GC/MS/MS和LC/MS/MS在现代农产品分析中的应用

介绍了食品安全的影响及食品中有害物质分析的特点，着重介绍了GC／MS／MS和LC／MS／MS法在食品中的农药残留和兽药残留的分析应用。     

ASES／MS智能质谱解析系统与HP5971MS ChemStation的软件接口

介绍了ASES／MS智能质谱结构解析系统与HP5971MS ChemStation的软件接口，由于使用了高质量的质谱数据和独特的解析算法，ASES／MS系统具有非常好的结构鉴定性能，经过对HP5971MS ChemStation原始数据文件格式的分析，成功地建立了ASES／MS系统与HP5971 MS ChemStation之间的接口软件，实现了两者间的直接联机使用。     

国产微流量LC/TOF-MS联用仪在食品安全检测中的应用

上海精科-复旦分析仪器研发实验室开发的微流量LC／TOF—MS联用仪是国内首创的通用液质联用系统。它的NanoLC部分采用了新型热膨胀高压泵体,实现了无活动部件的微流高压梯度HPLC;质谱部分使用先进的TOFMS技术,能够完成多数的LC—MS检测工作,并保持较低的拥有成本。在食品安全领域,该仪器可以检测苏丹红等有害物质。     

热电公司为环境、食品安全高灵敏度分析，打造最新TSQ Quantum^TM Access质谱仪

西雅图，华盛顿州（6月1日，2006）．世界领先的分析仪器公司热电公司，在5月28-6月1日的ASMS质谱学大会的上，推出TSQ Quantum家族中全新一款TSQ Quantum Access四极杆质谱仪。该仪器专门为环境和食品安全市场设计，提供快速、有效、可靠的分析。Quantum Access分析的质量范围可达到m／z 30-3000，可对超过300种不同被测物进行多化合物扫描。TSQ Quantum Access具有QED-MS／MS（Quantitation Enhancedby Datadependant MS／MS），同时提供定量分析和被测物离子谱图进行化合物鉴定。TSQ Quantum Access已经在ASMS质谱学大会热电公司的展台上展出。     

赛默飞世尔三聚氰胺检测方法夺得2009荣格技术创新大奖

2009年7月2日,“2009荣格食品饮料业技术创新奖“颁奖典礼在上海淳大万丽酒店隆重举行。赛默飞世尔科技公司凭借三聚氰胺检测技术——LC—MC／MS检则方法,一举夺得“食品安全类”技术创新大奖,也成为唯一一家上榜的科学仪器制造商。该奖项是全球著名工业资讯媒体荣格集团,自2005年创立技术创新奖以来,首次就食品安全技术设立的奖项,体现了荣格技术创新奖对食品工业社会责任承诺的重视,也是对2008至2009年度为中国食品安全乃至社会生活带来深刻影响的创新技术的肯定。     

Saturn 2000 GC/MS、GC/MS/MS,面向21世纪的技术

瓦里安公司以雄厚的科技实力一直领导着台式气一质联用仪的发展潮流，为无数的环境、药理、法医、制药和化工行业的用户提供了灵敏度高，性能可靠，操作、维护简单的台式气一质联用仪。最新型号质谱仪Saturn2000的问世，为实现气一质联用仪的全自动分析操作翻开了崭新的篇章。对于任何复杂的被分析物，您可以在分析中随意优化操作条件以达到最佳的灵敏度和选择性。只要简单地用鼠标选择不同的操作模式。全扫描EI／MS‘EI／MS／MS，选择离子储存（SIS），CI／MSfoCI／MS／MS，Saturn2000质谱仪可以完成剩余的一切。瓦里安公司的内…     

应用气相色谱-质谱技术保证农药残留分析质量的研究

应用气相色谱 -质谱 ( GC/ MS)对参加世界卫生组织食品安全项目的农药残留质量保证进行研究 ,讨论了该技术使用的有限性 ,并提出建议。在非最佳设备条件下 ,通过良好的样品制备及有效合理地使用毛细管或填充柱 GC/ MS方法 ,进行有效的、低成本的定性和定量农药残留分析     

GC／MS联用及其实验技术

叙述了当今GC／MS（Gas—chromatograph／Massspectrometer）联用的技术状态时GC／MS的分析结果作了评价，并详细讨论了提高检索匹配的诸因素。     

安捷伦科技动态

发布可用于实验室外分析的高性能车载GC／MS 安捷伦科技在“Pittcon2010”发布了5975T低热容（LTM）气相色谱／质谱检测仪（GC／MSD）。安捷伦采用低热容（LTM）专利技术将5975TLTMGC／MS开发得更为小巧耐用,耗电量远远低于常规实验室所用的GC／MS仪器,却在现场检测时具备与实验室仪器同样出色的分析性能。     

瓦里安Saturn 2000台式GC／MS

瓦里安Saturn2000GC／MS是一套完整的台式GC／MS／DS系统。该系统提供无与伦比的灵敏度和灵活性。Sat－urn2000可让您做全扫EI或CI，选择高于储存，及EI／MS／MS或CI／MS／MS。谱图可用标准谱库作正确检索，结果完全可信。数据系统完全与Windows95及标准网络软件兼容，标准报告和改编的报告软件设计完全满足您的最高要求，符合GLP要求的软件提供完整的调谐条件，分析条件，时间和日期记录以及其他必要信息。性能特点·瓦里安GCStar3400CX配ic78温度可编程分流／不分流进样口可分析各种类型的化合物，极性的，非极性的和热不…     

超高效液相色谱(UPLCTM)与质谱联用技术:-改善药残和代谢物分析的结果质量

介绍了最新的UPLC^TM技术及其与质谱联用对药残及代谢物分析。UPLC与质谱联用不仅获得高速、高分离度，而且显著地提高质谱检测的灵敏度。对于需要高灵敏度的药残及其痕量代谢物的分析，UPIC/MS/MS技术是当今最有效的工具之一。     

Recent advances in mycotoxin determination in food and feed by hyphenated chromatographic techniques/mass spectrometry

Mycotoxins are fungal toxins produced by molds, which occur universally in food and feed derivatives, and are produced under certain environmental conditions in the field before harvest, post-harvest, during storage, processing, and feeding. Mycotoxin contamination is one of the most relevant and worrisome problem concerning food and feed safety because it can cause a variety of toxic acute and chronic effects in human and animals. In this review we report the use of mass spectrometry in connection with chromatographic techniques for mycotoxin determination by considering separately the most diffuse class of mycotoxins: patulin, aflatoxins, ochratoxin A, zearalenone, trichothecenes, and fumonisins. Although the selectivity of mass spectrometry is unchallenged if compared to common GC and LC detection methods, accuracy, precision, and sensitivity may be extremely variable concerning the different mycotoxins, matrices, and instruments. The sensitivity issue may be a real problem in the case of LC/MS, where the response can be very different for the different ionization techniques (ESI, APCI, APPI). Therefore, when other detection methods (such as fluorescence or UV absorbance) can be used for the quantitative determination, LC/MS appears to be only an outstanding confirmatory technique. In contrast, when the toxins are not volatile and do not bear suitable chromophores or fluorophores, LC/MS appears to be the unique method to perform quantitative and qualitative analyses without requiring any derivatization procedure. The problem of exact quantitative determination in GC/MS and LC/MS methods is particularly important for mycotoxin determination in food, given the high variability of the matrices, and can be solved only by the use of isotopically labeled internal standards or by the use of ionization interfaces able to lower matrix effects and ion suppressions. When the problems linked to inconstant ionization and matrix effects will be solved, only MS detectors will allow to simplify more and more the sample preparation procedures and to avoid clean-up procedures, making feasible low-cost, high-throughput determination of mycotoxins in many different food matrices.     

高效液相色谱-质谱技术在食品安全检测中的应用

本文综述高效液相色谱及其与紫外、质谱检测器在食品安全检测中的应用。详述食品中三聚氰胺、苏丹红、食品添加剂、农药残留量、抗生素药物残留量、毒素的检测等的检测技术。对于保证食品质量、维护人民健康安全有着重要意义。     

液相色谱-质谱联用技术在中药农药残留分析中的应用进展

液相色谱-质谱联用(LC-MS/MS)技术在农药残留分析领域的研究已经显示出极大的发展潜力。本文阐述LC-MS/MS法在农残分析中的研究进展,特别强调了该技术在中药农残分析中的应用现状和发展前景。由于样品前处理是农残分析中耗时最多、最易引起误差的关键环节,本文也讨论了最近发展和广泛应用的前处理技术,分析了不同方法的特点,从而为我国中药行业在农药残留方面的监测工作提供参考。     

Current mass spectrometry strategies for the analysis of pesticides and their metabolites in food and water matrices

Analysis of pesticides and their metabolites in food and water matrices continues to be an active research area closely related to food safety and environmental issues. This review discusses the most widely applied mass spectrometric (MS) approaches to pesticide residues analysis over the last few years. The main techniques for sample preparation remain solvent extraction and solid‐phase extraction. The QuEChERS (Quick, Easy, Cheap, Effective, Rugged, Safe) approach is being increasingly used for the development of multi‐class pesticide residues methods in various sample matrices. MS detectors—triple quadrupole (QqQ), ion‐trap (IT), quadrupole linear ion trap (QqLIT), time‐of‐flight (TOF), and quadrupole time‐of‐flight (QqTOF)—have been established as powerful analytical tools sharing a primary role in the detection/quantification and/or identification/confirmation of pesticides and their metabolites. Recent developments in analytical instrumentation have enabled coupling of ultra‐performance liquid chromatography (UPLC) and fast gas chromatography (GC) with MS detectors, and faster analysis for a greater number of pesticides. The newly developed “ambient‐ionization” MS techniques (e.g., desorption electrospray ionization, DESI, and direct analysis in real time, DART) hyphenated with high‐resolution MS platforms without liquid chromatography separation, and sometimes with minimum pre‐treatment, have shown potential for pesticide residue screening. The recently introduced Orbitrap mass spectrometers can provide high resolving power and mass accuracy, to tackle complex analytical problems involved in pesticide residue analysis. © 2010 Wiley Periodicals, Inc., Mass Spec Rev 30:907–939, 2011     

Analysis of macrolide antibiotics, using liquid chromatography-mass spectrometry, in food, biological and environmental matrices

Macrolides are a group of antibiotics that have been widely used in human medical and veterinary practices. Analysis of macrolides and related compounds in food, biological, and environmental matrices continue to be the focus of scientists for the reasons of food safety, pharmacokinetic studies, and environmental concerns. This article presents an overview on the primary biological properties of macrolides and their associated analytical issues, including extraction, liquid chromatography-mass spectrometry (LC-MS), method validation, and measurement uncertainty. The main techniques that have been used to extract macrolides from various matrices are solid-phase extraction and liquid-liquid extraction. Conventional liquid chromatography (LC) with C18 columns plays a dominant role for the determination of macrolides, whereas ultra-performance liquid chromatography (UPLC) along with sub-2 microm particle C18 columns reduces run time and improves sensitivity. Mass spectrometry (MS), serving as a universal detection technique, has replaced ultraviolet (UV), fluorometric, and electrochemical detection for multi-macrolide analysis. The triple-quadrupole (QqQ), quadrupole ion trap (QIT), triple-quadrupole linear ion trap, time-of-flight (TOF), and quadrupole time-of-flight (QqTOF) mass spectrometers are current choices for the determination of macrolides, including quantification, confirmation, identification of their degradation products or metabolites, and structural elucidation. LC or UPLC coupled to a triple-quadrupole mass spectrometer operated in the multiple-reaction monitoring (MRM) mode (LC/MS/MS) is the first choice for quantification. UPLC-TOF or UPLC-QqTOF has been recognized as an emerging technique for accurate mass measurement and unequivocal identification of macrolides and their related compounds.     

黄泥煨制人参中皂苷成分的RRLC-Q-TOF MS分析

人参作为新资源食品,有多种炮制方法的应用。本研究对于黄泥煨制的人参化学成分是否安全、可靠提供了借鉴。利用高分离度快速液相色谱-四极杆-飞行时间质谱(RRLC-Q-TOF MS)法研究黄泥煨炮制方法的人参化学成分。鲜人参黄泥煨制的样品溶解离心过滤后,采用Agilent ZORBAX SB-C18色谱柱,以0.1%甲酸水-乙腈溶液作为流动相进行梯度洗脱,高分辨质谱进行检测,Masshunter Qualitative Analysis软件与人工相结合进行数据分析。结果表明,本研究鉴定了31种人参皂苷,比较了黄泥煨制人参与其他炮制方法人参中人参皂苷的相对百分含量差异,同时检测到F_2、Rg_3等稀有人参皂苷。该研究可为人参的使用提供更多的途径,能够为开发人参的多种保健功能提供依据。     

Mass spectrometry in grape and wine chemistry. Part II: The consumer protection

Controls in food industry are fundamental to protect the consumer health. For products of high quality, warranty of origin and identity is required and analytical control is very important to prevent frauds. In this article, the "state of art" of mass spectrometry in enological chemistry as a consumer safety contribute is reported. Gas chromatography-mass spectrometry (GC/MS) and liquid-chromatography-mass spectrometry (LC/MS) methods have been developed to determine pesticides, ethyl carbamate, and compounds from the yeast and bacterial metabolism in wine. The presence of pesticides in wine is mainly linked to the use of dicarboxyimide fungicides on vineyard shortly before the harvest to prevent the Botrytis cinerea attack of grape. Pesticide residues are regulated at maximum residue limits in grape of low ppm levels, but significantly lower levels in wine have to be detected, and mass spectrometry offers effective and sensitive methods. Moreover, mass spectrometry represent an advantageous alternative to the radioactive-source-containing electron capture detector commonly used in GC analysis of pesticides. Analysis of ochratoxin A (OTA) in wine by LC/MS and multiple mass spectrometry (MS/MS) permits to confirm the toxin presence without the use of expensive immunoaffinity columns, or time and solvent consuming sample derivatization procedures. Inductively coupled plasma-mass spectrometry (ICP/MS) is used to control heavy metals contamination in wine, and to verify the wine origin and authenticity. Isotopic ratio-mass spectrometry (IRMS) is applied to reveal wine watering and sugar additions, and to determine the product origin and traceability.