychophysics of NH?Cl taste. Rats' detection threshold for this salt was tested under a variety of conditions, including amiloride (100 μM) treatment and bilateral chorda tympani (CT) nerve transection. Detectability was measured with a 2-lever operant discrimination procedure used previously to measure detection thresholds for NaCl and KCl. Although NH?Cl and KCl appear to share a common taste quality and transduction mechanism, the logistic function and threshold for NH?Cl were found to be more similar to those of NaCl than to those of KCl. Like that of KCl, however, the detection threshold for NH4Cl increased significantly with CT transection (0.54 log?? units, p     

Diphasic allometric growth of some skeletal bones and the digestive tract in White Leghorn pullets consuming ad libitum and restricted diets

Growth data of some bones (shank, tibia, and keel) and the digestive tract in White Leghorn pullets, which consumed ad libitum and restricted diets, were analyzed by mono- and diphasic allometric functions. Fat-free plucked empty body mass (FFEBM) or a functional entity was used as the independent variable in the equations. Pullets had been fed a low-lysine diet or a daily restricted amount of an adequate diet, from 0 to 6 or 7 to 18 wk of age. An additional group of pullets consumed ad libitum a control starter and grower diet. Relative growth of the skeletal bones and parts of the digestive tract, vs FFEBM, was described most accurately by a diphasic model. For each constituent, allometric slopes of the first growth phase (beta1) vs FFEBM were smaller than 1 (beta1 varied from 0.39 to 0.43 for shank and tibia, from 0.48 to 0.73 for the keel, from 0.89 to 0.98 for the total digestive tract, and from 0.80 to 0.84 for the gizzard, separately). These results suggest that each of the assessed organs matured earlier than the FFEBM. Except for the keel, which grew relatively faster than FFEBM if an early nutrient restriction had been applied, beta1 of all other assessed structures was similar for all treatments. If the allometric slope of the second growth phase (beta2) was estimated to be not different from zero, then the breakpoint between both phases was defined as the moment of attainment of maturity for the respective constituent. The attainment of maturity of the different body structures confirmed the classical growth sequence studies of the Hammond School. No differences in mature weights for the assessed organs between the feeding regimens were observed. The results indicated that in studies in which a nutritional deficiency had been applied, the weights of several body structures, most often expressed in terms of weight per 100 g BW, are strongly related to the decrease in growth rate of the fat-free body. It was concluded that most of the reported effects on growth retardation as a result of nutrient restrictions are primarily a consequence of the mobilization of fat per se.     

Comparative ultrastructure of vallate, foliate and fungiform taste buds of golden Syrian hamster

A fine-structure study of the hamster fungiform, foliate and vallate taste buds was undertaken for comparative purposes. All three taste bud types shared in common composition of the dark cells, light cells, basal cells, nerve fibers and nerve endings and undifferentiated peripheral cells, but morphological difference existed among them. The foliate and vallate taste buds were quite similar in their ultrastructural morphology. Their dark cells displayed long apical necks, long apical microvilli, apical osmiophilic secretory granules and an abundant rough endoplasmic reticulum. The dark cells of the fungiform taste buds, however, showed no neck formation and lacked apical osmiophilic granules. They had short apical microvilli and relatively scant rough endoplasmic reticulum. There was no difference in the fine structure features of the light cells, basal cells and neural elements of different types of taste buds. Both light and dark cells were much more readily distinguishable in foliate and vallate buds than in fungiform buds at both light-and electron-microscopic levels. Foliate and vallate buds demonstrated homogeneous dense substance within the taste pores while fungiform pores were frequently empty. It is speculated that the differences in taste bud morphology may be due to their different lingual locations and/or may be a reflection of the differences in the inductive influences from different nerves. Furthermore, structural differences may be responsible for varying thresholds to different taste modalities.     

Dissociation of spatial discrimination deficits following frontal and parietal lesions in monkeys.

Gave 40 rhesus monkeys dorsolateral prefrontal, posterior parietal, or inferotemporal lesions. 4 additional Ss served as unoperated controls. Ss then received 2 forms of spatial discrimination training, based on body position ("egocentric" cues) and on the position of an external referent ("allocentric" cues), respectively. On the former, a place discrimination reversal, frontal Ss were impaired but not parietals. On the latter, a landmark discrimination reversal, parietal Ss were impaired but not frontals; this result was also obtained on a test involving distance discrimination without reversal. Finally, the inferotemporals but not the frontals or parietals were impaired on a nonspatial object discrimination reversal. Results suggest that the 2 modes of spatial orientation, egocentric and allocentric, are related to frontal and parietal mechanisms, respectively. (18 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Intrasexual competition and body weight dimorphism in anthropoid primates

Body weight dimorphism in anthropoid primates has been thought to be a consequence of sexual selection resulting from male-male competition for access to mates. However, while monogamous anthropoids show low degrees of weight dimorphism, as predicted by the sexual selection hypothesis, polygynous anthropoids show high variation in weight dimorphism that is not associated with measures of mating system or sex ratio. This observation has led many to debate the role of other factors such as dietary constraints, predation pressure, substrate constraints, allometric effects, and phylogeny in the evolution of anthropoid weight dimorphism. Here, we re-evaluate variation in adult body weight dimorphism in anthropoids, testing the sexual selection hypothesis using categorical estimates of the degree of male-male intrasexual competition ("competition levels"). We also test the hypotheses that interspecific variation in body weight dimorphism is associated with female body weight and categorical estimates of diet, substrate use, and phylogeny. Weight dimorphism is strongly associated with competition levels, corroborating the sexual selection hypothesis. Weight dimorphism is positively correlated with increasing female body weight, but evidence suggests that the correlation reflects an interaction between overall size and behavior. Arboreal species are, on average, less dimorphic than terrestrial species, while more frugivorous species tend to be more dimorphic than folivorous or insectivorous species. Several alternative hypotheses can explain these latter results. Weight dimorphism is correlated with taxonomy, but so too are competition levels. We suggest that most taxonomic correlations of weight dimorphism represent "phylogenetic niche conservatism"; however, colobines show consistently low degrees of weight dimorphism for reasons that are not clear.     

Discrimination of the direction and speed of motion in depth of a monocularly visible target from binocular information alone

Thresholds for discriminating a monocularly visible object's direction of motion in depth and speed of motion in depth were measured using only binocular cues. Observers could discriminate the direction of motion in depth while totally ignoring speed and discriminate the speed of motion in depth while totally ignoring direction. Direction discrimination thresholds were the same for motion in depth within the vertical and horizontal meridians, even though a cue to trajectory was available for motion within the horizontal meridian that is not available for motion within the vertical meridian. Speed discrimination thresholds also were the same for motion in depth within the vertical and horizontal meridians. For the 3 observers the lowest direction discrimination thresholds were 0.14 degree, 0.18 degree, and 0.22 degree (means of horizontal and vertical thresholds).